Les rhabdomyosarcomes embryonnaires et aléolaires (RMS) appartiennent aux tumeurs des tissus mous les plus fréquentes chez les enfants dont elles représentent 2/3 des cas. Plusieurs données suggèrent que la dérégulation des cellules progénitrices du muscle squelettique pourrait jouer un rôle dans l'émergence des cellules de RMS qui ont aussi bien perdu le contrôle de la régulation de la prolifération cellulaire que la capacité à se différencier.Néanmoins les mécanismes de développement des RMS restent à caractériser. La famille des IMPs et notamment IMP-2, protéines liant les ARN, sont à la fois fortement exprimées dans le muscle en régénération in vivo mais aussi dans les cellules de RMS.Au cours de ma thèse, j'ai pu mettre en évidence le rôle d'IMP-2 dans la motilité des cellules de RMS et dans les cellules musculaires ainsi que dans le contrôle de l'intégrité du cytosquelette de microtubules (MTs) et dans le remodelage des adhésions focales. En effet, IMP-2 est impliqué à la fois dans la régulation de l'expression de MuRF-3, une protéine lié àla stabilisation des MTs et de Pinch-2, un important médiateur de l'adhésion cellulaire.

Pseudomyxoma peritonei (PMP) is a rare disease characterized by mucinous peritoneal metastasis (PM). Different loco-regional treatment strategies, i.e. debulking surgery and cytoreductive surgery (CRS) in combination with hyperthermic intraperitoneal chemotherapy (HIPEC), have changed the prognosis for these patients. CRS is an aggressive surgical procedure with a long learning curve. PMP exists in different types; how many depends on which classification is used. The aims of this thesis were to investigate the time-frame of PMP development from an isolated appendiceal neoplasm, examine the learning process for CRS, evaluate the differences in treatment outcome between debulking surgery and CRS in combination with HIPEC, to evaluate a more detailed PMP classification and to investigate particularly interesting new cysteine-histidine (PINCH) protein as a prognostic factor for PMP. Retrospectively 26 PMP patients were identified as having had an appendectomy with a neoplasm in the appendix but with no evidence of PM at the appendectomy. They were treated for PMP within a median of 13.1 months (3.8-95.3) after the appendectomy. No difference was seen between the types of PMP regarding the time to a clinically significant development of PMP and how much tumour was found at treatment. CRS is a highly invasive treatment and stabilization in the learning curve was seen after 220±10 procedures. Patients treated with CRS+HIPEC had a better 5-year overall survival (OS) than patients treated with debulking surgery, 74% vs. 40%. CRS increased the rate of complete cytoreduction from 25% in patients treated with debulking surgery to 72%. The new four-grade PMP classification showed very good inter-rater agreement between two independent pathologists and a difference in survival rates was observed between the different grades. A positive PINCH staining was recorded in 83% of the tumours and that was associated with poorer survival.

The presence of a large pinch velocity in the edge pedestal of high confinement (H-mode) tokamak plasmas implies that particle transport in the plasma edge must be treated by a pinch-diffusion theory, rather than a pure diffusion theory. Momentum balance also requires the inclusion of a pinch term in descriptions of edge particle transport. A numerical investigation of solving generalized pinch-diffusion theory using methods extended from the numerical solution methodology of pure diffusion theory has been carried out. The generalized diffusion equation has been numerically integrated using the central finite-difference approximation for the diffusion term and three finite difference approximations of the pinch term, and then solved using Gauss reduction. The pinch-diffusion relation for the radial particle flux was solved directly and used as a benchmark for the finite-difference algorithm solutions to the generalized diffusion equation. Both equations are solved using several mesh spacings, and it is found that a finer mesh spacing will be required in the edge pedestal, where the inward pinch velocity is large in H-mode plasmas, than is necessary for similar accuracy further inward where the pinch velocity diminishes. An expression for the numerical error of various finite-differencing algorithms is presented.

No description available.

<p>A wide range of unstable current driven MHD modes is present in the re- versed τeld pinch (RFP) conτguration. An ideally conducting wall facing the plasma can stabilize the ideal MHD modes. In the presence of a resistive wall characterized by the wall time τw, fast mode rotation with the frequency exceeding the inverse wall time gives stabilization for resistive MHD modes. The ideal MHD modes in the RFP are non-rotating modes and can not be stabilized by the resistive wall. Instead they are converted into resistive wall modes (RWM) growing with a growth rate proportional to the inverse of the wall time τw. EXTRAP T2R is an RFP device equipped with a thin resistive wall having the wall time shorter than the plasma pulse duration τw < τp. This feature allows the study of non-resonant non-rotating resistive wall modes. Resistive wall modes dynamics has been studied in EXTRAP T2R . RWM growth rates has been measured and compared with linear MHD stability calculations. Quantitative agreement is observed. In the case τw < τp the RWM can cause discharge degradation and should be stabilized. Active feedback is the way to stabilize the RWM in the RFP. An intelligent shell scheme is one possible feedback scenario. An active feed- back system including a set of sensors and discrete active coils is installed in EXTRAP T2R. The intelligent shell tries to keep the magnetic flux zero at the positions of the sensor. The analog PID controller for the intelligent shell feedback scheme has been studied. A model of the active control system was developed and comparison with the experimental results showed good agree- ment. Encouraging experimental results on the active feedback stabilization of multiple RWMs in the RFP plasmas were obtained.</p>

<p>The determination of the plasma confinement propertiesdemand data as the electron temperature, the ionic and electrondensity profiles and the radiative emissivity profiles. Thefocus of this thesis is the importance of radial profiles inspectroscopic diagnostics applied to the EXTRAP-T2Rreversed-field pinch.</p><p>EXTRAP-T2R is a resistive shell reversed-field pinch with amagnetic field shell penetration time much longer than therelaxation cycle time scale. Significant improvements inconfinement properties derived by quantitative plasmaspectroscopy in the vacuum ultraviolet are observed compared tothe previous device EXTRAP-T2. The low level of magneticturbulence and the good magnetic surfaces in the edge regionexplain this observed improvement. A current profile controlexperiment reduces the stochastic transport, which is connectedto the dynamo, and improves the confinement in EXTRAP-T2R evenmore.</p><p>A comparison of the electron temperature estimated by usinga ratio of line intensities from the same ionization stage ofoxygen and the Thomson scattering system shows that thedifference is explained by the different spatial dependence ofthe excited state populations and the corresponding emissivityof these spectral lines. A collisional radiative model givesestimates for radial profiles of impurities which are notmeasured in EXTRAP-T2R. The estimated profiles can in turn beused to determine the radial profile of the effective ioncharge, the emissivity and finally the radiative power. Asinput, the model uses radial profiles.</p><p>Neutral hydrogen is predominantly present in the boundaryregion of the plasma. Spectroscopic investigations in this areashow very asymmetric spectral lines of hydrogen due to themovement of atoms. The velocity of the hydrogen atoms dependson the type of plasma-wall interaction and their measurementhelps to identify the different interaction processes. Theexistence of hydrogen molecules in the edge complicates theinterpretation of the line shapes and on the determination ofthe particle confinement time.</p><p><b>Keywords:</b>Reversed-field pinch, EXTRAP-T2R, quantitativeplasma spectroscopy, VUV spectroscopy, line-integrated electrontemperature, oxygen, profiles, confinement properties, powerbalance, hydrogen, particle confinement time.</p>

<p>The Reversed-Field Pinch (RFP) is one of the major alternatives for realizing energy production from thermonuclear fusion. Compared to alternative configurations (such as the tokamak and the stellarator) it has some advantages that suggest that an RFP reactor may be more economic. However, the conventional RFP is flawed with anomalously large energy and particle transport (which leads to unacceptably low energy confinement) due to a phenomenon called the "RFP dynam".</p><p>The dynamo is driven by the gradient in the plasma current in the plasma core, and it has been shown that flattening of the plasma current profile quenches the dynamo and increases confinement. Various forms of current profile control schemes have been developed and tested in both numerical simulations and experiments.</p><p>In this thesis an automatic current profile control routine has been developed for the three-dimensional, non-linear resistive magnetohydrodynamic computer code DEBSP. The routine utilizes active feedback of the dynamo associated fluctuating electric field, and is optimized for replacing it with an externally supplied field while maintaining field reversal. By introducing a semi-automatic feedback scheme, the number of free parameters is reduced, making a parameter scan feasible. A scaling study was performed and scaling laws for the confinement of the advanced RFP (an RFP with enhanced confinement due to current profile control) have been obtained.</p><p>The conclusions from this research project are that energy confinement is enhanced substantially in the advanced RFP and that poloidal beta values are possible beyond the previous theoretical limit beta β_Θ < ½. Scalings toward the reactor regime indicate strongly enhanced confinement as compared to conventional RFP scenarios, but the question of reactor viability remains open.</p>

The primary purpose of this study was to observe the relationship between muscle activation of the right hand with the force produced at the fingertips in an isometric precision pinch tracking task. Thirty right-handed subjects, 15 males and 15 females, with a mean age 23.5 (SD 3.5) years, free from any neurological disorder or physical ailment, had a pair of electromyography (EMG) electrodes placed over the first dorsal interosseous (FDI) muscle, which acts on the index finger, while performing a pinch force tracking task scaled to 20% maximum voluntary contraction (MVC). The tracking task was chosen because it created a continuously increasing force application to 20% MVC and then decreasing force release from 20% MVC at a prescribed rate in both cases of 6.66% MVC force per second. In addition to showing increases in EMG activation of the FDI with increases in force, the results revealed that muscle activation for a given force level was generally greater for force application than for force release. This may be due dynamics of muscle contraction or to patterns of multiple muscle coordination. / text

The reversed-field pinch (RFP) is a device for magnetic confinement of fusion plasmas. The main objective of fusion plasma research is to realise cost-effective thermonuclear fusion power plants. The RFP is highly unstable as can be explained by the theory of magnetohydrodynamics (MHD). Feed-back control technology appears to enable a robustly stable RFP operation.  Experimental control and identification of nonaxisymmetric multimode MHD is pursued in this thesis. It is shown that nonparametric multivariate identification methods can be utilised to estimate MHD spectral characteristics from plant-friendly closed-loop operational input-output data. It is also shown that accurate tracking of the radial magnetic field boundary condition is experimentally possible in the RFP. These results appear generically useful as tools in both control and physics research in magnetic confinement fusion. / <p>QC 20120508</p>

Thesis (M.Eng. (Chemical Engineering)) -- Universiteit van Pretoria, 2007. / Includes bibliographical references.