Diploma thesis describes Six Sigma methods and defines their application in manufacturing production. Study also analyze specific issue in manufacturing production and provide solutions.

This work deals with methods of lean six sigma methodology which are relate to industrial processes optimalization problems. Part of this work is devoted to progress optimalization solving by the help of DMAIC model and conection with six sigma and TOC. Main attention is set on using DMAIC model on data from technological line - Cobalt by Motorola.

Gábová P. Application of Six Sigma method in repair process. Master Thesis. Brno: Mendel University, 2019. Thesis describes application of Six Sigma method including DMAIC cycle in Zebra Technologies CZ s.r.o. Goal is to decrease number of defect products bouncing back into repair center along with material cost optimization. Prologue describes Six sigma principles and each individual step of DMAIC cycle. Next phase defines objective and scope, process mapping is part of Measure section. Further data analysis gives a definition to defect root cause. Project outcome are precautions proposals that lead to process quality improvement and cost optimization.

Metodologie Six Sigma se dnes používá v mnoha firmách a společnostech ke zlepšování kvality procesů a výrobků. Využívá k tomu různé statistické nástroje a jedním z hlavních je lineární regrese. Cílem této práce je stručný popis metodologie Six Sigma. V dalším kroku pak pomocí lineární regrese ale i jiných statistických nástojů eliminovat jednu výrobní operaci v konkrétním technickém procesu.

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Alcohol Use Disorder (AUD) is complex psychiatric disease characterized by increased alcohol intake, inability to control consumption, and a negative emotional state during withdrawal. In particular, one often-ignored feature of this negative state is the emergence of alcoholic-induced pain states, manifesting as both allodynia (when a non-noxious stimulus induces a nociceptive response) and hyperalgesia (when a noxious stimulus produces a heightened nociceptive response). Here, we first present evidence identifying standard chow diet as a factor in determining the amount of ethanol consumed as well as the preference for alcohol in an intermittent access to two bottle choice paradigm in mice. Additionally, while all ethanol experienced mice exhibit allodynia during withdrawal compared to the water drinking controls, the type of chow diet does not appear to affect its severity. We then investigated, using the same mouse model, the role of each of the two known subtypes of Sigma receptors, Sig-1R and Sig-2R, in both heavy alcohol drinking and associated pain states. We found that Sig-1R antagonists and Sig-2R modulators are able to decrease ethanol intake and hyperalgesia. Both excessive alcohol drinking and heightened pain states were found to be common outcomes also of another well-established model of alcohol dependence, the chronic intermittent ethanol vapor exposure (CIE), together with an increase of impulsive action. We, therefore, further investigated the role of Sig-1R in this post-dependent phenotype, and found that CIE increases Sig-1R levels in the prefrontal cortex, specifically in the anterior cingulate cortex (ACC) and the prelimbic cortex (PrL). Notably, knockdown of Sig-1Rs in the ACC via viral approach rescues hyperalgesia, but not allodynia nor impulsive action, suggesting that the ACC may be a critical area for alcohol-induced hyperalgesia, but not allodynia or impulsive action. Altogether, the results of this work give important insights into the role of Sig-1Rs in alcohol addiction, and have the potential to lead to novel pharmacological treatments for AUD. / 2023-03-27T00:00:00Z

The Focus of this mixed method research was the implementation of lean six sigma principles to improve productivity of outpatients’ programs where each case requires multiple scheduling, multiple visits to patients’ homes and multiple visits to the health department. The site is the Peoria City/County Health Department (PCCHD). The PCCHD is the delegate agency for Illinois Department of Public Health Childhood Lead Poisoning Prevention Program (EH). They are also a recipient of the Federal Lead-Based Paint Hazard Control (LHC) program from the Department of Housing and Urban Development (HUD). In line with their mission, they sought opportunities to review and streamline their lead abatement programs to improve productivity and effectiveness of service value offered to their recipients. This research analyzed the current state of lead abatement efforts in Peoria County and used lean six sigma methodologies to identify quantifiable opportunities to improve the effectiveness of PCCHD’s lead abatement efforts. Results show that through the use of lean six sigma methods, the lead time of the PCCHD lead abatement program Lead-Based Paint Hazard Control from the Department of Housing and Urban Development (HUD) was reduced by 30%. Secondly opportunities to eliminate duplication and omission of activities between lead abatement programs were identified and recommended. This research confirms that lean six sigma methods can also be applied successfully to more complex programs such as the lead abatement programs that require multiple scheduling, multiple visits to patients’ homes and multiple visits to the health department

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