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The use of treated wastewater (TWW) for crop irrigation is how many governments are looking to feed their large population due to urbanisation. Here, we outline and analyse the benefits of using TWW and the drawbacks of such practices in line with existing regulations. The review begins by highlighting the history of wastewater reuse in agriculture. The approach used in the write-up is outlined after the background. There is an in-depth look at three main areas: the uptake of heavy metals and pharmaceuticals on crop irrigation, plant yield, and the impact of regulations on these practices. Results demonstrate the presence of several pharmaceuticals, triclosan, acetaminophen, diazepam in lettuce, meprobamate, atenolol in celery, and carbamazepine, triclosan, and triclocarbon in soybean. Trace metals (Cd, Pb) are present in the edible part of the vegetable and arsenic is found in the ryegrass roots and maise. Some benefits derived from using TWW in crop irrigation include nutrient supply, water resource protection and food security, whereas the drawbacks are exposure of contaminants to food and humans.