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The diploma thesis deals with the impact of different fixed assets presentation standards according to the Czech Accounting Legislation (CAL) and International Financial Reporting Standard (IFRS) for Small and Medium-sized Entities (SMEs). The main goal of the diploma thesis is to evaluate the impact of different presentation standards from CAL and IFRS for SMEs perspective on the values of financial statement items that affect the transparency of the selected financial analysis indicators. The theoretical section of the thesis focuses mainly on fixed assets according to IFRS for SMEs and its comparison with fixed assets according to CAL and IFRS for SMEs. The practical section of this thesis identifies the areas of fixed assets which are described differently by CAL and by IFRS for SMEs and sets them to model cases. Then a quantification of the differences in the financial statements is performed by using model accounting units arising due to different ways of reporting. The quantification is then followed by an evaluation of the impact on selected indicators of financial analysis.

The repertoire of soloistic for cello is far narrower than those of other concertante instruments. So we tend to think that we know well of all the regularly performed cello concertos, in which the Elgar Concerto is among them.However, besides the concerto itself and some populare songs, variations or marches, there is little knowledge about the and work of the composer. Moreover, we have to take into account the massive influence of Jacqueline deu Pré, whose very personal and passionate performance has become an almost absolute point of refernece, above the annotations of Elgar himself. My work aims to give a broader approach to Edward Elgar ande his cwork, and to give an interpretation proposal, after having consulted the composers´marks and recordings, and contrast it with the opinions of other prestigious cellist ( Han-Na Chang and Kazimierz Michalik).

The diploma thesis is focused on computer modeling of the mechanics of the release gate used in agricultural practice. The theoretical part describes several computer programs that can be used for this purpose. Specifically, these programs are: SolidWorks, CA-TIA, Solid Edge, Pro/ENGINEER, NX, and Autodesk Inventor. For each program, their basic descrip-tion, user interface and basic features are provided. In the practical part of the diploma thesis a new design of the release goal was proposed. Using Autodesk Inventor Professional 2016, a mechanical simulation of this goal was performed step by step.

A socialização e a educação contribuem na formação dos indivíduos e favorecem o desenvolvimento do julgamento moral pró-social. Tal enunciado tem sido apresentado por estudos realizados com indivíduos de nível sócio-econômico médio em países desenvolvidos. O desenvolvimento do julgamento moral pró-social de indivíduosde nível sócio-econômico baixo e de países subdesenvolvidos ainda precisa ser investigada. Portanto, este estudo tem como objetivos: (a) investigar o julgamento moral pró-social de indivíduos que vivem nas ruas e não frequentam escolas comparando-os com indivíduos de nível sócio-econômico baixo, que frequentam escolas; (b) investigar os índices de ajuda diferencial dos indivíduos entre os potenciais receptores de ajuda. Quarenta meninos(as) de rua e 40 meninos(as) de escolas da Rede Municipal, de 9-12 e 13-16 anos de idade, metade de cada gênero, foram submetidos, individualmente, à Entrevista de Julgamento Moral Pró-social de Eisenberg. Algumas questões adicionais foram incluídas para avaliar os índices de ajuda diferencial entre os receptores de ajuda. Foram obtidos dados de identificação dos sujeitos por meio de uma Entrevista Inicial. Os dados coletados foram submetidos a análises quantitativas (frequências e ANOVAs). Os resultados revelaram que há diferença significativa no nível de julgamento moral pró-social de meninos(as) de rua e de escola (F[1,72] = 5.80; p< .05). Há, ainda, diferença significativa no índice de ajuda diferencial entre os receptores de ajuda (F[5,360]= 116.91; p<.OOI) e uma interação significativa de condição de vida e faixa etária (F[I,72]= 10.56; p<.Ol). Algumas análises extra-hipóteses foram realizadas, investigando a ocorrência e a clareza de expressão do julgamento moral pró-social. Os resultados são discutidos e comparados à literatura da área e a conclusão apresenta uma proposta para educação pró-social dos indivíduos aplicada à escola e às instituições de atendimento aos(às) meninos(as) de ruas.

abstract: A tumor is a heterogeneous combination of proliferating tumor cells, infiltrating immune cells and stromal components along with a variety of associated host tissue cells, collectively termed the tumor microenvironment (TME). The constituents of the TME and their interaction with the host organ shape and define the properties of tumors and contribute towards the acquisition of hallmark traits such as hypoxia. Hypoxia imparts resistance to cancer from chemotherapy and radiotherapy due to the decreased production of reactive oxygen species and also promotes angiogenesis, malignant progression and metastasis. It also provides a powerful physiological stimulus that can be exploited as a tumor-specific condition, allowing for the rational design of anticancer hypoxia-activated pro-drugs (HAP). Accurate evaluation of tumor oxygenation in response to therapeutics interventions at various stages of growth should provide a better understanding of tumor response to therapy, potentially allowing therapy to be tailored to individual characteristics. The primary goal of this research was to investigate the utility of prospective identification of hypoxic tumors, by two different Magnetic Resonance Imaging (MRI) based oximetry approaches, in successful treatment with hypoxia activated therapy. In the present study, I report the utility of these two techniques 1) PISTOL (Proton Imaging of Siloxanes to map Tissue Oxygenation Levels) and 2) use of a hypoxia binding T1 contrast agent GdDO3NI in reporting the modulations of hypoxia pre and post hypoxia activated therapies in pre-clinical models of cancer. I have performed these studies in non-small cell lung cancer (NSCLC) and epidermoid carcinoma (NCI-H1975 and A431 cell lines, respectively) as well as in patient derived xenograft models of NSCLC. Both the oximetry techniques have the potential to differentiate between normoxic and hypoxic regions of the tumor and reveal both baseline heterogeneity and differential response to therapeutic intervention. The response of the tumor models to therapeutic interventions indicates that, in conjunction with pO2, other factors such as tumor perfusion (essential for delivering HAPs) and relative expression of nitroreductases (essential for activating HAPs) may play an important role. The long term goal of the proposed research is the clinical translation of both the MRI techniques and aiding the design and development of personalized therapy (e.g. patient stratification for novel hypoxia activated pro-drugs) particularly for cancer. / Dissertation/Thesis / Doctoral Dissertation Bioengineering 2017

The main goal of this graduation thesis is graphic execution of the book ``Romance pro křídlovku{\crqq} written by František Hrubín. I propose novel dust cover design, flyleaf, main title, deducation and collection of illustrations suitable for this book. The graduation thesis consists of practical and theoretical parts. Comprehensive reading and deep study of literary work of Frantisek Hrubin preceded the graphic realization of his piece ``Romance pro křídlovku{\crqq}. My aim is to explicate both content and formal aspects. The comparison with a TV adaptation of this piece is mentioned as well. The practical impact in educational process and graphic interpretations made by other artists are discussed in details. The theoretical part contains a description of a graphic execution itself. General difficulties with graphic execution, patterns and hidden obstacles are outlined in a relation to complexity of analysed book. The graduation thesis is concluded by my reflection about passages of poem most suitable for illustrations and selection of appropriate artistic technique.