Die vorliegende retrospektive Studie untersuchte die lokale Rezidiv- und Überlebensrate von Patienten mit Plattenepithelkarzinomen in Abhängigkeit vom Randstatus und Resektionsabstand der Tumorresektion sowie von der postoperativen Therapie. Dabei wurden Daten von 351 Patienten mit Plattenepithelkarzinomen des Oropharynx, Hypopharynx und Larynx ausgewertet, welche zwischen 2005 und 2009 reseziert wurden. Der gesundheitliche Zustand der Patienten wurde anschließend bis Dezember 2011 beobachtet. Im Ergebnis konnte kein Einfluss des Randstatus und des Resektionsabstandes auf die lokale Rezidivrate nachgewiesen werden. Beide Faktoren hatten jedoch einen signifikanten Einfluss auf die Letalitätsrate. Die postoperative Therapie zeigte einen positiven Einfluss auf die lokale Rezidivrate. Sie konnte aber die negativen Prognosefaktoren, die eine Indikation dieser Therapie darstellen, bezüglich der Letalitätsrate nicht ausgleichen. Weiterhin war ein positiver Einfluss der postoperativen Therapie auf das rezidivfreie Überleben (DFS-disease-free survival) sowohl uni- als auch multivariat nachweisbar. Die Gesamtüberlebensrate (OS-overall survival) wurde signifikant positiv durch einen geringeren Randstatus und einen zunehmenden Resektionsabstand (ASR Klassifikation) beeinflusst. Das krankheitsspezifische Überleben (DSS-disease-specific survival) sank bei Auftreten eines lokalen Rezidivs. Aus diesen Ergebnissen kann geschlussfolgert werden, dass eine postoperative Therapie zur Kontrolle lokaler Rezidive von hoher Bedeutung ist. Da lokale Rezidive die Überlebensrate signifikant senken, hat die postoperative Therapie indirekt einen positiven Effekt auf das Überleben. Des Weiteren zeigt sich bei Patienten mit freien Resektionsrändern die höchste Überlebensrate, wobei diese mit zunehmendem Abstand des Karzinoms vom Resektionsrand steigt.

Occurrences of carbonate-cemented nodules and concretions exposed on the seafloor that contain cements with light carbon isotopes, indicating a contribution of methane-derived carbon, are commonly interpreted to be indicators of seafloor fluid venting. Thus, their presence is commonly used as an indicator of the possible occurrence of methane gas hydrate within the near subsurface. While some of these carbonates exhibit facies that require formation on the seafloor, the dominant fine-grained lithology associated with these carbonates indicates they were formed as sedimenthosted nodules within the subsurface and are similar to nodules that are obtained from the subsurface in Deep Sea Drilling Project, Ocean Drilling Project, and Integrated Ocean Drilling Project boreholes. Here we present the hypothesis that the occurrence of these carbonates on the seafloor may instead indicate areas of persistent seafloor erosion.

Remote determination of the hydrate content of marine sediments remains a challenging problem. In the absence of boreholes, the most commonly used approach involves the measurement of Pwave velocities from seismic experiments. A range of seismic effective medium methods has been developed to interpret these velocities in terms of hydrate content, but uncertainties about the pore-scale distribution of hydrate can lead to large uncertainties in this interpretation. Where borehole geophysical measurements are available, electrical resistivity is widely used as a proxy for hydrate content, and the measurement of resistivity using controlled source electromagnetic methods shows considerable promise. However, resistivity is commonly related to hydrate content using Archie’s law, an empirical relationship with no physical basis that has been shown to fail for hydrate-bearing sediments. We have developed an electrical effective medium method appropriate to hydrate-bearing sediments based on the application of a geometric correction to the Hashin-Shrikman conductive bound, and tested this method by making resistivity measurements on artificial sediments of known porosity. We have adapted our method to deal with anisotropic grains such as clay particles, and combined it with a well-established seismic effective medium method to develop a strategy for estimating the hydrate content of marine sediments based on a combination of seismic and electrical methods. We have applied our approach to borehole geophysical data from Integrated Ocean Drilling Program Expedition 311 on the Vancouver Island margin. Hydrate saturations were determined from resistivity logs by adjusting the geometric factor in areas of the log where hydrate was not present. This value was then used over the entire resistivity log. Hydrate saturations determined using this method match well those determined from direct measurements of the methane content of pressurized cores.

The purpose of this research was to quantify what value could be gained from cutting solid wood products from old-growth western hemlock (Tsuga heterophylla (Raf.) Sarg.) logs that are used to produce pulp in British Columbia. These logs represent a significant portion of the resource and increasing their value recovery would be beneficial to the forest industry. One hundred and sixteen logs were sampled from the coastal and interior regions of British Columbia. Dimension and quality attributes were measured to enable estimates of gross and merchantable volume. Logs deemed likely to yield lumber were sawn with the aim of maximizing value recovery. The nominal dimension and grade of all lumber recovered was recorded. Margins and breakpoints at which sawing became profitable were calculated. Models to predict the volume of lumber and proportion of Clear grade lumber recovered (“C Industrial” grade at the interior mill, “D Select” grade at the coastal mill) were developed. Lumber recovery, especially Clear grade lumber, was significantly higher from logs from the coastal site. At current market prices, cutting lumber from these logs was profitable, with the highest margins achieved when chips were produced from the milling residue. It was not profitable to recover lumber from the interior logs regardless of whether chips were produced. The disparity between locations was attributed to differences between the logs, the sawmilling equipment, the sawyers’ motivations and the lumber grades. Between 60% and 67% of coastal logs and 13% to 21% of interior logs returned a profit, depending on whether chips were produced. Models were developed to better identify these logs using observable attributes. A linear model described the total volume of lumber recovered. Significant predictor variables in the model were the gross log volume, the average width of the sound collar and the stage of butt/heart rot at the large end. A second model predicted the proportion of Clear grade lumber. Regional models were developed to account for different Clear lumber grades between sawmills. Significant predictor variables were knot frequency, diameter at the large end, volume, length, taper and the width of the sound collar at the large end.

Pastaruoju metu labai svarbus draudimo įmonių finansinės padėties stabilumo klausimas, kuris aktualus ne tik pačioms įmonėms ar jas kontroliuojančioms institucijoms, bet ir mums – pavieniams draudėjams. Šio darbo tyrimo tikslas – ne gyvybės draudimo kompanijų mokumo įvertinimas. Lietuvos draudimo įmonių mokumas vertinamas taikant modelį, pagal kurį draudimo kompanijos finansinė padėtis laikoma stabilia, jei apskaičiuota turima mokumo atsarga yra didesnė už būtiną mokumo atsargą. Tokį mokumo atsargų palyginimą atliksime kelioms ne gyvybės draudimo kompanijoms. Tačiau kyla klausimas, ar toks Lietuvos draudimo įmonėms taikomas modelis yra pakankamai geras. Tuo verčia abejoti ir draudimo kompanijos „Ingo Balt“ bankrotas. Darbe apžvelgsime užsienyje taikomus mokumo vertinimo metodus, iš jų išskirsime tuos elementus, kurie neįtraukti arba nepakankamai įtraukti į Lietuvos draudimo įmonių mokumo vertinimą. / Although Lithuanian insurance market is pretty young and is only in its growth stage, but the process itself grows really fast compared to other economy areas. The purpose of this work is to review the tendencies and perspectives of solvency estimations development of Lithuanian non-life insurance companies. Insurance companies raise deposits and their excuse is that payoffs are increasing as well. A statistic analysis was made in this work to estimate the validity of this growth of deposits. It was estimated that payoffs do not depend on the number of made contracts and deposits. The estimation of solvency in Lithuanian insurance companies was made by using a model in which the financial state of an insurance company is hold as stable if the evaluated owned solvency store is bigger than essential solvency store. This type of solvency store comparison was made with several non-life insurance companies. But is this model suitable for insurance companies in Lithuania that is the main question. The main reason to doubt about it is the bankrupt of “Ingo Balt” insurance company. In this research I will look trough solvency evaluation models that are used in other countries and separate elements that are not enough or not at all included into solvency evaluation in Lithuania. Based on the methods that are used in other countries I will evaluate risk of interest rate and deposits in leading insurance companies in Lithuania.

This thesis examines the sensitivity of the marine controlled source electromagnetic (CSEM) method to sub-seafloor resistivity structure, with a focus on gas hydrate and free gas occurrences. Different analysis techniques are applied with progressive sophistication to a series of studies based on simulated and measured data sets. CSEM data are modelled in time domain for one-dimensional models with gas hydrate, free gas and/or permafrost occurrences. Linearized and non-linear inversion methods are considered to infer subsurface models from CSEM data. One study applies forward modelling and singular value decomposition to estimate uncertainties for permafrost models of the Beaufort Sea. This simulation study analyzes the resolution of the CSEM data for shallow water depth which is a challenging case because the electromagnetic signature of the air-water boundary may mask the sub-seafloor response. The results reveal a blind window as a function of water depth in which the CSEM data are insensitive to the sub-seafloor structure. However, the CSEM data are sensitive to the top and the bottom of the permafrost with increasing uncertainties with depth. The next study applies non-linear Bayesian inversion to CSEM data acquired in 2005/2006 on the Northern Cascadia margin to investigate sub-seafloor resistivity structure related to gas hydrate deposits and cold vents. Bayesian inversion provides a rigorous approach to estimate model parameters and uncertainties by probabilistically sampling of the parameter space. The resulting probability density function is interpreted here in terms of posterior median models, marginal and joint marginal probability densities for model parameters and credibility intervals. The Bayesian information criterion is applied to determine the amount of structure (number of layers) that can be resolved by the data. The parameter space is sampled with the Metropolis-Hastings algorithm in principal-component space. Non-linear, probabilistic inversion allows the analysis of unknown acquisition parameters such as time delays between receiver and transmitter clocks or unknown source amplitude. The estimated posterior median models and credibility intervals from Bayesian CSEM inversion are compared to reflection seismic data to provide a more complete geological interpretation. The CSEM data on the Northern Cascadia margin generally reveal a 1 to 3 layer sediment structure. Inversion results at the landward edge of the gas hydrate stability zone indicate a sediment unconformity as well as several potential cold vents which were previously unknown. The resistivities generally increase upslope due to sediment erosion along the slope. Inversion results on the middle slope infer several vent systems close to well-known Bullseye vent in agreement with ongoing interdisciplinary observations. Finally, a trans-dimensional (trans-D) Bayesian inversion is applied to CSEM data acquired in 2012 in the German North Sea to investigate possible free gas occurrences. Trans-D inversion treats the number of layers as an additional unknown sampled probabilistically in the inversion. %over the parameter space by evaluating probabilistically the transition to a higher or lower number of interfaces. Parallel tempering is applied to increase sampling efficiency and completeness. Inversion results for the German North Sea yield resistivities at the seafloor which are typical for marine deposits, while resistivities at greater depth increase slightly and can be correlated with a transition from fine-grained marine deposits (Holocene age) to coarse-grained, glacial sediments (Pleistocene age), which is observed in a sediment core. The depths of layer interfaces estimated from CSEM inversion match the seismic reflector related to the contrast between the two depositional environments. The CSEM survey targeted a strong, phase-reversed, inclined seismic reflector within the glacial sediments, potentially indicating free gas. While interface-depth estimates from CSEM inversion do not correlate closely with this reflector, resistivities are generally elevated above the strong seismic amplitudes and the thickness of the resistive layer follows the trend of the inclined reflector. However, the uncertainties of deeper interface depth estimates increase significantly and overlap with the targeted reflector at some of the measurement sites. Relatively low resistivities of a third layer correlate with sediments of late-Miocene origin with a high gamma-ray count indicating an increased amount of fine-grained sediments with organic material. The interface at the bottom of the third layer has wide uncertainties which relates to the penetration limit of the CSEM array. / Graduate

Plant populations near the northern limits of their geographic distribution may experience different biotic pressures than southern populations. For instance, if herbivores are scarce in northern populations, performance of their host plants may benefit. In this study, I looked at populations of burdock (Arctium minus) along an 815 km latitudinal gradient from the northern range limit to more southern populations. I found that plant height, stem diameter, and number of seeds all increased on approaching the northern limit. In addition, I also found significant decreases in herbivory by generalist and specialist leaf and seed predators, even though northern plants invested less in physical and possibly chemical defenses. In an experiment in which seeds were planted in different soils, marginal soil initially produced smaller plants, but subsequently larger plants than soil from southern populations. These results indicate northern populations experience relaxed pressure from natural enemies and may benefit as a result.

Plant populations near the northern limits of their geographic distribution may experience different biotic pressures than southern populations. For instance, if herbivores are scarce in northern populations, performance of their host plants may benefit. In this study, I looked at populations of burdock (Arctium minus) along an 815 km latitudinal gradient from the northern range limit to more southern populations. I found that plant height, stem diameter, and number of seeds all increased on approaching the northern limit. In addition, I also found significant decreases in herbivory by generalist and specialist leaf and seed predators, even though northern plants invested less in physical and possibly chemical defenses. In an experiment in which seeds were planted in different soils, marginal soil initially produced smaller plants, but subsequently larger plants than soil from southern populations. These results indicate northern populations experience relaxed pressure from natural enemies and may benefit as a result.

Light delivery and sample handling systems are essential for any high performance imaging application. The custom design for two such devices with medical imaging applications are presented. The first device, a galvanometer-stage combination, is for general use optical coherence tomography and can be configured to scan over a large range of sample sizes and types. The second device, constructed in parallel, a rotation-linear stage combination, has been carefully designed for a specific imaging task: assessing tumour margins. The design of the two devices is driven by operational requirements and although requirements vary greatly from application to application, there are several common parameters that must be considered for every system. In this thesis, parameters like total scan time, scan resolution, sampling rate, and sample type flexibility are analysed and are some of the primary factors that influence the viability of a system for further development. This work's contribution to medical imaging research is the design of two light delivery systems and an analysis process that can be applied to future iterations of scan systems. The devices are shown to be flexible enough for use in test-bed systems, while providing the necessary functionality to meet the needs of medical histology and pathology. Controlling the light delivery and sample positioning of an imaging device adds important functionality to a scan system and is not a trivial task when high spatial-resolution scan spacing is required. The careful design of an imaging system to meet the unique requirements of the application enables better information and better resulting decision making. Advanced imagery provides new insights and perspectives to everyday scenes. It is these new perspectives that allow for re-evaluation and examination of problems with a fresh eye.

A new approach was developed to determine the operational stability margin of a laboratory scale combustor. Applying modern and robust techniques and tools from Dynamical System Theory, the approach was based on three basic steps. In the first step, a gray-box thermoacoustical model for the combustor was derived. The second step consisted in applying System Identification techniques to experimental data in order to validate the model and estimate its parameters. The application of these techniques to experimental data under different operating conditions allowed us to determine the functional dependence of the model parameters upon changes in an experimental control parameter. Finally, the third step consisted in using that functional dependence to predict the response of the system at different operating conditions and, ultimately, estimate its operational stability margin. The results indicated that a low-order stochastic non-linear model, including two excited modes, has been identified and the combustor operational stability margin could be estimated by applying a continuation method.