Technische Universität Berlin, Diss., 2005.

Universiẗat, Diss., 2008--Zürich.

Leipzig, Universiẗat, Diss. : 1993.

Ziel der Arbeit war es beim Menschen die Pathophysiologie neuronaler Funktion bei zerebraler Ischämie näher zu charakterisieren sowie Kenntnisse über Umorganisationsprozesse des motorischen Systems nach einem Schlaganfall zu gewinnen. Als Untersuchungsinstrument wurde die transkranielle Magnetstimulation (TMS) eingesetzt, die basierend auf der Analyse exzitatorischer und inhibitorischer Reizeffekte (kortikospinal vermittelte exzitatorische Reizantworten, postexzitatorische Inhibition, transkallosale Inhibition, intrakortikale Inhibition und Fazilitierung) einen nicht-invasiven Zugang zur Funktion kortikaler Neurone und ihrer Efferenzen ermöglicht. An Patienten mit einer Okklusion der A. carotis interna wurden die Auswirkungen einer Ischämie auf die neuronale Funktion des motorischen Kortex untersucht. Es konnte erstmals in vivo nachgewiesen werden, dass eine zerebrale Perfusionsminderung eine selektive Funktionsstörung kortikaler inhibitorischer Interneurone in der betroffenen Hemisphäre und eine Beeinträchtigung interhemisphärischer Hemmmechanismen induziert. An Patienten mit unterschiedlich lokalisierten ischämischen Läsionen wurde der Einfluss des interhemisphärischen Informationstransfers auf Reorganisationsprozesse in der kontralateralen Hemisphäre untersucht. Es zeigte sich, dass bei Schlaganfallpatienten die kortikale Erregbarkeit der nicht-geschädigten Hemisphäre durch eine über das Corpus callosum vermittelte Inhibition signifikant moduliert wird. In zukünftigen Studien ist zu klären, inwieweit sich die Veränderungen der kortikalen Erregbarkeit positiv auf die Funktionsrestitution auswirken und dies durch den Einsatz rehabilitativer Verfahren unterstützt werden kann. / The study was performed to investigate the pathophysiology of motoneuronal function in cerebral ischemia tand mechanisms of motor cortex reoganisation following stroke. The function of cortical neurons was assessed using transcranial magnetic stimulation of the motor cortex and by analysing the excitatory and inhibitory stimulation effects (corticospinally mediated excitatory response, postexcitatory inhibition, transcallosal inhibition, intracortical inhibition and facilitation). In patients with carotid occlusive disease we investigated the influence of hemispheric ischemia on motor cortex function. Patients with differently localised monohemispheric lesions served as a clinical model to investigate the impact of interhemispheric interaction on motor cortex reorganisation in the non-lesioned hemisphere. The present study is the first to demonstrate that hemispheric ischemia preferentially induces an impairment of trancallosally mediated interhemispheric inhibition and intracortical inhibitory processes. It could be further shown that in acute stroke interhemispheric interaction via callosal fibres significantly influences cortex excitability in the nonlesioned hemisphere e.g. loss of transcallosal inhibition induces hyperexcitability of the contralateral undamaged motor cortex. In the future it has to be elucidated what role excitability changes play for functional recovery and rehabilitation in stroke.

Zugl.: Bremen, Univ., Diss., 2009

The contemplation of the reorganisations of the Australian Defence Group of departments over the past 34 years led to a notion that for organisations operating in turbulent environments there may exist a hypothetical re1ationship between perceived environmental uncertainty and organised complexity. This hypothetica1 relationship is described as 'coping' and is based on an assumption that in an organisational setting, individuals make some form of response to changes in their environment and this response is manifest in organisational change. The notion of this hypothetical relationship also led to the development of two 'ideal type' models - the Coping Model and the Overload Model. The application of contingency theory through the Overload Model showed that the State of an Organisation could be defined acccrdicg to its mode of existence in relation to some optimal level of information processing and some optimal level of organised complexity. A typology of ths States of Organisations has been derived from the Overload Model and design strategies which are appropriate to each state have been ranked according to an ordinal preference scale. The 'ideal type' models have allowed subjectively weighted judgements to be made about the present state of the Defence organisation and the ranking of design strategies to avoid the perceived undesirable state of overload. The Department of Defence is now imputed to be in a state of 'disorganisation'. The Overload Model suggests that there has been an over-investment in vertical information systems at the expense of lateral relations. The policy-making implication of this suggestion is that the state of 'overload' can be avoided through a reduction in organised complexity and the creation of lateral relations. This can be achieved if the Central Office is restructured to reduce the number of committees and if appropriate co-ordinating representatives are placed in the Service Offices.

Techn. Univ., Diss.--Darmstadt, 2005.

This master`s research analyses reorganisation programme of the school system in Mažeikiai district. It reveals the essence and the expression of the reorganisation of the school system. It theoretically focuses on the situation of the education reform in Lithuania and involves a review on the reorganization of the foreign school system. Also, there are identified the determinants of the reorganization of the school system in Mažeikiai district and in the country. The main method of this research has been an oral interrogation as well as a qualitative interview. Obviously, the Protocol (the questionnaire of the qualitative interview) has been prepared for the research. Seventeen experts of education from Mažeikiai district has taken part in the interrogation. The content method of analysis has been applied for processing the research data as well as for the analysing data there was applied the logical – inductive method. Thus, the results of the interrogation permitted to define the weaknesses and strengths of the reorganisation programme of the school system in Mažeikiai district. In addition, the hypothetical premises (which were raised in the beginning of the research) confirmed only partly because the reorganization programme of the school system in Mažeikiai district is appraised quite propitious. Though, it has a lot of imperfections. The opinion of the education experts confirms the second hypothetical premise that there is a shortage of modern... [to full text]

Darmstadt, Techn. University, Diss., 2002.

Universiẗat Hohenheim, Diss.--Stuttgart, 2007. / Literaturverz. S. XXXV - LXXVII.