Magister Curationis - MCur / Women, who are HIV-positive, may transmit the virus to their babis during labour and through breast milk. HIV-positive mothers have to be counselled and encouraged to make informed decisions about the feeding of their babies to avoid this transmission. The feeding choices are exclusive breast-feeding , exclusive formula feeeding or modified feeding. this study focused on the perceptions, knowledge and experiences of breastfeeding women living with HIV/AIDS in the Oshakati district, Northern Namibia. A qualitative descriptive research design was used to conduct the study. The sresaerch was conducted at the Prevention of Mother-to-Child Transmission (PMTCT) Clinic, in the intermediate Hospital, Oshakati. The Medical Superitendant of the Hospital gave the researcher permission to conduct the study at the PMTCT clinic. A purposive sample was used consisting of 14 breastfeeding women who are HIV-positive and aged between 15-49 years. the ages of their babies were between one day and six months. The data collected through individual face-face-interviews. The interviews were tape-recorded with the permission of the respondents. The interviews were transcribed verbatim and data were analysed by thematic content analysis. The Health Belief Model guided the description and interpretation of the data. Th study revealed that some women had inadequate knowledge about the transmission of HIV through breastfeeding. Their breastfeeding choices were influennced by their knowledge and perceptions while their experiences were shaped by their relationships with their partners and family. / South Africa

Objectives: The aim of this study was to explore the experiences and perceptions of counsellors and patients towards a new counselling model for HIV-positive pregnant women on Option B+ at an antenatal clinic in South Africa and to describe the cohort of HIV-positive pregnant women who experienced the new counselling model. Methods: A mixed methods study design was employed. The quantitative data collection involved using retrospective cohort quantitative data of women that were initiated on Option B+ during the period of 1 October 2013 to 30 June 2014. The variables of interest included: age, gravidity, antiretroviral therapy initiation date, viral load result and number of counselling sessions completed. These were obtained from patient folders and from the Department of Health patient electronic health record. The data was analysed using STATA 12. The qualitative data involved semi-structured interviews of patients and counsellors who had experienced the counselling model. Results: The number of women who completed a total of 1, 2, 3 or 4 counselling sessions was 25%, 26%, 48% and 1% respectively. The percentage of women that were retained in care for more than 8 weeks postnatal was 53%. Of the women with VL results, 92% were virally suppressed. The Fisher's exact test showed a P-value of 0.05 at a level of significance of P ≤ 0.05. Therefore there is sufficient evidence to show that there is a positive association between the number of counselling sessions completed and number of postnatal days in care. The study also found that from the counselling, the women gained social support, knowledge about: antiretroviral therapy, HIV, drug side effects and infant feeding. Conclusion: The poor uptake of the counselling intervention includes poor communication, service delivery challenges and social factors. The main motivation for initiating ART and maintaining adherence to treatment was to protect the baby and as a result, some women maintained adherence despite not completing the counselling. Women valued the education that they received during the counselling sessions and this influenced their adherence. Psychosocial support from the counsellors and peers was found to be vital to the women and this highlighted the need to incorporate a support group for the pregnant women, as part of the intervention. The findings also suggest that when offering counselling interventions to pregnant women, a balance between psychosocial support, practical support and patient education needs to be struck. Finally, education of the community on the importance of counselling is important in order to improve the uptake of the counselling because interventions aimed at mothers do not always take into account the influence of the social environment on the uptake of the intervention.

Introduction: Use of highly effective antiretroviral drugs to eliminate new paediatric HIV infections is the keystone of all prevention of mother-to-child transmission (PMTCT) programmes. Time on antiretroviral treatment (ART) before delivery reduces maternal viral load and decreases the risk of transmission in utero, during labour and whilst breastfeeding. Currently, many PMTCT programmes across Africa initiate HIV-infected pregnant women on lifelong antiretroviral therapy (ART) on the first day of antenatal care ("same-day" initiation). However concerns have been raised regarding patient readiness and whether same-day initiation in pregnancy may contribute to subsequent ART non-adherence. Methods: As part of a larger study of ART in pregnancy, consecutive ART-eligible pregnant women making their first antenatal care (ANC) visit at a primary care facility in Cape Town, South Africa were enrolled into a prospective cohort between March 2013 and June 2014. Before July 2013, eligibility was based on CD4 cell count ≤350 cells/μL ("Option A"), with a 1-2 week delay from the first ANC visit to ART initiation; thereafter all women were eligible regardless of CD4 cell count ("Option B+") and typically offered ART on the same day as first ANC visit. All women received standardized counselling before starting a fixed-dose regimen. Study interviews were conducted separately from the ART service through one week postpartum with self-reported adherence from 30- day recall. Results: Among 625 consecutive ART-eligible women (median age, 28 years; median gestation, 21 weeks; 55% newly diagnosed with HIV), 72% of women started ART same-day; this proportion was higher under "Option B+" versus "Option A" (p< 0.001). Of those with adherence assessments data available (n=618), 29% reported at least one missed ART dose during pregnancy. Missed doses were reported more frequently among women with previous use of PMTCT (p=0.014), of younger age (p=0.029) and starting ART under Option B+ (p=0.019). In women initiating ART same-day, 31% reported a missed dose compared to 23% among women who delayed ART start following first ANC visit (odds ratio, 1.07; 95% CI: 0.61 – 1.88). This finding did not vary after adjustment for demographic and clinical measures, and was consistent when restricted to women with CD4 cell counts ≤350 cells/μL. Conclusions: These results suggest same-day ART initiation in pregnant women is not associated with increased non-adherence during the antenatal period. While these results are reassuring for ART programmes implementing "Option B+", further research is required to examine adherence over time, particularly postpartum.

Background and Objectives: Postpartum haemorrhage (PPH) and mother to child transmission (MTCT) of the Human Immune Deficiency Virus (HIV) are major threats to maternal and foetal health, especially in low and middle income countries. This thesis addressed two main objectives: 1) to investigate strategies for the prevention of PPH, with a focus on misoprostol; 2) to investigate strategies for prevention of mother to child transmission (PMTCT) of HIV, with a focus on the male partner. Methods: We employed a number of study designs including a cross sectional design, a retrospective chart review, and a systematic review which included Classical and Bayesian approaches of meta- analysis. Key methodological issues addressed include the use of propensity score matching methods to address channeling bias; comparison and combination of evidence from different sources; sensitivity analysis in health research; and methods for developing new tools for measurement in health research. Results and Conclusions: Our findings suggests that an oxytocin-misoprostol combination is better than the current standard of care of oxytocin-only which is recommended by the World Health Organisation for the prevention of PPH. Secondly, effectiveness data from well-designed observational studies may be used to inform clinical decisions on misoprostol in the prevention of PPH. Thirdly, using a new tool we have created, it is possible to objectively identify HIV positive women who lack the support of their male partners in adhering to PMTCT recommendations. / Background and Objectives: Postpartum haemorrhage (PPH) and mother to child transmission (MTCT) of the Human Immune Deficiency Virus (HIV) are major threats to maternal and foetal health, especially in low and middle income countries. This thesis addressed two main objectives: 1) to investigate strategies for the prevention of PPH, with a focus on misoprostol; 2) to investigate strategies for prevention of mother to child transmission (PMTCT) of HIV, with a focus on the male partner. Methods: We employed a number of study designs including a cross sectional design, a retrospective chart review, and a systematic review which included Classical and Bayesian approaches of meta- analysis. Key methodological issues addressed include the use of propensity score matching methods to address channeling bias; comparison and combination of evidence from different sources; sensitivity analysis in health research; and methods for developing new tools for measurement in health research. Results and Conclusions: Our findings suggests that an oxytocin-misoprostol combination is better than the current standard of care of oxytocin-only which is recommended by the World Health Organisation for the prevention of PPH. Secondly, effectiveness data from well-designed observational studies may be used to inform clinical decisions on misoprostol in the prevention of PPH. Thirdly, using a new tool we have created, it is possible to objectively identify HIV positive women who lack the support of their male partners in adhering to PMTCT recommendations. / Thesis / Doctor of Philosophy (PhD)

Magister Curationis - MCur / The pandemic of HIV is the most severe health challenge affecting children across the world and it is estimated that more than 90% of all HIV infections in children result from Mother to Child Transmissions (MTCT). The global target of <2% MTCT risk of HIV has still not been achieved despite the duration of the implementation of the programme and its great progress. The prevention of mother to child transmission (PMTCT) programme is a programme developed to enable health care practitioners to provide essential care to mothers in order to prevent the transmission of the virus to their infants.

Magister Public Health - MPH / The reproductive health of women is hugely dependent on the involvement of their male partners. Men also serve as gatekeepers to women’s access to reproductive health services. Male involvement is an important recommendation for the Prevention of Mother-to-Child Transmission of HIV (PMTCT) program as their participation in antenatal care and HIV testing has been found to decrease infant HIV infection and increase HIV free survival. Male involvement is not just about promoting men to accompany their partners to antenatal clinic, but for men to provide supportive roles in their families, and also to bring men into HIV preventive and care services. Male involvement in PMTCT is defined as the fathers’ active involvement in attending antenatal care services and HIV testing during the antenatal period as well as the couple’s acceptance of PMTCT if the mother is found to be HIV positive. Men are traditionally not directly involved in their partner’s health in many sub-Saharan countries, although they most often make decisions about use of services. They may provide financial support but attending health services with their partner is not seen as part of the male’s role. There are therefore huge challenges in efforts to get men involved in reproductive health services and there is a need to better understand how to promote male involvement in different settings. Male involvement in PMTCT was adopted by the Zambian Government in 1999 but not much is known on how best to initiate and develop male involvement in their partner’s health.

<p>Increased uptake of VCT services by pregnant women may be attributed to the development of counseling services and increased availability of rapid tests at the study clinics by the Namibian Health and Social Services. A high knowledge and understanding of HIV and VCT services by pregnant women also probably contributed.</p>

MPH, Faculty of Health Sciences, University of theWitwatersrand, 2011 / Introduction: In South Africa, over 25% of all babies born each year are exposed to HIV. The high antenatal HIV sero-prevalence rates coupled with high levels of maternal morbidity and mortality advocate for high quality maternal and child health care, which should include resilient PMTCT programs. This study aimed to explore infant feeding practices selected by HIV-positive women enrolled on a PMTCT program and describe some of the reasons for their choices, within the first 6 months postpartum. The study also reports on infant feeding practice and HIV status of the infant. Methodology: The study was a cross-sectional study which was carried out within the Perinatal Research Unit at Chris Hani Baragwanath hospital in Soweto. A sample of 200 women enrolled in the PMTCT program was interviewed, using a semi-structured questionnaire, during April 2007 – June 2007. Results: The study revealed that 84.5% of the study population had received infant feeding counseling. There was a high rate of exclusive formula feeding (EFF=84.5%), with lower exclusive breastfeeding (EBF=14%) and mixed feeding (MF=1.5%) rates. The corresponding HIV transmission rates were EFF – 26% (n=44/169); EBF – 75% (n=21/28); MF – 100% (n=3/3). The study demonstrated that babies born to mothers who did not receive information on infant feeding were twice as likely to be HIV positive (OR=2.43), which was statistically significant. The study also showed that the timing of the counseling was critical – all mothers who received counseling 6 weeks or more after delivery had HIV-positive babies. The overwhelming majority of women (78%) indicated that they would breast feed their babies if they were HIV-negative. Conclusion: The study demonstrated the vital role of infant feeding counseling in antenatal care and PMTCT programs. It illustrated that it was critically important that all HIV-infected women receive infant feeding counseling as soon as possible after the HIV diagnosis is made, prior to delivery and highlighted the importance of reinforcement of infant feeding choice at every antenatal care visit, for every woman. 5 The key recommendations focus on the need for: • Improved Antenatal care for all pregnant women • Improved care for HIV-positive pregnant women • Improvements in infant feeding counseling for HIV positive women • Integration of Maternal, Child health and PMTCT programs • Intensification of ongoing prevention efforts • The need for further research to: o identify some of the reasons HIV positive women choose certain infant feeding modalities throughout the country, and the challenges associated with these; and o critically evaluate the training that health care workers and counselors receive, regarding infant feeding counseling.

Student Number : 8044255 - PhD thesis - School of Pathology; Discipline Virology - Faculty of Health Sciences / Knowledge of the timing of mother-to-child transmission (MTCT) of HIV-1 is an important issue in reducing the risk of infant infection. Prior to giving birth therefore an HIV-1 positive mother should be provided with anti-HIV-1 drugs (antiretrovirals) during the shortest time possible to ensure both efficacy and minimal toxicity of the antiretrovirals to the newborn. However, in the absence of timeous administration of nevirapine (NVP) or zidovudine (AZT) to the mother at the onset of labour, infants are given post-exposure prophylaxis (PEP). Despite antiviral prophylaxis some infants still become infected. In an attempt to mimic the in vivo scenario we investigated, in Chapter Three, the replication ability of a primary isolate (M502L) in peripheral blood mononuclear cells (PBMC) isolated from healthy donors exposed to different concentrations of NVP or AZT either prior to or post-infection, but that reflected mean neonatal plasma concentrations measured following maternal dosing. In phytohaemagglutinin (PHA) stimulated cultures M502L exhibited some growth. Maintaining NVP and AZT in the culture medium resulted in decreased viral growth over time. In contrast to that expected certain donors demonstrated elevated p24 antigen levels in the presence of HIV-1 and NVP or AZT. This suggested that cells were more conducive to HIV-1 replication either because of cellular activation or due to cellular production of cytokines/chemokines. The in vitro study highlighted (i) the differential permissiveness of cells from different donors for HIV-1 infection, (ii) different abilities of antiretrovirals (ART) to circumvent infection in different individuals and (iii) immunomodulatory effects of ART in vitro. Commencing in Chapter Four we elected to investigate, in vivo, the immunomodulatory consequences of HIV-1 exposure and infection in two groups of HIV-1-exposed newborns whose mothers either received NVP at the onset of labour or who only received NVP as PEP within 72 hours of birth. Short-course antiretroviral drug regimens are known to reduce the risk of MTCT of HIV-1 but mechanisms affording protection of such interventions remain poorly defined. Since T-cell activation is an important factor in productive HIV-1 infection, we tested the hypothesis that single-dose NVP reduces immune activation, which in turn reduces the likelihood of transmission. We compared concentrations of cord and maternal blood plasma immune activation markers, neopterin, β2-microglobulin (β2-m) and soluble L-selectin (sL-selectin) in the two groups of HIV-1-exposed newborns and among HIV-unexposed controls. In utero exposure of the infant to HIV-1, regardless of NVP exposure, led to demonstrable increases in levels of immune activation markers, this being most notable in the presence of pre-existing infection. Contrary to what was hypothesized, immune activation was increased by pre-birth exposure to single-dose NVP, with this effect being enhanced in infants already infected at birth. Our data suggest that reductions in immune activation do not explain transmission prevention effects of single-dose NVP. Our data also suggest a biological explanation for why HIV-1 infected infants exposed perinatally to antiretroviral drugs might experience hastened disease progression, namely that the immunological mileau in some HIV-1 infected individuals treated with NVP favours increased HIV-1 replication. Cytokines and chemokines function to stimulate, or suppress cellular proliferation and differentiation and have unique immunomodulatory properties. Furthermore, they have the potential to protect against HIV-1 infection or to regulate HIV-1 replication. In Chapter Five we therefore questioned whether exposure to HIV-1 or NVP influences cytokine/chemokine levels of infants born to HIV-1 infected mothers. We compared levels of interleukin (IL)-7, IL-10, stromal cell-derived factor: SDF-1α (CXCL12), granulocyte-macrophage colony stimulating factor (GM-CSF), macrophage inflammatory protein-1α: MIP-1α (CCL3), macrophage inflammatory protein-1β: MIP-1β (CCL4) and regulated upon activation, normal T-cell expressed and secreted: RANTES (CCL5) of the two groups of HIV-1-exposed newborns and among the HIV-unexposed controls. HIV-1 exposure in the absence of single-dose NVP was not found to impact significantly on the levels of IL-7, IL-10, GM-CSF, CXCL12, CCL3, CCL4 or CCL5 and single-dose NVP had no appreciable effect on these cytokine/chemokine levels. Cord blood plasma levels of IL-7, CXCL12 and GM-CSF were found to be independent of mothers’ levels. Single-dose NVP reduced the ability of cord blood mononuclear cell (CBMC) to produce GM-CSF spontaneously. Maternal and infant (HIV-1 exposed NVP unexposed) IL-10 levels were significantly correlated. Significantly elevated levels of IL-10 were associated with pre-existing infection in NVP unexposed newborns. CCL3, CCL4 and CCL5 levels in NVP unexposed uninfected infants were not different from those of control infants but correlated significantly with IL-7 levels. HIV-1 specific cellular immune responses are elicited in a proportion of infants born to HIV-1 seropositive mothers and have been associated with protection from maternal HIV-1 transmission. In Chapter Six, levels of the immune activation markers neopterin, β2-m, sL-selectin, the immunomodulatory and haematopoietic factors IL-7, CXCL12, GM-CSF and the immunoregulatory cytokine IL-10 were examined amongst the group of newborns, that received NVP as PEP within 72 hours of birth, of which a proportion had specific cellular responses to HIV-1 envelope (Env) peptides. It was our aim to determine in infants that elicit HIV-1 specific cellular immune responses (Env+) and those that lack the specific responses (Env-), whether these factors could predict transmission and whether the former group of infants exhibit unique immune features that might distinguish them from Env- non-responders. Our data suggested that none of the factors tested were predictive of HIV-1 transmission but confirmed that infants with cellular responses to HIV-1 envelope peptides were associated with lack of subsequent infection. In particular, our data demonstrated an association between HIV-1 specific cellular immune responses, lower maternal viral load and lack of infection suggesting that sustained exposure to antigen (reduced maternal viral load) may be responsible for the strong priming effect. Furthermore, an association between reduced GM-CSF levels and the presence of HIV-1 specific responses was demonstrated, which suggested therefore that newborn infants that elicited HIV-1 specific cellular immune responses exhibited different immune capabilities from those without responses. Finally, in Chapter Seven we looked at how immune activation and priming impact on thymic output of T-cells in newborn infants. Unfortunately, sample volumes of the two groups of HIV-1-exposed newborns used in the previous three Chapters became limited with the result that we chose to address these questions using anonymously collected cord blood samples from infants, some of which were used to supplement the placebo group of the the UNAIDS-sponsored clinical trial of short-course zidovudine-lamivudine (AZT-3TC). At the time the AZT-3TC trial was conducted short-course antiviral prophlyaxis was not the standard of care for the prevention of MTCT of HIV-1. The thymus is known to be essential for establishing diversity of the T-cell pool, and morphological thymic changes and effects on naïve T-cells and T-cell receptor excision circle (TREC) concentrations have been reported in studies of HIV-1 infected children and adults. As it is not known to what extent in utero exposure to HIV-1 and infection affects T-cell division in newborn infants, we elected to determine TREC levels of infants born to HIV-1 seropositive mothers that were not exposed to antiretrovirals. The impact of increased immune activation on TREC levels and the consequence of HIV-1 exposure or infection on circulating levels of IL-7 (raised levels indicative of T-cell depletion) was also investigated. HIV-1 exposure or infection did not result in significant losses of TREC. TREC levels were not affected by immune activation associated with HIV-1 exposure and infection and IL-7 levels were not raised. Infants that elicited HIV-1 specific cellular immune responses exhibit TREC levels that were similar to those of infants without HIV-1 specific responses. These data suggested that newborn infants of HIV-1 seropositive mothers demonstrated no altered thymopoietic ability compared to control infants. Furthermore, HIV-1 specific immune responses, (indicative of post-thymic memory T-cell expansion) did not influence thymic output measured in newborn infants. In conclusion, the in vitro study demonstrated that there is a high degree of variability between PBMC isolated from different donors with respect to viral replication and drug effectivity which suggests that these phenomena are likely to exist within patient (infant as well as adult) populations. While immune activation is considered central to productive infection we demonstrated that immune activation is increased by HIV-1 exposure and by single-dose NVP. Exposure to HIV-1 alone or with NVP did not influence birth levels of IL-7, IL-10, CXCL12, GM-CSF, CCL3, CCL4 and CCL5. Furthermore, levels of these factors did not predict infection outcome in the infant. Immune activation and haematopoietic growth factors are modulated independently of the mother but maternal factors such as IL-10 and exposure to single-dose NVP, which reduces responsiveness of CBMC, could impact on the infant. HIV-1 specific cellular immune responses at birth, which are elicited in a proportion of infants born to HIV-1 positive mothers, are of immunological significance and can predict lack of subsequent infection. Disturbances in thymic output are not readily detectable at birth when using TREC to assess de novo T-cell synthesis, alternatively there is a homeostatic balance between thymic output and peripheral T-cell proliferation in newborns of HIV-1 infected mothers. Overall our data suggests that (i) there are immune consequences of being born to an HIV-1 positive mother, (ii) short-course antiretroviral prophylaxis does impact on the developing immune system of the infant and (iii) while the direct effects of single-dose NVP are not disputed, there are indirect consequences of NVP exposure on immune cells. Despite the consequences of HIV-1 exposure or the result of being born to a HIV-1 seropositive mother or exposure to single-dose NVP, our data proposes that the immune system of newborn infants is capable of responding as demonstrated by the enhanced immune activation. It remains important to determine the correlates of immune protection for the development of novel immuno-therapeutic and vaccine strategies and maternal-infant transmission of HIV-1 provides a model which can address questions of protective immune processes. Understanding the influence of antiretrovirals on immune processes remains an important component of the drug mechanisms, (aside from their direct antiretroviral activity), that may underlie reductions in maternal-infant transmission of HIV-1. Furthermore, how antiretrovirals influence immune processes and immune development (together with exposure to HIV-1/consequences of being born to an HIV-1 seropositive mother), may impact on subsequent immune responsiveness to infectious organisms or childhood vaccines.

O presente trabalho tem por objetivo investigar e fundamentar teoricamente, a partir da teoria psicanalítica de orientação freud-lacaniana, como se dá a experiência da revelação do diagnóstico de HIV, para a parceria afetivo-sexual, em adolescentes e jovens adultos infectados por transmissão vertical. É absolutamente compreensível a relação que se estabelece no âmbito da Saúde, entre revelação do diagnóstico e cuidados preventivos. No entanto, a clínica psicanalítica com os pacientes envolvidos nesta problemática nos indica que a revelação do diagnóstico é, para o paciente, uma experiência que ultrapassa muito o ato de informar um dado, sendo, antes, uma experiência subjetiva da revelação de uma identidade herdada. Por esse motivo, percebemos ser fundamental uma compreensão dos processos psíquicos envolvidos na experiência da revelação do diagnóstico destes jovens, levando em conta a singularidade de cada caso. Partimos de duas hipóteses: a revelação do diagnóstico ao parceiro afetivo-sexual pode ser influenciada por como lhe foi revelado seu diagnóstico, ou seja, sua herança do HIV, transmitida por sua mãe; a angústia associada à experiência da revelação do diagnóstico de HIV por transmissão vertical para o parceiro pode ser uma resposta à fantasia de desamparo. Na tentativa de compreender esse cenário, elegemos alguns conceitos psicanalíticos como bússola, que podem contribuir para o cerzimento de articulações teórico-clínicas, são eles: tabu, transmissão, identificação, fantasia e angústia. Além disso, realizamos entrevistas semi-dirigidas com quatro pacientes, que tinham diagnóstico de HIV/aids por transmissão vertical. A análise das falas dos entrevistados foi realizada a partir do referencial psicanalítico, utilizando principalmente as teorias construídas por Freud e Lacan. A partir disso, pudemos concluir que guardar o diagnóstico de HIV como segredo implica resguardar a posição do sujeito em sua fantasia fundamental, que funciona de anteparo para a angústia e está diretamente ligada ao Outro. Nesse sentido a solução para ausência de sofrimento psíquico não seria nem direcionar o sujeito para a denúncia do segredo, nem tampouco, sugestioná-lo a manter o segredo a sete chaves. Neste momento, é fundamental compreender o lugar que o segredo encena na subjetividade dos jovens, por meio da escuta psicanalítica. Além disso, é imprescindível cuidar da resposta do psicanalista no âmbito institucional, como membro da equipe de saúde, defendendo um manejo delicado entre o tempo de cada sujeito e a importância da revelação do diagnóstico, uma vez que o paradigma da subjetividade pode ser uma alternativa competente para resolver uma problemática ainda muito incompreendida em serviços de saúde especializados em HIV/Aids / The present study aims to investigate and to formalize theoretically, according to the psychoanalytic theory of Freud and Lacan, how is the experience of the disclosure of HIV serostatus to an intimate partnership, for adolescents and young adults infected by mother-to-child-transmission. The connection established under Healths context, between the disclosure of HIV serostatus and preventive care is absolutely understandable. However, the psychoanalytic treatment of patients involved in this issue indicates that disclosure of HIV diagnosis is an experience that exceeds just the act of informing, it is actually a subjective experience of revelation of an inherited identity. For this reason, we consider that it is fundamental to understand which psychological processes are involved in the experience of disclosing the HIV diagnosis, taking into account the uniqueness of each case. We have two hypotheses: the disclosure of HIV diagnosis to the partner may be influenced by how the individual received its own diagnosis, that represents the heritage of HIV, transmitted by the mother; the anguish associated with the experience of disclosing the HIV diagnosis through mother-to-child-transmission to the partner may be a response to the fantasy of helplessness. In trying to understand this scenario, we elect some psychoanalytic concepts such as a compass, that can contribute to make the theoretical and clinical link, they are: taboo, transmission, identification, fantasy and angst. In addition, we conducted semi-structured interviews with four patients who were diagnosed with HIV/AIDS through mother-to-child-transmission. The analysis of the interviewed peoples speeches was done by the psychoanalytic theoretical basis, mainly using the theories constructed by Freud and Lacan. The course of this research allowed us to conclude that keep HIV diagnosis as a secret means to safeguard the position of the individual in its fundamental fantasy, which works as a screen for anxiety and is directly linked to the Other. In this context, the solution to the absence of psychological pain would be neither to guide the individual to denunciate its secret, nor suggests to keep the secret under lock and key. At this point, it is essential to understand the place that the secret stages in the subjectivity of young people, through the psychoanalytic listening. Moreover, it is also essential to take care of the psychoanalysts work in the health institution, as a member of the health team, protecting the delicate handling between the time of each subject and the importance of disclosure, since the paradigm of subjectivity can be a competent alternative to solve a misunderstood issue inside the HIV/Aids specialized health services