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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
21

Humans Aren't Boxes, Art Isn't Finite

Humphreys, Brianne Alta 01 January 2019 (has links)
I am bored. All around me are systems that perpetuate repetitive, reductive, and mundane modes of living. In an attempt to counter a culture obsessed with singular ways of existence and bite-sized perfection, I utilize moving mediums of video and performance to dive head first into a vast array of sloppy sincerity. The crisp, white-washed, analytical, and restrictive is loudly replaced with the empirical, haphazard, and instinctual. My intention is to create and encourage raw, performative-based work that is as multifaceted as unbridled life itself. This alive and physical practice hosts a conglomeration of sweat, memories, heartbreaks, hymn singing, line dancing, cake eating, wig wearing, bedroom jamming, live streaming, code switching, hallway running, body dragging, easter egg hiding, angst, and hair salons. This is a refusal to slice up, organize, and distill myself and my work into one dish with convoluted, explanatory rhetoric stamped with institutionalized approval and topped with the cherry of MFA status for the sake of being justified and relevant. I have zero obligations to make polished art, resolve things, or pinpoint what makes me “me”, because humans are not boxes and art does not have to be finite.
22

A heterogenous three-dimensional computational model for wood drying

Truscott, Simon January 2004 (has links)
The objective of this PhD research program is to develop an accurate and efficient heterogeneous three-dimensional computational model for simulating the drying of wood at temperatures below the boiling point of water. The complex macroscopic drying equations comprise a coupled and highly nonlinear system of physical laws for liquid and energy conservation. Due to the heterogeneous nature of wood, the physical model parameters strongly depend upon the local pore structure, wood density variation within growth rings and variations in primary and secondary system variables. In order to provide a realistic representation of this behaviour, a set of previously determined parameters derived using sophisticated image analysis methods and homogenisation techniques is embedded within the model. From the literature it is noted that current three-dimensional computational models for wood drying do not take into consideration the heterogeneities of the medium. A significant advance made by the research conducted in this thesis is the development of a three - dimensional computational model that takes into account the heterogeneous board material properties which vary within the transverse plane with respect to the pith position that defines the radial and tangential directions. The development of an accurate and efficient computational model requires the consideration of a number of significant numerical issues, including the virtual board description, an effective mesh design based on triangular prismatic elements, the control volume finite element discretisation process for the cou- pled conservation laws, the derivation of an accurate dux expression based on gradient approximations together with flux limiting, and finally the solution of a large, coupled, nonlinear system using an inexact Newton method with a suitably preconditioned iterative linear solver for computing the Newton correction. This thesis addresses all of these issues for the case of low temperature drying of softwood. Specific case studies are presented that highlight the efficiency of the proposed numerical techniques and illustrate the complex heat and mass transport processes that evolve throughout drying.
23

Analise estrutural de silos metálicos prismáticos. / Structural analysis of prismaíic metallic silos.

LOPES NETO, José Pinheiro. 01 July 2018 (has links)
Submitted by Johnny Rodrigues (johnnyrodrigues@ufcg.edu.br) on 2018-07-01T14:05:21Z No. of bitstreams: 1 JOSÉ PINHEIRO LOPES NETO - DISSERTAÇÃO PPGEA 2005..pdf: 7816750 bytes, checksum: fac8dab7b69899332c5c31968b0fff94 (MD5) / Made available in DSpace on 2018-07-01T14:05:21Z (GMT). No. of bitstreams: 1 JOSÉ PINHEIRO LOPES NETO - DISSERTAÇÃO PPGEA 2005..pdf: 7816750 bytes, checksum: fac8dab7b69899332c5c31968b0fff94 (MD5) Previous issue date: 2005-10 / Capes / Nos últimos anos, o crescimento da agricultura brasileira tem forçado vários setores a se adequarem aos padrões produtivos com o intuito de se manterem competitivos frente ao processo de globalização económica. Neste contexto, as fábricas de produtos agroindustriais, em especial as de ração avícola, tendem a buscar novas alternativas que favoreçam a produção e reduzam custos sem afetar a qualidade do produto final. Entre estas alternativas, destaca-se o uso de silos verticais por facilitar o processo de confecção das rações e eliminar os grandes depósitos horizontais. Entretanto, a simples adoção de silos verticais sem um conhecimento prévio de algumas características como forma e dimensões mais apropriadas para cada situação pode não obter o resultado desejado além do fato de gerar problemas no fluxo dos produtos pelo dimensionamento inadequado das células armazenadoras. Diante desta insegurança, a presente pesquisa teve como objetivo estudar as tensões desenvolvidas nas paredes em conformação ziguezague de um silo metálico prismático 2m x lm e comparar os resultados obtidos com teorias e estudos semelhantes. Para a caracterização das propriedades de fluxo da soja em pelets (produto utilizado nos ensaios), adotou-se a metodologia proposta pela BMBH. Para o cálculo das pressões, adotaram-se as normas D1N 1055, ISO 11697, EUROCODE 1 e AS 3774 enquanto que, para o cálculo das tensões, utilizaram-se os métodos simplificados de Ravenet e Troitsky. Para a obtenção dos esforços reais nas paredes, utilizou-se extensômetros elétricos e transdutores de deslocamentos. Com bases nos resultados obtidos, ressalta-se que a soja em pelets apresentou característica granular e que o esforço gerado nas paredes pelo seu descarregamento aumentou com o tempo de armazenagem estudado. Com relação às teorias estudadas, conclui-se que tanto a teoria de Ravenet quanto de Troistky podem ser recomendadas para o dimensionamento de silos prismáticos por apresentarem boa aproximação com valores experimentais. / Last years in Brazil have shown an agricultural growth that has forced several sectors to fít in productive patterns to maintain competitiveness within the process of economic globalization. In this context, agroindustrial product factories, particularly the ones involved with rations, tend to search for new alternatives to favor production and reduce costs without affecting the quality of the final product. Among these alternatives there is the use of vertical silos due to their capacity to facilitate the process of rations production and remove the need for great horizontal warehouses. The mere use o f vertical silos without a previous knowledge of some characteristics such as the most appropriate shape and dimensions for each situation, however, may not produce the desired outcome and can create problems with the flow of products due to inadequate dimensioning of storage cells. Aware of such an insecurity, the present research had the objective to study the tensions produced on the zigzag shaped walls of a 2m x l m prismatic metallic silo, and to compare results found with theories and similar studies. The methodology proposed by BMBH was used to determine the flow properties of pelletized soybean (product used in the experiments). DIN 1055, ISO 11697, EUROCODE 1 and AS 3774 norms were used for the calculation of pressure whilst the simplifíed methods of Ravenet and Troitsky were used to calculate tension. Strain gauges and displacement transducers were used to obtain data concerning the real efforts on the walls. Based on results found it can be said that pelletized soybean presented granular characteristic and that the effort generated on the walls due to its unloading increased according to storage time studied. Concerning the theories studied, it was concluded that either Ravenet theory or Troitskys can be recommended for the design of prismatic silos since they present great accuracy when contrasted with experimental values.
24

Sistemas avançados em iluminação natural: análise da influência da configuração urbana na aplicação do painel de corte a laser em Maceió / Advanced daylight systems: analysis of the influence of urban configuration in the application of the laser CUT panel in Maceió

Ribeiro, Pedro Vitor Sousa 10 January 2017 (has links)
The use of elements that help the project designer to make the environments more comfortable and efficient comes from an analysis that identifies the best solutions for each reality. Studies show that the use of light redirection panels in side openings reduces the incidence of direct sunlight in the area near the window, increases diffuse light in the first third of the room closest to the window, and improves the overall distribution of light in the room. The present work studies the laser cut panel application in an urban verticalization scenario in Maceió. The methodology used is divided into two parts: the first one consists in the elaboration of an additional algorithm for the TropLux software that allows to simulate computationally the material chosen, and it’s performance was verified after a comparison of the reflectance and transmittance directional obtained, and the values found in literature; The second part aims to analyze the advanced element utilization in an denser urban environment using the developed algorithm, in which the models were analyzed using parameters of average illuminance and it’s uniformity, as well as the statistics analysis of the data. The validation carried out indicates that the operation of the module corresponds to other results obtained in literature, attesting its effectiveness. The urban models analysis results indicate that the panel positioned vertically, at 0 °, works well as sunscreen against the direct rays of the sun. For light redirection function the element presented better results for clear skies partially covered when applied at 30°, and at 45° of inclination for clear skies, independent of the urban canyon orientation. However, scenarios of reduced vision of sky, less than 20%, presented different behavior, this need complementary analysis. / Conselho Nacional de Desenvolvimento Científico e Tecnológico / A utilização de elementos que auxiliem o projetista a tornar os ambientes mais confortáveis e eficientes parte de uma análise que identifique as melhores soluções para cada contexto. Estudos mostram que a utilização de painéis de redirecionamento da luz em aberturas laterais reduz a incidência de luz direta do sol na área próxima da janela, aumenta luz difusa no primeiro terço da sala mais próximo a janela e melhora a distribuição total de luz no ambiente. O presente trabalho busca analisar a aplicação do painel de corte a laser em um cenário de verticalização urbana em Maceió. A metodologia utilizada se divide em duas partes: a primeira consiste na elaboração de um algoritmo adicional para o TropLux que permita simular computacionalmente o material escolhido, o seu desempenho foi verificado através da comparação da refletância e transmitância direcionais obtidas e os valores encontrados na literatura. A segunda parte busca analisar a utilização do elemento avançado em um cenário de adensamento urbano utilizando o algoritmo desenvolvido, onde os modelos foram analisados utilizando parâmetros de iluminância média e sua uniformidade, bem como uma análise estatística dos dados. A validação realizada aponta que o funcionamento do módulo corresponde a outros resultados da literatura, obtidos em medições com instrumentos, atestando a sua eficácia. A análise dos modelos urbanos aponta que o painel posicionado na vertical, a 0°, funciona bem como protetor solar contra os raios diretos do sol. Para função de redirecionamento da luz o elemento apresentou melhores resultados para céus parcialmente encobertos quando aplicado a 30° e para céus claros a 45° de inclinação, independente da orientação do cânion urbano. Entretanto cenários de reduzida visão de céu, menores que 20%, apresentaram comportamento distinto, requerendo análises complementares.
25

Les disconnexions de la substance blanche comme facteur prédictif de l’évolution de la négligence spatiale unilatérale / .

Lunven, Marine 19 December 2014 (has links)
La négligence spatiale unilatérale (NSU) est une affection neurologique fréquemment observée après une lésion de l'hémisphère cérébral droit. Les patients ne vont plus être en mesure de prendre en compte les stimuli présentés dans l'hémi-espace gauche. La NSU participe à l'aggravation du handicap des patients, par la réduction des possibilités en rééducation motrice et cognitive à la phase aigue d'un accident vasculaire comme sur le long terme. L'identification des facteurs prédictifs de sa chronicité pourrait permettre une meilleure prise en charge clinique de ces patients. Nous avons étudié les altérations des connexions anatomiques observées en IRM de diffusion sous-tendant la persistance de la NSU. Nos résultats démontrent qu'en plus d'un dysfonctionnement fronto-pariétal hémisphérique droit, la persistance de ce syndrome serait associée à une déconnexion interhémisphérique. L'hémisphère gauche isolé ne serait pas en mesure de compenser les déficits des patients. La récupération devrait s'effectuer par une amélioration dans les capacités d'échange des informations entre les deux hémisphères, notamment dans les régions postérieures pariétales et occipitales. Nous nous sommes intéressés à tester cette hypothèse par le biais d'une méthode de rééducation, l'adaptation prismatique (AP). Il s'agit d'une thérapie dont les effets sur la sémiologie des patients sont remarquables. Nos résultats suggèrent que l'amélioration de la NSU pourrait s'observer par le recrutement du réseau fronto-ponto-cérébelleux. Les régions frontales gauches seraient un relais anatomique entre le cervelet droit et le réseau fronto-pariétal gauche / Unilateral spatial neglect is a frequent neurological condition after right hemisphere damage. Patients behave as if objects on their left did not exist anymore. The presence of neglect has negative prognostic value for functional recovery in the acute and chronic phases after a stroke. Finding predictors of persistent neglect would permit to adapt rehabilitation procedures. We used diffusion MRI to define the state of anatomical connections in neglect and their predictor value for neglect persistence. Our results revealed that, together with right intra-hemispheric fronto-parietal disconnections, persistence of neglect is associated with inter-hemispheric disconnection. We concluded that an isolated left hemisphere may fail to compensate neglect because it cannot take into account left-sided objects. Recovery of neglect would instead occur thanks to the sharing of visual information between the two hemispheres, notably in posterior parietal and occipital cortices. We tested this hypothesis by using prism adaptation (PA) therapy. PA is a non-invasive and convenient technique to rehabilitate neglect. We showed that patients with damaged fronto-ponto-cerebellar pathways did not benefit from PA. This finding strongly suggests that PA can ameliorate signs of neglect by improving inter-hemispheric communication through enhanced activity of these connections. Left frontal areas may constitute the anatomical link between the right cerebellum and the left fronto-parietal network. Thus, connectional anatomy can help predict both neglect recovery and the quality of its response to rehabilitation therapies
26

DESIGN AND THERMOMECHANICAL ANALYSIS OF PRISMATIC BATTERY CELL ASSEMBLY

Thanh Nguyen (8803043) 21 June 2022 (has links)
<p>A battery assembly experiences both mechanical and thermal loadings during its operation. It is critical to perform the thermomechanical analysis to propose a novel design for the highest efficiency.In this study,two main goals include mechanical characterization and deformation responses for a battery cell and assembly, as well as air-cooled concepts design and analysis.Initially, the cell dimensions were measured by cell-sectioning method, and then the mechanical properties were empirically measured by both 3-point flexural, and nanoindentation experiments. Moreover, three pairs of experiments and simulations were conducted to study mechanical behaviors on both a single cell and a battery assembly. They include (1) point-force loading for single, open cell; (2) internal pressurization for single, sealed cell; and (3) internal pressurization for battery assembly.Additionally, both parametric and experimental studies were executed to design, analyze,and validate air-cooled concepts based on the idea of microchannel heatsink. The proposed concepts have the features, which are integrated into the battery cell for generating the cooling channels. A series of thermomechanical simulations and a forced convection testbed were built for computationally and empirically analyzing the performances of the concepts. The results from the mechanical characterization showed a significant difference between the actual and nominal values of both cell dimensions and mechanical properties. Therefore, the effect of the manufacturing process to such values must be considered before inputting for analyzing the deformation responses. From the thermomechanical analyses, it was found that the mechanical loading might negatively influence the thermal performance if there were not enough mechanical supports from the air-cooling structure. The impact was minimal in the tapered-channel battery assembly. This configuration also significantly reduced the temperature difference on the cell compared with other concepts and the reference design.<br></p>
27

Design and control of a three degree-of-freedom planar parallel robot

Joshi, Atul Ravindra January 2003 (has links)
No description available.
28

A teoria das cores de Goethe hoje / Goethe´s theory of colours today

Possebon, Ennio Lamoglia 08 May 2009 (has links)
Este trabalho investiga os pressupostos e fundamentos da Teoria das Cores de Goethe (Farbenlehre) como parte dos seus empenhos enquanto cientista da natureza. Apresenta a tradução de um texto seu sobre o método científico (Kautelen des Beobachters) e de um segundo texto sobre experimentos prismáticos (Beitrag zur Optik), no qual ele lança as bases do seu trabalho de mais de 30 anos sobre as cores. Estes textos, até então inexistentes em português, fornecem os subsídios para um entendimento mais amplo da Farbenlehre. E a pesquisa como um todo se orienta no sentido de contribuir para um resgate da fenomenologia goetheana para o ambiente cultural da atualidade. / This work investigates the principles and bases of Goethe\'s Theory of Colours (Farbenlehre\") as part of his studies as a Natures scientist. A translation of Goethe\'s essay on scientific methods (\"Kautelen des Beobachters\") and another on prismatic experiments (\"Beitrag zur Optik\"), where he sets the bases of his 30 years work on colours studies, are presented in this work too. The papers translated here were never before available in Portuguese, and they represent relevant subsidies for a comprehensive understanding of the \"Farbenlehre\". This research aims to contribute to the recovery of the Goethean\'s Phenomenology for the cultural enviroment of our days.
29

Self-Assembly and Cytotoxic Activity of Homometallic and Heterometallic Coordination Architectures

Adeyemo, Aderonke Ajibola January 2017 (has links) (PDF)
The alluring order in which complex biological networks exist in nature stimulated the interest of chemists to replicate such systems synthetically. With such examples as the deoxyribonucleic acid (DNA) double helix and the phospholipid bilayers, the influence of forces within these networks are solely credited for their excellent stability. The synthetically ordered chemical networks are also held together by interactions within them with little or no external force as seen in the natural systems. This spontaneous and reversible association of molecules or ions to form larger, more complex entities according to the intrinsic information contained in the molecules themselves is known as self-assembly. The self-assembly process is pre-eminent to the formation of ordered structures emerging spontaneously from the precursors in which, the overall structure of the final assemblies is controlled by the symmetry of each of the building blocks. The highly ordered and thermodynamically stable scaffolds are formed via non-covalent interactions including hydrophobic interaction, π-stacking, dipole-dipole interaction, ion-dipole interaction, hydrogen bonding, Van der Waals forces, solvophobic interaction and reversible metal-ligand coordination. These non-covalent interactions are termed as supramolecular interactions. Among several of these self-assembly protocols, the directional metal-ligand coordination strategy has evolved to be a well-established process for the preparation of supramolecular ensembles with pre-defined shapes, cavities and functionalities in a “one-pot” synthesis. Coordination-driven self-assembly strategy is governed by the combination of electron-deficient metal centres and electron-rich organic ligands. The outcome of the final supramolecular architecture is determined by the choice of the pre-designed metal acceptor building blocks as well as the flexibility and steric demands of the ancillary organic ligands. Accurate stoichiometry of each of the building blocks is also a very important factor in coordination-driven self-assembly; although serendipity sometimes happen which is quite unexpected. A large number of these self-assembled supramolecular networks have found useful applications in optoelectronics, material chemistry, adsorption, drug delivery, catalysis, host-guest chemistry, photo- and electro-chemical sensing as well as prospective chemotherapeutics. Transition metals are widely desired as electron-deficient building blocks in supramolecular chemistry. They readily accept lone pair of electrons from electron-rich building blocks. The functional properties of these metals have also been considered during the pre-design of these electron acceptors such that the functional property of each metal can be induced in the final architecture. Pd(II) and Pt(II) metals are highly desirable electron acceptors in supramolecular self-assembly because of their rigid square-planar nature. Nonetheless, Ru(II) and Fe(II) have also been explored as electron acceptors based on their octahedral geometry. Electron-rich building blocks have lone pairs of electrons on their donor sites (nitrogen, oxygen or sulphur) which effortlessly donate electrons to electron-deficient building blocks. The pyridyl appended ligands have been mostly used as the electron-rich building blocks in the construction of supramolecular architectures because of their predictable coordination modes and the symmetrical nature. However, imidazole appended ligands holds a distinctive spot in supramolecular chemistry because of its rotational flexibility and unpredictable binding modes which may lead to uncommon architectures not obtainable with pyridyl appended ligands. Thus, imidazole-based supramolecular architectures are less explored because the outcome of the final architecture cannot be pre-determined during the design. Ruthenium p-cymene complexes have spurred much interest in the last two decades because they possess extremely stable octahedral geometry and has been extensively used in the construction of 2D and 3D supramolecular architectures. The recent search for viable alternatives to platinum drugs in cancer chemotherapy discovered ruthenium as an excellent alternative to platinum because of its low toxicity when compared to platinum. The robustness of the arene head on interaction with biomolecules and the accumulation of large molecular weight compounds specifically in cancer cells rather than in healthy cells also improved the activity of ruthenium supramolecular architectures in cancer therapy. This recent outcome has propelled significant research channelled towards synthesizing better ruthenium-based chemotherapeutics. Additionally, the presence of two different metals in a single self-assembled architecture may also impart an increased activity when compared to the individual activity of each metal. Thus, the heterometallic supramolecular architectures can open a new kind of chemotherapeutics which may give a distinct mechanistic pathway different from those reported in literature. Chapter 1 of this thesis describes the coordination-driven self-assembly strategy with specific emphasis on ruthenium p-cymene self-assembled architectures and their applications. A brief introduction on cancer and cancer therapy is discussed. The use of mononuclear and dinuclear metal-based chemotherapeutics is included while the use of heterometallic complexes as anticancer agents was also highlighted. Chapter 2 showcases the self-assembly of a series of 2D and 3D ruthenium(II) p-cymene architectures constructed from bidentate and tridentate rigid imidazole-based ligands and dinuclear ruthenium(II) building units. The influence of the rotational flexibility of the imidazole ligands on the final architecture was probed. In spite of the likelihood of the formation of different conformational isomeric architectures (syn and anti) and/or polymeric products due to free rotation on the donor sites of the imidazole ligands, the exclusive formation of a single conformational isomer (anti) as the only product turned out to be a noteworthy observation. This indicates that the coordination mode and flexibility of imidazole ligand can control and determine the geometry, topology and conformations of the final molecular architectures. Scheme 1: Self-assembly of 2D macrocycles [2 - 7](OTf)4 employing dinuclear ruthenium(II) building units [1a - 1c](OTf)2 and bidentate rigid imidazole ligands L1 - L2 in methanol at room temperature. Furthermore, the unexpected formation of a tetranuclear cationic macrocycle [8](OTf)4 was reported in the 2 + 3 self-assembly reaction of triazine-based tridentate imidazole ligand L3 and dinuclear ruthenium(II) building unit [1a](OTf)4 over the expected hexanuclear prismatic cage [8a](OTf)6 which is quite surprising. Scheme 2: Schematic representation of the formation of an unexpected tetranuclear macrocycle [8](OTf)4 over the expected hexanuclear prismatic cage [8a](OTf)6. Chapter 3 reports the synthesis of eight octanuclear cages via the coordination-driven self-assembly of two tetradentate pyridyl-based organic ligands and four dinuclear p-cymene Ru(II) acceptor clips. These octanuclear cages were explored in vitro as potential anticancer agents against human lung adenocarcinoma A549 and human cervical cancer HeLa cell lines. Four of the cages with polyaromatic spacers in their Ru(II) acceptor clip unit showed very low micromolar IC50 values and also possess higher anticancer activity than cisplatin against the tested cancer cell lines. The four dinuclear p-cymene Ru(II) acceptor clips A3 in OC-3 and OC-7 revealed some kind of synergy which is evident in their IC50 values against the tested cancer cell lines. In addition, OC-3 and OC-7 trigger both early and late apoptotic phases while OC-4 and OC-8 trigger majorly late apoptotic phase in the cancer cell lines tested. The mechanistic pathway by which cell death is progressing is through the generation of reactive oxygen species (ROS) which is of significant amount in OC-4 and OC-8. Scheme 3: Self-assembly of the discrete octanuclear cages (OC-1 - OC-8) in methanol at room temperature and the schematic illustration of the apoptosis mechanistic pathway. Chapter 4 describes the use of “metalloligands” as electron-rich building blocks and the subsequent use of the metalloligand for “one-pot” self-assembly reactions in the presence of electron-deficient metal acceptor building blocks. The pyridyl donors are the most preferred in metalloligands because of their predictable directionality in self-assembly. The introduction of a second metal into the ligand component of the self-assembled architecture is to bestow additional functionality as well as to construct elegantly designed discrete heterobimetallic supramolecular architectures. Four discrete Ru(II)-Pt(II) hexanuclear trigonal prismatic cages were synthesized employing a tritopic platinum(II) metalloligand and four p-cymene ruthenium(II) clips via coordination-driven self-assembly. The formation of these cages were confirmed by well-known spectroscopic techniques and their structural features was elucidated by geometry optimization. In vitro anticancer studies of these heterometallic cages failed because of solubility challenges in the culture media presumably due to their high molecular weights and many alkyl groups. Scheme 4: Energy minimized structures of the heterometallic trigonal prismatic cages 3a (left) and 3b (right). Hydrogen atoms have been removed for the sake of clarity [Ru: green, Pt: pink, O: red, N: blue, P: orange, C: grey]. Chapter 5 discusses the synthesis of two bidentate platinum(II) metalloligands as well as the self-assembly of six new heterometallic rectangles obtained from four Ru2(OOꓵOO)2(p-cymene)2Cl2 pillars and two bidentate pyridyl-based platinum(II) metalloligands. The Ru4Pt2 and Ru4Pt4 rectangles were structurally characterized and supported by geometry optimisation. Additionally, two Ru4Pt2 and two Ru4Pt4 rectangles were examined for their anticancer properties in eight human cancer cell lines with the aim of checking if the platinum metal centres in the metalloligands can enhance the anticancer activity of the rectangles. The results showed that these heterometallic rectangles are cytotoxic against the cancer cell lines tested but the incorporation of platinum(II) metal(s) into the metalloligand did not further enhance the cytotoxicity in the rectangles tested as hypothesized. The mechanism of cell death is via the generation of reactive oxygen species (ROS) and two Ru4Pt4 rectangles activates both early and late apoptosis. Cell cycle analysis showed that one of the Ru4Pt4 rectangles is a moderate inhibitor of cell cycle progression at the sub G1 phase similar to cisplatin while nuclear condensation and cell blebbing in the cells was also observed in the presence of the two Ru4Pt4 rectangles tested. The overall activity of the heterometallarectangles against the cancer cell lines tested was increased when they exist as a single entity thus reiterating the importance of heterobimetallic supramolecular architectures in cancer therapy. Scheme 5: Schematic diagram of the discrete Ru4Pt4 heterometallic rectangles and illustration of the cell death pathway. The results of the investigation reported in this thesis contribute to the rapidly developing field of organometallic ruthenium(II) self-assembled anticancer chemotherapeutics with specific evidences of the mechanistic pathway of cell death. This results can further guide the design and development of better chemotherapeutics for future use.
30

A teoria das cores de Goethe hoje / Goethe´s theory of colours today

Ennio Lamoglia Possebon 08 May 2009 (has links)
Este trabalho investiga os pressupostos e fundamentos da Teoria das Cores de Goethe (Farbenlehre) como parte dos seus empenhos enquanto cientista da natureza. Apresenta a tradução de um texto seu sobre o método científico (Kautelen des Beobachters) e de um segundo texto sobre experimentos prismáticos (Beitrag zur Optik), no qual ele lança as bases do seu trabalho de mais de 30 anos sobre as cores. Estes textos, até então inexistentes em português, fornecem os subsídios para um entendimento mais amplo da Farbenlehre. E a pesquisa como um todo se orienta no sentido de contribuir para um resgate da fenomenologia goetheana para o ambiente cultural da atualidade. / This work investigates the principles and bases of Goethe\'s Theory of Colours (Farbenlehre\") as part of his studies as a Natures scientist. A translation of Goethe\'s essay on scientific methods (\"Kautelen des Beobachters\") and another on prismatic experiments (\"Beitrag zur Optik\"), where he sets the bases of his 30 years work on colours studies, are presented in this work too. The papers translated here were never before available in Portuguese, and they represent relevant subsidies for a comprehensive understanding of the \"Farbenlehre\". This research aims to contribute to the recovery of the Goethean\'s Phenomenology for the cultural enviroment of our days.

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