Cette thèse est consacrée à l’étude de la dynamique de quelques problèmes de proie-prédateur de type Leslie-Gower avec des systèmes d’équations différentielles ordinaires et des équations de réaction-diffusion. L’objectif principal est de faire l’analyse mathématique, la simulation numérique des modèles construits. La thèse est divisée en trois parties : La première partie est consacrée à un système proie-prédateur avec récolte de proie, le modèle est donné par un système d’équation différentielle ordinaire. Le but de cette partie est d’étudier l’impact de la récolte sur le comportement du système. Dans la deuxième partie, nous introduisons la dimension spatiale dans le modèle dynamique considéré sans récolte, modélisant une chaîne alimentaire de deux espèces avec diffusion sur un domaine circulaire et une fonction de réponse de Holling type II. Nous effectuons une analyse théorique complète de la dynamique spatio-temporelle du modèle construit ainsi que l’étude du système sur le domaine circulaire. Une étude mathématique similaire est menée dans le cadre de la réponse fonctionnelle de Benddington-DeAngelis. Nous étudions, aussi le comportement qualitatif d’une chaîne alimentaire de trois espèces avec une réponse fonctionnelle de Holling type II. Dans la dernière partie, nous introduisons des termes de diffusions croisées dans le modèle dynamique considéré dans le but d’avoir l’effet de ce dernier sur le comportement du système. / This thesis is devoted to the study of the dynamics of some problems Leslie Gower-type predator-prey with ordinary differential equations and reaction-diffusion equations. The main objective is to make mathematical analysis, numerical simulation of constructed models. The thesis is divided in three parts : The first part is devoted to a predator-prey system with prey harvesting, the model is given by an ordinary differential equation system. The aim of this part is to study the impact of harvesting on the system behavior. In the second part, we introduce the spatial dimension in the dynamic model considered without harvesting, modeling a food chain of two species with diffusion on the circular area and Holling Type II response function. We perform a complete theoretical analysis of the spatiotemporal dynamics model built and the system study on the circular area. A similar mathematical study is conducted as part of the functional response of Benddington-DeAngelis.We study, also the qualitative behavior of a food chain of three species with a Holling type II response function. In the last party, we introduce of cross-diffusion terms in the considered dynamic model in order to have the effect of the latter on the system behavior.

In this dissertation we generalise the basic theory of Hopf algebras to the context of autonomous pseudomonoids in monoidal bicategories. Autonomous pseudomonoids were introduced in [13] as generalisations of both autonomous monoidal categories and Hopf algebras. Much of the theory of autonomous pseudomonoids developed in [13] was inspired by the example of autonomous (pro)monoidal enriched categories. The present thesis aims to further develop the theory with results inspired by Hopf algebra theory instead. We study three important results in Hopf algebra theory: the so-called 'fundamental theorem of Hopf modules', the 'Drinfel'd quantum double' and its relation with the centre of monoidal categories, and 'Radford's formula'. The basic result of this work is a general fundamental theorem of Hopf modules that establishes conditions equivalent to the existence of a left dualization. With this result as a base, we are able to construct the centre (defined in [83]) and the lax centre of an autonomous pseudomonoid as an Eilenberg-Moore construction for certain monad. As an application we show that the Drinfel'd double of a finite-dimensional Hopf algebra is equivalent to the centre of the associated pseudomonoid. The next piece of theory we develop is a general Radford's formula for autonomous map pseudomonoids formula in the case of a (coquasi) Hopf algebra. We also introduce 'unimodular' autonomous pseudomonoids. In the last part of the dissertation we apply the general theory to enriched categories with a (chosen) class of (co)limits, with emphasis in the case of finite (co)limits. We construct tensor products of such categories by means of pseudo-commutative enriched monads (a slight generalisation of the pseudo-commutative 2-monads of [37], and showing that lax-idempotent 2-monads are pseudo-commutative. Finally we apply the general theory developed for pseudomonoids to deduce the main results of [27].

abstract: Cancer is a worldwide burden in every aspect: physically, emotionally, and financially. A need for innovation in cancer research has led to a vast interdisciplinary effort to search for the next breakthrough. Mathematical modeling allows for a unique look into the underlying cellular dynamics and allows for testing treatment strategies without the need for clinical trials. This dissertation explores several iterations of a dendritic cell (DC) therapy model and correspondingly investigates what each iteration teaches about response to treatment. In Chapter 2, motivated by the work of de Pillis et al. (2013), a mathematical model employing six ordinary differential (ODEs) and delay differential equations (DDEs) is formulated to understand the effectiveness of DC vaccines, accounting for cell trafficking with a blood and tumor compartment. A preliminary analysis is performed, with numerical simulations used to show the existence of oscillatory behavior. The model is then reduced to a system of four ODEs. Both models are validated using experimental data from melanoma-induced mice. Conditions under which the model admits rich dynamics observed in a clinical setting, such as periodic solutions and bistability, are established. Mathematical analysis proves the existence of a backward bifurcation and establishes thresholds for R0 that ensure tumor elimination or existence. A sensitivity analysis determines which parameters most significantly impact the reproduction number R0. Identifiability analysis reveals parameters of interest for estimation. Results are framed in terms of treatment implications, including effective combination and monotherapy strategies. In Chapter 3, a study of whether the observed complexity can be represented with a simplified model is conducted. The DC model of Chapter 2 is reduced to a non-dimensional system of two DDEs. Mathematical and numerical analysis explore the impact of immune response time on the stability and eradication of the tumor, including an analytical proof of conditions necessary for the existence of a Hopf bifurcation. In a limiting case, conditions for global stability of the tumor-free equilibrium are outlined. Lastly, Chapter 4 discusses future directions to explore. There still remain open questions to investigate and much work to be done, particularly involving uncertainty analysis. An outline of these steps is provided for future undertakings. / Dissertation/Thesis / Doctoral Dissertation Applied Mathematics 2020

We present the supersymmetry and localization of an N=2 theory on S3b along with that of an N=(2,2) theory on S2. Performing the dimensional reduction of the theory on S3b produces a theory on S2 with no flux-sectors. A re-evaluated version of twisted reduction is applied on the level of the S3b partition function, arguing for a splitting of the partition function into pieces. The splitting produces flux-like sectors correspondent to the S2 theory but holds the potential for superfluous sectors. An argument interpreting these sectors as true flux is given and utilized to remove superfluous sectors due to topological restrictions on S2. The final result is a method which gives a bijective mapping ZS3b to ZS2 . / Vi utför konstruktionen av två supersymmetriska teorier på en deformerad 3-sfär samt en 2-sfär. Den utökade symmetrin tillåter oss att använda en lokaliseringsmetod för att reducera partitionsfunktionerna till ändligt-dimensionella integraler. På 2-sfären finner vi diskreta konfigurationer vars tolkning vi vill finna i konstruktionen på 3-sfären. Vi utför en dimensionell reduktion ifrån 3-sfären till 2-sfären och finner en ekvivalens som saknar dessa konfigurationer. Som substitut presenteras en metod där integralen delas upp i delar som kan tolkas att vara ekvivalenta med de avsaknade diskreta konfigurationerna. Slutligen framförs ett argument för vilka delar av integralen som kan existera på 2-sfären och resterande delar avfärdas. Resultatet är en exakt avbilding mellan partitionsfunktionerna.

The N= 4 Super Yang-Mills theory in four dimensions admits deformations and the exactly marginal deformations of its SU(3) R-symmetry sub-sector are known as Leigh-Strassler. Leigh-Strassler deformations break the N= 4 supersymmetry down to N= 1 while preserving conformal symmetry. With exactly marginal deformations only the F-terms are deformed thus Leigh-Strassler deformations only affect the superpotential in the Lagrangian. In this thesis we study the symmetry of the marginally deformed N= 4 SYM and demonstrate that its algebraic structure can be understood in terms of quasi-Hopf algebras. Quasi-Hopf algebras have a notion of twisting due to Drinfeld which makes them a natural mathematical language with which to treat deformations. Furthermore the deformation of the N= 4 SYM superpotential is automated by the definition of a suitable star product. / Thesis (PhD)--University of Pretoria, 2020. / NiTheP / Physics / PhD / Unrestricted

We define a faithful linear monoidal functor from the partition category, and hence from Deligne's category Rep(S_t), to the additive Karoubi envelope of the Heisenberg category. We show that the induced map on Grothendieck rings is injective and corresponds to the Kronecker coproduct on symmetric functions. We then generalize the above results to any group G, the case where G is the trivial group corresponding to the case mentioned above. Thus, to every group G we associate a linear monoidal category Par(G) that we call a group partition category. We give explicit bases for the morphism spaces and also an efficient presentation of the category in terms of generators and relations. We then define an embedding of Par(G) into the group Heisenberg category associated to G. This embedding intertwines the natural actions of both categories on modules for wreath products of G. Finally, we prove that the additive Karoubi envelope of Par(G) is equivalent to a wreath product interpolating category introduced by Knop, thereby giving a simple concrete description of that category.

In this thesis, we study the population dynamics of predator-prey interactions described by mathematical models with age/stage structures. We first consider fixed development times for predators and prey and develop a stage-structured predator-prey model with Holling type II functional response. The analysis shows that the threshold dynamics holds. That is, the predator-extinction equilibrium is globally stable if the net reproductive number of the predator $\mathcal{R}_0$ is less than $1$, while the predator population persists if $\mathcal{R}_0$ is greater than $1$. Numerical simulations are carried out to demonstrate and extend our theoretical results. A general maturation function for predators is then assumed, and an age-structured predator-prey model with no age structure for prey is formulated. Conditions for the existence and local stabilities of equilibria are obtained. The global stability of the predator-extinction equilibrium is proved by constructing a Lyapunov functional. Finally, we consider a special case of the maturation function discussed before. More specifically, we assume that the development times of predators follow a shifted Gamma distribution and then transfer the previous model into a system of differential-integral equations. We consider the existence and local stabilities of equilibria. Conditions for existence of Hopf bifurcation are given when the shape parameters of Gamma distributions are $1$ and $2$.

No description available.

Significant progress has been made in understanding different scenarios for disease transmissions and behavior of epidemics in recent years. A considerable amount of work has been done in modeling the dynamics of diseases by systems of ordinary differential equations. But there are very few mathematical models that deal with the genetic mutations of a pathogen. In-fact, not much has been done to model the dynamics of mutations of pathogen explaining its effort to escape the host's immune defense system after it has infected the host. In this dissertation we develop an SIR model with variable infection age for the transmission of a pathogen that can mutate in the host to produce a second infectious mutant strain. We assume that there is a period of temporary immunity in the model. A temporary immunity period along with variable infection age leads to an integro-differential-difference model. Previous efforts on incorporating delays in epidemic models have mainly concentrated on inclusion of latency periods (this assumes that the force of infection at a present time is determined by the number of infectives in the past). We begin with reviewing some basic models. These basic models are the building blocks for the later, more detailed models. Next we consider the model for mutation of pathogen and discuss its implications. Finally, we improve this model for mutation of pathogen by incorporating delay induced by temporary immunity. We examine the influence of delay as we establish the existence, and derive the explicit forms of disease-free, boundary and endemic equilibriums. We will also investigate the local stability of each of these equilibriums. The possibility of Hopf bifurcation using delay as the bifurcation parameter is studied using both analytical and numerical solutions.

Our goal in this thesis is to study the dynamics of the classical predator-prey model and the predator-prey model in the chemostat when a discrete delay is introduced to model the time between the capture of the prey and its conversion to biomass. In both models we use Holling type I response functions so that no oscillatory behavior is possible in the associated system when there is no delay. In both models, we prove that as the parameter modelling the delay is varied Hopf bifurcation can occur. However, we show that there seem to be differences in the possible sequences of bifurcations. Numerical simulations demonstrate that in the classical predator-prey model period doubling bifurcation can occur, possibly leading to chaos while that is not observed in the chemostat model for the parameters we use. For a delay differential equation, a prerequisite for Hopf bifurcation is the existence of a pair of pure imaginary eigenvalues for the characteristic equation associated with the linerization of the system. In this case, the characteristic equation is a transcendental equation with delay dependent coefficients. For our models, we develop two different methods to show how to find values of the bifurcation parameter at which pure imaginary eigenvalues occur. The method used for the classical predator-prey model was developed first. However, it was necessary to develop a more robust, less complicated method to analyze the predator-prey model in the chemostat with a discrete delay. The latter method was then generalized so that it could be applied to any second order transcendental equation with delay dependent coefficients. / Thesis / Doctor of Philosophy (PhD)