Healthcare problems are complex; they exhibit both detail and dynamic complexity. It has been argued that Discrete Event Simulation (DES), with its ability to capture detail, is ideal for problems exhibiting this type of complexity. On the other hand, System Dynamics (SD) with its focus on feedback and nonlinear relationships lends itself naturally to comprehend dynamic complexity. Although these modelling paradigms provide valuable insights, neither of them are proficient in capturing both detail and dynamic complexity to the same extent. It has been argued in literature that a hybrid approach, wherein SD and DES are integrated symbiotically, will provide more realistic picture of complex systems with fewer assumptions and less complexity. In spite of wide recognition of healthcare as a complex multi- dimensional system, there has not been any reported study which utilises hybrid simulation. This could be attributed to the fact that due to fundamental differences, the mixing of methodologies is quite challenging. In order to overcome these challenges a generic theoretical framework for hybrid simulation is required. However, there is presently no such generic framework which provides guidance about integration of SD and DES to form hybrid models. This research has attempted to provide such a framework for hybrid simulation which can be utilised in healthcare domain. On the basis of knowledge induced from literature, three requirements for the generic framework have been established. It is argued that the framework for hybrid simulation should be able to provide answers to Why (why hybrid simulation is required), What (what information is exchanged between SD and DES models) and How (how SD and DES models are going to interact with each other over the time to exchange information) within the context of implementation of hybrid simulation to different problem scenarios. In order to meet these requirements, a three-phase generic framework for hybrid simulation has been proposed. Each phase of the framework is mapped to an established requirement and provides guidelines for addressing that requirement. The proposed framework is then evaluated theoretically based on its ability to meet these requirements by using multiple cases, and accordingly modified. It is further evaluated empirically with a single case study comprising of Accident and Emergency department of a London district general hospital. The purpose of this empirical evaluation is to identify the limitations of the framework with regard to the implementation of hybrid models. It is realised during implementation that the modified framework has certain limitations pertaining to the exchange of information between SD and DES models. These limitations are reflected upon and addressed in the final framework. The main contribution of this thesis is the generic framework for hybrid simulation which has been applied within healthcare context. Through an extensive review of existing literature in hybrid simulation, the thesis has also contributed to knowledge in multi-method approaches. A further contribution is that this research has attempted to quantify the impact of intangible benefits of information systems into tangible business process improvements. It is expected that this work will encourage those engaged in simulation (e.g., researchers, practitioners, decision makers) to realise the potential of cross-fertilisation of the two simulation paradigms.

Submitted by Jefferson Aparecido Dias null (jeffdias2000@yahoo.com.br) on 2016-12-16T20:10:01Z No. of bitstreams: 1 Jefferson_Dissertação_Defesa_Final_Total.pdf: 15671726 bytes, checksum: 47295ea03b01caf30d94930c08e18934 (MD5) / Approved for entry into archive by Felipe Augusto Arakaki (arakaki@reitoria.unesp.br) on 2016-12-20T16:54:34Z (GMT) No. of bitstreams: 1 dias_ja_me_bauru.pdf: 15671726 bytes, checksum: 47295ea03b01caf30d94930c08e18934 (MD5) / Made available in DSpace on 2016-12-20T16:54:34Z (GMT). No. of bitstreams: 1 dias_ja_me_bauru.pdf: 15671726 bytes, checksum: 47295ea03b01caf30d94930c08e18934 (MD5) Previous issue date: 2016-11-29 / A crescente demanda de energia elétrica devido ao crescimento populacional nos últimos anos, resultou em uma necessária expansão da matriz energética por meio de fontes alternativas, incluindo os consumidores também geradores de energia de pequeno porte, em baixa ou média tensão. Sendo assim, estudos vêm sendo realizados para inserir a automação no controle desses sistemas, porém ainda não foi estabelecido o que será controlado e como obter os dados de forma eficaz. No cenário de microrredes, um dos grandes desafios é a automação do processo de comunicação da rede entre diferentes dispositivos, tais como controladores de geradores, medidores inteligentes, etc., a fim de facilitar a troca de informações e melhorar o desempenho da rede. Portanto, este trabalho apresenta um estudo de simulação de microrredes (MR) com geração distribuída (GD) controlada remotamente, através de uma comunicação sem fio. A metodologia é apresentada através da simulação integrada de redes inteligentes, na qual o sistema elétrico foi implementado através do software PLECS – blockset, enquanto a rede sem fio foi projetada através do software TrueTime – toolbox, ambos simulados no Matlab®/Simulink®. Nesta aplicação de MR, é avaliado o uso de uma rede sem fio ZigBee e Wi-Fi, para controlar a geração da potência ativa da GD sob diferentes parâmetros de rede, tais como a probabilidade de perda e distância entre os dispositivos. Os resultados mostram que a simulação apresenta uma proposta viável para uma análise de rede de comunicação, com controle da GD e modelagem e desenvolvimento da rede elétrica nas MR inteligentes. / The increasing use of electricity due to the population growth in recent years has resulted in a necessary expansion of the energy matrix through alternative sources, including prosumers in low or medium voltage. Therefore, studies have been carried out to introduce automation in the control of these systems, but it has not yet been established what will be controlled and how to get the data effectively. In the microgrids scenario, one of the great challenges is the automation of the process of communication of the network between different devices, such as generators controllers, smart meters, etc., in order to facilitate the information exchange and improve network performance. Therefore, this work presents a study of a Microgrid (MG) with a Distributed Generator (DG) controlled remotely through a wireless communication. The methodology is presented through the integrated of smart grid simulations, where the electrical system was implemented through PLECS – blockset software, while the wireless network was developed using TrueTime – toolbox software, both simulated in Matlab®/Simulink®. In this application, the use of a ZigBee and Wi-Fi wireless network is evaluated to control the generation of the active power of DG under different network parameters, such as the loss probability and distance between devices. The simulation results show that the effectiveness of networked solution for developing MG. The results show that the simulation presents a feasible proposal for a communication networks analysis, with control of the DG and modeling and development of electric network in the smart MG.

Abstract Most of the current building simulation tools are the results of funded projects for particular research purposes. Normally, these tools are developed in one research organization and utilized by the organization's own staff rather than by external personnel. Financially and intellectually, it is definitely a huge waste that designers and engineers rarely use those tools while they have to deal with increasingly complex issues and surely need the assistance of building simulation tools in building practice. Therefore, this thesis is dedicated to bringing building simulation closer to practice. The general goal is to promote the usage of simulation tools not only by simulation experts for research purposes but also by designers and engineers in practical work. Abstract Since the well-adopted tool could only be established based on appropriate requirements analysis, attention is firstly devoted to perceiving engineer or practice demands in building design and operation activities. Building multi-criteria analysis, whole life cycle integration, interdisciplinary interaction, control-wise integration/optimization together with the influence of “Industry 4.0” in building discipline are discussed in sequence. This is not only an enumeration of emerging scenarios, but also an exploration to figure out that integrated requirement is of growing significance as buildings are becoming increasingly advanced and complex. Abstract Multi-criteria simulation analysis indicates that designers and engineers need to consider, at least, energy efficiency and initial cost simultaneously; human comfort, environmental impact, life cycle cost are also involved; however, current workflow and cooperation mechanism among different simulation tools could not sufficiently fulfill multi-criteria analysis demand in building design and operation activities. Other detailed discussions on energy and cost integrated simulation, energy and human comfort integrated simulation, control related simulations all indicate one conclusion that building practice is increasingly integrated but simulation ability is still insufficient and isolated. Therefore, related tools must be coordinated and connected from the socio-technical point of view to support building practice eventually. Abstract Recent development in multi-domain modeling language Modelica and Functional Mock-up Interface (FMI) standard has provided an efficient solution for both integration and practical utilization. The ideology of the transfer layer is introduced; open-to-public and free usable framework and associated collaborative mechanisms are proposed. Individual models and tools could be integrated together through co-simulation or model exchange under FMI standard; along with complete and accurate database, the integrated tools could be validated and documented together, then transferred to commercial partners for further improvement, marketing and sale. In such way, a collaborative framework to transfer knowledge from research to practice could be formed in order to sufficiently process integrated requirement issues; the usage of research-oriented tools could be intensified in building industrial practice. Abstract Connection, interoperability, technical standard, and workflow protocol, those general terms for cooperative simulation development are further discussed. Cooperative Modelica library development is taken as an example to illustrate associated problems and their solutions from both detailed technical and generalized socio-technical perspectives. Abstract Individual model quality is a fundamental guarantee for successful cooperative simulation system. Therefore a model comparison project is carried out for quality assurance purpose. First, a series of comparison validation tests are established with a stepwise increased level of complexity. Then, multiple participants with a diversity of simulation tools contribute simulation models and results for listed validation scenarios. During the result comparison process, the deviation is detected, the bug is fixed, the model is improved; cooperative relationship and workflow standard are formed. Abstract In the last, a multi-criteria and interdisciplinary simulation case is conducted as a demonstrated example of actual integrated requirement along with integration and practical utilization effort of simulation. This case aims to select an appropriate energy solution for a building from four alternatives. Traditional HVAC equipment, renewable energy devices, storage facilities are applied and arranged in groups under Demand Side Management strategy and dynamic control. Financial and environmental impacts are also calculated along with the traditional result of annual energy consumption. Multiple Criteria Decision Analysis (MCDA) method is applied to analyze the four alternative energy solutions with an overall consideration of energy consumption, energy production, initial cost, life-cycle cost, and CO2 emission.:Chapter 1 Introduction Chapter 2 Integrated requirements in building practice Chapter 3 Isolated and insufficient building simulation tools Chapter 4 Practice oriented tool integration and improvement Chapter 5 Cooperative development in Modelica and Annex 60 Chapter 6 Model comparison cooperation Chapter 7 Conclusion and future work

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[ES] En los últimos años, la industria de la automoción ha hecho un gran esfuerzo para producir sistemas de propulsión más eficientes y menos contaminantes sin menguar su rendimiento. Las nuevas regulaciones impuestas por las autoridades han empujado a la industria hacia la electrificación de los sistemas de propulsión mientras que las tecnologías desarrolladas para el sistema de propulsión convencional, basado en motores de combustión interna alternativos (MCIA), ya no son suficientes. El modelado numérico ha demostrado ser una herramienta indispensable para el diseño, desarrollo y optimización de sistemas de gestión térmica en trenes motrices electrificados, ahorrando costes y reduciendo el tiempo de desarrollo. La gestión térmica en los MCIA siempre ha sido importante para mejorar el consumo, las emisiones y la seguridad. Sin embargo, es todavía más importante en los sistemas de propulsión híbridos, a causa de la complejidad del sistema y al funcionamiento intermitente del MCIA. Además, los trenes motrices electrificados tienen varias fuentes de calor (es decir, MCIA, batería, máquina eléctrica) con diferentes requisitos de funcionamiento térmico. El objetivo principal de este trabajo ha sido desarrollar modelos térmicos para estudiar la mejora de los sistemas de gestión térmica en sistemas de propulsión electrificados (es decir, vehículo híbrido), estudiando y cuantificando la influencia de diferentes estrategias en el rendimiento, la seguridad y la eficiencia de los vehículos. La metodología desarrollada en este trabajo consistió tanto en la realización de experimentos como en el desarrollo de modelos numéricos. De hecho, se llevó a cabo una extensa campaña experimental para validar los diferentes modelos del tren motriz electrificado. Los datos obtenidos de las campañas experimentales sirvieron para calibrar y validar los modelos así como para corroborar los resultados obtenidos por los estudios numéricos. En primer lugar, se estudiaron las diferentes estrategias de gestión térmica de manera independiente para cada componente del tren motriz. Para el MCIA se estudió el uso de nanofluidos, el aislamiento del colector y puertos de escape, así como el cambio de volumen de sus circuitos hidráulicos. De igual forma, se evaluó el impacto de diferentes estrategias para la mejora térmica de las baterías. Además, el modelo de máquina eléctrica se utilizó para desarrollar pruebas experimentales que emulaban el daño térmico producido en ciclos reales de conducción. En segundo lugar, los modelos de tren motriz se integraron utilizando un estándar de co-simulación para evaluar el impacto de un sistema de gestión térmica integrado. Finalmente, se implementó un nuevo control del sistema de gestión de energía para evaluar el impacto de considerar el estado térmico del MCIA al momento de decidir la distribución de potencia del vehículo híbrido. Los resultados han demostrado que el uso de nanofluidos tiene un impacto muy limitado tanto en el MCIA como en el comportamiento térmico de la batería. Además, también mostraron que al reducir el volumen de refrigerante en un 45 %, la reducción en el tiempo de calentamiento del MCIA y el consumo de combustible en comparación con el caso baso fue del 7 % y del 0.4 %, respectivamente. Además, para condiciones de frio (7ºC), el impacto fue todavía mayor, obteniendo una reducción del tiempo de calentamiento y del consumo de combustible del 13 % y del 0.5 % respectivamente. Por otro lado, los resultados concluyeron que durante el calentamiento del MCIA, el sistema integrado de gestión térmica mejoró el consumo de energía en un 1.74 % y un 3 % para condiciones de calor (20ºC) y frío (-20ºC), respectivamente. Esto se debe al hecho que el sistema de gestión térmica integrado permite evitar la caída de temperatura del MCIA cuando el sistema de propulsión está en manera eléctrica pura. / [CA] En els últims anys, la indústria de l'automoció ha fet un gran esforç per a produir sistemes de propulsió més eficients i menys contaminants sense minvar el seu rendiment. Les noves regulacions imposades per les autoritats han espentat a la indústria cap a l'electrificació dels sistemes de propulsió mentre que les tecnologies desenvolupades per al sistema de propulsió convencional, basat en motors de combustió interna alternatius (MCIA), ja no són suficients. El modelatge numèric ha demostrat ser una eina indispensable per al disseny, desenvolupament i optimització de sistemes de gestió tèrmica en trens motrius electrificats, estalviant costos i reduint el temps de desenvolupament. La gestió tèrmica en els MCIA sempre ha sigut important per a millorar el consum, les emissions i la seguretat. No obstant això, és encara més important en els sistemes de propulsió híbrids, a causa de la complexitat del sistema i al funcionament intermitent del MCIA. A més, els trens motrius electrificats tenen diverses fonts de calor (és a dir, MCIA, bateria, màquina elèctrica) amb diferents requisits de funcionament tèrmic. L'objectiu principal d'aquest treball va ser desenvolupar models tèrmics per a estudiar la millora dels sistemes de gestió tèrmica en sistemes de propulsió electrificats (és a dir, vehicle híbrid), estudiant i quantificant la influència de diferents estratègies en el rendiment, la seguretat i l'eficiència dels vehicles. La metodologia desenvolupada en aquest treball va consistir tant en la realització d'experiments com en el desenvolupament de models numèrics. De fet, es va dur a terme una extensa campanya experimental per a validar els diferents models del tren motriu electrificat. Les dades obtingudes de les campanyes experimentals van servir per a calibrar i validar els models així com per a corroborar els resultats obtinguts pels estudis numèrics. En primer lloc, es van estudiar les diferents estratègies de gestió tèrmica de manera independent per a cada component del tren motriu. Per al MCIA es va estudiar l'us de nanofluids, l'aïllament del col·lector i ports d'eixida així com el canvi de volum dels seus circuits hidràulics. D'igual forma, es va avaluar l'impacte de diferents estratègies per a la millora tèrmica de les bateries. A més, el model de màquina elèctrica es va utilitzar per a desenvolupar proves experimentals que emulaven el mal tèrmic produït en cicles reals de conducció. En segon lloc, els models de tren motriu es van integrar utilitzant un estàndard de co-simulació per a avaluar l'impacte d'un sistema de gestió tèrmica integrat. Finalment, es va implementar un nou control del sistema de gestió d'energia per a avaluar l'impacte de considerar l'estat tèrmic del MCIA al moment de decidir la distribució de potència del vehicle híbrid. Els resultats han demostrat que l'us de nanofluids té un impacte molt limitat tant en el MCIA com en el comportament tèrmic de la bateria. A més, també van mostrar que en reduir el volum de refrigerant en un 45 %, la reducció en el temps de calfament del MCIA i el consum de combustible en comparació amb el cas base va ser del 7 % i del 0.4 %, respectivament. A més, per a condicions de fred (-7ºC), l'impacte va ser encara major, obtenint una reducció del temps de calfament i del consum de combustible del 13 % i del 0.5 % respectivament. D'altra banda, els resultats van concloure que durant el calfament del MCIA, el sistema integrat de gestió tèrmica va millorar el consum d'energia en un 1.74 % i un 3 % per a condicions de calor (20ºC) i fred (-20ºC), respectivament. Això es deu al fet que el sistema de gestió tèrmica integrat permet evitar la caiguda de temperatura del MCIA quan el sistema de propulsió està en manera elèctrica pura. / [EN] In recent years, the automotive industry has made a great effort to produce more efficient and less polluting propulsion systems without diminishing their performance. The new regulations imposed by the authorities have pushed the industry towards the electrification of powertrains while, technologies developed for the conventional propulsion system based on alternative internal combustion engines (ICEs), are no longer sufficient. Numerical modeling has proven to be an indispensable tool for the design, development and optimization of thermal management systems in electrified powertrains, saving costs and reducing development time. Thermal management in ICEs has always been important for improving consumption, emissions and safety. However, it is even more important in hybrid powertrains, due to the complexity of the system and the intermittent operation of the ICE. In addition, electrified powertrains have various heat sources (i.e., ICE, battery, Electric machine) with different thermal operating requirements. The main objective of this work was to develop thermal models to study the improvement of thermal management systems in electrified powertrains (i.e., hybrid electric vehicle), shedding light and quantifying the influence of different strategies on performance, safety and efficiency of the vehicles. The methodology developed in this paper consisted both in carrying out experiments and in developing numerical models. In fact, an extensive experimental campaign was carried out to validate the various models of the electrified powertrain. The data obtained from the experimental campaigns served to calibrate and validate the models as well as to corroborate the results obtained by the numerical studies. Firstly, the different thermal management strategies were studied independently for each component of the powertrain. For the ICE, the use of nanofluids, insulation of exhaust manifold and ports as well as the volume change of its hydraulic circuits were studied. Similarly, the impact of different strategies for the thermal improvement of batteries was evaluated. Furthermore, the electric machine model was used for developing experimental tests which emulated the thermal damage produced in real driving cycles. Secondly, the powertrain models were integrated using a co-simulation standard to assess the impact of an integrated thermal management system. Finally, a new control energy management system was implemented to assess the impact of considering the ICE thermal state when deciding the power split of the hybrid vehicle. The results have shown that the use of nanofluids has a very limited impact on both the ICE and the battery's thermal behaviour. In addition, they also showed that by reducing the volume of coolant by 45 %, the reduction in ICE warm up time and fuel consumption compared to the base case were 7 % and 0.4 %, respectively. In addition, for cold conditions (-7ºC), the impact was even greater, obtaining a reduction in warm up time and fuel consumption of 13 % and 0.5 % respectively. On the other hand, the results concluded that during the warming of ICE, the integrated thermal management system improved energy consumption by 1.74 % and 3 % for warm (20ºC) and cold (-20ºC) conditions, respectively. This is because the integrated TMS makes it possible to prevent the ICE temperature drop when the powertrain is in pure electric mode. Finally, significant gains during Worldwide harmonized Light vehicles Test Cycles (WLTC) and Real Driving Emissions (RDE) cycles were observed when the ICE thermal state was chosen when deciding the power distribution. / The author would like to sincerely acknowledge the founding support pro- vided by Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital in the framework of the Ayuda Predoctoral GVA. (ACIF/2020/234). Additionally the author would also acknowledge the support provided by Renault S.A.S. / Dreif Bennany, A. (2023). Development of Integrated Models for Thermal Management in Hybrid Vehicles [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/194060

Preface - Biotechnology is generally accepted to be the next economical wave of the future. In order to attain the many benefits associated with this growing industry simulation modelling techniques have to be implemented successfully. One of the simulations that ne' ed to be performed is that of the human energy system. Pharmaceutical companies are currently pouring vast amounts of capital into research regarding simulation of bodily processes. Their aim is to develop cures, treatments, medication, etc. for major diseases. These diseases include epidemics like diabetes, cancer, cardiovascular diseases, obesity, stress, hypertension, etc. One of the most important driving forces behind these diseases is poor blood sugar control. The blood glucose system is one of the major subsystems of the complete human energy system. In this study a simulation model and procedure for simulating blood glucose response due to various external influences on the human body is presented. The study is presented in two parts. The first is the development of a novel concept for quantifying glucose energy flow into, within and out of the human energy system. The new quantification unit is called ets (equivalent teaspoons sugar). The second part of the study is the implementation of the ets concept in order to develop the simulation model. Development of the ets concept - In the first part of the study the ets concept, used for predicting glycaemic response, is developed and presented. The two current methods for predicting glycaemic response due to ingestion of food are discussed, namely carbohydrate counting and the glycaemic index. Furthermore, it is shown that it is currently incorrectly assumed that 100% of the chemical energy contained in food is available to the human energy system after consumption. The ets concept is derived to provide a better measure of available energy from food. In order to verify the ets concept, two links with ets are investigated. These are the links with insulin response prediction as well as with endurance energy expenditure. It is shown that with both these links linear relationships provide a good approximation of empirical data. It is also shown that individualised characterisation of different people is only dependent on a single measurable variable for each link. Lastly, two novel applications of the ets concept are considered. The first is a new method to use the ets values associated with food and energy expenditure in order to calculate both short-acting and long-acting insulin dosages for Type 1 diabetics. The second application entails a new quantification method for describing the effects of stress and illness in terms of ets. Development of the blood glucose simulation model - The second part of the study presents a literature study regarding human physiology, the development for the blood glucose simulation model as well as a verification study of the simulation model. Firstly, a brief overview is given for the need and motivation behind simulation is given. A discussion on the implementation of the techniques for construction of the model is also shown. The procedure for solving the model is then outlined. During the literature study regarding human physiology two detailed schematic layouts are presented and discussed. The first layout involves the complex flow pathways of energy through the human energy system. The second layout presents a detailed discussion on the control system involved with the glucose energy pathway. Following the literature review the model for predicting glycaemic response is proposed. The design of the component models used for the simulations of the internal processes are developed in detail as well as the control strategies implemented for the control system of the simulation model. Lastly, the simulation model is applied for glycaemic response prediction of actual test subjects and the quality of the predictions are evaluated. The verification of the model and the procedure is performed by comparing simulated results to measured data. Two evaluations were considered, namely long-term and short-term trials. The quality of both are determined according to certain evaluation criteria and it is found that the model is more than 70% accurate for long-term simulations and more than 80% accurate for short-term simulations. Conclusion - In conclusion, it is shown that simplified simulation of the human energy system is not only possible but also relatively accurate. However, in order to accomplish the simulations a simple quantification method is required and this is provided by the ets concept developed in the first part of this study. Some recommendations are also made for future research regarding both the ets concept and the simulation model. Finally, as an initial endeavour the simulation model and the ets concept proposed in this study may provide the necessary edge for groundbreaking biotechnological discoveries. / PhD (Mechanical Engineering) North-West University, Potchefstroom Campus, 2003

Preface - Biotechnology is generally accepted to be the next economical wave of the future. In order to attain the many benefits associated with this growing industry simulation modelling techniques have to be implemented successfully. One of the simulations that ne' ed to be performed is that of the human energy system. Pharmaceutical companies are currently pouring vast amounts of capital into research regarding simulation of bodily processes. Their aim is to develop cures, treatments, medication, etc. for major diseases. These diseases include epidemics like diabetes, cancer, cardiovascular diseases, obesity, stress, hypertension, etc. One of the most important driving forces behind these diseases is poor blood sugar control. The blood glucose system is one of the major subsystems of the complete human energy system. In this study a simulation model and procedure for simulating blood glucose response due to various external influences on the human body is presented. The study is presented in two parts. The first is the development of a novel concept for quantifying glucose energy flow into, within and out of the human energy system. The new quantification unit is called ets (equivalent teaspoons sugar). The second part of the study is the implementation of the ets concept in order to develop the simulation model. Development of the ets concept - In the first part of the study the ets concept, used for predicting glycaemic response, is developed and presented. The two current methods for predicting glycaemic response due to ingestion of food are discussed, namely carbohydrate counting and the glycaemic index. Furthermore, it is shown that it is currently incorrectly assumed that 100% of the chemical energy contained in food is available to the human energy system after consumption. The ets concept is derived to provide a better measure of available energy from food. In order to verify the ets concept, two links with ets are investigated. These are the links with insulin response prediction as well as with endurance energy expenditure. It is shown that with both these links linear relationships provide a good approximation of empirical data. It is also shown that individualised characterisation of different people is only dependent on a single measurable variable for each link. Lastly, two novel applications of the ets concept are considered. The first is a new method to use the ets values associated with food and energy expenditure in order to calculate both short-acting and long-acting insulin dosages for Type 1 diabetics. The second application entails a new quantification method for describing the effects of stress and illness in terms of ets. Development of the blood glucose simulation model - The second part of the study presents a literature study regarding human physiology, the development for the blood glucose simulation model as well as a verification study of the simulation model. Firstly, a brief overview is given for the need and motivation behind simulation is given. A discussion on the implementation of the techniques for construction of the model is also shown. The procedure for solving the model is then outlined. During the literature study regarding human physiology two detailed schematic layouts are presented and discussed. The first layout involves the complex flow pathways of energy through the human energy system. The second layout presents a detailed discussion on the control system involved with the glucose energy pathway. Following the literature review the model for predicting glycaemic response is proposed. The design of the component models used for the simulations of the internal processes are developed in detail as well as the control strategies implemented for the control system of the simulation model. Lastly, the simulation model is applied for glycaemic response prediction of actual test subjects and the quality of the predictions are evaluated. The verification of the model and the procedure is performed by comparing simulated results to measured data. Two evaluations were considered, namely long-term and short-term trials. The quality of both are determined according to certain evaluation criteria and it is found that the model is more than 70% accurate for long-term simulations and more than 80% accurate for short-term simulations. Conclusion - In conclusion, it is shown that simplified simulation of the human energy system is not only possible but also relatively accurate. However, in order to accomplish the simulations a simple quantification method is required and this is provided by the ets concept developed in the first part of this study. Some recommendations are also made for future research regarding both the ets concept and the simulation model. Finally, as an initial endeavour the simulation model and the ets concept proposed in this study may provide the necessary edge for groundbreaking biotechnological discoveries. / PhD (Mechanical Engineering) North-West University, Potchefstroom Campus, 2003