Exposure to hyperoxia has been shown to have detrimental effects on newborn hemodynamics and antioxidant activities in males. These effects are unknown in the newborn female, despite clinical data showing that in children undergoing surgery females have poorer outcomes. This thesis explored whether newborn females respond worse than males to hyperoxia, specifically in hemodynamics and antioxidant activity. Hemodynamic results showed continual decreases in DBP and MAP, increases in HR, decreases in SBP, and increases in PP, which were experienced earlier and to a greater degree in the female. Additionally, reduced antioxidant activity seen in newborns was worse in females in both the heart and skeletal muscle. These results suggest that in response to hyperoxia, newborn females are at a hemodynamic disadvantage when compared to males, which may be a contributing factor for why female children are at a higher risk during surgery or medical management involving hyperoxia.

Exposure to hyperoxia has been shown to have detrimental effects on newborn hemodynamics and antioxidant activities in males. These effects are unknown in the newborn female, despite clinical data showing that in children undergoing surgery females have poorer outcomes. This thesis explored whether newborn females respond worse than males to hyperoxia, specifically in hemodynamics and antioxidant activity. Hemodynamic results showed continual decreases in DBP and MAP, increases in HR, decreases in SBP, and increases in PP, which were experienced earlier and to a greater degree in the female. Additionally, reduced antioxidant activity seen in newborns was worse in females in both the heart and skeletal muscle. These results suggest that in response to hyperoxia, newborn females are at a hemodynamic disadvantage when compared to males, which may be a contributing factor for why female children are at a higher risk during surgery or medical management involving hyperoxia.

Ego identity and intimacy statuses were determined for 88 college students, 44 men, and 44 women, and related to each other and to measures of intimacy-isolation, loving and liking, Sex differences were also investigated. Identity achievement subjects were more likely to be engaged in intimate relationships. Students having foreclosure. moratorium. and diffusion identities were variable in their intimacy statuses. A stronger association exists between intimacy and loving than intimacy and liking. While no significant sex differences were found on the overall ego identity and intimacy comparisons, sub scale differences were noted. The evidence suggests identity achievement status is predictive of highly intimate relations while foreclosure, moratorium and diffusion identities are highly variable.

published_or_final_version / Linguistics / Master / Master of Philosophy

The motivation to explore the subject matter of this thesis arises from two interlinked processes: (1) the experience of the power and pervasiveness of a "basic split" experienced in therapy in the unity of the individual, (2) the tendency in the unitary discipline psychology for theorists to adopt views which are polar opposites. In trying to understand these phenomena one has to explore the basic paradox of being which has fascinated thinkers and mystics down through the ages, the paradox of the One and the many, and thus the phenomenon of change. This paradox is explored in mythology, in the "philosophia perennis" and as encountered in high-energy sub-atomic physics. Out of this emerges the awareness of Being as One but as embodying a dynamic polar process, the first of whose manifestations is the male and the female process (or Yin/Yang in Chinese). The male/female process is defined and explored and it is shown that the female process has been progressively ignored and largely repressed in the West. I demonstrate this process in a metabletic (hermeneutical phenomenological) study of Greek sacred architecture. Metabletics as defined by its originator, J.H. van den Berg, is "the theory of change" or a psychology of history. It is thus a particularly suitable method of analysing the cultural-historical process of the repression of the female process in Western society. The emergence of the male process as predominant in the West is explored hermeneutically through the emergence of the individual and the suppression of the old unity centred in the Mother Goddess, and the receding of the Father God to the heavens. The choice by the great Greek philosophers of the male process is particularly important because of their emphasis on the Logico-Mathematical Sequential (L.M.S.) mode of knowing and perception at the expense of the female process, Intuitive-Creative Holistic (I.C.H.) mode.The dominance of the male process in the West is traced from the aboriginal female-process state through neolithic village culture to the rise of the first cities. Processes studied are the rise of kingship, war, private property and the splitting of labour. The roots of anomie and alienation are described. The emergence of god as powerful ruler and lawgiver is shown. The splitting of the male/female process leads to the splitting of the individual from him/herself, from others, from the world and from the divine. This is traced in the mystery religions, in religious dualism, in the rise of the Judaeo-Christian tradition and Gnosticism. The split and its effects are demonstrated in Western science and psychology. The necessity and possibility of integration in science and in psychology is demonstrated through the integration of our process of knowing and perceiving which is used as a model for the integration of psychology. The effects of the male/female split on the individual in Western society are shown. The split in our society leads to anomie and alienation, which produce "socioses". These affect the child born into the society and lead to a "Parent/Child" split. The possibility of healing the split in the individual, between people, between humankind and the world and in re-establishing our unity in the One is illustrated. The unity of the One is experienced through the dynamic polar interaction of the male/female process.

Naked mole-rats live in large colonies and exhibit a strict reproductive hierarchy. Each colony has 1 breeding female and 1-3 breeding males; all other individuals are non-reproductive subordinates. Subordinates show a remarkable lack of sex differences in behavior and anatomy, but can become reproductive if removed from the colony. The striated perineal muscles and their innervating motoneurons, which are sexually dimorphic in all other mammals examined, are not dimorphic in subordinate naked mole-rats. Here I asked whether sexual differentiation of this neuromuscular system occurs when subordinates become breeders. Sex differences in perineal motoneurons were not observed, regardless of social status. To my surprise counts of motoneurons in Onuf’s nucleus were increased in breeders of both sexes. This was accompanied by a reciprocal decrease in cells in Onuf’s nucleus that were characterized by small soma size. The neuronal changes correlate with increased perineal muscle volumes in breeders. Although not exhibiting typical motoneuron morphology, some small cells fit a neurochemical or functional definition of a motoneuron. I propose that small cells are recruited to the pool of large Onuf’s nucleus motoneurons when subordinate naked mole-rats become breeders. I then looked at naked mole-rats of varying status (subordinates, paired animals that have never reproduced, intact breeders, and gonadectomized breeders) to determine which cues elicit changes in perineal muscles and small cells in Onuf’s nucleus. I found that pairing is sufficient to cause decreases in the population of small cells in Onuf’s nucleus, while production of litters is necessary for increasing in perineal muscle size. The gonads were not necessary to maintain changes in small cells or perineal muscles. I hypothesized that the lack of sex differences in naked mole-rats might be related to their unusual social structure. To test this, I compared the genitalia and perineal muscles in three African mole-rat species: the naked mole-rat, the solitary silvery mole-rat, and the Damaraland mole-rat, a species considered to be eusocial, but with less reproductive skew than naked mole-rats. My findings support a relationship between social structure, mating system, and sexual differentiation.

The purpose of the present study was to determine olfactory detection thresholds in human subjects for a set of six sulfur-containing odorants which are known to be components of mammalian predator odors. Using a threealternative ascending staircase procedure, the olfactory sensitivity of 12 healthy adult human subjects, 6 males and 6 females was assessed with 2-propylthietane, 2,2-dimethylthietane, 3-mercapto-3-methylbutan-1-ol, 3-mercapto-3- methylbutyl formate, 3-methyl-1-butanethiol, and methyl-2-phenylethyl sulfide. The results showed that A) all six predator odorants were detected at concentrations below 1 ppb (parts per billion), and one of them (3-mercapto-3-methylbutyl formate) even at a concentration below 1 ppt (parts per trillion), B) structurally similar odorants yielded significantly different threshold values, and C) no significant sex differences were found in olfactory sensitivity with any of the six odorants. The findings obtained from the present study show that human subjects were not generally less sensitive to the predator odorants tested here compared to spider monkeys despite having a markedly lower number of olfactory receptor types. Further, they suggest that humans may be more sensitive to predator odorants compared to a variety of non-predator odorants. One possible explanation for the high olfactory sensitivity observed here is the fact that sulfur compounds typically can be detected at low concentrations. An alternative explanation derives from an evolutionary perspective as our human ancestors were a potential prey of large carnivores and  thus a high olfactory sensitivity for predator odors should be adaptive for humans.

No description available.

There is a large sex difference in the prevalence of attention deficit disorder; yet, little is known about sex differences in prefrontal attention circuitry. We investigated sex differences in the developmental nicotinic excitation of corticothalamic layer VI neurons, which play an important role in attention. Using whole cell recording in prefrontal brain slices, we examined the inward currents elicited by nicotinic stimulation in rodents. We found a prominent sex difference in the currents during the first postnatal month when males had significantly greater α4β2* nicotinic currents. Immunohistochemical analysis of α4YFP mice revealed no sex difference in the pattern or proportion of YFP-positive neurons in layer VI. Further electrophysiological experiments revealed that progesterone is able to rapidly and significantly suppress nicotinic currents in layer VI neurons. This is the first illustration at a cellular level that prefrontal attention circuitry is differently excited by nicotinic stimulation in males and females during development.

There is a large sex difference in the prevalence of attention deficit disorder; yet, little is known about sex differences in prefrontal attention circuitry. We investigated sex differences in the developmental nicotinic excitation of corticothalamic layer VI neurons, which play an important role in attention. Using whole cell recording in prefrontal brain slices, we examined the inward currents elicited by nicotinic stimulation in rodents. We found a prominent sex difference in the currents during the first postnatal month when males had significantly greater α4β2* nicotinic currents. Immunohistochemical analysis of α4YFP mice revealed no sex difference in the pattern or proportion of YFP-positive neurons in layer VI. Further electrophysiological experiments revealed that progesterone is able to rapidly and significantly suppress nicotinic currents in layer VI neurons. This is the first illustration at a cellular level that prefrontal attention circuitry is differently excited by nicotinic stimulation in males and females during development.