Le présent travail de doctorat vise à proposer une méthode de post-traitement de la plasticité, à partir de deux calculs éléments finis en élasticité, afin de déterminer la durée de vie de structures avec concentration de contraintes, comme les disques ou les aubes de turbines. Leur dimensionnement en fatigue avec des calculs éléments finis en plasticité conduit à des temps de calcul longs, voir prohibitifs. Les méthodes de types Neuber et l’analyse par changement d’échelles sont des alternatives beaucoup moins couteuses en temps de calcul. En effet, ces méthodes permettent d’estimer la plasticité localisée uniquement à l’aide de calculs éléments finis en élasticité. Néanmoins, lorsque l’état de contrainte est multiaxial, le post-traitement de la plasticité est très imprécis. Cette imprécision provient d’une mauvaise estimation de la triaxialité des contraintes. Les méthodes de type Neuber ont été d’abord enrichies par une description plus précise de la triaxialité des contraintes. Elles ont ensuite été validées sur des structures soumises à des chargements monotones. Cependant, cette méthodologie n’est pas adaptée pour les chargements multiaxiaux alternés. Pour remédier à ce problème, une approche fondée sur les lois de changement d’échelles a été développée. Les zones de plasticité confinée sont considérées comme des inclusions. Cette approche est également enrichie par une meilleure description de la triaxialité des contraintes. Le post-traitement de la plasticité obtenue sur les bords libres de structures soumises à des chargements alternés est précis. Cette méthode a finalement été appliquée sur les cas d’un disque et d’une aube de turbine. / This work aims to propose a method to estimate plasticity from two structural analyses in elasticity in order to determine the lifetime of structures with stress concentration, such as turbine discs or turbine blades. Fatigue analyses computed by the finite element method in plasticity leads to costly computations not always suitable. Energetic methods such as Neuber’s and the scale transition approach are much less expensive alternatives. Indeed, these methods are able to estimate localized plasticity at free edges only from both computations in elasticity. However, when the stress state is multiaxial, the estimation of the plasticity is inaccurate. This inaccuracy comes from a wrong estimation of the stress triaxiality. Expressions for the stress triaxiality at free edges of elastoplastic structures are established. These expressions are derived thanks to a new heuristic that unify uniaxial tension (plane stress condition) and plane deformation in a single case. The proposed expressions for the stress triaxiality are then used to enhance energetic methods (as Neuber and Glinka rules). Notched specimens subjected to monotonic loadings are studied. However, this methodology is not able to handle alternating loadings. To deal with this problem, a new scale transition approach is developed. Localized plastic areas are considered as inclusions. This approach is enhanced by the new heuristic of multiaxiality. The elastoplastic notch tip strains and stresses of structure subjected to complex alternating loadings are accurately estimated from both elastic analyses. This method is finally applied to the case of a turbine disk and a turbine blade of a jet engine.

Managing soil hydrophobicity caused by localized dry spots (LDS) on sand based golf greens has become one of the greatest challenges for golf course superintendents and managers, especially as water restrictions intensify. The purpose of this study was to evaluate the effectiveness of thirteen soil surfactants in eliminating LDS and in maximizing root zone soil moisture on a sand based USGA golf green located on the California Central Coast. Potential water repellency of air dried cores (measured utilizing the water droplet penetration time (WDPT) method), phytotoxicity, and climate were analyzed during two experimental trials. Phytotoxicity data was collected for Trial I using visual quality ratings and for Trial II using a chlorophyll meter. Phytotoxicity decreased during Trial I. Differences in phytotoxicity as measured using chlorophyll index were not at all significant during Trial II (p = 1). Ten of the thirteen wetting agent treatments significantly (p < 0.001) decreased soil hydrophobicity compared with the other wetting agent treated plots and the non-treated control. More frequent application of Cascade Plus resulted in a more significant reduction in soil hydrophobicity. Increasing the application rates also resulted in the reduction of soil hydrophobicity. Wetting agent treatment 6-CP(10day) maintained the highest volumetric water content (VWC) but treatment 13-2079337 maintained the highest levels for wetting agents treated monthly.

With the rapid development of digital multimedia and internet techniques in the last few years, more and more digital images are being distributed to an ever-growing number of people for sharing, studying, or other purposes. Sharing images digitally is fast and cost-efficient thus highly desirable. However, most of those digital products are exposed without any protection. Thus, without authorization, such information can be easily transferred, copied, and tampered with by using digital multimedia editing software. Watermarking is a popular resolution to the strong need of copyright protection of digital multimedia. In the image forensics scenario, a digital watermark can be used as a tool to discriminate whether original content is tampered with or not. It is embedded on digital images as an invisible message and is used to demonstrate the proof by the owner. In this thesis, we propose a novel localized geometric-distortion resilient digital watermarking scheme to embed two invisible messages to images. Our proposed scheme utilizes two complementary watermarking techniques, namely, local circular region (LCR)-based techniques and block discrete cosine transform (DCT)-based techniques, to hide two pseudo-random binary sequences in two kinds of regions and extract these two sequences from their individual embedding regions. To this end, we use the histogram and mean statistically independent of the pixel position to embed one watermark in the LCRs, whose centers are the scale invariant feature transform (SIFT) feature points themselves that are robust against various affine transformations and common image processing attacks. This watermarking technique combines the advantages of SIFT feature point extraction, local histogram computing, and blind watermark embedding and extraction in the spatial domain to resist geometric distortions. We also use Watson’s DCT-based visual model to embed the other watermark in several rich textured 80×80 regions not covered by any embedding LCR. This watermarking technique combines the advantages of Harris feature point extraction, triangle tessellation and matching, the human visual system (HVS), the spread spectrum-based blind watermark embedding and extraction. The proposed technique then uses these combined features in a DCT domain to resist common image processing attacks and to reduce the watermark synchronization problem at the same time. These two techniques complement each other and therefore can resist geometric and common image processing attacks robustly. Our proposed watermarking approach is a robust watermarking technique that is capable of resisting geometric attacks, i.e., affine transformation (rotation, scaling, and translation) attacks and other common image processing (e.g., JPEG compression and filtering operations) attacks. It demonstrates more robustness and better performance as compared with some peer systems in the literature.

Data aggregation is an important technique in wireless sensor networks. The data are gathered together by data fusion routines along the routing path, which is called data-centralized routing. We propose a localized, Delay-bounded and Energy-efficient Data Aggregation framework(DEDA) based on the novel concept of DEsired Progress (DEP). This framework works under request-driven networks with realistic MAC layer protocols. It is based on localized minimal spanning tree (LMST) which is an energy-efficient structure. Besides the energy consideration, delay reliability is also considered by means of the DEP. A node’s DEP reflects its desired progress in LMST which should be largely satisfied. Hence, the LMST edges might be replaced by unit disk graph (UDG) edges which can progress further in LMST. The DEP metric is rooted on realistic degree-based delay model so that DEDA increases the delay reliability to a large extent compared to other hop-based algorithms. We also combine our DEDA framework with area coverage and localized connected dominating set algorithms to achieve two more resilient DEDA implementations: A-DEDA and AC-DEDA. The simulation results confirm that our original DEDA and its two enhanced variants save more energy and attain a higher delay reliability ratio than existing protocols.

Ovarian cancer has the highest mortality rate of all gynecological malignancies, due to inadequate treatment strategies and poor early diagnosis. Intraperitoneal (IP) chemotherapy administered on an intermittent schedule has been pursued for ovarian cancer treatment. However, local toxicities and complications associated with indwelling IP catheters required to deliver the chemotherapeutics have been documented. Furthermore, shortening or completely removing treatment-free periods between each chemotherapy cycle has shown improved efficacy compared to intermittent chemotherapy. The focus of this thesis was to develop and characterize a biocompatible and biodegradable IP injectable depot sustained drug delivery system as a new treatment strategy for ovarian cancer. A polymer-lipid injectable formulation (PoLigel) was developed and used for sustained docetaxel (DTX) delivery. The PoLigel resulted in homogeneous DTX peritoneal distribution and sustained plasma levels in healthy mice, which was in contrast to Taxotere®, the clinically used formulation of DTX. Sustained plasma, tissue, tumor and ascites DTX concentrations were observed in mice bearing IP SKOV3 tumors or ID8 ascites over a 3 week period following IP administration of the PoLigel. The intratumoral distribution and tumor penetration of DTX in subcutaneous (SC) and IP SKOV3 tumors were characterized. DTX distributed more towards the tumor core and diffused 1.5 fold further from blood vessels of the IP tumors compared to the SC tumors. The high efficacy observed in the IP SKOV3 and ID8 models and the SC SKOV3 model was attributed to favorable drug distribution at the whole-body, peritoneal and intratumoral levels in combination with local and systemic sustained drug exposure. Sustained chemotherapy with DTX alone and in combination with a drug efflux transporter inhibitor was investigated in multidrug resistant (MDR) ovarian cancer. In vitro, combination delivery via the PoLigel resulted in more apoptosis, greater intracellular accumulation of DTX, and lower DTX efflux in MDR ovarian cancer cells. Sustained combination chemotherapy was more than twice as efficacious as intermittent Taxotere® treatment in MDR ovarian cancer. Significant anti-tumor efficacy was also observed in the MDR model following sustained DTX chemotherapy compared to intermittent Taxotere®. Overall, results presented here encourage the clinical investigation of IP sustained chemotherapy for ovarian cancer treatment.

This thesis proposes and demonstrates a hydrogenated amorphous silicon passivated, inverted photovoltaic device on n-type silicon, utilizing a Laser Fired Emitter on a rear i-a- Si:H/SiOx dielectric stack. This novel low-temperature-fabricated device architecture constitutes the first demonstration of an LFE on a dielectric passivation stack. The optimization of the device is explored through Sentaurus computational modeling, predicting a potential efficiency of >20%. Proof of concept devices are fabricated using the DC Saddle Field PECVD system for the deposition of hydrogenated amorphous silicon passivation layers. Laser parameters are explored highlighting pulse energy density as a key performance determining factor. Annealing of devices in nitrogen atmosphere shows performance improvements albeit that the maximum annealing temperature is limited by the thermal stability of the passivation. A proof of concept device efficiency of 11.1% is realized forming the basis for further device optimization.

This thesis proposes and demonstrates a hydrogenated amorphous silicon passivated, inverted photovoltaic device on n-type silicon, utilizing a Laser Fired Emitter on a rear i-a- Si:H/SiOx dielectric stack. This novel low-temperature-fabricated device architecture constitutes the first demonstration of an LFE on a dielectric passivation stack. The optimization of the device is explored through Sentaurus computational modeling, predicting a potential efficiency of >20%. Proof of concept devices are fabricated using the DC Saddle Field PECVD system for the deposition of hydrogenated amorphous silicon passivation layers. Laser parameters are explored highlighting pulse energy density as a key performance determining factor. Annealing of devices in nitrogen atmosphere shows performance improvements albeit that the maximum annealing temperature is limited by the thermal stability of the passivation. A proof of concept device efficiency of 11.1% is realized forming the basis for further device optimization.

Ovarian cancer has the highest mortality rate of all gynecological malignancies, due to inadequate treatment strategies and poor early diagnosis. Intraperitoneal (IP) chemotherapy administered on an intermittent schedule has been pursued for ovarian cancer treatment. However, local toxicities and complications associated with indwelling IP catheters required to deliver the chemotherapeutics have been documented. Furthermore, shortening or completely removing treatment-free periods between each chemotherapy cycle has shown improved efficacy compared to intermittent chemotherapy. The focus of this thesis was to develop and characterize a biocompatible and biodegradable IP injectable depot sustained drug delivery system as a new treatment strategy for ovarian cancer. A polymer-lipid injectable formulation (PoLigel) was developed and used for sustained docetaxel (DTX) delivery. The PoLigel resulted in homogeneous DTX peritoneal distribution and sustained plasma levels in healthy mice, which was in contrast to Taxotere®, the clinically used formulation of DTX. Sustained plasma, tissue, tumor and ascites DTX concentrations were observed in mice bearing IP SKOV3 tumors or ID8 ascites over a 3 week period following IP administration of the PoLigel. The intratumoral distribution and tumor penetration of DTX in subcutaneous (SC) and IP SKOV3 tumors were characterized. DTX distributed more towards the tumor core and diffused 1.5 fold further from blood vessels of the IP tumors compared to the SC tumors. The high efficacy observed in the IP SKOV3 and ID8 models and the SC SKOV3 model was attributed to favorable drug distribution at the whole-body, peritoneal and intratumoral levels in combination with local and systemic sustained drug exposure. Sustained chemotherapy with DTX alone and in combination with a drug efflux transporter inhibitor was investigated in multidrug resistant (MDR) ovarian cancer. In vitro, combination delivery via the PoLigel resulted in more apoptosis, greater intracellular accumulation of DTX, and lower DTX efflux in MDR ovarian cancer cells. Sustained combination chemotherapy was more than twice as efficacious as intermittent Taxotere® treatment in MDR ovarian cancer. Significant anti-tumor efficacy was also observed in the MDR model following sustained DTX chemotherapy compared to intermittent Taxotere®. Overall, results presented here encourage the clinical investigation of IP sustained chemotherapy for ovarian cancer treatment.

Data aggregation is an important technique in wireless sensor networks. The data are gathered together by data fusion routines along the routing path, which is called data-centralized routing. We propose a localized, Delay-bounded and Energy-efficient Data Aggregation framework(DEDA) based on the novel concept of DEsired Progress (DEP). This framework works under request-driven networks with realistic MAC layer protocols. It is based on localized minimal spanning tree (LMST) which is an energy-efficient structure. Besides the energy consideration, delay reliability is also considered by means of the DEP. A node’s DEP reflects its desired progress in LMST which should be largely satisfied. Hence, the LMST edges might be replaced by unit disk graph (UDG) edges which can progress further in LMST. The DEP metric is rooted on realistic degree-based delay model so that DEDA increases the delay reliability to a large extent compared to other hop-based algorithms. We also combine our DEDA framework with area coverage and localized connected dominating set algorithms to achieve two more resilient DEDA implementations: A-DEDA and AC-DEDA. The simulation results confirm that our original DEDA and its two enhanced variants save more energy and attain a higher delay reliability ratio than existing protocols.

This minor field study has explored what factors cause vulnerability to community members living in informal settlements exposed to localized urban flooding. Particularly, the effects of flooding that women living in Bwaise Parish III, Kampala, Uganda have to encounter were studied. Eight weeks were spent in Kampala, Uganda for field work, which included interviews and a workshop with community members from Bwaise Parish III, interviews with scientists at Makerere University and thesis writing. Generally, small-scale disasters surface because of poor urban management. The results showed that inadequate urban planning was affecting the poor that were living on marginal lands. Bwaise Parish III had emerged on a location that was both hazardous and unhealthy. The analysis showed that poor people were limited in their options of risk limitation because of their lack of basic capabilities. Women in Bwaise Parish III were affected by flooding directly and indirectly through the loss of livelihoods and belongings and through time spent getting water out of their houses. Women were generally disproportionally affected by flooding because of their vulnerabilities such as lower socioeconomic status and responsibilities that confined them to their homes. The way forward in order to mitigate localized flooding impacts would entail reducing vulnerabilities, strengthening capabilities and developing infrastructure. / Denna Minor Field Study har undersökt vilka faktorer som orsakar sårbarheter för samhällsmedlemmar som bor i informella bosättningar som exponeras av småskaliga  översvämningar. Det som studerades var effekterna av dessa översvämningar och hur kvinnor i Bwaise Parish III i Kampala, Uganda drabbades. Åtta veckor tillbringades i Kampala för fältarbete som innehöll intervjuer och en workshop med samhällsmedlemmar från Bwaise Parish III, intervjuer med forskare vid Makerere Univeritetet samt uppsatsskrivande. Generellt sätt så brukar småskaliga katastrofer uppstå på grund av dålig stadsförvaltning. Resultaten visade att bristande stadsplanering påverkade de fattiga som levde på marginella marker och att Bwaise Parish III låg på en plats som var både farlig och ohälsosam. Analysen visade att fattiga människor var begränsade i sina möjligheter att minska sina risker på grund av att de saknade grundläggande förutsättningar. Kvinnor i Bwaise Parish III påverkades av översvämningar både direkt och indirekt genom förlusten av försörjningsmöjligheter och tillhörigheter och genom att de var tvungna att spendera tid med att få bort vatten från deras hem. I allmänhet drabbas kvinnor oproportionerligt av översvämningar på grund av deras sårbarhet såsom lägre socioekonomisk status och ansvar som begränsar dem till deras hem. Vägen framåt för att minska småskaliga översvämningar och konsekvenser skulle innebära att minska sårbarheten för samhällsmedlemmarna, öka deras förutsättningar och utveckla en fungerande infrastruktur.