Ce résumé étendu prend son origine a par tir de la thèse “L'écran de Charon: la traversée du sujet du langage dans la narration cinématographique” réalisée en régime de cotutelle entre les universités de Brasília, Brésil, et Nice Sophia Antipolis, Fance. Il s'agit d'une synthèse de l'investigation psychanalytique concernant deux styles narratifs: moderne et classique. Ils sont pensés, avant tout, par rapport la production cinématographique. Dans le présent rapport, nous discutons de la question de la jouissance à partir de l'amalgame signifiant des mots français jeu et jouissance. Ainsi, notre mot-valise - “la jeuïssance” - nous permettra d'articuler la jouissance du sujet du langage à la production narrative. Il sera évoqué les catégories engendrées dans le Triskel lacanien, à savoir: la jouissance de l'Autre, la jouissance du sens et la jouissance Phallique. Elles sont articulées sur la logique borroméenne avec les productions narratives moderne, classique et classique-industrielle. Avec un montage de notre triskel, nous identifions dans la figure du trompe-l'oeil la fonction de l'objet petit a du champs narratif. Pour notre traversée des inferos lacaniens, nous pensons avoir trouvé dans la figure de jeuïssance un dispositif pour analyser la narration, composé exclusivement de matériel psychanalytique. Ainsi, dans n'importe quelle production narrative du sujet de langage, les narrations sont enterrées dans la supposée terre-ferme de la science ou de la religion, ou bien dans les sables mouvants des arts. Ce voyage psychanalytique nous fera atteindre un champs bien delà du principe du plaisir. / This extended summary originates from the thesis "The screen of Charon: the crossing of the subject of language in the cinematographic narrative" carried out under collaboration between the universities of Brasília, Brazil, and Nice Sophia Antipolis, Fance. It is a synthesis of psychoanalytic investigation concerning two narrative styles: modern and classical. First and foremost, they are concerned with film production. In this report we discuss the issue of pleasure from the amalgam formed by the French words “jeu” (game, play) and “jouissance” (the act of experiencing pleasure). Thus, our “mot-valise” "jeuïssance" (“playsure”) will allow us to articulate the experience of pleasure undergone by the subject of language with the narrative production. The categories created in the Lacanian Triskel will be evoked, namely: the pleasure of the Other, the pleasure of meaning and the pleasure of the Phallic. They are articulated on a borromean logic with modern, classical and classical-industrial narrative productions. By creating our triskel, we identify, in the figure of the trompe-l'oeil, the function of the small object as the narrative field. By crossing the lacanian inferos, we believe to have found in the figure of “playsure” a device for analyzing narration, composed exclusively of psychoanalytic material. Thus, in any narrative production of a subject of language, narratives are either buried in the supposed firm land of science or religion or in the moving sands of the arts. This psychoanalytic journey will take us far beyond the principle of pleasure.

<p>The main objective of this thesis is to analyze the transportation infrastructure based on performance measures. In doing so, the abstract presents a transportation network as a system of nodes and links. It is important to identify critical components in transportation networks. In identifying critical components of the network, performance measures such as nodal degree, nodal closeness, nodal eigen vector, nodal betweenness, which are the most widely used were explored in the analysis of the network. These measures account for the vulnerability of a node to failure in the transportation network.</p> <p>In our daily use of transportation networks, we are faced with disruptions that engender change in the transportation network. Disruptions tend to be commonplace in transportation systems. These include manmade disruptions such as accidents to natural disasters such as floods due to rainfall and hurricanes, seismic activities among others which are unprecedented. These incidents change how road users interact with the transportation system due to the disruptions that occur. The disruptions cause increased travel time, delays and even loss of property. These disruptions lead to direct, indirect and induced impacts.</p> <p>This study provides a firsthand diagnosis of the vulnerability of the transportation network to flood by ranking the nodes using performance measures and multicriteria evaluation. The paper found out that various performance measures may produce different critical nodes but with the employment of sensitivity analysis and veto rule, the most critical node can be established The paper found out that node 80 is the most critical and essential node of the entire network after the impact of flood. </p>

Denna rapport kommer behandla det projekt som en grupp på sju personer gjorde i kursen TDDD96 på Linköpings universitet våren 2020. Projektet var att utveckla en webbapplikation som kunde visualisera en översikt av data från olika källor, en så kallad dashboard, åt kunden Skira. Rapporten kommer beskriva hur utvecklingsarbetet utfördes samt försöka besvara de uppsatta frågeställningarna. Den huvudsakliga frågeställningen är hur webbapplikationen som tidigare beskrevs kan skapas för att tillföra värde till kunden. För att utveckla webbapplikationen användes ramverket React på klientsidan. Verktyget Node användes på serversidan. Gruppen adopterade ett agilt arbetssätt med iterativ utveckling. Övriga metoder för att utveckla webbapplikationen redovisas mer utförligt i metod-delen tillsammans med tillvägagångssätten för att besvara övriga frågeställningar. Sammantaget blev slutsatsen att den metod som valdes framgångsrikt kan användas för att utveckla en webbapplikation som tillför värde till kunden. Kravspecifikationen som skapades tillsammans med kunden uppfylldes. Varje medlem i gruppen har också bidragit med en individuell del om ett ämne relaterat till projektet. Dessa delar finns i slutet av rapporten.

Municipalities increasingly have less financial resources to spend on implementation of transport strategies and plans. This situation is putting pressure on transport professionals to minimize wasteful expenditure on projects that do not deliver high transport service improvements. As such, the need for efficient, pragmatic decision making on policy direction, infrastructure expenditure, or any transport interventions is becoming very critical. Thus, transport professionals are increasingly in need of tools to help them predict with increased accuracy the outcomes of their intended transport interventions. The City of Cape Town has a Bus Rapid Transport system called MyCiTi. Current MyCiTi operations are incurring losses. The service is kept running on the back of subsidies from the federal government. There is a need for rationalization of the system. However, with strained resources, the interventions on the system have to guarantee improvements. Overemphasis on the ability of MyCiTi BRT service to support transportation during the 2010 soccer world cup event heavily influenced the design of the network. As a result, network appraisal is one area that can be done on the system to identify areas of improvement. In this thesis, decision making support will be demonstrated using a network design appraisal process for the MyCiTi BRT system in Cape Town. The existing MyCiTi network will undergo network improvement using heuristic node insertion technique leading to multiple network scenarios in a modeling environment. Agent-Based demand mobility behavior simulation will be used on each of the network scenarios to come up with network performance indicators. These network performance indicators will be used in the multi-criteria decision analysis (MCDA) model to come up with a ranking of the network scenarios and help in deciding on the optimum network improvement intervention. Overall, findings of this research show the importance of weighting of the performance indicators. Where networks that score well in the performance indicator with the high weights also rank high. In conclusion, the study has demonstrated the importance of decision making support in interventions on complex systems like bus systems. Recommendations on the possible avenues of research stemming from this thesis have also been outlined.

X-Linked Sinus Node Dysfunction and Atrial Fibrillation. Introduction: Atrial fibrillation (AF) is a heritable disorder with male predilection, suggesting a sex chromosome defect in certain patients. Loss-of-function truncation mutations in EMD, encoding the nuclear membrane protein emerin, cause X-linked Emery-Dreifuss muscular dystrophy (EDMD) characterized by localized contractures and skeletal myopathy in adolescence, sinus node dysfunction (SND) in early adulthood, and atrial fibrillation as a variably associated trait. This study sought to identify the genetic basis for male-restricted, nonsyndromic sinus node dysfunction and AF in a multigenerational family. Methods and Results: Genealogical and medical records, and DNA samples, were obtained. Progressive SND and AF occurred in four males related through maternal lineages, consistent with X-linked inheritance. Skeletal myopathy was absent, even at advanced ages. Targeted X chromosome genotyping mapped the disease locus to Xq28, implicating EMD as a positional candidate gene. DNA sequencing revealed hemizygosity for an in-frame 3-bp deletion in EMD (Lys37del) in affected males, disrupting a residue within the LEM binding domain critical for nuclear assembly but leaving the remainder of the protein intact. Buccal epithelial cell staining with emerin antibody demonstrated near-total functional loss of emerin. Female relatives underwent prospective electrocardiographic and genetic testing. Those heterozygous for Lys37del had ∼50-70% emerin-positive nuclei and variable degrees of paroxysmal supraventricular arrhythmia. Conclusions: Mutation of EMD can underlie X-linked familial AF. Lys37del is associated with epithelial cell emerin deficiency, as in EDMD, yet it causes electrical atriomyopathy in the absence of skeletal muscle disease. Targeted genetic testing of EMD should be considered in patients with SND-associated AF and/or family history suggesting X-linked inheritance.

Rationale: Cardiac function is under exquisite intrinsic cardiac neural control. Neuroablative techniques to modulate control of cardiac function are currently being studied in patients, albeit with variable and sometimes deleterious results. Objective: Recognizing the major gaps in our understanding of cardiac neural control, we sought to evaluate neural regulation of impulse initiation in the sinoatrial node (SAN) as an initial discovery step. Methods and Results: We report an in-depth, multiscale structural and functional characterization of the innervation of the SAN by the right atrial ganglionated plexus (RAGP) in porcine and human hearts. Combining intersectional strategies, including tissue clearing, immunohistochemical, and ultrastructural techniques, we have delineated a comprehensive neuroanatomic atlas of the RAGP-SAN complex. The RAGP shows significant phenotypic diversity of neurons while maintaining predominant cholinergic innervation. Cellular and tissue-level electrophysiological mapping and ablation studies demonstrate interconnected ganglia with synaptic convergence within the RAGP to modulate SAN automaticity, atrioventricular conduction, and left ventricular contractility. Using this approach, we comprehensively demonstrate that intrinsic cardiac neurons influence the pacemaking site in the heart. Conclusions: This report provides an experimental demonstration of a discrete neuronal population controlling a specific geographic region of the heart (SAN) that can serve as a framework for further exploration of other parts of the intrinsic cardiac nervous system (ICNS) in mammalian hearts and for developing targeted therapies.

京都大学 / 0048 / 新制・課程博士 / 博士(理学) / 甲第20894号 / 理博第4346号 / 新制||理||1624(附属図書館) / 京都大学大学院理学研究科物理学・宇宙物理学専攻 / (主査)教授 川上 則雄, 教授 松田 祐司, 教授 前野 悦輝 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DFAM

My project seeks to produce a building type that addresses the undeniable need of the Town of Orange, Massachusetts to be revitalized as a town and community. While Orange has a great deal of potential, it is for all intents and purposes a dying hill town, in need of being reconnected to the larger world, and indeed itself. As I discovered through my research and participation with the Sustainable Design Assessment Team of the AIA, Urban revitalization is a complex issue. It is through these SDAT sponsored community charretts that I have gleaned the basic information needed to program a design. The chief aim of this project is then to produce what the people want – simply, an enhanced quality of life for the community and its visitors. This project attempts to satisfy this need by activating heretofore neglected and overlooked space in the heart of the town as a new town node. It is also my goal to establish a re-branding of the town with a contemporary image, asserting and producing convenience, sustainability, enhanced mobility, economic expansion, health and leisure, and community social connections. The project is not intended to merely stand on its own legs, so to speak. Rather, it aspires to mesh-together with preexisting conditions, enhancing nearby commerce, while simultaneously providing connection to both nearby neighborhoods and communities, and far away destinations such as Boston, New York and Canada.

No description available.

[pt] Este trabalho apresenta um algoritmo de construção de malhas em grafos conexos orientados definidos pela matriz de incidência. Se o grafo é planar e conexo é obtida a matriz de malhas, com o fim de permitir alternativa de análises, por nós ou malhas, de redes elétricas lineares ativas descritas apenas por seus nós. Foi desenvolvido também um algoritmo que realiza essas 2 análises e que aceita elementos ideais como fontes de tensão e corrente, controladas ou não, amplificadores operacionais ideais, indutâncias mútuas. A dimensão do programa foi reduzida pelo fato da representação de um elementos em um método ser igual a de seu dual em outro método. É feita também uma comparação entre os métodos de anos métodos de análise existente. / [en] An algorithm is presented that defines all the internal meshes of na oriented connected graph described by its incidence matrix. In the case of a planar, connected graph, a mesh matrix is obtained, which allows either nodal or mesh analysis of an active linear network described by its nodes. A further algorithm is developed ehich applies both these types of analysis to networks with ideal elements, such as controlled or uncontrolled current and voltage sources, operational amplifiers and mutual inductances. Owing to the fact that the representation of an element in one of these methods is identical to that of the dual element in the other, a program which performs nodal analysis may easily be adapted to perform mesh analysis. The methods are compared with existing methods of circuit analysis and some conclusions are drawn.