The effect of papaverine on the albumin permeability-surface area product (PS), reflection coefficient (σ), and capillary filtration coefficient (K(f)) was examined in isolated rabbit lungs. Because PS and K(f) are functions of vascular surface area and permeability, we also compared papaverine with two other means of maximizing lung surface area: isoproterenol (1 x 10-7 M) and a mild increase in vascular pressure. Only lungs perfused with 0.1 mg/ml papaverine were significantly different from control. PS increased from control (2.80 ± 0.16 to 5.53 ± 0.20 ml · min-1 · g dry lung-1 x 10-2), whereas σ decreased from control (0.92 ± 0.01 to 0.78 ± 0.03). K(f) after papaverine was significantly lower than baseline predrug K(f) (5.60 ± 0.78 to 4.56 ± 0.53 ml · s-1 · cmH2O-1 · g dry lung-1 x 10-3). However, this group's predrug K(f) was higher than that of any other group. Our results indicate that papaverine increases albumin permeability and decreases endothelial selectivity. The isolated perfused lung appears fully recruited, because K(f) and PS did not increase with isoproterenol or increased vascular pressure. Papaverine should be used with caution in the Ringer-perfused lung.

Composite flow simulation tools for LCM processing can be expensive and time-consuming but necessary to design a mold system with proper placement of resin inlets and vacuum outlets. Composites manufacturing engineers would benefit from data regarding the impact of mold curvature radius on resin flow. This could help determine whether or not a particular part and mold would require expensive simulation software designed to handle complex flow paths through curved fabric architectures exhibiting variable permeability over the curvature, or if simple flow modeling would provide accurate enough simulations for sound tooling setup decision making. Four molds, with double curvature having equal radii, were fabricated with radii ranging from 3.2 to 25.4 mm to characterize the permeability of two different fiber reinforcements 1) a carbon biaxial NCF and 2) a fiberglass CSM over the mold curvatures. Three infusions of each material type were conducted on each of the 4 molds for a total of 24 test infusions. Flow front position vs. time data was captured during each experimental infusion. The permeability in the bend regions, KB, was first estimated by the integrated form of Darcy's Law to evaluate the permeability for average flow across the entire bend region. This was done for both the convex and concave regions using a geometric estimate for the increased compaction in the bend regions. The permeability increases as the tool radius increases, and the rate of increase diminishes as the tool radius increases and the permeability approaches the flat region permeability. An estimate of KB for VI was then made by applying a ratio calculated from the resulting permeability from the rigid- and VI-based models in the flat regions. Generic power law fits are reported that could be used in LCM process simulation, to give a model to estimate the permeability for any bend in the reinforcement part geometry. The results suggest that any curve with a radius higher than 25 mm requires no adjustment to the flat permeability.

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Serpentinization is a complex set of hydration reactions, where olivine and pyroxene are replaced by serpentine, magnetite, brucite, talc and carbonate minerals. Serpentinization reactions alter chemical, mechanical, magnetic, seismic, and hydraulic properties of the crust. To understand the complicated nature of serpentinization and the linkages between physical and chemical changes during the reactions, I performed flow-through laboratory experiments on cylindrically cored samples of ultramafic rocks. Each core had a well-mated through-going tensile fracture, to investigate evolution of fracture permeability during serpentinization. The samples were tested in a triaxial loading machine at an effective pressure of 30 MPa, and temperature of 260°C, simulating a depth of 2 km under hydrostatic conditions. Fracture permeability decreased by one to two orders of magnitude during the 200 to 340 hour experiments. Electron microprobe and SEM data indicated the formation of needle-shaped crystals of serpentine composition along the walls of the fracture, and chemical analyses of sampled pore fluids were consistent with dissolution of ferro-magnesian minerals. The rate of transformation of olivine to serpentine in a tensile fracture is calculated using the data on evolution of fracture permeability assuming the fracture permeability could be represented by parallel plates. Assuming the dissolution and precipitation reactions occur simultaneously; the rate of transformation at the beginning of the experiments was ~ 10-8-10-9 (mol/m2s) and decreased monotonically by about an order of magnitude towards the end of the experiment. Results show that dissolution and precipitation is the main mechanism contributing to the reduction in fracture aperture. The experimental results suggest that the fracture network in long-lived hydrothermal circulation systems may be sealed rapidly as a result of mineral precipitation, and generation of new permeability resulting from a combination of tectonic and crystallization-induced stresses may be required to maintain fluid circulation. Another set of flow through experiments were performed on intact samples of ultramafic rocks at room temperature and effective pressures of 10, 20 and 30 MPa to estimate the pressure dependency of intact permeability. Porosity and density measurements were also performed with the purpose of characterizing these properties of ultramafic rocks. The pressure dependency of the coefficient of matrix permeability of the ultramafic rock samples fell in the range of 0.05-0.14 MPa-1. Using porosity and permeability measurements, the ratio of interconnected porosity to total porosity was estimated to be small and the permeability of the samples was dominantly controlled by microcracks. Using the density and porosity measurements, the degree of alteration of samples was estimated. Samples with high density and pressure dependent permeability had a smaller degree of alteration than those with lower density and pressure dependency. / Ph. D.

Call number: LD2668 .T4 1984 S22 / Master of Science

The objective of this study is to provide an experimental performance assessment of cement borehole plugs subjected to dynamic loadings. This includes the study of dried-out plugs as well as of plugs that have remained wet throughout the testing period. Literature review indicates lack of quantitative data on plug performance under dynamic loading. Nevertheless, it shows that deep underground structures in competent rocks are safer than surface structures, openings at shallow depth, and openings in fractured rocks, when subjected to earthquakes and subsurface blasts. Flow test results indicate that wet cement seals are less permeable than Charcoal granite. Sealing performance is severely degraded when cement seals are allowed to dry. Dye injection tests show that the flow penetrates uniformly through the wet plugs, but occurs only along the plug/rock interface of the dried-out plugs. The permeability of wet and dried-out cement seals does not change significantly after the application of dynamic loads.

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