ITC/USA 2010 Conference Proceedings / The Forty-Sixth Annual International Telemetering Conference and Technical Exhibition / October 25-28, 2010 / Town and Country Resort & Convention Center, San Diego, California / This paper will discuss the design of a new antenna element for use on vehicles requiring a thin conformal antenna such as on missiles or targets. The new element employs a partial shorted edge, which reduces the size of the element compared to a traditional microwave patch, while maintaining the impedance bandwidth.

Sensitivity analysis was performed on a soot model using a partially stirred reactor (PaSR) in order to determine the effects of mixing model parameters on soot scalar values. The sensitivities of the mixture fraction zeta and progress variable C to the mixing model constant C_phi were calculated; these values were used to compute the sensitivity of water mass fraction Y_H2O to C_phi and several soot quantities to soot moments. Results were validated by evaluating the mean mixture fraction sensitivity and a long simulation time case. From the baseline case, it was noted that soot moment sensitivities tended to peak on the rich side of the stoichiometric mixture fraction zeta_st. Timestep, number of notional particles, mixing timescale tau_mix, and residence time tau_res were varied independently. Choices for timestep and notional particle count were shown to be sufficient to capture relevant scalar profiles, and did not greatly affect sensitivity calculations. Altering tau_mix or tau_res was shown to affect sensitivity to mixing, and it was concluded that the soot model is more heavily influenced by the chemistry than mixing. / text

Magister Scientiae Dentium - MSc(Dent) / Three dental laboratories in the Cape Town Metropole that were known to fabricate “flexible” or NMCDs for dental practices were identified and were invited to participate in the study. Their participation consisted of emailing photographs of completed metal-frame, acrylic and flexible RPDs and their casts prior to sending them to the practices for delivery to patients. Specimens were collected until a total of 20 metal-frame, 20 acrylic resin and 20 flexible RPDs were received. A design was drawn for each submitted RPD. For each RPD, an “ideal” design was drawn, using the image of the cast. This was done by two observers, who are experienced members of staff in the Department of Restorative Dentistry (Prosthetics), independently. The designs from both observers were later compared for similarity. Where differences existed in the designs, these were resolved by means of discussion until agreement was reached. Each ideal design served as the control for each clinical design.The number of rests, their configuration, the type of support, number of clasps, the presence of indirect retention, cross-arch stabilization, the number of teeth whose periodontal tissues were covered by design components for each design among the different denture type groups, and corresponding control designs were identified and reported. The ratios of teeth replaced/teeth covered per denture type groups and per classification, and corresponding control designs were compared.

Recent years have seen an expansion beyond the more druggable biological targets into novel areas of biological space. However, drug discovery campaigns against these challenging targets have been afflicted with low hit rates during screening campaigns and high levels of candidate attrition during clinical trials. Subsequent studies have looked to explore the underlying factors to these challenges and have identified the lack of scaffold diversity and poor physicochemical properties in screening libraries as the leading causes. In an attempt to address this issue drug discovery strategies such as fragment-based drug discovery and lead-oriented synthesis have been developed which control and direct the compound properties within screening libraries towards relevant areas of chemical space. In addition, strategies such as diversity oriented synthesis aim to synthesise structurally complex and diverse compounds, expanding screening collections into previously under-explored areas of chemical space. This thesis reports the development of a step-efficient, modular and highly adaptable synthetic route for the synthesis of partially saturated bicyclic heteroaromatic scffolds (Figure i). The designed route takes advantage of the large chiral pool provided by amino acids, with each scaffold synthesised in just 4-6 steps from these readily available enantiopure starting materials. The mild conditions allow for excellent functional group tolerance, thus enabling the incorporation of growth vectors for chemical elaboration from the outset, a strong advantage in the drug discovery process. Overall, 29 partially saturated bicyclic heteroaromatic compounds were synthesised based around 7 different scaffolds. These demonstrated a number of possible areas for diversifation both on and around the scaffold, including variation of functional groups (Figure i, red), double (cis-diastereoisomers) and single (R2- and R3-positions) substitution patterns, variation of the 5-membered heterocycle (Figure i, green) and increased size of the saturated ring (Figure i, blue). Furthermore, careful selection of the substituents, heterocycle and size of the saturated ring would enable the synthesis of screening libraries within the constraints of fragment-like, lead-like or drug-like structures. The final library has been incorporated into the Diamond XChem high-throughput crystallography program and initial screening has identified a weakly binding hit for Activin A.

If a partially hyperbolic diffeomorphism on a torus of dimension d greater than 3 has stable and unstable foliations which are quasi-isometric on the universal cover, and its center direction is one-dimensional, then the diffeomorphism is leaf conjugate to a linear toral automorphism. In other words, the hyperbolic structure of the diffeomorphism is exactly that of a linear, and thus simple to understand, example. In particular, every partially hyperbolic diffeomorphism on the 3-torus is leaf conjugate to a linear toral automorphism.

If a partially hyperbolic diffeomorphism on a torus of dimension d greater than 3 has stable and unstable foliations which are quasi-isometric on the universal cover, and its center direction is one-dimensional, then the diffeomorphism is leaf conjugate to a linear toral automorphism. In other words, the hyperbolic structure of the diffeomorphism is exactly that of a linear, and thus simple to understand, example. In particular, every partially hyperbolic diffeomorphism on the 3-torus is leaf conjugate to a linear toral automorphism.

State-of-the-art reacting-flow computations have to compromise either on the detail of chemical reactions or on the dimensionality of the solution, while experiments in flames are limited by the flow accessibility and provide at best a limited number of observables. In the present work, the partially premixed laminar flame structure is examined using a detailed-chemistry, one-dimensional simulation. The computational results are compared to unpublished single-point multiscalar measurements obtained at Sandia National Labs in 2001. The study is focused on axisymmetric laminar partially-premixed methane/air flames with varying premixture strength values of 1.8, 2.2, and 3.17. The combination of computational and experimental results is used to analyze the spatial and scalar flame structure under the overarching concept of flamelets. The computations are based on the Cantera open-source software package developed at CalTech by D. Goodwin, and incorporating the GRI 3.0 chemical kinetic mechanism utilizing 325 chemical reactions and 53 species for methane combustion. Cross-transport effects as well as an optically-thin radiation model are included in the calculations. Radiation changes the flame profiles due to its effect on temperature, and the attendant effects on a number of species. Using the detailed analysis of different reaction rates, the adiabatic and radiative nitric oxide concentrations are compared. The cross-transport effects, i.e. Soret and Dufour, were studied in detail. The Soret term has a small but important effect on the flame structure through a reduction of the hydrogen mass fraction, which changes the conserved scalar values. Based on the flamelet approach and a unique formulation of the conserved scalar, the flame thermochemistry can be analyzed and understood. A number of interesting effects on the flame thermochemistry can be discerned in both experiments and computations when the premixture strength is varied. An increase in premixing results in a counterintuitive decrease in intermediate species such as carbon monoxide and hydrogen, as well as an expected increase in nitric oxide concentrations. Good agreement is found between experiments and calculations in scalar space, while the difference in dimensionality between axisymmetric measurements and opposed jet computations makes comparison in physical space tentative.

Partially clustered design is common in medicine, social sciences, intervention and psychological research. With some participants clustered and others not, the structure of partially clustering data is not parallel. Despite its common occurrence in practice, limited attention has been given regarding the evaluation of intervention effects in partially clustered data. Mediation analysis is used to identify the mechanism underlying the relationship between an independent variable and a dependent variable via a mediator variable. While most of the literature is focused on conventional frequentist mediation models, no research has studied a Bayesian mediation model in the context of a partially clustered design yet. Therefore, the primary objectives of this paper are to address conceptual considerations in estimating the mediation effects in the partially clustered randomized designs, and to examine the performances of the proposed model using both simulated data and real data from the Early Childhood Longitudinal Study, Kindergarten Class of 1998-99 (ECLS-K). A small-scale simulation study was also conducted and the results indicate that under large sample sizes, negligible relative parameter bias was found in the Bayesian estimates of the indirect effects and of covariance between the components of the indirect effect. Coverage rates for the 95% credible interval for these two estimates were found to be close to the nominal level. These results supported use of the proposed Bayesian model for partially clustered mediation in conditions when the sample size is moderately large. / text

According to the work of Dennis Sullivan, there exists a smooth flow on the 5-sphere all of whose orbits are periodic although there is no uniform bound on their periods. The question addressed in this thesis is whether such an example can occur in the partially hyperbolic context. That is, does there exist a partially hyperbolic diffeomorphism of a compact manifold such that all the leaves of its center foliation are compact although there is no uniform bound for their volumes. We will show that the answer to the previous question under the very mild hypothesis of dynamical coherence is no. The thesis is organized as follows. In the first chapter we give the necessary background and results in partially hyperbolic dynamics needed for the rest of the work, studying in particular the geometry of the center foliation. Chapter two is devoted to a general discussion of compact foliations. We give proof or sketches of all the relevant results used. Chapter three is the core of the thesis, where we establish the non existence of Sullivan's type of examples in the partially hyperbolic domain, and generalize to diffeomorphisms whose center foliation has arbitrary dimension. The last chapter is devoted to applications of the results of chapter three, where in particular it is proved that if the center foliation of a dynamically coherent partially hyperbolic diffeomorphism is compact and without holonomy, then it is plaque expansive.

According to the work of Dennis Sullivan, there exists a smooth flow on the 5-sphere all of whose orbits are periodic although there is no uniform bound on their periods. The question addressed in this thesis is whether such an example can occur in the partially hyperbolic context. That is, does there exist a partially hyperbolic diffeomorphism of a compact manifold such that all the leaves of its center foliation are compact although there is no uniform bound for their volumes. We will show that the answer to the previous question under the very mild hypothesis of dynamical coherence is no. The thesis is organized as follows. In the first chapter we give the necessary background and results in partially hyperbolic dynamics needed for the rest of the work, studying in particular the geometry of the center foliation. Chapter two is devoted to a general discussion of compact foliations. We give proof or sketches of all the relevant results used. Chapter three is the core of the thesis, where we establish the non existence of Sullivan's type of examples in the partially hyperbolic domain, and generalize to diffeomorphisms whose center foliation has arbitrary dimension. The last chapter is devoted to applications of the results of chapter three, where in particular it is proved that if the center foliation of a dynamically coherent partially hyperbolic diffeomorphism is compact and without holonomy, then it is plaque expansive.