Group of specialized cells that form cardiac conduction system is responsible for generation and coordinated propagation of the electrical impulse in the heart. Changes in its development can be connected with arrhythmias; therefore, a good level of knowledge is necessary and relevant for basic science and clinical practice. For correct development of the conduction system are important genes coding gap junctions proteins, ion channels, transcription factors and other molecules involved in signaling cascades (endothelin, neuregulin). Development of conduction system is determined in addition to genetic factors also by epigenetics and environmental factors. This thesis with its individual papers on which it is based is addressing different aspects of conduction system development, which appears to be a complex process. Another feature which is linking all papers together, is the methodological approach enabling us to study function of the conduction system - optical mapping. In the first publication we studied by the means of in vitro organ culture the impact of work load without interfering hemodynamics on the conduction system maturation in the chick embryonic heart. The phenotype observed during experiments was developmental regression of conduction system maturation together with changes in...

This diploma work is concerned in evaluation of map bases, superposition of different quality maps and preparation of basic materials for the project of land adjustment. The main attention was given to cadastral maps of Land Registr of Czech Republic. The part of the cadastral unit Staré Hodějovice was chosen as given locality, where was proclaimed the beginning of land consolidation in 2004.

Sand-pits which were formed especially in the floodplain of the Lužnice River since the 1950s currently constitute important landscape element of the Třeboň Basin. My diploma thesis is focused on the assessment of the impact of land use on the former sand-pits in the region of Veselí nad Lužnicí. Field investigations were carried out from the beginning of June till the end of August 2008. I mapped the land use of this area by using a map key. I put down particular areas {--} agricultural areas, forest areas, water areas, bild-up areas, other areas {--} into map photographs. The total area of the mapped territory was 989 hecteres. The biggest part of the area comprises of forest growths and field-grown plants. Water areas (with the main element of the mapped area {--} a system of former sandpits) formed 23% of the total area. On the bank sof the sand-pits were placed phytosociological relevé, which illustrated littoral vegetation and environment in which this vegetation is located, and what is the influence of human activity on vegetation. I placed 74 phytosociological relevé in this system. I recorded 125 plant species {--} out of these were 104 herb plants and 21 woody species. I recorded 41 nitrophilous, 52 wetland, 16 ruderal and 2 stronngly endangered species. Altogether, 20 water samplings were carried out. Horusice I sand-pit is the richest in nutrient, the poorest in nutrients is Horusice sand-pit.

The topic of this thesis is to optimize the production process of ferrite cores in the company Epcos, Ltd. The work is divided into theoretical, analytical and design part. The first part of the thesis contains theoretical knowledge within the field of lean manufacturing, process mapping and mapping value streams. Based on these findings is determined the theoretical basis for the processing of other parts of the thesis. The aim of the analytical part of the analysis is to map the current state of the manufacturing process, finding bottlenecks, evaluating the results of analysis of the current state, which will be used for the design part of the thesis, to develop proposals for optimizing production bottlenecks and evaluate their contribution.

The Ortolan Bunting (Emberiza hortulana) is a farmland bird species, whose population size has declined very sharply in recent decades, especia ll y in Western and Central European countries. The aim of our study in 2015 was to record where the last populations of this critically endangered species in the Czech Republic are located and also what habitat the species associated with. We examined nine areas (925 km2 in total). Two main areas of occurrence (surface mines in northern Bohemia and farmland landscape of Silesia) and two small isolated populations in central Bohemia were registered for this species. In contrast, observations in some traditional areas of its occurence (České středohoří in northern Bohemia, Hovorany-Čejkovice region in southe r n Moravia and Javoricko region in Silesia) were negative. Altogether, we counted 75-79 singing males. Our estimation of the size of the Czech population in 2015 is 75-100 singing males, which indicates further population decline compared to the last mapping in 2001-2003. Furthermore, habitat associat io ns were investigated at two spatial scales and we made habitat compar is o n between farmland and post-mining landscape. Our research highlights a high degree of flexibility in habitat selection of Ortolan Bunting and also positive association with high...

This thesis is focused on mapping control processes in a state-funded institution. In the theoretical part, concepts related to the issues of cities and state-funded institution are explained. Smart Administration strategy is discussed as well as principles of processes, process management and modeling necessary for understanding the practical part of this thesis. The practical part contains research on the state of process management in cities with 5000 to 20000 citizens in relation to state-funded institution. It was discovered that surveyed cities are not very interested in the topic and lack process management completely in most cases, despite the possibility of EU subsidies for these projects. Based on the survey, a process map was created from which certain processes were selected, described and modeled. This blue-print should help employees of municipalities to orientate in performed processes and make them more efficient. ATTIS software, developed by ATTN Consulting, s.r.o., was used for modeling processes in this thesis

Search for the knowledge within big companies could become pain not only for knowledge seekers, but as well for knowledge managers in case they want a solution, that reflects well actual state of knowledge of a company, allows discovering emerging areas of knowledge and at the same time its maintenance does not require huge amounts of effort. This doctoral thesis starts by a comprehensive analysis of needs of expertise location of current company, description of theoretical backgrounds, related approaches and fundamental directions in expertise location, analyses their advantages and disadvantages and on the ground of this analysis presents a new expertise location technique that tries to avoid disadvantages of current expertise location systems by keeping their advantages. The technique is designed to respect the needs of effective knowledge management within a company, which main assets are their employees, their knowledge reflected in unstructured documents they produce as a part of their daily work. Described knowledge mapping technique analyses document publication history of company members and proposes various measures to asses and characterize their knowledge. The implementation of the knowledge mapping technique allows its direct usage (as an expert search engine) as well as its own evaluation (validity of search engine results). The efficiency of proposed measures on various types of document sources (project directories/versioning repositories/etc.) and within various dimension configurations (current/overall knowledge search) is evaluated by the practical evaluation method introduced within the thesis. The evaluation took place in the environment of a middle-sized software company allowing seeing directly a practical usability of the expertise location technique. The results of the evaluation are presented not only in statistical form, but in a form of suggestions of how to implement the model on various document sources within the company. The results suggest that described knowledge mapping technique is a viable approach in expertise location.

The thesis studies feasibility of using mind mapping applications for IT project management. The main objective is the analysis of using mind mapping applications in the context of project management and finding the links between mind maps and components of project management. The thesis is divided into two parts -- theoretical and practical. In the theoretical part the author clarifies the mind mapping concept, how to create mind maps and the use of those. The relatively broad area of project management is introduced in the same manner starting with the main terms, brief overview of the project management methodologies and standards. The introduction further continues by describing individual project phases, their dimensions and provides examples of tools and techniques. The practical part consists of three chapters. In the first chapter the author analyses mind mapping SW applications, describes the mind mapping software market and explains the selection of an appropriate tool using multi criteria evaluation and using hands on experience with the tools. The second chapter demonstrates practical examples of project management topics with related instances of mental models and everyday activities where mind maps can be used. The last chapter describes a survey related to the awareness of mind mapping concepts which also gathers feedback about mind mapping application experience from IT project management professionals.

The theoretical part will be focused on presenting information within the process management. Some of the pieces of this theoretical information will be were slightly modified by internal Continental procedures and applied in the practical part of the thesis in order to redesign current purchasing process of non production material. The contents of the practical part of this thesis are the analysis of the current purchasing process of non-production material in the plant of Continental. The intention is to identify the waste and obstacles in the process. The main target is to improve the process in consideration of efficiency, lead time reduction and, if applicable, cost savings. Once the waste in the process is identified, the 100% value added ideal state is going to be developed, under consideration of implementing the improvements, which have been identified in the current state. Based on the differences between the current state and the ideal state of the process, the future state is going to be mapped.

This diploma thesis deals with eliminating of bottlenecks in a production of eletrical devices, focusing mainly on the production line. It analyzes the current situation and using value stream mapping for a selected product it identifies bottlenecks of the production process. Further it proposes remedial measures to improve current situation.