This theoretical thesis covers the issues of Autism Spectrum Disorders (ASD) in relation to the brain connectome research. ASD belong to the group of neurodevelopmental syndromes and are characterized by deficits in communication skills, social interaction and stereotypic behaviors. The prevalence of ASD increases, its etiopathogenesis is very likely multifactorial. Within the ASD syndrome, precise differential diagnostic algorithms are difficult to implement in the absence of objective biomarkers. Extensive neuroscientific research, including the connectome projects, might improve the diagnostic and therapeutic procedures in the field of Psychiatry, including ASD. The individual's connectome profile might well serve as a new biomarker in psychiatric diagnostic and therapeutic approaches. The brain connectome represents the net of all neuronal connections in the brain. Mapping of the connectome across all ages, in health and in disease, is the main goal of the Human Connectome Project (HCP). The first HCP data show great interindividual variability with the environmental factors playing a crucial role. Extensive neurobiology research data on mechanisms of memory support the vital role of environmental stimulation in compensating for behavioral symptoms in ASD. Applied behavior analysis (ABA) is an...

The thesis deals with the dilemma of the believer and the position of the Catholic Church on assisted reproduction. It describes the origins of human life, reflections on its origins, and mentions the need for its protection and the preservation of dignity, as well as referring to the Church's view of its creation in marriage. It points out the issue of infertility and possible ways of its solution, including assisted reproduction. There is emphasized the rejection of the Catholic Church's assisted reproduction and its thorough explanation from the churches of the documents. The final chapter offers possible solutions to fulfilling the desire for a child that are morally acceptable, including both the methods of natural parenting planning and the possibility of alternative family care but also the accepting the fact of childlessness.

This thesis contains theoretical definitions of a knowledge-based company, human capital development and education. The second part analyzes the data obtained from the monitored period 2008-2012 and includes standardized and non-standardized interviews, overt participant observation and a questionnaire survey.

The thesis deal with the topic of induced abortion and euthanasia as the basic issue of the theme of process of dying and death. The theoretical part presents how an acceptation of death have been changing during the human history, deals with the concept of after-life in five world religions, presents how death is perceived in different life period, gives the analysis of abortion and euthanasia as an issue of ethics. The second part od the thesis is to serve as the background material to design lessons of ethics for the secondary schools according to the RWCT program (Reading and Writing Critical Thinking). The aim is to depict the topicality and importance of these issues that a disciple is not only to meet during the lesson, but also to be able to handle, to judge and to draw conclusions for his behaviour.

Nowadays quality of life is often discussed topic. In defining this term, there is considerable ambiguity and disunity, since there is no universally accepted definition, nor theoretically sophisticated model. However, despite this fact, the level of quality of life is currently one of the most discussed topic. Monitoring the quality of life by using a variety of indicators are engaged in several international organizations, one of them is the Development Programme of the United Nations. This organization annually publishes the Human Development Index, which divides the world´s countries into four groups according to their level of development: low, medium, high and very high development. The aim of this thesis is to analyze the quality of life in 125 countries by using cluster analysis, accurately the Ward's method. Quality of life in this thesis is evaluated based on 19 demographic and economic indicators, which include life expectancy, literacy rate, access to drinking water and infant mortality rate. The cluster analysis divided the country into individual clusters by their similarities. Six clusters were created by this analysis, which had been compared with the results of Human Development Index. The clusters very well reflect the division, which is commonly used in the characterization of developing and developed countries. Each of the six clusters can be very well described and characterized in terms of quality of life. It is also possible qualify those clusters as poorest developing, low developed, moderately developed, medium development, high and very high development countries. Based on the results it can be stated that this analysis is consistent with other indicators of quality of life and the resulting clusters are identical with the division of countries which is commonly used.

The aim of this thesis is to statistically determine the dependence rate of software piracy in the cultural foundation of the country and other factors. Data obtained from internet were the resources of my work. They were from the results of different surveys and case studies. The data contain values of individual indicators, each for a maximum number of countries. The nature of the collected data leads to the analysis of quantitative variables such were selected correct statistical methods. Dependence of the quantitative variables was measured by simple linear regression. The rate of this dependence determines the correlation analysis. In my case Spearman's correlation coefficient was used. Any dependence was investigated with a pair of indicators. In each of pairs was as the dependent variable rate of software piracy. For better understanding I have used the graphs. From my thesis, I expect evaluate past and current situation about software piracy in the Czech Republic and in the world, and that shows influences the amount of computer crime.

The economic concept of health is defined as an ability to fully utilize human capital. The health promotion shall procure healthy lifestyle among the population. It also appears as the most efficient way to prevent diseases, in particular the non-communicable diseases (NCD). Economic analysis of human behavior offers the explanation of the rational choices as well as the decisions with bounded rationality affecting people's' health conditions. The Czech population health development analysis shows tendencies to careless approach in this area, that is illustrated by the increase incidence of sick leaves caused by NCD in higher age categories. Application of the health promotion in Czech Republic may be significantly improved by the outcomes of economic analysis of human behavior in these regards. Incidental issues are to be analyzed by the methods of logical deduction logical deduction, comparative analysis and empirical results of the statistical survey. Synthesis of the findings and conclusions of the analysis is the starting point for the modeling of health strategies, policies and programs promoting health in the Czech Republic. The main hypothesis is supported by the outcomes of this analysis with regards to the applicability of the economic analysis of human behavior on the health promotion and its positive macroeconomical impact on the current medical system sustainability. The primary contribution of the thesis consist in formulation of specific outcomes of the economic analysis of human behavior for the health promotion concept development. A secondary benefit is the proposal to measure personal productive incapacity in time by the indicator of work incapacity. In this context, the risk of non-infectious diseases impact deepening in older age categories of workers in Czech Republic is emphasized

1 Abstract This doctoral thesis focuses on the analogies between Virginia Woolf's "personal philosophy" and Alfred North Whitehead's process philosophy, or in his own words "philosophy of organism." The thesis does not claim that Whitehead's thought directly influenced Woolf's fiction, rather, it makes use of a zeitgeist model. The two contemporaries shared the rejection of long-established dualisms, particularly the Cartesian mind-body dualism, the binaries of subject and object, animate and inanimate matter, the human and the nonhuman, and last but not least the individual and the community. Interested in the philosophical enquiry into the problem of reality and the visible world, Woolf redefines the notion of "things" in her fiction and adopts the processist view that objects may be defined as clusters of events, which are not separate from the perceiving subject but interrelated with it. Moreover, Woolf illustrates her interest in the natural world in most of her works and often suggests that what we normally think to be inert and lifeless matter, may, in fact, also have some proto-conscious, or proto- experiential, qualities like Whitehead's "actual occasions." The second part of the thesis focuses on Woolf's attempt to overcome one's individual identity in favour of adopting a more inclusive and...

This diploma thesis discusses the selection process and increasing its efficiency. It deals with selection of employees in manufacturing positions at Lear Corporation Czech Republic s. r. o. It includes analysis of the current situation of recruitment and selection of employees in that company and proposals for changes to increase the efficiency of HR assistants work and help to select appropriate personnel.

This doctoral thesis focuses on computational modelling of human vocal folds and vocal tract functions using finite element method (FEM). Human voice is crucial in human communication. Therefore one of the main targets of current medicine is creation of artificial vocal folds, which would substitute the original vocal folds. The computational modelling can be used to understand principles of voice production, determination of parameters that the artificial vocal folds have to meet and verification of their functionality. First part of this thesis focuses on modelling of human voice creation by whisper. Influence of intraglottal gap on eigenvalues distribution for individual vowels was analysed using FEM vocal tract and trachea model. Further there is presented two-dimensional (2D) finite element model of the flow-induced self-oscillation of the human vocal folds in interaction with acoustic spaces of the vocal tract. The 2D vocal tract model was created on the basis of converting the data from magnetic resonance images (MRI). Explicit coupling scheme with separated solvers for structure and fluid domain was used for modelling of the fluid-structure interaction. Created computational model comprises: large deformations of the vocal folds tissue, contact between vocal folds, fluid-structure interaction, morphing the fluid mesh according to the vocal-fold motion (Arbitrary Lagrangian-Eulerian approach), unsteady viscous compressible or incompressible airflow described by the Navier-Stokes equations and airflow separation during glottis closure. This model is used to analyse the influence of stiffness and damping changes in individual vocal fold tissue layers (in particular in superficial lamina propria). Part of this computational analysis is also comparison of vocal folds behaviour for compressible and incompressible flow model. Videokymograms (VKG) are subsequently created from obtained results of FEM calculations which enable to compare individual variants between themselves and with motion of real human vocal folds. In next part of this thesis is presented three-dimensional (3D) finite element model of the flow-induced self-oscillation of the human vocal folds. This 3D model was created from a previous 2D model by extrude to the third direction. Using this model was again compared influence of compressible and incompressible flow model on vocal folds motion and generated sound by using videokymograms and acoustic spectra. The last part of this thesis focuses on the possibility to replace missing natural source voice in form reed-based element. Behaviour of reed-based element was analysed using computational modelling and using measurements on experimental physical model. The physical model enables changes in setting gap between reed and reed stop and performing acoustical and optical measurements.