Introdução: Poucos estudos avaliaram marcadores inflamatórios associados à nitração da placa aterosclerótica no prognóstico da doença arterial coronariana (DAC). Assim, o objetivo deste estudo é analisar a influência dos níveis de atividade da mieloperoxidase (MPO) e nitrotirosina (NT) na sobrevida em curto e longo prazo, em uma coorte prospectiva de síndrome coronariana aguda (SCA), Estratégia de Registro de Síndrome Coronariana Aguda (estudo ERICO). Métodos: Avaliou-se a influência da atividade da MPO e dos níveis de NT, ambos dosados até 10 dias após a síndrome coronariana aguda (SCA), em relação à mortalidade em até 4 anos de seguimento. A atividade da MPO e os níveis de NT, coletados durante a fase aguda e subaguda do início dos sintomas da síndrome coronariana aguda (SCA) (infarto do miocárdio (IAM) com supra e sem supra do segmento ST e angina instável), foram avaliados em 342 pacientes. Em 180 dias, 1 ano, 2 anos e 4 anos foram calculadas as taxas de letalidade geral, assim como as curvas de sobrevivência de Kaplan-Meier e os modelos de regressão logística de Cox com respectivas razões de risco (RR) cumulativas (intervalo de confiança de 95%; IC 95%), de acordo os tercis de atividade da MPO e de NT para mortalidade (geral, cardiovascular e por IAM fatal). As RR cumulativas para atividade da MPO e NT foram calculadas sem ajuste, ajustadas por idade e sexo e com ajuste adicional para tabagismo, diabetes, hipertensão e níveis de colesterol LDL e HDL. Resultados: No geral, o valor mediano para a atividade da MPO foi de 29,6 mU / ml (variação: 1,8 a 282,1 mU / ml) e NT foi de 208,33 nmol / L (variação: 3,09 a 1.500,00 nmol / L), independentemente do subtipo de SCA. Durante o seguimento de 4 anos, observamos 55 (16,1%) óbitos. A taxa de sobrevida global foi de 287 (83,9%) (tempo mediano de sobrevida foi 1.517, IIQ: 1.1391.904 dias). A atividade de MPO e os níveis de NT não se associaram com as taxas de letalidade e nem de sobrevivência (mortalidade geral, cardiovascular e por IAM fatal) pelas RR de 180 dias até 4 anos de seguimento. Conclusões: A atividade da MPO, assim como, os níveis de NT não foram preditores de morte após SCA em curto e longo prazo no estudo ERICO / Introduction: Few studies have evaluated inflammatory markers associated with atherosclerotic plaque nitration in the prognosis of coronary artery disease (CAD). Thus, the objective of this study is to analyze the influence of levels of myeloperoxidase (MPO) activity and nitrotyrosine (NT) on short- and long-term survival in a prospective cohort of acute coronary syndrome (ACS), Coronary Syndrome Registry Strategy Acute (ERICO study). Methods: The influence of MPO activity and NT levels, both dosed up to 10 days after acute coronary syndrome (ACS), was evaluated in relation to mortality up to 4 years of follow-up. The MPO activity and NT levels, collected during the acute and subacute phase of the onset of ACS symptoms (myocardial infarction (MI) with supra and non-ST-segment elevation and unstable angina), were evaluated in 342 patients. Overall, case-fatality rates, as well as, Kaplan-Meier survival curves and Cox logistic regression models with cumulative hazard ratios (HR) were calculated for 180 days, 1 year, 2 years and 4 years (range (95% confidence interval, 95% CI), according to tertiles of MPO and NT activity for mortality (overall, cardiovascular and fatal MI). Cumulative RRs for MPO and NT activity were calculated as crude, age and sex-adjusted, and with additional adjustment for smoking, diabetes, hypertension, and LDL and HDLcholesterol levels. Results: Overall, the median value for MPO activity was 29.6 mU / ml (range: 1.8 to 282.1 mU / ml) and NT of 208.33 nmol / L (range: 3, 09 to 1,500.00 nmol / L), regardless of the subtype of ACS. During the 4-year follow-up, we observed 55 (16.1%) deaths. The overall survival rate was 287 (83.9%) (median survival time was 1,517, IQR: 1,139-1,904 days). MPO activity and NT levels were nor associated with case-fatality neither survival rates (overall, cardiovascular and fatal MI mortality ) by HRs from 180 days to 4 years of follow-up. Conclusions: MPO activity, as well as, NT levels were not predictors of short- and long-term mortality after ACS in the ERICO study

Le syndrome de l’intestin irritable (SII) et le syndrome de la vessiedouloureuse (SVD) sont tous deux caractérisés par une hypersensibilité viscérale àla distension. Sur le plan épidémiologique, ces deux syndromes sont étroitementassociés puisque les patients SII ont une prévalence du syndrome de la vessiedouloureuse 7 fois plus élevée que la population générale. Cependant, le mécanismeresponsable de la sensibilisation du tube digestif et de l’appareil urinaire n’a jamaisété étudié. Compte tenu de l’innervation commune de ces deux organes, il estprobable que ce mécanisme mette en jeu sur le long terme des phénomènes de laplasticité neuro-gliale aux niveaux communs d’intégration de la sensibilité pelvienne.L’objectif général de ce travail était d’établir et de caractériser un modèleanimal de sensibilisation croisée vessie/colon, aigu et chronique, afin de mieuxcomprendre les mécanismes impliqués dans l’hypersensibilité viscérale croisée. / Irritable bowel syndrome (IBS) and Bladder pain syndrome (BPS) are bothcharacterized by visceral hypersensitivity to distension. Epidemiology showed thatthese two syndromes are closely associated since IBS patients have a prevalence ofbladder pain syndrome that is 7 times higher than the general population. However,the mechanism responsible for sensitization of the gastrointestinal tract and theurinary tract has never been studied. Given the common innervation of these twoorgans, it is likely that this mechanism involves long-term phenomena of neuro-glialplasticity at the common levels of integration of pelvic sensitivity.The overall objective of this work was to establish and characterize an animalmodel of bladder / colon cross-sensitization, acute and chronic, to better understandthe mechanisms involved in cross-visceral hypersensitivity.