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Purpose: We determined the indication, outcome and risk factors of single and multiple hematopoietic stem cell transplantation(s) (HSCT) in children and adolescents mostly with advanced disease. Methods: Forty-one out of 483 patients (8.5%; median age 9 years) diagnosed at the University of Leipzig with haematological and oncological diseases required HSCT from 1999 to 2011. Results: Patients had overall survival (OS) of 63±10% and 63±16%, event-free survival (EFS) of 57±10% and 42±16%, relapse incidence (RI) of 39±10% and 44±18% and non-relapse mor-tality (NRM) of 4±4% and 13±9% at 10-years after one or more HSCT for allogeneic and autologous HSCT, respectively. One patient in complete remission (CR)1 and five with advanced disease received two HSCT. Four of the six patients maintained/achieved CR for a median of 13 months. Three died of progression and one of NRM. Two patients had a third HSCT and one survived in CR +231 days after HSCT. Risk factors for OS and EFS were disease stage at HSCT and EBMT risk-score. Center (paediatric or JACIE accredited paediatric/adult) was not a determinant for survival. Conclusion: Paediatric single and multiple HSCT are important curative approaches for high-risk malignant diseases with low NRM. Efforts to reduce high RI remain the major aim.

South Africa has eleven official languages, ten of which are considered “resource-scarce”. For these languages, even basic linguistic resources required for the development of speech technology systems can be difficult or impossible to obtain. In this thesis, the process of developing Spoken Language Identification (S-LID) systems in resource-scarce environments is investigated. A Parallel Phoneme Recognition followed by Language Modeling (PPR-LM) architecture is utilized and three specific scenarios are investigated: (1) incomplete resources, including the lack of audio transcriptions and/or pronunciation dictionaries; (2) inconsistent resources, including the use of speech corpora that are unmatched with regard to domain or channel characteristics; and (3) poor quality resources, such as wrongly labeled or poorly transcribed data. Each situation is analysed, techniques defined to mitigate the effect of limited or poor quality resources, and the effectiveness of these techniques evaluated experimentally. Techniques evaluated include the development of orthographic tokenizers, bootstrapping of transcriptions, filtering of low quality audio, diarization and channel normalization techniques, and the human verification of miss-classified utterances. The knowledge gained from this research is used to develop the first S-LID system able to distinguish between all South African languages. The system performs well, able to differentiate among the eleven languages with an accuracy of above 67%, and among the six primary South African language families with an accuracy of higher than 80%, on segments of speech of between 2s and 10s in length. AFRIKAANS : Suid-Afrika het elf amptelike tale waarvan tien as hulpbron-skaars beskou word. Vir die tien tale kan selfs die basiese hulpbronne wat benodig word om spraak tegnologie stelsels te ontwikkel moeilik wees om te bekom. Die proses om ‘n Gesproke Taal Identifisering stelsel vir hulpbron-skaars omgewings te ontwikkel, word in hierdie tesis ondersoek. ‘n Parallelle Foneem Herkenning gevolg deur Taal Modellering argitektuur word ingespan om drie spesifieke moontlikhede word ondersoek: (1) Onvolledige Hulpbronne, byvoorbeeld vermiste transkripsies en uitspraak woordeboeke; (2) Teenstrydige Hulpbronne, byvoorbeeld die gebruik van spraak data-versamelings wat teenstrydig is in terme van kanaal kenmerke; en (3) Hulpbronne van swak kwaliteit, byvoorbeeld foutief geklasifiseerde data en klank opnames wat swak getranskribeer is. Elke situasie word geanaliseer, tegnieke om die negatiewe effekte van min of swak hulpbronne te verminder word ontwikkel, en die bruikbaarheid van hierdie tegnieke word deur middel van eksperimente bepaal. Tegnieke wat ontwikkel word sluit die ontwikkeling van ortografiese ontleders, die outomatiese ontwikkeling van nuwe transkripsies, die filtrering van swak kwaliteit klank-data, klank-verdeling en kanaal normalisering tegnieke, en menslike verifikasie van verkeerd geklassifiseerde uitsprake in. Die kennis wat deur hierdie navorsing bekom word, word gebruik om die eerste Gesproke Taal Identifisering stelsel wat tussen al die tale van Suid-Afrika kan onderskei, te ontwikkel. Hierdie stelsel vaar relatief goed, en kan die elf tale met ‘n akkuraatheid van meer as 67% identifiseer. Indien daar op die ses taal families gefokus word, verbeter die persentasie tot meer as 80% vir segmente wat tussen 2 en 10 sekondes lank. Copyright / Dissertation (MEng)--University of Pretoria, 2010. / Electrical, Electronic and Computer Engineering / unrestricted

Purpose: We determined the indication, outcome and risk factors of single and multiple hematopoietic stem cell transplantation(s) (HSCT) in children and adolescents mostly with advanced disease. Methods: Forty-one out of 483 patients (8.5%; median age 9 years) diagnosed at the University of Leipzig with haematological and oncological diseases required HSCT from 1999 to 2011. Results: Patients had overall survival (OS) of 63±10% and 63±16%, event-free survival (EFS) of 57±10% and 42±16%, relapse incidence (RI) of 39±10% and 44±18% and non-relapse mor-tality (NRM) of 4±4% and 13±9% at 10-years after one or more HSCT for allogeneic and autologous HSCT, respectively. One patient in complete remission (CR)1 and five with advanced disease received two HSCT. Four of the six patients maintained/achieved CR for a median of 13 months. Three died of progression and one of NRM. Two patients had a third HSCT and one survived in CR +231 days after HSCT. Risk factors for OS and EFS were disease stage at HSCT and EBMT risk-score. Center (paediatric or JACIE accredited paediatric/adult) was not a determinant for survival. Conclusion: Paediatric single and multiple HSCT are important curative approaches for high-risk malignant diseases with low NRM. Efforts to reduce high RI remain the major aim.:Bibliographic description 3 Introduction: 4 Infections 6 Veno-occlusive disease (VOD) 7 Graft rejection 7 Graft-versus Host Disease (GvHD) 8 Non-relapse mortality (NRM) 9 Relapse of the underling disease 9 Indications for HSCT 10 HSCT in Children. 10 Research questions: 12 Publication 13 Discussion 22 Future developments 25 References 26 Abbreviations 28 Summary 29 Zusammenfassung 33 Erklärung über die eigenständige Abfassung der Arbeit 38 Curriculum vitae 39 Acknowledgement 42