Thesis (Ph.D. ) -- University of Adelaide, Dept. of Paediatrics, 2000. / Copy of author's previously published work inserted. Bibliography: leaves 193-216.

Thesis (Ph. D.)--University of Queensland, 2003. / Includes bibliographical references.

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Orientador: Stélio Pacca Loureiro Luna / Banca: Rogério Martins Amorim / Banca: Márcia Valéria R. S. Szabó / Resumo: Problemas como a incoordenação (ataxia), paresias e paralisias são freqüentes no atendimento clínico veterinário em ambulatórios de pequenos animais. Os sinais clínicos abrangem desde dores na coluna vertebral até a ausência de dor profunda. Várias afecções podem estar associadas a esses sintomas, a saber, as discopatias, mielopatias, fusão de vértebras, displasia coxofemoral e enfermidades causadas por bactérias, vírus e protozoários. O objetivo deste estudo retrospectivo foi avaliar o uso do Aparelho de Fisioterapia Veterinária (AFV) em animais com paresias e paralisias causadas por diversas afecções, para favorecer a higiene, mobilidade e reabilitação social em casos irreversíveis, além de auxiliar no restabelecimento fisioterápico em casos reversíveis, e ainda, traçar o perfil dos pacientes que fazem o uso deste aparelho. Para tanto, foram cadastrados 1203 cães e 47 gatos oriundos de várias cidades brasileiras, por meio de fichas de avaliação previamente elaboradas com questões que traçam o perfil clínico e físico dos animais. A espécie canina foi a mais acometida por paralisias, sendo os SRDs mais representativos. A lesão medular foi a causa principal de paralisias em cães e gatos; as paresias flácidas foram as mais observadas, sendo que a média das idades em que ocorreram paralisias decorrentes de diferentes enfermidades encontrou-se entre os 3 e 9 anos. Na associação entre as categorias de raça, idade e enfermidades, os cães da raça Teckel mostraram maior incidência de lesões de medula e de discos intervertebrais quando comparados às demais categorias de raça. A idade de acometimento dos animais diferiu entre as categorias de raça. Não houve diferença na associação entre raça e sexo / Abstract: Incoordination (ataxia), paresis and paralysis are frequent in the small animal veterinary clinics. The clinical signs include from back pain to the absence of deep pain reflex. Several pathologies can be associated with these symptoms, such as the discopathies, spinal cord lesions, vertebrae fusion, hip dysplasia and others caused by bacteria, virus and protozoary agents. The objective of this retrospective study was to evaluate the use of the Veterinary Physiotherapic Equipment (AFV) in animals with paresis, paraplegy and tetraplegy to improve hygiene, mobility and social rehabilitation in irreversible cases, and to aid the physiotherapic rehabilitation in reversible cases, establishing the profile of the patients that made use of the AFV. A total of 1203 dogs and 47 cats originated from various brazilian cities were recorded by evaluation data sheets previously elaborated with questions to delineate the animals' clinical and physical characteristics. The canine species was the most affected by paralysis, and the non-specific breed (mongrel) was the most representative. The lesions that mostly caused paralysis in dogs and cats were the spinal cord lesions and those of the intervertebral disks. The partial and flaccid paralysis were the most commonly observed paralysis, and the average of ages in which paralysis caused by different pathologies occurred was between 3 and 9 years. The Teckel breed had the biggest incidence of paralysis caused by spinal cord and disks lesions, when compared to other breeds. The ages of occurrence were different among the breeds. There were no differences in the association between breed and gender / Mestre

Some studies have demonstrated that the effects of a drug may be different, depending on whether the drug is self-administered or passively received by the subject. Most of the studies which have examined this phenomenon have not examined the effects of a drug following each of a series of administrations. Moreover, the mechanism mediating differences between self-administered and passively received drugs has not been determined. The present experiments used a yoked-control design to examine the development of tolerance to the ataxic effects of heroin and of ethanol in rats that self-administer the drugs and rats that passively received them. Results demonstrate that rats that passively received heroin, but not those that self-administered the drug, were significantly impaired following the initial administrations. During the first administration sessions, rats that self-administered ethanol were as impaired as their partners that passively received, but within a few sessions self-administering rats developed tolerance to the ataxic effect of the ethanol, while their yoked partners did not. The results also suggest that the faster tolerance development in rats that self-administered ethanol may have been mediated by differences in Pavlovian conditioning in these subjects, which demonstrated larger compensatory conditional responses in the form of “hypertaxia” than did their yoked partners. The results indicated that some component of the self-administration process contributed to the Pavlovian conditioning, and hence, faster tolerance development, of self-administering animals. The data suggest that studies in which drugs are passively received may overestimate the dose that is necessary to produce tolerance in self-administering animals. Models based on such studies, then, may require modification before they are applied to situations which involve self-administration of drugs. / Thesis / Doctor of Philosophy (PhD)

Copy of author's previously published work inserted. Bibliography: leaves 193-216. Thesis which examines in detail the genetics of congental ataxias, and early and late onset ataxias.

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Copy of author's previously published work inserted. / Bibliography: leaves 193-216. / ix, 268 leaves : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis which examines in detail the genetics of congental ataxias, and early and late onset ataxias. / Thesis (Ph.D.)--University of Adelaide, Dept. of Paediatrics, 2000

Thesis (Ph.D.) -- McMaster University, 1999. / Includes bibliographical references (leaves 44-51). Also available via World Wide Web.