O 67Ga é um importante radiofármaco usado para identificar processos inflamatórios em doenças crônicas, diagnóstico por imagem de tumores em tecidos moles e a possibilidade de avaliar o resultado para intervenção terapêutica. Neste trabalho desenvolveu-se um módulo de processamento de 67Ga, com o objetivo de reduzir as intervenções na célula quente, causadas pela oxidação dos materiais metálicos e desgastes nas mangueiras das bombas peristálticas, que soltavam resíduos e bloqueavam a passagem através das válvulas utilizadas no processo. Utilizaram-se materiais como: acrílico, PVC, PEEK e teflon e vácuo como meio de transferência de fluidos líquidos na maioria dos procedimentos, com estas modificações obteve-se redução no comprimento das mangueiras de transferência, aumentando o rendimento do processo com menos intervenções para manutenção e menos tempo de exposição dos trabalhadores à radiação, garantindo a qualidade e reduzindo-se o tempo do processamento. Utilizando-se um sistema móvel para deslocamento do módulo de processamento, facilitou-se a limpeza e manutenção da célula que opera com material radioativo, atendendo-se a Resolução da Diretoria Colegiada da ANVISA que dispõe sobre as Boas Práticas de Fabricação de Medicamentos (RDC-17). / The 67Ga is an important radiopharmaceutical used to identify inflammatory processes in chronic illnesses, diagnosis by image of tumors in soft tissues and the possibility to evaluate the result for therapeutic intervention. In the present work a module of 67Ga processing was developed with the objective to reduce the interventions in the hot cell, in order to avoid oxidation caused by metallic materials, and consuming in hoses of the peristaltic pumps, that release residues that blocked the valves used in the process. With materials such as: acrylic, PVC, PEEK e teflon and they are used vacuum as method (way) of fluid transferences instead of peristaltic pump in the majority of the procedures, with this improvements the system can make shorter the lengths of transference hoses, increasing the yield in the process with less interventions for maintenance and time exposure of the workers, guaranteeing the quality and reducing the time of the processing. using a mobile system for displacement of the processing module making in the cleanness and maintenance of the cell that works with radioactive material. Reducing the time of exposure dose of the workers in compliance with RDC-17 of ANVISA, which ruling the Good Manufacturing Practice Procedures.

The widely collected and analyzed genetic data help in understanding the underlying mechanisms of heterogeneous diseases. Cellular components interact in a network fashion where genes are nodes and edges are the interactions. The failure in individual genes lead to dys-regulation of sub-groups of genes which causes a disease phenotype, and this dys-functional region is called a disease module. Disease module identification in complex diseases such as asthma and cancer is a huge challenge. Despite the development of numerous sophisticated methods there is a still no gold standard. In this study we apply different parameter settings to test the performance of a widely used method for disease module detection in multi-omics data called Weighted Gene Co-expression Network Analysis (WGCNA). A systematic approach is used to identify disease modules in asthma and arthritis diseases. The accuracy of obtained modules is validated by a pathway scoring algorithm (PASCAL) and GWAS SNP enrichment. Our results differ between the tested data sets and therefore we cannot conclude with recommendations for an optimal setting that could perform best for multiple data sets using this method.

For an extension of local fields, a scaffold is shown to be a powerful tool for dealing with the problem of the freeness of fractional ideals over their associated orders (Byott, Childs and Elder: \textit{Scaffolds and Generalized Integral Galois Module Structure}, Ann. Inst. Fourier, 2018). The first class of field extensions admitting scaffolds is \enquote*{near one-dimensional elementary abelian extension}, introduced by Elder (\textit{Galois Scaffolding in One-dimensional Elementary Abelian Extensions}, Proc. Amer. Math. Soc. 2009). However, the scaffolds constructed in Elder's paper arise only from the classical Hopf-Galois structure. Therefore, the study in this thesis aims to investigate scaffolds in non-classical Hopf-Galois structures. Let $L/K$ be a near one-dimensional elementary abelian extension of degree $p^2$ for a prime $p \geq 3.$ We show that, among the $p^2-1$ non-classical Hopf-Galois structures on the extension, there are only $p-1$ of them for which scaffolds may exist, and these exist only under certain restrictive arithmetic condition on the ramification break numbers for the extension. The existence of scaffolds is beneficial for determining the freeness status of fractional ideals of $\mathfrak{O}_L$ over their associated orders. In almost all other cases, there is no fractional ideal which is free over its associated order. As a result, scaffolds fail to exist.

O 67Ga é um importante radiofármaco usado para identificar processos inflamatórios em doenças crônicas, diagnóstico por imagem de tumores em tecidos moles e a possibilidade de avaliar o resultado para intervenção terapêutica. Neste trabalho desenvolveu-se um módulo de processamento de 67Ga, com o objetivo de reduzir as intervenções na célula quente, causadas pela oxidação dos materiais metálicos e desgastes nas mangueiras das bombas peristálticas, que soltavam resíduos e bloqueavam a passagem através das válvulas utilizadas no processo. Utilizaram-se materiais como: acrílico, PVC, PEEK e teflon e vácuo como meio de transferência de fluidos líquidos na maioria dos procedimentos, com estas modificações obteve-se redução no comprimento das mangueiras de transferência, aumentando o rendimento do processo com menos intervenções para manutenção e menos tempo de exposição dos trabalhadores à radiação, garantindo a qualidade e reduzindo-se o tempo do processamento. Utilizando-se um sistema móvel para deslocamento do módulo de processamento, facilitou-se a limpeza e manutenção da célula que opera com material radioativo, atendendo-se a Resolução da Diretoria Colegiada da ANVISA que dispõe sobre as Boas Práticas de Fabricação de Medicamentos (RDC-17). / The 67Ga is an important radiopharmaceutical used to identify inflammatory processes in chronic illnesses, diagnosis by image of tumors in soft tissues and the possibility to evaluate the result for therapeutic intervention. In the present work a module of 67Ga processing was developed with the objective to reduce the interventions in the hot cell, in order to avoid oxidation caused by metallic materials, and consuming in hoses of the peristaltic pumps, that release residues that blocked the valves used in the process. With materials such as: acrylic, PVC, PEEK e teflon and they are used vacuum as method (way) of fluid transferences instead of peristaltic pump in the majority of the procedures, with this improvements the system can make shorter the lengths of transference hoses, increasing the yield in the process with less interventions for maintenance and time exposure of the workers, guaranteeing the quality and reducing the time of the processing. using a mobile system for displacement of the processing module making in the cleanness and maintenance of the cell that works with radioactive material. Reducing the time of exposure dose of the workers in compliance with RDC-17 of ANVISA, which ruling the Good Manufacturing Practice Procedures.

A wavelet is a function which is used to construct a specific type of orthonormal basis. We are interested in using C*-algebras and Hilbert C*-modules to study wavelets. A Hilbert C*-module is a generalisation of a Hilbert space for which the inner product takes its values in a C*-algebra instead of the complex numbers. We study wavelets in an arbitrary Hilbert space and construct some Hilbert C*-modules over a group C*-algebra which will be used to study the properties of wavelets. We study wavelets by constructing Hilbert C*-modules over C*-algebras generated by groups of translations. We shall examine how this construction works in both the Fourier and non-Fourier domains. We also make use of Hilbert C*-modules over the space of essentially bounded functions on tori. We shall use the Hilbert C*-modules mentioned above to study wavelet and scaling filters, the fast wavelet transform, and the cascade algorithm. We shall furthermore use Hilbert C*-modules over matrix C*-algebras to study multiwavelets.

Le développement des convertisseurs d'électronique de puissance pour les applications aéronautiques nécessite de travailler sur les modules de puissance. Le but est d'obtenir des systèmes fiables et compacts, points qui sont critiques dans les applications embarquées. Le dimensionnement reste un point délicat à cause de la multitude des composants présents et des physiques mises en jeu. L'étude s'intéresse à la modélisation des phénomènes liés aux aspects thermiques et à la compatibilité électromagnétique. Son originalité porte sur l'optimisation des solutions réalisées qui réduit simultanément, dès la phase de conception, les disparités thermiques et les courants perturbateurs. Ce travail s'inscrit parfaitement dans le cadre du prototypage virtuel des convertisseurs. Dans un second temps, deux solutions ont été proposées pour réduire encore plus l'émission des courants perturbateurs. Ce travail constitue une avancée importante dans la conception des convertisseurs.

Ce travail part de l'observation d'un résultat de P. Robba établi en 1982 dont l'énoncé est le suivant : si l est un entier p-adique, alors la série (1+T)l à coefficients dans l'anneau des entiers p-adiques, réduite modulo p, est algébrique sur le corps des fractions rationnelles à coefficients dans le corps fini à p éléments si et seulement si l est rationnel. En remarquant que cette série a une expression très proche de celle d'un endomorphisme du groupe multiplicatif sur l'anneau des entiers p-adiques, on généralise ce résultat à une classe de groupes formels de Lubin-Tate dont le logarithme vérifie une certaine condition d'algébricité. Nous interprétons ensuite ce résultat via le foncteur XK de Fontaine et Wintenberger et en tirons des conséquences sur l'indépendance algébrique des automorphismes de corps locaux. Dans la deuxième partie de ce travail, nous établissons l'analogue du théorème de P. Robba dans le cas des modules de Drinfeld de rang 1 définis sur le complété P-adique de l'anneau des polynômes à coefficients dans un corps fini où P est un polynôme irréductible, unitaire et à coefficients dans ce même corps fini.

<p>This report studies a low cost hardware platform for Fleet Management Services, FMS. The platform manages vehicle data, positioning and wireless communication. The core of the platform is a new kind of ‘intelligent’ GSM modem, called a GSM module. A GSM module is basically a stripped down mobile phone that allows embedded third party application code and has an IP-stack. The report reviews the modules available on the market today and presents experiences from the implementation of a prototype based on the Aplicom A12 module. The main conclusion is that the concept is feasible though the modules' limited performance must be considered in the design.</p>

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