No description available.

A Senna occidentalis (sinônimo Cassia occidentalis) é uma planta amplamente utilizada pela população para fins medicinais, embora esteja associada a casos de intoxicação humana e animal. Por isso, além de ser considerada um problema de saúde pública, é tida também como uma planta tóxica de interesse pecuário. Sua toxicidade é atribuída à diantrona, uma quinolona, cujo mecanismo de ação tóxico se deve ao desacoplamento da fosforilação oxidativa mitocondrial, promovendo dano mitocondrial especialmente nos órgãos com maior demanda de oxigênio. O objetivo deste trabalho foi estudar, em ratos, os possíveis efeitos tóxicos causados pela exposição à Senna occidentalis durante o período de gestação. Para tanto, 36 fêmeas prenhes foram divididas em 5 grupos, que foram tratados do 6º ao 20º dia de gestação (período de organogênese e de desenvolvimento fetal) com 1%, 2%, 3% e 4% de sementes da planta na ração; o grupo controle recebeu a ração normal do laboratório. A escolha dessas concentrações foi embasada em estudos prévios de toxicidade subaguda em ratos, que mostraram efeito dose-dependente. Durante o período de gestação foram avaliados o peso corpóreo e o consumo de ração e água das fêmeas. Após o nascimento, os filhotes foram analisados quanto ao número de vivos e mortos e para a detecção de possíveis malformações externas. Foi avaliado também o desempenho reprodutivo e o comportamento materno das fêmeas. Com relação à prole, observou-se o seu desenvolvimento físico e de reflexos, bem como atividade geral no campo aberto, comportamento de brincar, labirinto em cruz elevado e labirinto em T. Os resultados do presente estudo mostraram diminuição no ganho de peso das ratas tratadas com 2%, 3% e 4% da planta na ração, além de diminuição no consumo de ração, prejuízo no desempenho reprodutivo e sinais de intoxicação em ratas do grupo de 4%. Ratas tratadas com 2% de S. occidentalis na ração apresentaram prejuízo no comportamento materno. Ainda, houve adiantamento para o aparecimento de pelos e erupção dos dentes incisivos em filhotes do grupo de 1%, bem como adiantamento para o desenvolvimento do reflexo de geotaxia negativa e para a perda do reflexo de preensão palmar em filhotes dos grupos de 3% e 1% respectivamente. Estes resultados indicam que a exposição à S. occidentalis durante a gestação causou toxicidade materna acompanhada de prejuízo no comportamento materno e alteração no desenvolvimento físico e reflexológico da prole destas ratas. / The Senna occidentalis (synonym Cassia occidentalis) is a plant widely used by people for medicinal purposes, although it is associated with cases of human and animal poisoning. So, besides being considered a public health problem, it is also regarded as a toxic plant of livestock interest. Its toxicity is attributed to diantrone, a quinolone, whose mechanism of action is due to the toxic uncoupling of mitochondrial oxidative phosphorylation, promoting mitochondrial damage especially in organs with higher oxygen demand. The objective of this work was to study, in rats, the possible toxic effects caused by exposure to Senna occidentalis during the gestation period. For this purpose, 36 female rats were divided into 5 groups, which were treated from the 6th to the 20th day of gestation (period of organogenesis and fetal development) with 1%, 2%, 3% and 4% of plant seeds in the diet; the control group received normal chow lab. The choice of these concentrations was based on previous studies of subacute toxicity in rats, which showed dose-dependent effect. During the period of gestation were evaluated: body weight, feed intake and water consumption of females. After birth, pups were analyzed for the number of living and dead, and for the detection of possible external malformations. We also evaluated the reproductive performance and maternal behavior of females. With regard to offspring, it was observed their physical and reflexes development, their general activity in the open field, their play behavior and their behavior in elevated plus maze and T maze. The results of this study showed a decrease in body weight of dams treated with 2%, 3% and 4% of the plant in the diet, in addition to reduced feed intake, impaired reproductive performance and signs of poisoning in dams of group 4%. Dams treated with 2% of S. occidentalis in diet showed impaired maternal behavior. Still, there was an advance for the appearance of hair and for the eruption of incisors in pups from 1%, as well as an advance to the development of negative geotaxis reflex and to the loss of palmar grasp reflex in puppies of 3% and 1% groups respectively. These results indicate that exposure to S. occidentalis during pregnancy caused maternal toxicity accompanied by impairment in maternal behavior and change in reflexology and physical development of the offspring of these rats.

A Senna occidentalis (sinônimo Cassia occidentalis) é uma planta amplamente utilizada pela população para fins medicinais, embora esteja associada a casos de intoxicação humana e animal. Por isso, além de ser considerada um problema de saúde pública, é tida também como uma planta tóxica de interesse pecuário. Sua toxicidade é atribuída à diantrona, uma quinolona, cujo mecanismo de ação tóxico se deve ao desacoplamento da fosforilação oxidativa mitocondrial, promovendo dano mitocondrial especialmente nos órgãos com maior demanda de oxigênio. O objetivo deste trabalho foi estudar, em ratos, os possíveis efeitos tóxicos causados pela exposição à Senna occidentalis durante o período de gestação. Para tanto, 36 fêmeas prenhes foram divididas em 5 grupos, que foram tratados do 6º ao 20º dia de gestação (período de organogênese e de desenvolvimento fetal) com 1%, 2%, 3% e 4% de sementes da planta na ração; o grupo controle recebeu a ração normal do laboratório. A escolha dessas concentrações foi embasada em estudos prévios de toxicidade subaguda em ratos, que mostraram efeito dose-dependente. Durante o período de gestação foram avaliados o peso corpóreo e o consumo de ração e água das fêmeas. Após o nascimento, os filhotes foram analisados quanto ao número de vivos e mortos e para a detecção de possíveis malformações externas. Foi avaliado também o desempenho reprodutivo e o comportamento materno das fêmeas. Com relação à prole, observou-se o seu desenvolvimento físico e de reflexos, bem como atividade geral no campo aberto, comportamento de brincar, labirinto em cruz elevado e labirinto em T. Os resultados do presente estudo mostraram diminuição no ganho de peso das ratas tratadas com 2%, 3% e 4% da planta na ração, além de diminuição no consumo de ração, prejuízo no desempenho reprodutivo e sinais de intoxicação em ratas do grupo de 4%. Ratas tratadas com 2% de S. occidentalis na ração apresentaram prejuízo no comportamento materno. Ainda, houve adiantamento para o aparecimento de pelos e erupção dos dentes incisivos em filhotes do grupo de 1%, bem como adiantamento para o desenvolvimento do reflexo de geotaxia negativa e para a perda do reflexo de preensão palmar em filhotes dos grupos de 3% e 1% respectivamente. Estes resultados indicam que a exposição à S. occidentalis durante a gestação causou toxicidade materna acompanhada de prejuízo no comportamento materno e alteração no desenvolvimento físico e reflexológico da prole destas ratas. / The Senna occidentalis (synonym Cassia occidentalis) is a plant widely used by people for medicinal purposes, although it is associated with cases of human and animal poisoning. So, besides being considered a public health problem, it is also regarded as a toxic plant of livestock interest. Its toxicity is attributed to diantrone, a quinolone, whose mechanism of action is due to the toxic uncoupling of mitochondrial oxidative phosphorylation, promoting mitochondrial damage especially in organs with higher oxygen demand. The objective of this work was to study, in rats, the possible toxic effects caused by exposure to Senna occidentalis during the gestation period. For this purpose, 36 female rats were divided into 5 groups, which were treated from the 6th to the 20th day of gestation (period of organogenesis and fetal development) with 1%, 2%, 3% and 4% of plant seeds in the diet; the control group received normal chow lab. The choice of these concentrations was based on previous studies of subacute toxicity in rats, which showed dose-dependent effect. During the period of gestation were evaluated: body weight, feed intake and water consumption of females. After birth, pups were analyzed for the number of living and dead, and for the detection of possible external malformations. We also evaluated the reproductive performance and maternal behavior of females. With regard to offspring, it was observed their physical and reflexes development, their general activity in the open field, their play behavior and their behavior in elevated plus maze and T maze. The results of this study showed a decrease in body weight of dams treated with 2%, 3% and 4% of the plant in the diet, in addition to reduced feed intake, impaired reproductive performance and signs of poisoning in dams of group 4%. Dams treated with 2% of S. occidentalis in diet showed impaired maternal behavior. Still, there was an advance for the appearance of hair and for the eruption of incisors in pups from 1%, as well as an advance to the development of negative geotaxis reflex and to the loss of palmar grasp reflex in puppies of 3% and 1% groups respectively. These results indicate that exposure to S. occidentalis during pregnancy caused maternal toxicity accompanied by impairment in maternal behavior and change in reflexology and physical development of the offspring of these rats.

Perinatal  psykisk  ohälsa  (psykisk  ohälsa  under  graviditet  eller  efter  förlossning)  drabbar kvinnor under en känslig period i livet. Forskning har tidigare fokuserat mer på psykisk ohälsa efter förlossning, men det är nu känt att psykisk ohälsa är vanligt även under graviditeten. För att kunna hjälpa kvinnor med perinatal psykisk ohälsa och stödja dem i föräldrarollen behöver barnmorskor  kunskap  om  hur  kvinnor  upplever  fenomenet.  Syftet  med  denna  studie  var  att belysa  kvinnors  upplevelse  av  perinatal  psykisk  ohälsa.  En  systematisk  litteraturstudie inspirerad av meta-syntes utfördes. Elva kvalitativa studier analyserades. Två huvudkategorier framkom, Att leva med perinatal psykisk ohälsa samt Att ta sig ur perinatal psykisk ohälsa. Varje huvudkategori innehöll i sin tur fyra underkategorier. Kvinnors upplevelser av perinatal psykisk ohälsa innebar att verkligheten inte motsvarade förväntningarna, livet och identiteten förändrades,  de  förlorade  kontrollen  över  känslor  och  tankar  och  tvivlade  på  sig  själva.  De hade svårt att berätta om sina känslor och önskade stöd och information från professionella. Processen  av  tillfrisknande  ledde  tillslut  till  att  kvinnorna  upplevde  ökad  självkännedom. Upplevelsen  av  perinatal  psykisk  ohälsa  genomsyrades  av  känslan  av  att  förlora  kontrollen över  sitt  liv.  Barnmorskor  kan  använda  studiens  resultat  kliniskt,  bland  annat  genom  att uppmuntra kvinnor till reflektion kring perinatal psykisk ohälsa.

Made available in DSpace on 2014-06-11T19:29:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-02-26Bitstream added on 2014-06-13T18:59:47Z : No. of bitstreams: 1 moura_pmss_me_botfm.pdf: 389492 bytes, checksum: 520725d1bf0b29083e7b633d40e6c27e (MD5) / Financiadora de Estudos e Projetos (FINEP) / Avaliar as causas mais freqüentes e fatores de risco associados com óbito perinatal em dois centros de diferentes níveis de atenção. Estudo caso-controle incluindo 299 casos de óbitos perinatais e 1161 recém-nascidos que sobreviveram ao período neonatal precoce (controles) entre 2001 e 2006 em dois hospitais de diferentes níveis de atenção (secundária e terciária) localizados em Botucatu/SP. Fatores maternos, gestacionais e neonatais associados com óbitos perinatais foram investigados. As causas básicas dos óbitos perinatais foram estratificadas dentro de 5 grupos de acordo com a classificação de Wigglesworth modificada. Correlações entre variáveis do estudo e óbito perinatal foram avaliadas pela análise univariada. Odds ratio foi calculado com intervalo de confiança a 95%. Análise de regressão logística múltipla foi realizada para obtenção de estimativas independentes para o risco de óbito perinatal. No centro de atenção terciária, fatores de risco independentes para óbito perinatal incluíram idade gestacional, primiparidade, gênero masculino e doença materna (hipertensão arterial, infecção intra-uterina). No centro de atenção secundária, nenhum fator de risco independente foi identificado ainda que Apgar de quinto minuto < 7, baixo peso ao nascer e hemorragia materna foram associados com óbito perinatal. As causas mais freqüentes de óbito perinatal no centro secundário foram asfixia e morte anteparto, enquanto no terciário prevaleceu malformação seguida por imaturidade e morte anteparto. Nossos resultados mostram que ambas, atenção obstétrica e neonatal, estão integradas num sistema hierarquizado, mas destacam a importância de melhorar a assistência pré-natal, ao parto e nascimento. / To assess the most frequent causes and risk factors associated with perinatal death in two centers at different care levels. Case-control study including 299 perinatal death cases and 1161 infants who survived the early neonatal period (controls) between 2001 and 2006 in two hospitals at different levels of care (secondary and tertiary) located in Botucatu/SP. Maternal, gestational and neonatal factors associated with perinatal death were investigated. The basic causes of perinatal death were stratified into 5 groups according to the modified Wigglesworth’s classification system. Correlations between study variables and perinatal death were evaluated by univariate analysis. Odds ratio was calculated with a 95% confidence interval. Multiple logistic regression analysis was performed to estimate independent perinatal death risk. Results: In the tertiary care center, independent perinatal death risk factors included gestational age, primiparity, male gender and maternal disease (arterial hypertension, intrauterine infection). In the secondary care center, no independent risk factors were identified although five-minute Apgar score <7, low birthweight and maternal hemorrhage were associated with perinatal death. The most frequent causes of perinatal death in the secondary center were asphyxia and antepartum death while in the tertiary center they included malformation, imaturity and antepartum death. Our results show that both obstetric and neonatal care were integrated into a hierarchized system but highlight the importance of improving prenatal, delivery and birth care.

Introduction: The perinatal period, which consists of pregnancy and up to one year postpartum, is considered a period of vulnerability. During this time, women are at higher risk than at other times in their lives of developing a mental health disorder, particularly anxiety and depressive disorders. Perinatal mental health disorders have a tremendous negative impact on not only the mother, but also their children who may develop cognitive, behavioural, and emotional problems that last well into adulthood. Emotion dysregulation has been implicated in both anxiety and depressive disorders and, due to endocrine changes during the perinatal period, may play an important role in perinatal mental health. Perinatal emotion dysregulation has yet to be explored. The purpose of this thesis was to 1) better understand the link between emotion dysregulation and perinatal mental health, 2) assess whether current perinatal treatments effectively target emotion dysregulation, and 3) develop an effective psychological treatment protocol for perinatal emotion dysregulation. Methods: We designed and conducted three studies to meet our research aims. The first study compared emotion reactivity and emotion regulation, two aspects of emotion dysregulation, in perinatal women with an anxiety and/or depressive disorder to better understand perinatal emotion dysregulation. The second study examined the bidirectional relationship between Cognitive Behavioural Therapy (CBT) for perinatal anxiety and emotion dysregulation to examine whether emotion dysregulation moderates CBT treatment outcomes and whether CBT is an effective treatment modality for perinatal emotion dysregulation. This was examined in two samples of participants: participants from a randomized controlled trial and routine clinical care. In the third study, we developed a novel Dialectical Behavioural Therapy (DBT) informed treatment program for perinatal emotion dysregulation and examined the effectiveness of the program through a pilot study. Results: Our research revealed several important findings. First, heightened emotional reactivity may be a protective factor during the perinatal period; less flexibility in emotional reactivity and difficulties with emotion regulation were associated with worse perinatal mental health, and relationship dissatisfaction. Second, CBT was an effective treatment for low levels of emotion dysregulation but not for moderate or severe perinatal emotion dysregulation. Only 16% of routine clinical care participants and 28% of participants from the randomized controlled trial demonstrated clinically reliable change in emotion dysregulation. Emotion dysregulation did not moderate CBT treatment outcomes on anxiety or depression. This suggest that emotion dysregulation appears to be a distinct factor that may warrant more specialized treatment. Third, our short term, DBT informed, skills group was effective in significantly reducing perinatal emotion dysregulation. The DBT informed treatment may be more effective in targeting perinatal emotion dysregulation than CBT as illustrated by 48% of participants demonstrating clinically reliable change compared to the 16%-28% in the CBT treatment. Conclusions: This line of research allows us to have a better understanding of perinatal emotion dysregulation and may aid in the development of best practice assessment and treatment guidelines for emotion dysregulation during the perinatal period. Limitations and future directions are discussed. / Dissertation / Doctor of Philosophy (PhD)

No description available.

The total number of births among immigrants is on the rise and currently exceeds one fifth of live births within industrialized countries. The relation between adverse birth outcomes and migration remains unclear. The objectives of this thesis are to undertake a literature review to clarify the relation between migration and adverse birth outcomes, and to examine the interplay between duration of residence, maternal country of origin, and the residential environment using data on immigrants to Ontario Census Metropolitan Areas. The findings indicate that: a) Analyzing disparities in birth outcomes by migrant status with migrants defined as a single category is not informative. Rather, ethnicity and country of origin are important predictors of birth outcomes among immigrants. b) Duration of residence is linearly associated with low infant birth weight and preterm birth, mainly driven by decreases in gestational age with prolonged stay in Canada. c) The detrimental effects of long duration of residence on preterm birth are modestly attenuated, but not prevented, among immigrants living in urban neighbourhoods characterized by low material deprivation. d) Neighbourhood material deprivation has little, if any, influence on birth outcomes of recent immigrants, and only becomes influential after 15 years of stay in Canada. Maternal world region of origin constitutes a stronger predictor of adverse birth outcomes among recent immigrants. These findings stress the importance of the maternal country of birth and duration of residence as key predictors of immigrants’ health. They also support further research aimed at clarifying the nature of the association between time spent in Canada after migration and decreases in gestational age at delivery, and the identification of immigrant groups at high risk of adverse birth outcomes, based on these two key predictors.

Made available in DSpace on 2019-03-29T23:50:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-05-28 / Syphilis is an ancient disease that has prevailed over all attempts to eradication. Despite the effectiveness of penicillin in the treatment and cure of this disease, the affected pregnant women are not treated or are inadequately treated. When it occurs during pregnancy, syphilis is responsible for approximately 40% of perinatal mortality rates, 25% of stillbirths and 14% of neonatal deaths. In Brazil, between 1998 and June 2012, were reported 80,041 cases of congenital syphilis in infants under one year of age. Regarding the incidence of congenital syphilis in Brazil, in 2011 there was a rate of 3.3 cases per 1,000 live births, while the Northeast Region had the highest rates in that year, with 3.8 cases. In 2012, the State of Ceará notified 965 cases of congenital syphilis with an incidence rate of 7.6 / 1,000 live births. In 2013 for the city of Fortaleza, the incidence of congenital syphilis cases reached 15.0 per 1,000 live births. This study aimed to analyze reports of pregnant women with their cases of congenital syphilis in the years 2008-2010; evaluate the database of the Information System for Notifiable Diseases (Sinan) and the Mortality Information System (SIM) in Fortaleza, Ceará, fetal and infant deaths due to congenital syphilis. Cross-sectional study conducted analysis of 175 cases of syphilis in pregnant women with corresponding notifications of congenital syphilis during the years 2008 to 2010 and analysis of databases of Sinan and SIM. In Sinan we analyzed reported cases of congenital syphilis and in SIM infant and fetal syphilis deaths from 2007 to 2013 were analyzed. Was used descriptive statistics with absolute and relative frequencies, measures of central tendency and dispersion, and chisquare test to analyze the statistical significance using the p value <0.05.Sociodemographic variables of pregnant / postpartum women, the care provided to infants and outcome of cases were analyzed. The results showed that the incidence of syphilis in young women over 85.0% of inappropriate treatment , 62.9 % of sexual partners untreated or ignored information and high percentages of non- achievement of the recommended tests for the investigation of congenital syphilis. It was observed that over the years there was a remarkable absence of registration of the disease as a cause of fetal and infant death, reaching 90.1% of underreported cases. Of the 41 deaths reported in the SIM as syphilis, 16 (39.0%) were not in Sinan. The year 2012 had the highest number of notifications, 591 cases and an incidence of 15.92 / 1,000 live births. Congenital syphilis was responsible for 268 abortions and 373 perinatal deaths during the study period with a perinatal mortality rate of 1.66 / 1,000 live births and stillbirths rate of 1.34 / 1,000 live births. Maternal age, conducting prenatal and maternal moment of diagnosis, persistent high titers in them, the inadequate treatment of these and their sexual partners, the prevalence titers greater than 1: 8 in peripheral blood of the newborn and these symptoms present themselves were associated with morbidity and mortality of fetuses and has contributed to the uncontrolled situation. Thus, vertical transmission of syphilis has been causing high mortality among fetuses, keeping this infection as a burden on the list of public health problems. / A sífilis é uma doença milenar que vem prevalecendo sobre todas as tentativas de sua erradicação. Apesar da eficácia da penicilina no tratamento e cura desta doença, as gestantes acometidas não são tratadas ou são inadequadamente tratadas. Quando ocorre durante a gravidez, a sífilis é responsável por aproximadamente 40% das taxas de mortalidade perinatal, 25% de natimortalidade e 14% de mortes neonatais. No Brasil, entre 1998 e junho de 2012, foram notificados 80.041 casos de sífilis congênita em menores de um ano de idade. Com relação à taxa de incidência de sífilis congênita no Brasil, em 2011 observou-se uma taxa de 3,3 casos por 1.000 nascidos vivos, sendo que a Região Nordeste apresentou das maiores taxas nesse ano, com 3,8 casos. No ano de 2012, o Estado do Ceará notificou 965 casos de sífilis congênita com uma taxa de incidência de 7,6/1.000 nascidos vivos. Para o ano de 2013 no município de Fortaleza, a incidência de sífilis congênita atingiu 15,0 casos por 1.000 nascidos vivos. Este estudo objetivou analisar as notificações de gestantes com os respectivos casos de sífilis congênita nos anos de 2008 a 2010; avaliar no banco de dados do Sistema de Informação de Agravos de Notificação (Sinan) e do Sistema de Informação Sobre Mortalidade (SIM) do município de Fortaleza, Ceará, os óbitos fetais e infantis por sífilis congênita. Estudo transversal que realizou análise de 175 casos notificados de sífilis em gestantes com as correspondentes notificações de sífilis congênita durante os anos de 2008 a 2010 e análise dos bancos de dados do Sinan e do SIM. No Sinan foram analisados os casos notificados de sífilis congênita e no SIM os óbitos infantis e fetais pela doença de 2007 a 2013. Utilizou-se estatística descritiva com frequências absolutas e relativas, medidas de tendência central e dispersão e qui-quadrado de Pearson para analisar a significância estatística, utilizando o valor de p<0,05. Foram analisadas variáveis sociodemográficas das gestantes/puérperas, da assistência prestada aos recém-nascidos e desfecho dos casos. Os resultados mostraram a ocorrência da sífilis em mulheres jovens com mais de 85,0% de tratamentos inadequados, 62,9% dos parceiros sexuais não tratados ou com informação ignorada e percentuais elevados da não realização dos exames preconizados para a investigação de sífilis congênita. Observou-se que ao longo dos anos ocorreu importante ausência de registro da doença enquanto causa de óbito fetal e infantil, chegando a atingir 90,1%de casos sub-registrados. Dos 41 óbitos declarados no SIM como sífilis, 16 (39,0%) não estavam notificados no Sinan.O ano de 2012 apresentou o maior número de notificações, 591 casos e uma incidência de 15,92/1.000 nascidos vivos.A sífilis congênita foi responsável por 268 abortos e 373 óbitos perinatais no período do estudo com uma taxa de mortalidade perinatal de 1,66/1.000 nascidos vivos e taxa de natimortalidade de 1,34/1.000 nascidos vivos. A idade materna, a realização de pré-natal e momento do diagnóstico materno, persistência de altos títulos sorológicos nas mesmas, o tratamento inadequado destas e de seus parceiros sexuais, a prevalência títulos superiores a 1:8 em sangue periférico do recém-nascido e estes se apresentarem sintomáticos estiveram associados à morbimortalidade dos conceptos e vem contribuindo para o descontrole da situação. Assim, a transmissão vertical da sífilis vem acarretando elevada mortalidade entre os conceptos, mantendo essa infecção como um fardo no rol dos problemas de saúde pública.

Aim. The aim of the present research was to investigate the relationship of personality guilt- and shame-proneness to grief and psychological dysphoria following bereavement due to stillbirth or death in the newborn period. Methods. Participating parents completed self-report questionnaire measures of proneness to situational guilt and shame (Test of Self-Conscious Affect-2), chronic guilt and shame (Personal Feelings Questionnaire-2) and interpersonal guilt (Interpersonal Guilt Questionnaire-67), grief (Perinatal Grief Scale-33) and psychological dysphoria (General Health Questionnaire-28) one month (�early�, N = 158) and 13 months (�late�, N = 149) after a perinatal death. Results. Women compared with men self-reported more intense grief, anxiety and depression one month after the death, but there were no significant sex differences in grief or psychological dysphoria one year later. Hierarchical multiple regression analyses showed that composite shame (situational and chronic) explained a small but statistically significant proportion of the variance in early total grief (adjusted R 2 = .09) and anxiety (adjusted R 2 = .07) in women, and early total grief (adjusted R 2 = .19), anxiety (adjusted R 2 = .13) and depression (adjusted R 2 = .10) in men. Composite guilt (situational, chronic and interpersonal) controlled for shame did not make a significant further contribution to the variance in early total grief, anxiety or depression in either sex. Composite shame explained not only significant but meaningful proportions of the variance in late grief (adjusted R2=.27), anxiety (adjusted R2=.21) and depression (adjusted R2=.27) in women, and late grief (adjusted R2= .56),anxiety (adjusted R 2= .30) and depression (adjusted R2= .51) in men. Composite guilt controlled for shame made significant further contributions to the variancein late grief (∆R 2 = .21), anxiety (∆R 2 = .16) and depression (∆R 2 = .25) in women, and late grief (∆R 2 = .11) in men. Shame and guilt together explained a substantial proportion of the variance in late grief (adjusted R2= .45), anxiety (adjusted R2= .33) and depression (adjusted R2= .49) in women, and late grief (adjusted R2= .64), anxiety (adjusted R2= .35) and depression (adjusted R2= .56) in men. Situational shame, chronic guilt and survivor guilt made positive unique contributions to the variance in late grief in women. Chronic shame and survivor guilt made unique contributions to the variance in late grief in men. Situational guilt made a significant unique negatively valenced contribution to the variance in late grief in women. Early composite shame, but not guilt, predicted late grief, anxiety and depression in men. Early composite shame and/or guilt did not predict late grief, anxiety or depression in women. Conclusion. Personality proneness to shame was more relevant to late grief, anxiety and depression in men than in women, but survivor guilt was equally important to late grief in both sexes. Chronic guilt and functional situational guilt were pertinent to late grief, anxiety and depression in women, but not in men. Personality shame- and guilt-proneness have important relationships with parental grief after perinatal death that have not hitherto been recognised.