Global ETD Search

1	Cholinergic Neuromodulation of Activity-dependent Disinhibition-mediated Plasticity Takkala, Petri 27 November 2012 (has links) Activation of muscarinic acetylcholine receptors (mAChRs) has pronounced effects on GABAergic interneurons, including depolarization of their resting membrane potential, and increasing their action potential and vesicular release frequency. Moreover, postsynaptic mAChR activation in hippocampal pyramidal neurons reduces the expression of the K+-Cl- cotransporter (KCC2). However, whether mAChR activation modulates the expression of disinhibition-mediated synaptic plasticity has not been examined. I induced inhibitory long-term potentiation (LTP) by applying coincident pre/postsynaptic stimulation in the hippocampus. This plasticity was characterized by an increase in the postsynaptic potential (PSP) amplitude and a depolarization in the inhibitory postsynaptic potential (IPSP) reversal potential; characteristics of disinhibition-mediated LTP (dmLTP). Activation of mAChRs during this plasticity induction protocol prevented the expression of dmLTP via a presynaptic downregulation of transmitter release. This was concluded from evidence that the PSP amplitude and IPSP reversal potential were unaltered, and paired-pulse depression occurred following plasticity induction in the presence of mAChR activation. dmLTP cholinergic mAChR neuromodulation plasticity GABA 0317 0379
2	Cholinergic Neuromodulation of Activity-dependent Disinhibition-mediated Plasticity Takkala, Petri 27 November 2012 (has links) Activation of muscarinic acetylcholine receptors (mAChRs) has pronounced effects on GABAergic interneurons, including depolarization of their resting membrane potential, and increasing their action potential and vesicular release frequency. Moreover, postsynaptic mAChR activation in hippocampal pyramidal neurons reduces the expression of the K+-Cl- cotransporter (KCC2). However, whether mAChR activation modulates the expression of disinhibition-mediated synaptic plasticity has not been examined. I induced inhibitory long-term potentiation (LTP) by applying coincident pre/postsynaptic stimulation in the hippocampus. This plasticity was characterized by an increase in the postsynaptic potential (PSP) amplitude and a depolarization in the inhibitory postsynaptic potential (IPSP) reversal potential; characteristics of disinhibition-mediated LTP (dmLTP). Activation of mAChRs during this plasticity induction protocol prevented the expression of dmLTP via a presynaptic downregulation of transmitter release. This was concluded from evidence that the PSP amplitude and IPSP reversal potential were unaltered, and paired-pulse depression occurred following plasticity induction in the presence of mAChR activation. dmLTP cholinergic mAChR neuromodulation plasticity GABA 0317 0379
3	Trafficking der muskarinergen Acetylcholinrezeptoren in Detrusorzellen bei IC/BPS. Eine immunhistochemische Studie unter Verwendung des Proximity Ligation Assays (PLA). Herbst, Luise 21 March 2019 (has links) Die Interstitielle Zystitis / Bladder Pain Syndrome (IC/BPS) ist eine chronische Erkrankung der Harnblase, deren Ätiologie und Pathogenese nicht abschließend geklärt ist. Es wird von einem multifaktoriellen Geschehen ausgegangen. Eine Rolle spielt dabei ein verändertes Expressionsmuster muskarinerger Acetylcholinrezeptoren (mAChR) in Detrusorzellen. Allerdings zeigt sich keine Korrelation zwischen der Rezeptor-Protein- und -Gen-Expression. Eine mögliche Erklärung könnte ein verändertes Rezeptor-Trafficking liefern. Ziel dieser Arbeit war es daher, das intrazelluläre Trafficking der mAChR M2 und M3 im Detrusor von IC-Gewebe zu untersuchen. Dies erfolgte mittels Proximity Ligation Assay und konfokaler Laser Scanning Mikroskopie an Paraffinschnitten von sieben weiblichen IC-Biopsien. Mit dieser Methoden konnten tatsächlich Veränderungen im Trafficking von M2 und M3 detektiert werden, die dazu beitragen können, die Pathogenese der Erkrankung besser zu verstehen. IC/BPS, mAChR, PLA info:eu-repo/classification/ddc/610 ddc:610
4	Pharmacological studies on the contribution of the neuropeptide proctolin to the cephalic control of singing behavior in grasshopper Chorthippus biguttulus (L.1758) / Pharmakologische Untersuchungen zu der Beteiligung des Neuropeptides Proctolin an der Cephalen Kontrolle der Stridulation bei der Heuschreke Chorthippus biguttulus (L.1758) / Фарамакологично изследване на ролята на невропептида проктолин в мозъчния контрол на стридулацията (пеенето) при скакалеца Chorthippus biguttulus (L.1758) Vezenkov, Stoyan Raykov 02 November 2004 (has links) No description available. 570 Biowissenschaften, Biologie Mathematics and Computer Science neuropeptide proctolin singing behavior stridulation Chorthippus biguttulus insect brain neuronal circuit phonotactic approach step-wise making decision mAChR nAChR co-transmission modulation oscillation glutamate central pattern generator signal transduction glycine GABA histamine dopamine AC PLC PKC Ca2+ signaling Li+ pharma neuropeptide proctolin singing behavior stridulation Chorthippus biguttulus insect brain neuronal circuit phonotactic approach step-wise making decision mAChR nAChR co-transmission modulation oscillation glutamate central pattern generator signal transduction glycine GABA histamine dopamine AC PLC PKC Ca2+ signaling Li+ pharma 42.63 Tierphysiologie

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