The Compact Linear Collider (CUC) is a proposed electron-positron collider with a centre- of-mass energy of 0.5 to 5 TeV, optimised for a nominal centre-of-mass energy of 3 TeV, at high luminosities exceeding 1034 cm-2s-J. The high beam charges in the CUC beams make classical techniques for measuring the transverse beam size such as optical transition radiation (OTR) screens or wire scanners very difficult, which necessitates the use of non-invasive beam- size monitors. The laser-wire is a system that meets these requirements; it uses inverse Compton scattering to determine transverse beam-sizes by scanning a laser beam across the electron beam. This thesis describes how such a laser-wire system was installed and operated at PETRA-III at DESY, which uses an automated mirror to scan a Q-switched laser pulse across the electron beam and is developed from the system previously operated at PETRA-II. The measurements of key performance parameters are described and used in determining the emittance of the PETRA-III beam. The thesis includes a detailed investigation of the laser .' system as well as the collision measurements. Furthermore, simulations were carried out to design a similar system for the proposed transfer line of the CUC Drive-Beam and the necessary baseline characteristics of such a system are described.

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K+Λ photoproduction provides the best possibility for a model independent extraction of the photoproduction process and contributing resonances. To do this, it is vital that cross section measurements are well understood. This thesis presents pγ K+Λ differential cross sections from the reaction threshold, to an invariant centre of mass energy of 1.87 GeV. The data was taken at MAMI-C electron microtron facility in Mainz, Germany, during July 2007 and April 2009. The 1.5 GeV MAMI-C electron beam was used to produce an energy tagged bremsstrahlung photon beam with a maximum energy of 1.4 GeV and an intensity of 105γs-1MeV-1. The beam impinged upon a liquid hydrogen target, with reaction products detected in two segmented calorimeter arrays; the Crystal Ball detector and TAPS. This work pioneers a new method of K+ detection in segmented calorimeters, in which the K+ was identified from the signature of its weak decay inside the crystals of the calorimeter. This proved to be an excellent method of isolating K+ and accessing strangeness photoproduction channels, with good agreement between experimental and Geant4 simulated data. A novel method in seperating K+Λ and K+Σ0 final states was also developed by identifying the photon from the decay: Σ0 → Λγ. The intense photon beam at the MAMI-C facility enabled differential cross section data with greater invariant mass resolution than previous measurements. The new measurement near threshold imposes important constraints to effective field theories based on the approximate chiral symmetry of QCD. At higher centre of mass energies it also addresses the current problem of discrepant data sets and will form an important constraint on partial wave analysis for the nucleon excitation spectrum. As such, this work contributes to a major world wide programme aiming to extract the excitation spectrum of the nucleon and to understand the dynamics and interactions of its constituents. The greater statistics near threshold, and particularly at backwards K+ centre of mass angles will give new valuable constraints to contributions from meson and hyperonic resonances on the reaction mechanism. The high resolution of the photon beam (approximately 2 MeV) also allows the first search for narrow resonances coupling to KΛ final states. The differential cross sections give good agreement with Kaon-MAID partial wave solutions, apart from at backward angles close to threshold, where the data is lower. Near threshold, the data agrees with calculations from the chiral unitary framework of Borasoy et al, tending to be in better accordance with the model than previous data. No strong structure from potential narrow resonance states was observed over the centre of mass energy region of 1650-1700 MeV, where narrow structure has been observed in recent η photoproduction of the neutron.

The Industrial Laser is firmly established in metalcutting as the tool of choice for many applications. The elevator division of Montgomery KONE Inc., in an effort to move towards quality, ontime, complete deliveries and 100% customer satisfaction, decided to invest in new equipment to improve manufacturing processes. A huge investment is proposed for a laser-cutting machine. It is the responsibility of Manufacturing Engineering to direct the management by justifying its benefits, which includes payback time and financial gains. Factors such as common line cutting, automated material handling system and cutting time were involved in justification of the initial cost of a laser-cutting machine. Comparative statistics on appropriate factors accurately determine and justify the initial cost of a laser-cutting machine.

The non-linear beam dynamics of a circular accelerator, such as the Large Hadron Collider, can have a significant impact on its operation. In order to avoid limitations on the performance reach of the accelerator, and ensure machine protection, it is vital that the beam dynamics are well understood and controlled. This thesis presents the results of studies of non-linear beam dynamics undertaken on the Large Hadron Collider at CERN, during the 2010 to 2013 period. It sets out to quantify the understanding of the non-linear beam dynamics through the comparison of beam-based measurements to simulation, and where able and appropriate seeks to explain deviations of measurement from the model, and define corrections for relevant aspects of the dynamics. The analyses presented in this thesis represent considerable advances in the understanding of the LHC beam dynamics which should allow for an improved operation of the machine in the coming years.

The aim of this study was to evaluate whether volumetric changes in persistent periapical lesions can be detected in follow-ups six months to five years after apicoectomy using cone-beam computed tomography. Patients with a previous treatment history of apicoectomy and for whom a pre-surgical CBCT scan was taken between November 2010 and December 2015 were invited to participate in the study. A post-surgical CBCT image of the treated tooth was obtained at the recall visit. Volumetric and linear measurements of periapical lesions on initial and postoperative CBCT images were performed using DiThreshGUI software and two calibrated examiners—a board-certified endodontist and a board-certified oral radiologist. Repeated-measures ANOVA were used to estimate the magnitude of reduction and to test for differences (at alpha=0.05). A total of 20 patients with 27 surgically treated teeth were recalled at an average interval of 37 months. Reduction in the size of lesions was observed in 24 teeth (88%); overall, the volumes significantly decreased as detected by software-assisted measurement of volume (P = .0002) and by calculation from linear measurements (P < .0001). Volumetric analysis detected a reduction of 86% in lesions while the linear-derived volume measurements yielded an average reduction of 96%. These two methods of lesion assessment were strongly correlated with one another in pre-surgical scans (r>0.88) when apical lesions are measurable.

As a cutting-edge technology for photoinjectors, SRF guns are expected to provide CW electron beams with high bunch charge and low emittance, which is critical to the development of future FELs, ERLs and 4th/5th generation light sources. However, existing research has not explored the full potential of SRF guns as predicted by theory. Currently, the research activities at ELBE focus on solving technological challenges of a 3.5 cell SRF gun as well as applying it to high-bunch-charge experiments. This thesis aims to optimize the ELBE SRF gun and the relevant beam transport for future high-bunch-charge applications at pELBE, nELBE, TELBE and CBS experimental stations. Chapter 1 describes the demands of these applications on the SRF gun in detail. Chapter 2 outlines the development of a simulation tool based on ASTRA and Elegant, followed by the optimized gun parameters and the beam transport for the four experimental stations. Chapter 3 introduces beam diagnostic methods and data processing applied in this thesis. Chapter 4 presents results of experiments, including the pulse length measurement of the UV laser for generating electrons from the photcathode, the commissioning of ELBE SRF Gun II, a verification experiment on the LSC effect conducted at PITZ and a beam transport experiment with the bunch charge of 200 pC. Simulation results have determined the effect of each SRF gun parameter on the beam quality and have provided optimized settings according to the requirements in Chapter 1. Experimentally, the LSC effect was confirmed at PITZ, in agreement with simulations which indicated that LSC significantly influences beam quality. The performance of ELBE SRF Gun II was improved and a beam with a bunch charge of 200 pC and an emittance of 7.7 μm from ELBE SRF Gun II has been transported through ELBE without visible beam loss. The development of the simulation tool and beam diagnostics will serve further research at ELBE. Results of both simulations and experiments enrich the understanding of the existing SRF gun as well as the ELBE beamline and will guide continuing improvements. Already, ELBE SRF Gun II can deliver twice the bunch charge and lower emittance compared to the thermionic injector routinely used for ELBE. Ongoing modifications and development of the gun-cavity and photocathodes are expected to provide still further improvements. Progress on high-bunch-charge experiments at ELBE can be expected by applying the SRF gun.

Hip fracture has been identified as a major worldwide health problem among the elderly population. A fast, accurate and effective evaluation of hip fracture risk is essential for accurate health care planning and selecting a proper treatment. Therefore, the high applicability and the universal availability are required for assessing a technique. The objective of this study was to develop a two-dimensional subject-specific beam model, which is easy to be adopted into a clinical environment to assess hip fracture risk. First, the equivalence between CTXA (computed tomography X-ray absorptiometry) and QCT (quantitative computed tomography) derived femur cross-section stiffness was studied. Then, the CTXA-based femur cross-section stiffness was used in the beam model to calculate the hip fracture risk index (FRI) during sideways fall and single-leg stance loading configuration. Finally, the test of discrimination between PPI (proton-pump inhibitor) users and non-PPI users based on cross-sectional stiffness, BMD (bone mineral density) and FRI was conducted to demonstrate if PPI use is associated with the presence of osteoporosis or accelerated BMD loss. Strong correlation is found between CTXA and QCT derived femur cross-section stiffness, which indicates that QCT can be replaced by CTXA in assessing femur bone quality. Therefore, DXA can be a replacement of QCT to calculate femur cross-sectional properties due to the equivalence between CTXA and DXA derived mechanical properties. It is also demonstrated that the cross-sectional stiffness, BMD, and FRI cannot discriminate the PPI users from non-PPI users, which means that there is no difference between PPI users and non-PPI users in cross-sectional stiffness, BMD, and FRI. This may suggested that PPI use is not associated with the presence of osteoporosis or accelerated BMD loss. The proposed beam model can be easily adopted into clinic to predict hip fracture risk, and this beam model derived FRI can be used in some clinical verification. Yet its accuracy of discriminate fracture will be investigated in a future study. / May 2017

Master of Science / Department of Civil Engineering / Asad Esmaeily / Performance-based building design is a necessity in geographic locations where buildings are susceptible to large earthquakes and high winds. This design method requires an analysis of the performance of the structural system with loadings and deflections caused by earthquakes and wind. Current design codes include the load intensity in analysis procedures, but do not consider the effect of load pattern in the performance analysis of reinforced concrete columns. Because a thorough analysis must take into consideration load pattern and load intensity, computer software is ideal to analyze these systems. A computer program was originally developed by Esmaeily (USC_RC), and was revised later to be renamed (KSU_RC) in order to make the analysis of concrete column performance accurate, yet simple for design purposes. This analytical tool used analytical methods and material models, verified against experimental data, to accurately predict the performance of reinforced concrete columns under various loading conditions, including any pattern in lateral direction and independently variable axial load. However, the program was limited to circular, rectangular, hollow circular and rectangular sections and uniaxial lateral curvature and displacement. The next generation of the program, KSU RC 2.0, was developed to overcome the aforesaid limitations.

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