System requirements: Adobe Acrobat Reader. Includes bibliographical references (p. 106).

Texte remanié de: Habilitationsschrift--Philosophische Fakultät IV--Freiburg--Albert-Ludwigs-Universität, 1995. / Bibliogr. p. 867-911. Index.

Diss.--Frankfurt am Main, 1990. / Bibliogr. p. 139-147.

Thesis (M.Sc.)--The University of Manitoba, 1999. / Includes bibliographical references.

As its title suggests, this thesis is concerned with the role of politics in Joseph Conrad's major fiction. It is not, however, an attempt to use the novels as a guide to Conrad's politics, but rather the reverse. To this end, the thesis is conceived around two principal aims. First, to establish what kinds of political issues Conrad explores in his fiction. Second, to determine, where possible, the ways in which Conrad's political views and predilections affect the quality of the works. The thesis is divided into five major chapters and deals with four of Conrad's works. The first chapter discusses Heart of Darkness and argues that it establishes fundamental principles about the natures of civilisation, man and reality. The following two chapters deal with the novel Nostromo. The first reviews the critical response to the novel. In the second I argue that the novel is not simply about materialism or imperialism, but that it is a work which explores fundamental social and political issues, amongst them the natures of historical development, of institutions, of leadership and of ideologies. The fourth chapter concentrates on The Secret Agent and argues that it is a serious attempt to dramatize particular forms of anarchism in a particular type of human society. Under Western Eyes is the subject of the final chapter which argues that Conrad's attack on Russian mysticism in the last of his great political novels is balanced by his vision of Western failings and limitations.

Thesis (Ph.D.)--Boston University / Since the 1920's, when Joseph Hergesheimer was widely acclaimed as one of America's greatest writers, the reputation of his fiction has declined precipitously. Although the quality of his fiction gives ample reason for correcting the inflated estimation of him of the 'twenties, it should also prevent his complete rejection by posterity. This dissertation, therefore, attempts to study Hergesheimer's fiction sympathetically but critically, recognizing both its excellences and its limitations. The result is an understanding of Hergesheimer's total achievement in the art of fiction. The method of this study is to give careful examination both to a number of his individual works and to certain crucial aspects of his whole body of fiction. The first of the ten chapters briefly defines Hergesneimer's main interest in his writing--a specific emotional effect he hoped to produce in himself and in the reader. He achieved this effect principally by building most of his works around a certain kind of action--a dramatic gesture of self-assertion made by a protagonist in the face of extreme adversity. The second chapter classifies the fictional motifs in Hergesheimer's fiction--the life-situations which he uses in his works to project this dramatic gesture. The underlying themes of these two chapters are the narrowness of Hergesheimer's range and intent, and the reiteration which exists in his works. Each of the next six chapters begins with a self-contained analysis of a novel, and then uses that novel to introduce some important feature of Hergesheimer's whole body of fiction. The third chapter presents a complete discussion of The Three Black Pennys, and then uses that novel to initiate a discussion of character in Hergesheimer's fiction; it is demonstrated that his characters clearly run in types and subserve his preoccupation with the dramatic gesture. The fourth chapter analyzes Java Head and evaluates plot in Hergesheimer's fiction, demonstrating that resolution and causality are generally quite simple and direct and sometimes arbitrarily manipulated in the interest of the overall effect. Chapter V analyzes Cytherea and discusses the overall social and moral environment which his fictions create; emphasis falls on his use of antithesis and moral dilemma to create dramatic situations and on the hostility which cnaracterizes virtually all human relations in his works. Chapter VI discusses the Limestone Tree and narrative technique in the episodic novels and shows how Hergesheimer achieves unity by means of overall theme, continuity of historical background, anu certain reiterated motifs. Chapter VII discusses Tampico and the narrative technique in the novels having a single continuous action; this chapter explains how he achieves coherence and form by means of symbolism, structural division, and selectivity. The last novel to be analyzed is Balisand, in the eighth chapter, where discussion focusses on Hergesheimer's preoccupation with atmosphere and the suggestive qualities of settings and events. Hergesheimer's uneven prose style is the subject of the ninth chapter, and again a number of writings are used as data. His theory of style is examined as well as the characteristics of diction and cadence in his fiction. The tenth and final chapter studies Hergesheimer's commitment to the commercial fiction he wrote for the mass magazines; this chapter traces the influence of this commitment on his more serious work, and then develops a general evaluation of Hergesheimer as a distinctly minor writer, but one whose fiction can be justifiably appreciated for certain of its tecbnical achievements as well as certain of its insights.

" ... the central concern of this thesis, which is to investigate the ways in which Conrad uses a particular technique (that of the first-person narrator ) to focus our attention, to secure our involvement, and to direct our sympathies. At the same time I wish to examine the extent to which the central themes or concerns of each work derive from the interaction between the narrator and the man whose experience he confronts, from "the challenging interplay of two frames of reference, two schemes of values, two sets of attitudes" that the use of a dramatized narrator makes possible." (Introd., p. 5) / Adobe Acrobat 9.53 Paper Capture Plug-in

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Orientador: Iscia Lopes Cendes / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas / Made available in DSpace on 2018-08-10T16:11:43Z (GMT). No. of bitstreams: 1 Barreto_DanielaMedeirosdeCastro_D.pdf: 3392835 bytes, checksum: 1207196c754a9cd271ea32132416763b (MD5) Previous issue date: 2007 / Resumo: A ataxia espinocerebelar tipo 3 (SCA 3) ou doença de Machado-Joseph (MJD) faz parte de um grupo heterogêneo de doenças neurodegenerativas do sistema nervoso central, caracterizadas por degeneração do cerebelo e de suas vias aferentes e eferentes. O gene para a SCA3/MJD foi mapeado no braço longo do cromossomo 14 e foi denominado MJD1. A mutação é caracterizada pela expansão de trinucleotídeos CAG instáveis e o produto gênico, a proteína ataxina-3 mutante ou MJD1a, apresenta expansões do trato de poliglutamina (poliQ) próximas à região C-terminal. Evidências experimentais relacionam os mecanismos de neurodegeneração ao acúmulo da proteína ataxina-3 mutante no núcleo de neurônios levando à formação de inclusões intranucleares ubiquitina-positivas e à morte celular. Porém, a função da proteína normal permanece desconhecida. Já que muitas funções celulares são realizadas quando as proteínas interagem umas com as outras, a caracterização de seus ligantes poderá fornecer informações importantes sobre os processos biológicos dos quais elas participam. Assim, a identificação de interações de proteínas com a ataxina-3 juntamente com seu estudo estrutural, são o ponto de partida para análises funcionais bem como para a compreensão dos mecanismos patológicos da doença. Isto possibilitará, no futuro, a habilidade no projeto e síntese de novos catalisadores, materiais e fármacos que poderão contribuir para a eliminação da doença e/ou melhoria da qualidade de vida dos pacientes. Com este objetivo, este trabalho implementou um protocolo reprodutível, robusto e confiável de expressão e purificação das formas normal e mutante da ataxina-3 humana, com isso, iniciando uma importante linha de pesquisa em nosso laboratório / Abstract: Spinocerebellar ataxia type 3 (SCA 3) also known as Machado-Joseph disease (MJD) belongs to a heterogeneous group of neurodegenerative diseases of the central nervous system and is characterized by the degeneration of cerebellum and its afferent and efferent ways. The SCA3/MJD gene was mapped on chromosome 14 and was named MJD1, the causative mutation is an instable CAG trinucleotide expansion in the gene product, the mutant ataxin-3, and polyglutamine tract is located near the C-terminus region. Several experiments relate the ataxin-3 neurodegeneration mechanism with the formation of ubiquitin-positive neuronal intranuclear inclusions leading to cell death. However, the normal functions of the protein remain unknown. Protein function is usually carried-out through protein interactions; therefore, the identification of protein binding substrates can give important functional information on relevant biological function and pathways. Therefore, the identification of proteins that interact with ataxin-3 and its structural studies are important starting points for function analysis, as well as to better understand the mechanisms underlying the neurodegeneration in the disease condition. This will eventually lead to the development of compounds and drugs that could eliminate the disease or improve the patients' quality of life. At completion of our study we were able to develop a robust and efficient protocol for expression and purification of large amounts of human ataxin-3 in its normal and expanded forms; thus starting a new line of research in our laboratory / Doutorado / Ciencias Biomedicas / Doutor em Ciências Médicas