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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Génération de progéniteurs hépatiques dérivés de cellules souches : application à l’hypercholestérolémie familiale / Generation of stem cell-derived hepatic progenitors : application to familial hypercholesterolaemiaCorbineau, Sébastien 05 October 2011 (has links)
La transplantation d’hépatocytes représente une alternative à la transplantation hépatique pour le traitement de certaines maladies métaboliques dont l’hypercholestérolémie familiale. Les cellules souches embryonnaires (ES) et les cellules souches pluripotentes induites (iPS) humaines représentent de nouvelles sources de cellules hépatiques. Nous avons mis au point une approche de différenciation des cellules souches humaines en cellules hépatiques et généré ainsi des cellules dérivées de cellules iPS de patients atteints d’hypercholestérolémie familiale. / Hepatocyte transplantation represents an alternative to liver for the treatment of metabolic diseases including familial hypercholesterolaemia. Embryonic stem cells (ES) and induced pluripotent stem cells (iPS) represent new sources of hepatic cells. We have developed an approach to differentiate human stem cells into hepatic cells and thus we have generated hepatic cells derived from iPS of familial hypercholesterolaemia patients.
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