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11	The effect of photoperiod and high fat diet on the cognitive response in photoperiod-sensitive F344 rats McLean, Samantha L., Yun, Haesung, Tedder, Andrew, Helfer, Gisela 05 July 2021 (has links) yes / In many species, seasonal changes in day length (photoperiod) have profound effects on physiology and behavior. In humans, these include cognitive function and mood. Here we investigated the effect of photoperiod and high fat diets on cognitive deficits, as measured by novel object recognition, in the photoperiod-sensitive F344 rat, which exhibits marked natural changes in growth, body weight and food intake in response to photoperiod. 32 male juvenile F344 rats were housed in either long or short photoperiod and fed either a high fat or nutrient-matched chow diet. Rats were tested in the novel object recognition test before photoperiod and diet intervention and re-tested 28 days after intervention. In both tests during the acquisition trials there was no significant difference in exploration levels of the left and right objects in the groups. Before intervention, all groups showed a significant increase in exploration of the novel object compared to the familiar object. However, following the photoperiod and diet interventions the retention trial revealed that only rats in the long photoperiod-chow group explored the novel object significantly more than the familiar object, whereas all other groups showed no significant preference. These results suggest that changing rats to short photoperiod impairs their memory regardless of diet. The cognitive performance of rats on long photoperiod-chow remained intact, whereas the high fat diet in the long photoperiod group induced a memory impairment. These findings suggest that rats exposed to long photoperiod have different cognitive responses to rats exposed to short photoperiod and high fat diet. Photoperiod Seasonal Rhythms F344 Cognition High fat diet Novel object recognition Memory impairment
12	Diagnostika poruch paměti u pacientů s Alzheimerovou chorobou Podtitul: Vztah mezi poruchou paměti a vybranými všedními denními činnostmi / Memory disorders assessment in patients with Alzheimer's disease Subtitle: Relationship between memory disorders and selected Activities of Daily Living Košnarová, Lenka January 2016 (has links) THESIS ABSTRACT Name: Bc. Lenka Košnarová Supervisor: Mária Krivošíková, M.Sc. Opponent: Title of thesis: Memory disorders assessment in patients with Alzheimer's disease Abstract: Objective: The main objective of the thesis was to investigate the impact of memory disorders on self-care in patients with Alzheimer's disease (AD). Another objective of the thesis was to determine whether age of patients with AD affects occupational performance in daily living activities. Methods: The sample was consist of 50 probands (11 men, 39 women), who were diagnosed AD by physician. For data collection was used a questionnaire Bristol Activities of Daily Living scale (BADLS) evaluating self-care and Contextual Memory Test (CMT) for evaluation of memory disorders. Testing the hypothesis was performed by correlation the corrected Spearman correlation coefficient and regression analysis. Results: The thesis results confirmed a significant correlation between BADLS scores and CMT scores - immediate recall (rSp = .51; p<0.05), delay recall (rSp = .42; p<0.05), total (rSp = .48; p<0.05). Furthermore, research results suggest that memory impairment occur more with PADLS. There also was no statistically significant relationship between age and performance of activities of daily living (ADL) coefficient (rSp = .07; p<0.05)....
13	DISTINCT ROLES OF THE aD HELIX IN aCAMKII ACTIVATION CHARACTERIZED USING A DE NOVO MUTATION FROM CHILDREN WITH LEARNING DISABILITIES Walter Saide (16650807) 07 August 2023 (has links) <p>This dissertation describes the effects of a <i>de novo</i> mutation of CaMKII found in children with learning disabilities and describes its effect on catalytic activity. We develop a malachite green assay for the measurement of CaMKII activation and use it for high-throughput chemical screening to identify CaMKII inhibitors and enhancers. We also propose a new mechanism of regulation of CaMKII activity by ADP.</p><p><br></p> Cell neurochemistry Enzymes Basic pharmacology Biologically active molecules Biomolecular modelling and design Proteins and peptides Catalysis and mechanisms of reactions Reaction kinetics and dynamics CaMKII α learning and memory impairment calmodulin calcium signaling kinase activity medicinal chemistry molecular pharmacology enzyme kinetics western blotting biochemistry molecular modeling high throughput chemical screening assay development protein structure enzyme coupled assays malachite green assay cellular biology fluorescence microscopy hplc lc-ms/ms autophosphorylation ATP:ADP ratios

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The effect of photoperiod and high fat diet on the cognitive response in photoperiod-sensitive F344 rats

DISTINCT ROLES OF THE aD HELIX IN aCAMKII ACTIVATION CHARACTERIZED USING A DE NOVO MUTATION FROM CHILDREN WITH LEARNING DISABILITIES