Yes / Reducing tube voltage is an effective dose saving method in computed tomography (CT) assuming tube current is not concurrently increased. Recent innovations in scanner technology now enable CT tube voltage reduction to 70 kV thereby increasing opportunities for dose reduction in paediatric patients, but it is unclear if the increased image noise associated with 70 kV impacts on ability to visualise renal stones accurately. The purpose was to assess detectability of nephrolithiasis using a bespoke paediatric phantom and low kV, non-contrast CT and to assess inter-observer agreement. Methods: Forty-two renal stones of different size and chemical composition were inserted into porcine kidneys and positioned in a bespoke, water-filled phantom mimicking a 9-year-old child weighing approximately 33kg. The phantom was scanned using 120 and 70 kV CT protocols, and the detectability of the stones was assessed by three radiologists. Absolute agreement and Fleiss’ kappa regarding detectability were assessed. Results: The mean diameter of renal stones as measured physically was 4.24 mm ranging from 1 to 11 mm. Four stones were missed by at least one observer. One observer had a sensitivity of 93 and 95% at 70 and 120 kV, respectively, while the sensitivity for observers 2 and 3 was 98% at both kV levels. Specificity was 100% across readers and kV levels. Absolute agreement between the readers at 70 kV was 92% (kappa = 0.86) and 98% (kappa = 0.96) at 120 kV indicating a strong agreement at both kV levels. Conclusions: The results suggest that lowering the kV does not affect the detection rate of renal stones and may be a useful dose reduction strategy for assessment of nephrolithiasis in children.

In recent years, reconfigurable devices are developing fast because of its flexibility and less development cost. But intrinsic shortcomings of reconfigurable devices, for example, high power, low speed, etc. induce difficulties in complex designs realizations. So people began to consider combination of ASIC (Application-Specific Integrated Circuit) and reconfigurable device on a single chip, which is SOPC (System on Programmable Chip). SOPC can not only decrease development risk and timing to market, but also be used in different applications, especially of products that keep varying, for example, communication and network products. Dynamically reconfiguration means reconfigurable device of the chip can be reconfigured repeatable, and performs different functions at different times. Compared with static reconfiguration, dynamic reconfiguration can use the reconfigurable device more thoroughly. It‟s a hot spot of research in the world, especially in reconfigurable computing. This paper mainly concludes my research work in reconfigurable SOPC in 3 major parts: hardware, software and application. The following works and innovations are completed: 1. SOPC hardware system architecture design and discussion. Helps to define the system architecture and design goals. The design of EBI controller which is used in the SOPC. The integration of the blocks in the system. 2. The building-up of the SOPC system-level verification and block-level verification environment. The set-up of the hardware-software co-simulation environment. The post-layout simulation and formal verification tasks. We propose an innovative automated regression system. The system helps to achieve the same simulation coverage (95%) and the total simulation time is reduced by approximately 30%. 3. SOPC software design, including the OS kernel porting, drivers design and application design. The design of the PowerPC initialization program and UART (Universal Asynchronous Receiver/Transmitter), reconfiguring communication driver programs. Writing the test-cases which are specialized for the system verification and hardware testing. 4. Being the co-designer of the novel bus macro based on the FDP reconfigurable logic core. And we realize the whole reconfigurable system based on this bus macro. 5. The reconfigurable application research based on Reconfigurable Logic Core. The reconfigurable image filter designed implemented on FDP300K Reconfigurable Logic Core device. Using self-design Reconfigurable Logic Core internal bus macro to implement the partial reconfigurable system. The test results showed that the reconfigurable filter has the feature of fast configuration speed and good output image quality.

Yes / Cardiologists use x-ray image sequences of the moving heart acquired in real-time to diagnose and treat cardiac patients. The amount of radiation used is proportional to image quality; however, exposure to radiation is damaging to patients and personnel. The amount by which radiation dose can be reduced without compromising patient care was determined. For five patient image sequences, increments of computer-generated quantum noise (white + colored) were added to the images, frame by frame using pixel-to-pixel addition, to simulate corresponding increments of dose reduction. The noise adding software was calibrated for settings used in cardiac procedures, and validated using standard objective and subjective image quality measurements. The degraded images were viewed next to corresponding original (not degraded) images in a two-alternativeforced- choice staircase psychophysics experiment. Seven cardiologists and five radiographers selected their preferred image based on visualization of the coronary arteries. The point of subjective equality, i.e., level of degradation where the observer could not perceive a difference between the original and degraded images, was calculated; for all patients the median was 33% 15% dose reduction. This demonstrates that a 33% 15% increase in image noise is feasible without being perceived, indicating potential for 33% 15% dose reduction without compromising patient care. / Funded in part by Philips Healthcare, the Netherlands. Part of this work has been performed in the project PANORAMA, co-funded by grants from Belgium, Italy, France, the Netherlands, and the United Kingdom, and the ENIAC Joint Undertaking.

Bisher sind in der Schnittbildgebung zwei Projektionsverfahren üblich: Die Average-Projektion, die das Bildrauschen gut unterdrückt, jedoch die Kantenschärfe verringert und die Maximum-Intensitäts-Projektion (MIP), deren Bilder sich durch eine gute Kantenschärfe auszeichnen, gleichzeitig aber ein höheres Bildrauschen aufweisen. Daher wurde in der vorliegenden Arbeit eine Synthese beider Verfahren, softMip, mit dem Ziel die jeweiligen Vorteile zu vereinen, entwickelt. In einer Phantom-Studie mit sieben verschiedenen CT-Geräten wurden das Bildrauschen und die Kantenschärfe der drei Projektionsverfahren (MIP, Average und softMip) ermittelt. Anschließend wurden die drei Verfahren in einer klinischen Studie bei der Suche nach Harnwegskonkrementen in 31 ULD-CT-Abdomenaufnahmen eingesetzt. Für jedes Projektionsverfahren wurden sowohl Anzahl, Größe und Lokalisation der Harnwegskonkremente als auch die subjektiven Kriterien Bildrauschen, Kontrast, Konturschärfe, Artefakte und Bildeindruck erhoben. softMip weist im Phantomversuch ein geringeres Bildrauschen als MIP auf (p / Two projection algorithms exist in the cross sectional imaging: Average projection, which features good suppression of image noise, however the edge sharpness diminishes. In maximum-intensity-projection (MIP), images show good edge sharpness, but also amplified image noise. We developed softMip, a synthesis of both algorithms which tries to unite the respective advantages. In a phantom trial on seven different CT-devices, image noise and edge sharpness of the three projection algorithms (MIP, Average and softMip) were aquired. Furthermore image quality of the transition from Average to MIP by means of softMip was compared to the image quality of alpha blending average projection and MIP. In a clinical trial we investigated softMip compared to MIP and average projection in ULDCT examinations of 31 patients with suspected calcifications in the urinary tract. For each projection algorithm amount, size and localization of the calcifications as well as the subjective criteria image noise, contrast, contour sharpness, artifacts and overall image impression were documented. softMip showed a less image noise than a MIP (p

With arrival of affordable digital technology we are increasingly coming into contact with digital images. Cameras are no longer dedicated devices, but part of almost every mobile phone, PDA and laptop. This paper discusses methods for enhancing quality of digital images with focus on removing noise, creating high dynamic range (HDR) images and extending depth of field (DOF). It contains familiarization with technical means for acquiring digital image, explains origin of image noise. Further attention is drawn to HDR, from explaining the term, physical basis, difference between HDR sensing and HDR displaying, to survey and historical development of methods dealing with creating HDR images. The next part is explaining DOF when displaying, physical basis of this phenomenon and review of methods used for DOF extension. The paper mentions problem of acquiring images needed for solving given tasks and designs method for acquiring images. Using it a database of test images for each task was created. Part of the paper also deals with design of a program, that implements discussed methods, for solving the given tasks. With help of proposed class imgmap, quality of output images is improved, by modifying maps of input images. The paper describes methods, improvements, means of setting parameters and their effects on algorithms and control of program using proposed GUI. Finally, comparison with free software for extending DOF takes place. The proposed software provides at least comparable results, the correct setting of parameters for specific cases allows to achieve better properties of the resulting image. Time requirements of image processing are worse because designed software was not optimised.

Yes / Dynamic X-ray imaging systems are used for interventional cardiac procedures to treat coronary heart disease. X-ray settings are controlled automatically by specially-designed X-ray dose control mechanisms whose role is to ensure an adequate level of image quality is maintained with an acceptable radiation dose to the patient. Current commonplace dose control designs quantify image quality by performing a simple technical measurement directly from the image. However, the utility of cardiac X-ray images is in their interpretation by a cardiologist during an interventional procedure, rather than in a technical measurement. With the long term goal of devising a clinically-relevant image quality metric for an intelligent dose control system, we aim to investigate the relationship of image noise with clinical professionals’ perception of dynamic image sequences. Computer-generated noise was added, in incremental amounts, to angiograms of five different patients selected to represent the range of adult cardiac patient sizes. A two alternative forced choice staircase experiment was used to determine the amount of noise which can be added to a patient image sequences without changing image quality as perceived by clinical professionals. Twenty-five viewing sessions (five for each patient) were completed by thirteen observers. Results demonstrated scope to increase the noise of cardiac X-ray images by up to 21% ± 8% before it is noticeable by clinical professionals. This indicates a potential for 21% radiation dose reduction since X-ray image noise and radiation dose are directly related; this would be beneficial to both patients and personnel. / This work was funded by Philips Healthcare, NL. Part of this work has been performed in the project PANORAMA, cofunded by grants from Belgium, Italy, France, the Netherlands, and the United Kingdom, and the ENIAC Joint Undertaking.

This thesis focuses on image processing using wavelet transform. The usage of wavelet transform is analysed especially for image compression and image noise reduction purposes. The analysis describes in detail aspects and application of the following wavelet transform methods: CWT, DWT, DTWT, 2D DWT. The thesis further explains the meaning of the mother wavelet and studies certain specific kinds of wavelets, kinds of thresholding and its purposes and also touches on the JPEG2000 standard. Mathematica and Sage software packages were used to design algorithms for image compression and image noise reduction, utilising relevant wavelet transform findings. The concluding part of the thesis compares the two software packages and results obtained using different algorithms.

This thesis describes the theoretical, experimental, and practical aspects of a noise-limited method for scene-change detection in images. The research is divided into three sections: noise analysis and modelling, dual illumination scene-change modelling, and integration of noise into the scene-change model. The sources of noise within commercially available digital cameras are described, with a new model for image noise derived for charge-coupled device (CCD) cameras. The model is validated experimentally through the development of techniques that allow the individual noise components to be measured from the analysis of output images alone. A generic model for complementary metal-oxide-semiconductor (CMOS) cameras is also derived. Methods for the analysis of spatial (inter-pixel) and temporal (intra-pixel) noise are developed. These are used subsequently to investigate the effects of environmental temperature on camera noise. Based on the cameras tested, the results show that the CCD camera noise response to variation in environmental temperature is complex whereas the CMOS camera response simply increases monotonically. A new concept for scene-change detection is proposed based upon a dual illumination concept where both direct and ambient illumination sources are present in an environment, such as that which occurs in natural outdoor scenes with direct sunlight and ambient skylight. The transition of pixel colour from the combined direct and ambient illuminants to the ambient illuminant only is modelled. A method for shadow-free scene-change is then developed that predicts a pixel's colour when the area in the scene is subjected to ambient illumination only, allowing pixel change to be distinguished as either being due to a cast shadow or due to a genuine change in the scene. Experiments on images captured in controlled lighting demonstrate 91% of scene-change and 83% of cast shadows are correctly determined from analysis of pixel colour change alone. A statistical method for detecting shadow-free scene-change is developed. This is achieved by bounding the dual illumination model by the confidence interval associated with the pixel's noise. Three benefits arise from the integration of noise into the scene-change detection method: - The necessity for pre-filtering images for noise is removed; - All empirical thresholds are removed; and - Performance is improved. The noise-limited scene-change detection algorithm correctly classifies 93% of scene-change and 87% of cast shadows from pixel colour change alone. When simple post-analysis size-filtering is applied both these figures increase to 95%.

This thesis focuses on image processing using wavelet transform. The usage of wavelet transform is analysed especially for image compression and image noise reduction purposes. The analysis describes in detail aspects and application of the following wavelet transform methods: CWT, DWT, DTWT, 2D DWT. The thesis further explains the meaning of the mother wavelet and studies certain specific kinds of wavelets, kinds of thresholding and its purposes and also touches on the JPEG2000 standard. Mathematica and Sage software packages were used to design algorithms for image compression and image noise reduction, utilising relevant wavelet transform findings. The concluding part of the thesis compares the two software packages and results obtained using different algorithms.