Issued also as thesis, Münster.

Thesis (Ph. D.)--UCLA, 2007. / Vita. Includes bibliographical references (leaves 299-336).

Issued also as thesis, Leyden. / "Sommaire": p. [217]-219. Errata slip inserted.

CoordenaÃÃo de AperfeiÃoamento de NÃvel Superior / CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior / RESUMO As doenÃas trombÃticas constituem um sÃrio problema de saÃde pÃblica. Diversas desordens hereditÃrias e ambientais, que afetam o sistema fisiolÃgico anticoagulante, estÃo atualmente estabelecidas como fatores de risco para a ocorrÃncia do evento trombÃtico. Dentre os fatores hereditÃrios, as mutaÃÃes G1691A do gene do fator V e G20210A do gene da protrombina sÃo os mais freqÃentes. A associaÃÃo entre estas alteraÃÃes genÃticas e a ocorrÃncia de eventos trombÃticos desencadeou o desenvolvimento de diversas pesquisas. Neste estudo, 189 pacientes portadores de eventos trombÃticos, atendidos no ambulatÃrio de Hematologia do Centro de Hematologia e Hemoterapia do Cearà - HEMOCE/SESA/UFC, foram analisados para a detecÃÃo da presenÃa das mutaÃÃes G1691A do gene do fator V e G20210A do gene da protrombina. O grupo controle consistiu de 349 voluntÃrios. A freqÃÃncia encontrada na populaÃÃo controle foi de 2% (7/349) para a mutaÃÃo do fator V e 1,7% (6/349) para a mutaÃÃo da protrombina, enquanto que nos pacientes trombofÃlicos a freqÃÃncia destas mutaÃÃes foi de 9% (17/189) e 2,1% (4/349), respectivamente. Dentre os fatores hereditÃrios, apenas a mutaÃÃo do fator V foi significante (p<0,001). Considerando os fatores ambientais de risco, o tabaco, idade > 40 anos e sexo feminino apresentaram significÃncia estatÃstica (p<0,001). Os riscos foram estimados em anÃlises pareadas e nÃo pareadas para o fator V de Leiden (4,8; 5,3; 9,8), tabaco (17,6; 14,9; 33,3), idade idade > 40 anos (2) e sexo feminino (3,7 e 4,1). Os fatores de risco para eventos trombÃticos no Cearà foram tabagismo, idade > 40 anos, sexo feminino, e a mutaÃÃo G1691A do fator V.foram associados com o desenvolvimento de trombose no estado do CearÃ. / Thrombotic diseases are a serious problem for public health. Several hereditary and environmental factors, that affect physiological anticoagulant system, have been nowadays well established as risk factors for thrombosis. Among hereditary factor V Leiden and prothrombin G20210A mutation are the most frequents. The association between several modifications on factor V gene and prothrombin gene in the development of thrombotic events has brought about future searches. In this study, 189 patients with thrombosis attended at the Hematology and Hemoterapy Center of Cearà state âHEMOCE/ Brazil, were analyzed to find out the presence of factor V Leiden and prothrombin G20210A mutation The control group was made up 349 healthy volunteers. In this study, the frequency found of factor V Leiden the control population was of 2% (7/349) and in the patients was 9% (17/189) while the frequency found of prothrombin G20210A mutation the control population was of 1,7% (6/349) and in the patients was 2,1% (4/189). Among hereditary factors only factor V Leiden was significant statistic (p<0,001). Among environmental factors studied, tabagism, age > 40 anos and femele were significant statistic (p<0,001). The ODDS RATIO of the risk factors with significant statistic were factor V de Leiden (4,8; 5,3; 9,8), tabaco (17,6; 14,9; 33,3), age > 40 years old (2) and female (3,7 e 4,1). Our results demonstrate that factor V Leiden, tabagism, age > 40 years old and female were associated with development trombosis in CearÃ.

Die Dissertation "Untersuchungen von Reliefstelen aus Nordafrika. Beiträge zur Akkulturation und Romanisierung in der kaiserzeitlichen Provincia Africa Proconsularis" von Ulrike Wurnig behandelt Reliefstelen aus dem heutigen Tunesien und Algerien, die während des 1. bis 3. Jahrhunderts n. Chr. in verschiedenen Zentren der römischen Provinz entstanden sind. Eine Gruppe von größtenteils noch unpublizierten Reliefstelen, die sich heute im Rijksmuseum van Oudheden in Leiden befindet, bildet den Ausgangspunkt der Dissertation. Um die verschiedenen kulturellen Einflüsse besser fassbar zu machen, die auf die Reliefskunst des römischen Nordafrikas einwirkten, werden im ersten Hauptkapitel die Denkmäler der vorrömischen Epoche, die punischen Stelen, ausführlich vorgestellt. Hierbei wird zwischen den punischen Grabstelen und den punischen Votivstelen unterschieden. Letztere gelten als Weihegaben an die punischen Gottheiten Baal Hammon und Tanit, welche schließlich in römischer Zeit jeweils in Gestalt als eine interpretatio Romana, nämlich des römischen Saturnus Africanus und der Dea Caelestis verehrt wurden. Im zweiten Hauptkapitel werden die verschiedenen Stelengruppen vorgestellt, die in römischer Zeit in verschiedenen Zentren Nordafrikas entstanden sind. Hierbei wird zwischen Reliefstelen unterschieden, die noch stärker in punischer Tradition stehen – die so genannten neopunischen Reliefs -, und solchen, die eine deutlich römische Ausprägung erkennen lassen. Die folgenden Abschnitte sind dem Thema der "Typologie" sowie der "Ikonographie" der Reliefstelen gewidmet. Durch die Zuweisung von sowohl einem "Formtypus" als auch einem "Gliederungstypus" werden die einzelnen Monumente typologisch genau beschrieben. Dadurch können auch die einzelnen kulturellen Einflüsse besser identifiziert werden, die auf jedes Monument wirkten. Das Kapitel zur "Ikonographie" ist unterteilt in Tiermotive, Darstellungen von einzelnen Gottheiten, mythologische Szenen, das Bankettmotiv sowie bukolische Szenen.Im Anschluss daran werden Überlegungen zu den verschiedenen Funktionsbestimmungen der Monumente gegeben. Im letzten Hauptkapitel werden die Monumente als kulturhistorische Quellen ausgewertet. Am Beispiel der Stadt Mactaris wird der Prozess eines allmählichen Wandels von einer punisch-numidischen Siedlung in eine romanisierte Stadt exemplarisch ausgeführt. Anhand der Studien zur Tracht der auf den Reliefs dargestellten Porträtfiguren werden Belege ausgeführt, anhand derer sich der in den unterschiedlichen Zentren völlig unterschiedlich verlaufende Romanisierungsprozess nachvollziehen lässt. Der Arbeit ist ein Katalogteil angegliedert, in welchem die 14 Reliefstelen im Rijksmuseum van Oudheden aufgeführt sind. Hierbei werden jeweils eine ausführliche Beschreibung sowie eine Analyse der Darstellung gegeben. / The PhD-thesis "Untersuchungen von Reliefstelen aus Nordafrika. Beiträge zur Akkulturation und Romanisierung in der kaiserzeitlichen Provincia Africa Proconsularis" of Ulrike Wurnig discusses reliefs of Tunisia and Algeria, which were originally produced in different centers of the Roman province from the 1st to the 3rd century A.D. The scientific research of the thesis is based on a group of mostly unpublished reliefs, which are stored in the Rijksmusuem van Oudheden at Leyden today. Within the first main chapter the Punic stelae, the monuments of the pre Roman period, are presented to show all the different cultural influences during the Roman period. Here, a differentiation is made between the Punic funeral stelae and the Punic votive stelae. The latter are votives to the Punic god Baal Hammon and the goddess Tanit, which were celebrated as interpretatio Romana, Saturnus Africanus and Dea Caelestis, within Roman times. The next chapter of the thesis discusses the main different groups of reliefs produced in different centers of the Roman North Africa. There are differences between reliefs with stronger Punic characteristics – the so called Neopunic reliefs – and those, which are more Roman. The following chapters are dedicated to the topics "Typology" and "Iconography". Each relief can be classified into a "form type" and into a "arrangement type". Therefore each monument can be identified by the cultural influences, which affected it. The iconographic part of the thesis is divided into animal motives, presentations of gods and goddesses, mythological scenes, banquet scenes and bucolic scenes. Considerations regarding the functions of the monuments are described in the following part. In the last main chapter of the thesis, the reliefs are interpreted as cultural historical sources. The Roman city Mactaris is given as an example for the process of the slowly developing change of a Punic-Numidian settlement into a romanisized city. In addition, studies that focus on the different costumes of relief portrait figures are included. Theses studies indicate the often completely different Romanization process in various local centers. In the catalogue of the addendum one can find detailed descriptions of the 14 reliefs of the Rijksmuseum van Oudheden in Leyden.

Thesis (doctoral)--Rijksuniversiteit te Leiden, 1934. / Includes bibliographical references (p. [142]-151) and index.

Intro/Aims: Venous thromboembolism (VTE) is a common complication in cancer patients. The role of thrombophilic polymorphisms in cancer related VTE remains poorly explored. Aim 1 of this study was to determine if Factor V Leiden (G1691A), Prothrombin (PT) G20210A or methylenetetrahydrofolate reductase (MTHFR) C677T are associated with the increased occurrence of VTE in adult oncology subjects compared to nononcology subjects. Aim 2 of this study was to determine if cancer patients with the MTHFR C677T polymorphism who are treated with antimetabolite therapy have an increased incidence of VTE compared to cancer patients who are treated with other chemotherapy.Setting/Methods: A descriptive, comparative, retrospective chart analysis was utilized for this study in an outpatient hematology, oncology clinic in Southern Arizona. Enrolled were 100 adult subjects (age 18 - 85) with documented history of VTE (27 subjects with cancer and 73 noncancer). Subjects were evaluated for Factor V Leiden, PT G20210A, and MTHFR C677T prior to the study. Eleven subjects were treated with antimetabolite chemotherapy and 8 subjects were treated with other chemotherapy.Results: The overall polymorphism frequency for Factor V Leiden was 21%, PT G20210A 4%, and MTHFR C677T 50%. Factor V Leiden was found in 11.1% of cancer subjects and 24.7% of noncancer subjects. Prothrombin G20210A was found in 3.7% of cancer subjects and 4.1% of noncancer subjects. MTHFR C677T was present in 25.9% of cancer subjects and 58.9% of noncancer subjects. No statistical significance was observed between subjects treated with an antimetabolite and positive for MTHFR C677T compared with those treated with other types of chemotherapy.Conclusion: Analysis of the data collected in this study demonstrated overall higher rates than the expected frequencies of all polymorphism for both the cancer and noncancer patients with documented VTE. In this small retrospective study, the only significant finding was that the MTHFR C677T polymorphism was more prevalent in the noncancer group.Currently, there are no specific guidelines for VTE prevention in the outpatient oncology setting. Identification of risk factors, including prothrombotic mutations may reduce risk of VTE and provide guidance for prophylactic treatment recommendations in the outpatient setting.

Thesis (doctoral)--Rijksuniversiteit te Leiden, 1934. / Includes bibliographical references (p. [142]-151) and index.

Inaug.-diss.--Leipzig. / Vita.

Made available in DSpace on 2014-06-12T15:53:41Z (GMT). No. of bitstreams: 2 arquivo4865_1.pdf: 636757 bytes, checksum: 3ec4d860f40ad4f5b5ca4be630dcde22 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2006 / A incidência de trombose venosa profunda (TVP) na população pediátrica (0-18 anos) tem sido descrita como mais baixa que nos adultos. Em quase a metade das crianças, três ou quatro fatores de risco para trombose estão presentes simultaneamente. Distúrbios tromboembólicos não causam trombose espontaneamente, o defeito hemostático se torna aparente porque a trombose ocorre quando um ou mais fatores de risco adquiridos estão também presentes. O objetivo desse trabalho foi estudar um caso de um jovem rapaz que aos 13 anos apresentou TVP, depois de um trauma jogando futebol. Atividades de proteína C (PC), proteína S (PS), antitrombina, lúpus anticoagulante, fibrinogênio, resistência à proteína C ativada (RPCA), tempo de protrombina (TP) e tempo de tromboplastina parcial ativada foram analisados em um coagulômetro ACL 7000 (IL, Spain) depois de consentimento formal. O fator II (G20210A) e o fator V de Leiden (FVL) (G1691A) foram pesquisados com kit comercial para PCR. O paciente foi heterozigotos para FVL e com RPCA. Seu pai também foi heterozigoto, mas que até o momento não teve trombose. Sua mãe apresentou resultados normais. As outras análises foram normais. Existe menor probabilidade para desenvolvimento de trombose nos portadores de FVL que nas deficiências de PC, PS, AT. Entretanto, o efeito da presença do FVL associado com outras condições clínicas, tende a ser multiplicativo no risco relativo a trombose, doença multifatorial. Condições circunstanciais, como um trauma, podem agir como um precipitante de TVP em portadores jovens do FVL, a mais comum causa de trombofilia hereditária