Title: Effects of isokinetic strength and postural muscles on dynamic strength, velocity and angular velocity of a front kick with and no carried load. Objectives: The aim of the work was to find the effect of the isokinetic strength of hip and knee flexors and extensors of the lower limb performing a front kick, hip rotators during concentric and eccentric contraction of the standing lower limb and the postural muscles on dynamic forces, velocity and angular velocity of a front kick with and no carried load. Methods: This correlation study was conducted on 16 male participants (age: 22 ± 1,5 years⁏ weight: 79 ± 6,6 kg⁏ height: 182 ± 6,1 cm) studying military physical education at the Faculty of Physical Education and Sports of Charles University in Prague. Participants performed 5 consecutive front kicks with or without additional load (0 kg, 5 kg, 15 kg, 30 kg, 45 kg). The dynamic strength of the kicks was measured using a Kistler force plate. The velocity and angular velocity of the kicks were measured using a motion capture system (Qualisys). The isokinetic strength of hip and knee flexors and extensors and hip internal and external rotators were measured using a Humac Norm isokinetic dynamometer (CSMI). Postural muscles strength was assessed using 5 different stability tests. The correlation...

The abuse of anabolic androgenic steroids (AAS) is becoming increasingly common and may result in a range of physiological as well as psychological effects such as altered behavior in terms of increased aggression, cognitive dysfunction and addictive behavior. AAS comprise testosterone and its derivatives, of which nandrolone is one of the more common. Previous studies have shown nandrolone-induced effects in male rats on peptide levels within the Substance P (SP) system and the dynorphinergic system; these effects may be linked to some of the reported behavior alterations. The studies presented in this thesis aimed to investigate the mechanisms underlying these peptide alterations and also to further investigate neuropeptidergic effects attributed to nandrolone administration. The results display significant effects on the enzymatic conversion of SP and Dynorphin A into their bioactive metabolites SP(1-7) and Leu-enkephalin-Arg6, respectively, as a result of nandrolone treatment. More profound investigations on the dynorphinergic system displayed effects on the kappa opioid receptor density in various brain regions. There was also a significant increase in the expression of the gene transcript of prodynorphin in the hippocampus, a brain region associated with cognitive processes. In addition, impaired spatial learning and memory in the Morris water maze task following nandrolone administration was encountered. The results provide further understanding regarding neuropeptidergic mechanisms underlying AAS-induced behavioral effects.

This study presents a holistic view of which factors small and medium-sized enterprises (SMEs) have to consider, in moving their customer order decoupling point (CODP) further from the customer, thereby becoming more customized. The study also investigate whether SMEs and larger enterprises differ in the strategic questions relating to what influences an enterprise to become more customized, which prerequisites are required and which problems enterprises should anticipate and prepare for. These questions are important, given that strategic change is challenging, and can take considerable time to accomplish; it therefore needs to be based on the right decisions. This study is motivated by the fact that the markets SMEs are selling to tend to become more and more complex and harder to anticipate. Increased globalisation and use of IT and ICT have lead to greater uncertainty in customer demand. At the same time customers have ever more demanding needs and specifications; if these are not met, they will go elsewhere rather than reducing or adapting them. This complexity requires a more customized production and is a way to gain commercial advantages.       Customised production includes many benefits such as reduced uncertainty, by producing totally customized products less capital bound is tied up. But meanwhile many challenges such as reduced production efficiency, furthermore flexibility must be increased and higher demands on communications and IT systems are often necessary. The study starts with a wide and thorough theoretical overhaul around the movement of the CODP, but also addresses other parts of the organization to get the all-important big picture. This theoretical work is leading to a work-model which is used in six interviews within SMEs. In order to get a thorough picture, the enterprises that take part in the study are from different line of business and have from 18 to 235 employees. During these interviews, conducted on a single occasion per company, the model and related questions are discussed. Thereby an analysis of the interviews and the theory is done, with the model as the starting-point.   The result of this study is a basic model, which SMEs can use as an analytical tool, and a checklist, to facilitate a move towards a make-to-order manufacturing strategy, thereby gaining more flexibility. The study provides a basic generic framework which can be adapted and tailored by the company in question to see which parts are relevant to specific circumstances.

Syfte – Examensarbetets syfte  är att beskriva utvecklingsprocessen för utbildningar inom en konsultverksamhet utifrån kundorderpunktsmodeller som används inom tillverkande verksamheter. Syftet har brutits ned i två delmål: Delmål: Att beskriva utvecklingsprocessen för utbildningar inom en konsultverksamhet. Delmål: Att placera in utvecklingsprocessen för utbildningar i kundorder­punkts­modellerna. Metod – För att uppfylla examensarbetets syfte genomfördes en fallstudie på teknikkonsultföretaget Combitech AB i Jönköping. För att ge en grund till det teoretiska ramverket gjordes en litteraturstudie. Empiri samlades in genom en fallstudie, innehållande intervjuer och dokumentstudie. Empirin har sedan analyserats mot det teoretiska ramverket och genom mönsterjämförelse placerades kundorderpunkterna in i modellerna. Analysen har bidragit till att uppnå examensarbetets syfte. Resultat – De utvecklingsprocesser som identifierades för de tre utbildnings­kategorierna saknade ett standardiserat arbetssätt. I stället var utbildningarna ofta enskilt framtagna och hårt knutna till de enskilda konsulterna. Examensarbetet visar att de två kundorderpunktsmodellerna från tillverkande verksamhet fungerade olika bra för att visualisera graden av kundorderstyrning i utvecklingsprocessen för en konsultverksamhet. Som visualiseringsverktyg fungerade den tvådimensionella kundorderpunktsmodellen lite sämre då den inte visade så stor skillnad mellan de beskrivna processerna. Modellen för utvecklings- och designprocessen var mer nyanserad och fungerade bättre för att indikera vilken aktivitet i utvecklingsprocessen som var kundorderdriven. Implikationer – Kundorderpunktsmodellerna är skapade för en tillverkande verksamhet som producerar fysiska varor och genom att testa modellerna på en tjänsteverksamhet utmanas modellens ramverk och funktion. Detta examensarbete har bidragit till att täcka en del av det identifierade teoretiska gapet i användningen av kundorderpunktsmodeller mellan tillverkande verksamhet och tjänsteverksamhet. Vidare forskning – För att bidra till att täcka det teoretiska gapet kan förslagsvis den tvådimensionella kundorderpunktsmodellen vidareutvecklas och anpassas helt för tjänsteverksamhet. En person med akademisk kunskap om tjänsteverksamhet och kundorderpunktsteorier skulle kunna bidra med ny teori inom området. Det skulle också vara intressant att undersöka om det går att kombinera de två kundorderpunktsmodellerna som presenterats i detta examensarbete. / Purpose – The purpose of this thesis is to describe the development process for educations within consulting with customer order decoupling point models commonly used within manufacturing operations. The purpose has been broken down into two parts: Objective: To describe the development process for educations within a consultancy. Objective: To position the development process for educations based on the customer order decoupling point models. Method – In order to meet the thesis purpose, a case study was conducted on the engineering consultancy Combitech AB in Jönköping. To provide a basis for the theoretical framework a literature study was performed. To collect empirical data a case study including interviews and a document study was conducted. The empirical data were then analysed against the theoretical framework, and through pattern matching the customer order decoupling points were positioned into the models. The analysis has helped to achieve the thesis purpose. Findings – The engineering process that was identified for the three educational categories lacked a standardized approach. Instead, programs were often individually designed and tightly tied to the individual consultants. The thesis shows that the two customer order decoupling point models from manufacturing operations varied in usefulness to visualize the degree of customer order management in the engineering process of a consultancy business. As a visualization tool the two-dimensional customer order decoupling point model was of limited value because it didn’t show much difference between the processes described. The model for the engineering and design process was more nuanced and worked better to indicate which activities in the engineering process that were customer order driven. Implications – The customer order decoupling point models are created for manufacturing operations that produce physical goods and by testing these models on a service, the model framework and function is challenged. This thesis has helped to cover a part of the identified theoretical gap in the use of customer order decoupling point models between manufacturing operations and service operations. Limitations – To help cover the theoretical gap the two-dimensional customer order decoupling point model can tentatively be further developed and fully customized for service operations. A person with an academic knowledge of service and customer order decoupling point theories could help create new theory in the field. It would also be interesting to investigate whether it is possible to combine the two customer order decoupling point models presented in this thesis. / KOPtimera