This research has been conducted at Hunter Engineering Company. It aims to Design a Kit Packing Weighing System which performs a Quality Assessment of tool-kits while packing them on weighing scales. The main aspects of Kit-Packing are documented and suitable terminologies to address the process are established. The kits are categorized and a process for packing kits of different categories is suggested. A system to weigh Heavy, Medium and Light kits is presented. A Monte-Carlo Simulation Tool is developed and an Analysis using the Risk Solver Software is conducted to select the preferable method of establishing Tolerance Limits. A design for a Visual Basic coded Interface is outlined that will guide the Operator through the kit packing process and indicate whether to Accept or Inspect the kit. A Windows application of the Software was prototyped to demonstrate the System’s functionality which also is documented herein.

Om två parter med delad ekonomi vill se över och räkna på sina inköp gjort från matvarubutiker finns två alternativ. Att spara alla fysiska kvitton för att sedan manuellt hantera uträkningen eller att använda digitala kvitton, vilket långt ifrån alla matvarubutiker erbjuder. Det finns heller inga bestämmelser mellan företagen kring vart dessa kvitton ska lagras vilket medför att en användare kan behöva logga in på flera olika platser. Användaren har alltså valet att manuellt hantera fysiska kvitton eller att manuellt hantera digitala kvitton, alternativt en blandning av båda. Oavsett kvittots form måste alla kvitton gås igenom för att se vilken person som gjort köpet, vilka eventuella varor som ska plockas bort och vad totalsumman är. Syftet med detta projekt har därför varit att skapa en applikation i Android som med hjälp av OCR-biblioteket Google ML Kit tillåter två användare att hantera sina kvitton. Rapporten undersöker de svårigheter som finns vid textigenkänning samt presenterar de tekniker och metoder som har använts under skapandet av applikationen. Applikationen utvärderades sedan genom att extrahera text från flera olika kvitton. Google’s OCR-bibliotek jämfördes också med Tesseract OCR för att undersöka om valet av ett annat OCR-bibliotek hade kunnat förbättra pålitligheten i kvittoskanningen. Slutresultatet är att applikationen fungerar väl vid korrekt inskanning, det finns dock stora svårigheter att extrahera text från kvitton som avviker från de kvittomallar som använts under implementationen. / For two parties with shared finances who wants to review and count their purchases made from grocery stores, there are two options. To save all physical receipts and then handle the calculation manually or to use digital receipts, which far from all grocery stores offer. There are also no provision between companies on where these receipts should be stored, which means that a user may have to log in at several different locations. The user thus has the choice of manually managing physical receipts or manually managing digital receipts, or in worst case a mixture of both. Regardless of the form of the receipt, all receipts must be reviewed to see which person made the purchase, which items, if any, should be removed and what the total cost is. The aim of this project has therefore been to create an application in Android using the Google ML Kit OCR library that allows two users to manage their receipts. The report examines the difficulties encountered in text recognition and presents the techniques and methods used during the creation of the application. The application was then evaluated by extracting text from several different receipts. Google’s OCR library was also compared with Tesseract OCR to investigate whether the choice of a different OCR library could have improved the reliability of receipt recognition. The final result is a application that works well when a receipt is scanned correctly, however there are significant difficulties in extracting text from receipts that differ from the receipt templates used during implementation.

The VSWR is an important entity when assessing the properties of an antenna. This report presents measurements of the VSWR, related to antennas, by means of a Vector Network Analyzer. The open/short/load calibration method is used as a preparation before the actual measurement in order to obtain accurate results. The way that the VSWR depends on frequency is illustrated by three measurment methods: direct measurement of the VSWR, by using 𝑆11, or by using the Smith chart. The results are compared and conclusions are drawn.

The research investigates the influence on the human body on a communication system. To understand this, the effect of hands free kit (HFK) on energy absorption in the body was investigated when operating a smart phone at 2G. Findings on the research are given in the thesis report. Also, the influence of the way in which a phone is held on a phone s received power was investigated. The result was compared to that obtained using a hand phantom acquired from SPEAG. This was to check if the hand phantom best represents the human hand when using it in experiments. The setup for the experiment was in an anechoic chamber at Loughborough University. The mobile phone transmitted in the 2G system. In further experiments carried out on the body, two antennas were attached to the body in six different orientations to receive power from a source creating a Single Input Multiple Output (SIMO) system. The antennas used were monopoles mounted on a circular ground plane. These antennas were designed and constructed with the influence of the body taken into consideration. The use of diversity techniques to improve transmission to an on-body system is investigated with the antennas on the body. For each alignment, the transmission to the on-body was compared with the transmission to the corresponding off-body (free space). Experiments for this work were carried out in three environments.

Visais laikais žmonės savo kūnui skyrė ypatingą dėmesį, noras gražiai atrodyti vertė kentėti skausmą ir nepatogumą. Kad kūnas įgautų trokštamą siluetą, dažnai buvo naudojama pagalbinė priemonė - korsetas. Korsetas ilgus metus buvo privaloma kostiumo dalis, tik keitėsi forma, medžiagos iš kurių jis buvo gaminamas, bei dėvėjimo būdas. 1900m. korsetas išgyveno didžiausio populiarumo metą, tačiau ir šiomis dienomis aukštoji mada neišsiverčia be šios aprangos detalės. Istoriniai šaltiniai liudija, kad korsetu kūnas buvo dažniau žalojamas, nei dailinamas. Kūrybinio darbo tikslas sukurti ir įgyvendinti aksesuarų komplektą, kuris perteiktų kūno suvaržymo korsetu idėją, panaudojant netradicinį korseto vaizdą, norint pademonstruoti absurdišką savęs kankinimą dėl mados. Kūrybinio darbo pavadinimas „Deformacijos“, todėl, siekiant perteikti įvardintą temą, ypatingas dėmesys skiriamas paties kūrinio formai ir jo funkcijai, deformuoti natūralų žmogaus kūną. / At all times people gives special attention for theirs bodys, wish to be beautiful makes life uncomfortable and full of pain. To have desire siluet, often was used auxiliary tool – corset. Long time corset was mandatory costume element, only form, background material and wearing way was changed. In 1990 corset was on top of the popularity, even today haute couture fashion can not visualize models without corset. Historic resources testify, that corset ofter damaging body, than retouched. Aim of the creativ work is develop and implement accessory kit, which shows the idea of restraining the body with the unusual corset representation and also it shows absurd body torture for fashion. Title of the creative work is “Deformations”, for this reason special attention is given for item form and function, to deform natural human body.

KIT receptor (CD117) is a receptor tyrosine kinase crucial for homeostasis of mast cells (MCs) in tissues and recruitment to sites of inflammation and tumors in response to its ligand Stem cell factor (SCF). Gain of function mutations in KIT (e.g. D816V) are frequently observed in systemic mastocytosis and other cancer types. Src Homology 2 domain containing phosphatase-2 (SHP2 or PTPN11) is a protein tyrosine phosphatase that promotes cell proliferation, survival and motility in multiple pathways and cell types. To study SHP2 function in MCs, we generated novel MC-specific Shp2 knock-out (KO) mice (MC-shp2 KO). These mice had reduced numbers of MCs in skin and peritoneum, and defective contact hypersensitivity responses compared to control mice, consistent with SHP2 promoting MC homeostasis. Using an inducible SHP2 KO bone marrow-derived MC (BMMC) culture model, we found that SHP2 KO cells were prone to apoptosis and had no MC repopulating activity in vivo. Mechanistically, SHP2 enhanced ERK activation and downregulation of pro-apoptotic protein Bim. SHP2 KO BMMCs also had defects in chemotaxis towards SCF, due to impaired activation of a Lyn/Vav/Rac pathway in SHP2 KO BMMCs. This correlated with defects in cell spreading, and F-actin polymerization in response to SCF. Treatment of BMMCs with a SHP2 inhibitor (II-B08) also led to reduced chemotaxis, consistent with SHP2 phosphatase activity being required for KIT-induced chemotaxis. Lastly, we tested whether SHP2 regulates oncogenic KIT signaling using a P815 mouse mastocytoma model. Stable silencing of SHP2 in P815 cells led to reduced cell growth and survival in vitro, and less aggressive systemic mastocytosis development in syngeneic mice. Overall, these studies identify SHP2 as a key node in SCF/KIT and oncogenic KIT pathways, and as a potential therapeutic target in several human diseases. / Thesis (Ph.D, Biochemistry) -- Queen's University, 2013-06-25 12:03:57.818

Submitted by SILVIO LUIS AGOSTINHO DOS SANTOS null (silvioluis_26@hotmail.com) on 2017-03-06T19:50:30Z No. of bitstreams: 1 Versão Final da Dissertação do Mestrado de Silvio Luis Agostinho dos Santos.pdf: 3738913 bytes, checksum: bca1c0bfeff575f21eed73a5fa2cc3d4 (MD5) / Approved for entry into archive by Juliano Benedito Ferreira (julianoferreira@reitoria.unesp.br) on 2017-03-10T15:02:10Z (GMT) No. of bitstreams: 1 santos_sla_me_prud.pdf: 3738913 bytes, checksum: bca1c0bfeff575f21eed73a5fa2cc3d4 (MD5) / Made available in DSpace on 2017-03-10T15:02:10Z (GMT). No. of bitstreams: 1 santos_sla_me_prud.pdf: 3738913 bytes, checksum: bca1c0bfeff575f21eed73a5fa2cc3d4 (MD5) Previous issue date: 2017-02-23 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Na presente dissertação, descrevemos uma metodologia de ensino de Física que vem sendo implementada no Ensino Médio na ETEC Profº Eudécio Luiz Vicente localizada na cidade de Adamantina, SP. A proposta valoriza a compreensão da ciência como produção humana e fundamenta o processo ensino de uma aprendizagem significativa de Ausubel e na atividade experimental, de modo a articular o conhecimento formal da Física com os saberes do aluno. Em comparação com o chamado ensino tradicional, o que se propõe é um ensino mais atraente para os alunos, com ênfase na compreensão dos conceitos físicos e na relação destes com acontecimentos e fatos do dia a dia. Neste trabalho é apresentada uma proposta de inserção de experimentos de baixo custo e fácil acesso, no ensino de Física. Durante sua execução os alunos perceberam que os experimentos, aliados à analogia dos acontecimentos cotidianos, permitem a facilitação da construção do conhecimento. Foram realizados experimentos de Física, em que o aprendiz pudesse alcançar a compreensão das Leis que regem: a Mecânica, na Óptica, na Termologia, na Eletricidade, Magnetismo e no Eletromagnetismo. No final foi feito a montagem de 03 Kits de Experimentos, 01 Kit para cada série do Ensino Médio. Foi construído, também, um site do qual traz várias informações pertinentes ao desenvolvimento do projeto. O envolvimento dos alunos foi, inicialmente, empolgante para a realização dos experimentos e o rendimento escolar e a satisfação dos alunos foi maior. / In the present work, we describe a Physics teaching methodology that has been implemented in high school in ETEC Prof. Eudécio Luiz Vicente located in Adamantina, SP. The proposal values the understanding of science as a human production and founded the teaching process of meaningful learning of Ausubel and experimental activity, in order to articulate the formal knowledge of physics with the student's knowledge. Compared to the so-called traditional teaching, what is proposed is a more attractive school for students with an emphasis on understanding of physical concepts and their relationship with events and facts of everyday life. This paper presents a low-cost experiments insertion proposal and easy access, the teaching of physics. During its execution the students realized that the experiments together with the analogy of everyday events, allows the facilitation of knowledge building. We conducted physics experiments, in which the apprentice reached the understanding of the laws governing: Mechanical, in optics, in Thermology in Electricity, Magnetism and electromagnetism. At the end we were made to mount 03 Experiment Kits, 01 Kit for each high school grade. It was built also a site which brings various information relevant to the development of the project. The involvement of students was initially exciting for the experiments and school performance and student satisfaction was higher.

Tese de mestrado. Mestrado Integrado em Informática e Computação. Faculdade de Engenharia. Universidade do Porto. 2012

La mastocytose est une maladie hétérogène, caractérisée par une accumulation de mastocytes dans l'organisme. Les enfants et les adultes ont des mutations différentes de c-Kit. Dans un premier travail, nous avons montré que seules les formes adultes sont associées à la réactivation de la télomérase, alors que les formes pédiatriques ne sont pas. Cela semble être lié aux différences de mutations de c-Kit observées entre adultes et enfants et pourrait expliquer pourquoi seules les formes pédiatriques de mastocytose régressent spontanément et non les formes adultes. Ces résultats aident à mieux comprendre la physiopathologie de la mastocytose. Dans un second travail, nous a étudié le lien entre la longueur des télomères et les troubles psychologiques des adultes atteints de mastocytose. Nous avons montré que réactions émotionnelles négatives sont corrélées au raccourcissement de la longueur des télomères des leucocytes et que l'érosion télomérique est fortement prédite par les défauts de régulation des émotions. Nous émettons l'hypothèse qu'au cours des troubles neuropsychologiques, le mastocyte pourrait être impliqué dans le raccourcissement de la longueur des télomères en périphérie.

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