The current study examined the relationships between Major Depressive Disorder, negative life events, perceived parenting style, perceived family environment and Disruptive Behavior Disorders, specifically Conduct Disorder, Oppositional Defiant Disorder, and Attention-Deficit/Hyperactivity Disorder, in adolescent participants, (N = 381). Results indicated that those factors, with the exception of authoritarian parenting, correlated positively with symptoms consistent with Disruptive Behavior Disorders. In addition, the overall effect of those factors predicted symptoms consistent with Disruptive Behavior Disorders more strongly than each risk factor in isolation. In conclusion, results indicated that negative life events and symptoms consistent with Major Depressive Disorder mediated the effects of perceived parenting and perceived family environment on symptoms consistent with Disruptive Behavior Disorders.

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We tested 42 strains of amikacin-resistant gram-negative bacilli with amikacin in combination with six beta-lactam antibiotics using the checkerboard and time kill curve techniques. Synergism was demonstrated with time-killing curve in 43-68% of the strains tested. Ceftazidime plus amikacin was the most active combination by the checkerboard technique, while amikacin-cefoperazone was the most active combination by the time-killing curve technique against Pseudomonas aeruginosa. Discrepancies were found between the results of the two methods used.

The general aggression model (GAM) has suggested that the interaction between person factors (e.g., personality variables) and situation factors (e.g., playing violent video games [VVGs]) can increase individuals’ aggressive behaviors through their cognition (e.g., hostile attributions), affect (e.g., negative affect), and/or arousal. The present study employed a modified competitive reaction time task to test the effects of shyness, violent (vs. nonviolent) gameplay, and shyness on individuals’ positive–negative affect, hostile attributions, and aggressive behaviors. In addition, the present study also employed structural equation modeling (SEM) to test the mediation (by cognition and affect) and moderation (by shyness). Results showed that playing a VVG increased aggressive behaviors, negative affect, and hostile attributions primarily among shy participants. In addition, the results of SEM also revealed that this moderating role was mediated by negative affect and hostile attributions. The present study supported GAM and showed that individuals’ aggressive behaviors are differentially susceptible to VVGs, depending on their level of shyness in a “for bad and for worse” manner.

abstract: Obesity is associated with many well-established health risks as well as high annual public health costs. Intervening in the trajectory of obesity becomes significantly more difficult after a child has reached obesity. Therefore, it is crucial to understand the processes that influence weight early in life. Parents serve as one of the main influences on child health, have a significant impact on the weight of their offspring, and are often incorporated into childhood obesity prevention programs. However, the mutual influence that parents and children have on each other is not accounted for. Using an Actor-Partner Interdependence model, the current study 1) examined the effect of children’s and mother’s temperament (e.g., negative affectivity, effortful control, and impulsivity) on their own weight as well as the weight of the other dyad member, 2) explored the effect of the interaction between mother and child temperament on both members’ weight, 3) assessed the effect of mother’s approach to food on mother and child weight, and 4) investigated how temperament might moderate the relationships between mother’s approach to food and mother and child weight. The sample consisted of 220 mother-child dyads. Children ranged from 4 to 6 years of age. Mothers completed self-report questionnaires on their own temperament and approach to food as well as their child’s temperament. Weight measures were assessed in the laboratory for both mother and child. Results indicated children’s impulsivity was related to their mother’s higher weight. The interaction between mother and child temperament was not significantly associated with weight. However, the interaction between child impulsivity and mother’s approach to food was significant; the effect of the mother’s approach to food on her own weight depended on their child’s impulsivity behaviors. Specifically, mothers’ approach to food on her own weight was nonsignificant when her child showed higher levels of impulsivity. The association of mother’s approach to food with her own weight was stronger when her child exhibited average to low impulsivity levels. This investigation of the influence of mother and child on each other’s weight is well-placed for translation into later obesity preventative and intervention efforts for family systems. / Dissertation/Thesis / Doctoral Dissertation Psychology 2021

The objective of this thesis is to examine the relationship between CAIX (a biomarker for insufficient oxygen in tumor microenvironment) and CD8+ T cells (the immune cells for killing cancer cells) for ovarian cancer. We approach the problem from two perspectives. The first approach is to set up count models such as Poisson, negative binomial, and zero-inflated Poisson models to examine the cell counts between CAIX and CD8+ T cells in the tumor microenvironment. The second approach is to apply the cross-K function, which is a second-order property of the point pattern process. We find that the tissue microarray (TMA), which is a technique to assemble hundreds of tissue samples on one TMA block, has a fixed effect on the CD8+ T cell counts. There are two TMA blocks A2 and B1. The relationship between CAIX and CD8+ T cells highly depends on TMAs. On TMA B1 stroma, a negative relationship between CAIX and CD8+ T cell counts is observed in the negative binomial models. When taking the spatial domain into account and comparing the estimated cross-K function of CAIX and CD8+ T cells to the simulated envelopes generated by a homogeneous Poisson process, we find that CAIX and CD8+ T cells are regulated and repel each other on TMA B1. Tissue category also plays an influential role in analyzing the relationship. The estimated cross-K function of CAIX and CD8 + T cells is more dispersed on tumors than on stroma. / Graduate

Sexual minorities must deal daily with their stigmatized identities. Specifically, depression and anxiety as well as psychological distress and self-stigma are common among people with stigmatized identities. Self-compassion has been linked to enhanced psychological well-being and less negative feelings toward the self. The aim of this study was to investigate selfcompassion as a potential buffer of the effects of sexual minority related rejection experiences on self-perceptions of stigma and psychological symptoms. Participants were randomly assigned to a self-compassion induction group versus 1 of 3 control groups (self-esteem only induction; expressive writing condition; true control) to examine whether self-compassion can be induced to reduce self-stigma, negative mood, and fear of negative evaluation. Results did not support hypotheses; analyses revealed nonsignificant effects for the self-compassion induction. However, results revealed a significant main effect for trait self-compassion predicting outcomes of decreased self-stigma, fear of negative evaluation, and negative mood, and increased positive mood.

Introduktion/Bakgrund: Negative Pressure Wound Therapy är en sårbehandling som är vanlig vid sekundär sårläkning och kan användas på många olika typer av sår. Undertryck skapas med ett specifikt skumförband som placeras i sårhålan och kopplas till en vakuumpump. Syfte: Syftet med litteraturstudien var att beskriva patienters erfarenhet av Negative Pressure Wound Therapy (NPWT). Metod: Litteraturstudien utformades utifrån Polit och Becks (2021) nio steg. I databaserna Cinahl och PubMed genomfördes litteratursökning, samt en kompletterande manuell sökning. Totalt elva artiklar var relevanta för studiens syfte och granskades utifrån granskningsmallarna ”Guide to a Focused Critical Appraisal of Evidence Quality in an Qualitative Research Report” samt “Guide to a Focused Critical Appraisal of Evidence Quality in a Quantitative Research Report. Resultat: Artiklar som belyste patienters erfarenhet av Negative Pressure Wound Therapy resulterade i tre teman: ”Sjuksköterskans kompetens vid NPWT”, ”Påverkan på livssituationen vid NPWT”, samt ”Oro och smärta”. Slutsats: Sjuksköterskans kompetens inom sårbehandling samt Negative Pressure Wound Therapy visade sig ha en stor betydelse för patienters negativa och positiva erfarenheter av Negative Pressure Wound Therapy. Därav finns ett behov av adekvat kompetens hos sjuksköterskor för att patienters behov ska tillgodoses samt för att styrka patientsäkerheten.

Two steel pipe piles in place in abutments for two different bridge constructions sites were instrumented with strain gauges to measure the magnitude of negative skin friction. The piles were monitored before, during and up to 19 months after construction was completed. The load versus depth and time in each pile is discussed. Maximum observed dragloads ranged from 98 to 127 kips. A comparison with two methods for calculating dragloads is presented. Both comparison methods were found to be conservative, with the Briaud and Tucker (1997) approach more closely estimating the observed load versus depth behavior.

It is estimated that one third of the world's population is infected with tuberculosis. Though once thought a "dead" disease, tuberculosis is very much alive. The rise of drug resistant strains of tuberculosis, and TB-HIV coinfection have made tuberculosis an even greater worldwide threat. While HIV, poverty, and public health infrastructure are historically assumed to affect the burden of tuberculosis, recent research has been done to implicate smoking in this list. This analysis involves combining data from multiple sources in order determine if smoking is a statistically significant factor in predicting the number of incident tuberculosis cases in a country. Quasi-Poisson generalized linear models and negative binomial regression will be used to analyze the effect of smoking, as well as the other factors, on tuberculosis incidence. This work will enhance tuberculosis control efforts by helping to identify new hypotheses that can be tested in future studies. One of the main hypotheses is whether or not smoking increases the number of tuberculosis cases above and beyond the effects of other factors that are known to influence tuberculosis incidence. These known factors include TB-HIV coinfection, poverty and public health infrastructure represented by treatment outcomes.