This study examined maternal depression status from month 1 to 36 after birth using data from the NICHD Study of Early Child Care and Youth Development. Maternal depression was assessed with the Center of Epidemiological Studies Depression Scale. The prevalence of maternal depression was highest at 1 month, decreased at 6 months, and then kept fairly stable to 36 months. The prevalence was higher in blacks than other races, in 18-24 than 25-46 years old, and in single mothers than non-single mothers. Mothers with better physical health, social support, or employed had a lower prevalence than their counterparts. Mothers in poverty, receiving public assistance, or who had more parental stress had a higher prevalence. Social support and parental stress had a statistically significant relationship with maternal depression even after adjusting for other variables. In conclusion, this longitudinal study found that several maternal, child, and family factors were associated with maternal depression.

No description available.

The purpose of this study was to focus on whether solely obesity (measured by BMI) leads to an increased risk of COVID-19 mortality in terms of excess in-hospital deaths. As the grim milestone of one million deaths in the United States from COVID-19 was reached, one could assume the disease would continue to coexist with humanity in the long term. While vaccination continued to limit the spread of COVID-19, it was essential to investigate risk factors that may exacerbate the severity of the illness in humans. Obesity is already a global pandemic affecting 40% of Americans and over 650 million people worldwide. Obesity is connected to an entire range of clinical conditions including some of the leading causes of death worldwide making it a more generalizable statistic. Furthermore, the purpose of this study was to conduct a systemic review of major risk factors between obesity and COVID-19, and this analysis shall ascertain which factors have the most predictive value in determining mortality and severity of the condition. Ten research studies of 3,780,926 COVID-19 patient cases were included. Meta-analysis results indicate a pooled OR of 0.93 (0.71-1.23, p = 0.627) for in-hospital mortality of obese patients relative to non-obese patients when adjusted for confounders. All comorbidities associated with the development of severe disease were found to have an equal chance of leading to mortality. In other words, obesity did not lead to a statistically significant risk of dying from COVID-19.

No description available.

京都大学 / 新制・課程博士 / 博士(医学) / 甲第24089号 / 医博第4865号 / 新制||医||1059(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 武藤 学, 教授 万代 昌紀, 教授 松田 文彦 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

<p>Antibiotic use is generally regarded as the major driver for resistance. Many studies reporting an association between antibiotic use and the emergence of resistance have been published. However, most studies have significant limitations such as single center data with comparably low number of cases, using retrospective designs with limited data availability, ecological studies with lack of assessing the individual level and risk for ecological fallacy, and inappropriate selection of controls in case-control studies.</p> <p>A cohort study in adult patients hospitalized in 15 participating acute care hospital sites in Ontario, Canada, was conducted from April 1 2005 to June 30 2006. Antibiotic use on the unit level in defined daily doses (DDD) was only available for 3 sites. In order to assess antibiotic use on both the individual as well as on the unit level as a risk factor for resistance, days of therapy (DOT) could be calculated. However, it was unclear whether this approach would results in similar findings as when using DDD. Thus, the impact of using either DDD or DOT on the risk estimates for resistance was assessed for three antimicrobial-bacteria combinations, i.e. fluoroquinolone use and fluoroquinolone resistance in enterobacteriaceae an in <em>Pseudomonas aeruginosa</em>, and the use of betalactams and resistance to third generation cephalosporins in enterobacteriaceae.</p> <p>The risk estimates for resistance were very similar for all three antimicrobial-bacteria combinations on acute care units, there were some discrepancies on the unit level on intensive care units, and discrepancies on both levels for step down and rehabilitation units.</p> <p>In conclusion, the approach to use DOT instead of DDD to measure antibiotic utilization revealed similar results. However, the lack of comprehensive information on patient transfers when calculating DOT may bias the findings on units with frequent patient transfers such as intensive care units and step down and rehabilitation units.</p> / Master of Science (MSc)

Objectives: To assess the stability of lipid profiles throughout childhood and evaluate their onset and dynamic. Materials and methods: Lipid markers were longitudinally measured in more than 1300 healthy children from the LIFE Child study (Germany) and categorized into normal, at-risk, or adverse. Year-to-year intra-person persistence of the categories during follow-ups was examined and Pearson’s correlation coefficient was calculated. Results: We found strong positive correlations for TC, LDL-C and ApoB (r > 0.75, p < 0.001) from the age of four years. Correlations were lowest during the first two years of life. Most children with normal levels also had normal levels the following year. Children with at-risk levels showed a tendency towards normal levels at the follow-up visit. Adverse levels of TC, LDL-C, ApoB (all ages), and HDL-C (from age 15) persisted in more than half of the affected children. Agedependent patterns of stability were most pronounced and similar for TC, LDL-C, and ApoB. Conclusions: Normal levels of serum lipids show high stability and adverse levels stabilized in early childhood for TC, LDL, and ApoB. At-risk and adverse levels of TC, LDL-C or ApoB may warrant further or repeated diagnostic measurements with regards to preventing CVD in the long run.

No / PURPOSE. Epidemiologic studies have indicated that elderly people who wear multifocal spectacles have an increased risk of tripping, particularly on stairs. Yet no studies have experimentally examined how wearing multifocal spectacles affects stair and step negotiation. The purpose of this study was to determine the effects of wearing multifocal compared with single-distance vision spectacles on minimum toe clearance and risk of tripping during step negotiation in the elderly. METHODS. Nineteen healthy subjects (mean age, 71.4 years) performed a single step up to a new level (heights, 7.5, 15, and 22 cm) while wearing multifocal (bifocals and progressive addition lenses) or single-distance vision spectacles. Minimum horizontal and vertical toe clearance were assessed by analyzing data collected with a five-camera, three-dimensional motion-analysis system. RESULTS. There was no difference in mean minimum toe clearance in subjects when wearing multifocal compared with single-distance vision spectacles. However, there was greater within-subject variability in vertical toe clearance when wearing multifocal spectacles (variance ratio, 1.53; P = 0.0004). Subjects were also significantly more likely to trip when wearing multifocal compared with single-vision spectacles (one-sided Fisher's exact test P = 0.025). CONCLUSIONS. Because of increased within-subject variability in vertical toe clearance when wearing multifocal spectacles, elderly individuals may be at greater risk of falling when negotiating steps and stairs if they do not also consistently increase margins of safety (mean vertical toe clearance). This suggests that some elderly who are at high risk of falling may benefit from wearing single-distance vision rather than multifocal spectacles when walking.

Abdominal Aortic Aneurysm (AAA) is a disease that mainly affects elderly men, and ruptured AAA (rAAA) is associated with a mortality of &gt; 80%. AAA seldom gives any symptoms prior to rupture. The aims of this thesis were to investigate different aspects of how to affect mortality from rAAA. In Study I, we identified 849 patients treated for rAAA during 1987-2004, and studied the 30-day survival after surgery, depending on whether they came directly to the treating hospital (one-stop) or were transferred via another hospital (two-stop). A two-stop referral pattern resulted in a 27% lower population-based survival rate for patients 65-74 years of age. However, the consequences would be small even if a one-stop referral pattern could be generally accomplished, due to the huge over-all mortality related to rAAA, hence an argument to find and treat AAA before rupture, e.g. by screening. In Study II, we examined the AAA-prevalence and the risk factors for AAA among 70-year-old men. The screening-detected AAA-prevalence was 2.3%, thus less than half the predicted. The most important risk factor was smoking. In Study III, we compared the screening-detected AAA-prevalence, the attendance rate, and the rate of opportunistic detection of AAA, between almost 8000 65- and 6000 70-year-old men. There was no difference in the screening-detected prevalence; probably due to the fact that almost 40% of the AAAs among the 70-year-old were already known prior to screening, compared to roughly 25% in the 65-year-old. The attendance rate was higher among the 65-year-old men, 85.7% compared 84.0% in the 70-year-old. Thus, there is no benefit of screening for AAA among 70- instead of 65-year-old men. In Study IV, a cost-effectiveness analysis, we found that screening for AAA still appears to be cost-effective, despite profound changes in disease pattern and AAA-management. In conclusion, we found that mortality from rAAA is not affected in any substantial way by different referral patterns and hence centralisation of services for AAA/rAAA is not a solution. A better alternative is to prevent rupture through early detection by screening. Screening 65-year-old men for AAA still appears to be cost-effective, despite profound changes in disease pattern and AAA-management during the last decade. Screening 70- instead of 65-year-old men will not increase the efficacy of screening.

The main purpose of this dissertation is to lessen the gap in the Islamic finance and investment literature by providing new answers to the most vital question raised in that literature: Is the adherence to the Shariah law associated with at any cost? The first chapter provides a primer on Islamic finance. It discusses several restrictions and necessary adaptations that must be made to have a Shariah-compliant product. The takeaway is that Shariah law mandates is related to fundamentals and, thus has a direct effect on the risk-return profile of all sorts of different products. This is referred to as the “Islamic-effect.” The second chapter investigates that Islamic-effect in a cross-sectional stock return context. This is done in two steps. First, looking at differences in stock returns between Islamic and conventional firms in Saudi Arabia during the period from January 2003 to April 2011. Results indicate that there is a negative relationship between Saudi Islamic firms and average returns. This is referred to as the “negative Islamic-effect.” Second, examine whether that negative Islamic-effect is considered a common, systematic, and undiversified risk factor that affects cross-sectional expected stock returns. Time-series regressions results indicate that the Islamic risk factor (CMI) does indeed capture strong common variation in Saudi stock returns regardless what is included in the model. Also, findings suggest that using a four-factor model that controls for the Islamic-effect is more appropriate than using a single- or a three-factor model in Islamic finance applications that require estimates of expected stock returns. The third chapter investigates the Islamic-effect in a mutual fund context. A unique sample of 143 Saudi mutual funds (96-Islamic and 47-conventional) is used to assess the performance and riskiness of Saudi Islamic funds relative to Saudi conventional funds and relative to different Islamic and conventional indices for the period from July 2004 to January 2010. Findings suggest that there is a benefit (cost) from adhering to the Shariah law when locally-focused (internationally-focused) fund portfolios are investigated. When Arab-focused fund portfolios are investigated, findings suggest that there is neither a cost nor a benefit from adhering to the Shariah law.