The goal of this dissertation is to develop a model relating LENSâ„¢ process parameters to deposited thickness, incorporating the effect of substrate heating. A design review was carried out, adapting the technique of functional decomposition borrowed from axiomatic design. The review revealed that coupling between the laser path and laser power caused substrate heating. The material delivery mechanism was modeled and verified using experimental data. It was used in the derivation of the average deposition model which predicted deposition based on build parameters, but did not incorporate substrate heating. The average deposition model appeared capable of predicting deposited thickness for single line, 1- layer and 2-layer builds, performing best for the 1- layer builds which were built under essentially isothermal conditions. This model was extended to incorporate the effect of substrate heating, estimated using an energy partition approach. The energy used for substrate heating was modeled as a series of timed heating events from an instantaneous point heat source along the path of the laser. The result was called the spatial deposition model, and was verified using the same set of experimental data. The model appeared capable of predicting deposited thickness for single line, 1- layer and 2- layer builds and was able to predict the characteristic temperature rise near the borders as the laser reversed direction.

The focus of this dissertation is on the development of a solid freeform fabrication (SFF) process for the design and manufacture of porous biodegradable orthopaedic implants from calcium polyphosphate (CPP). Porous CPP structures are used as bone substitutes for regenerating bone defects and/or as substrates in formation of so-called “biphasic” implants for repair of damaged osteochondral tissues. The CPP implants can be utilized in the treatment of many musculoskeletal diseases, osteochondral defects, and bone tumours while replacement of the defect site is required. In this study, the fabrication of CPP structures was developed through a powder-based SFF technique known as adhesive bonding 3D-printing. SFF is an advanced alternative to the “conventional” fabrication method consisting of gravity sintering of CPP pre-forms followed by machining to final form, as SFF enables rapid manufacturing of complex-shaped bio-structures with controlled internal architecture. To address the physical and structural properties of the porous SFF-made components, they were characterized using scanning electron microscopy, micro-CT scanning and mercury intrusion porosimetry. Specific surface area and permeability of the porous structures were also determined. Additionally, the chemical properties (crystallinity) of the specimens were identified by X-ray diffraction. The mechanical properties of the crystalline CPP material were also measured by micro- and nano-indentation. Moreover, the porous structures were tested by uniaxial and diametral mechanical compression to determine the compressive and tensile strengths, respectively. Furthermore, the effect of the stacked-layer orientation on the mechanical properties of the SFF-made constructs was investigated through the production of samples with horizontal or vertical stacked-layers. The properties of the SFF-made samples were compared with those of the conventionally-made CPP constructs. The SFF-made implants showed drastically higher compressive mechanical strength compared to the conventionally-formed samples with identical porosity. It was also shown that the orientation of the stacked-layer has substantial influence on the mechanical strengths. Moreover, this thesis examined the ability of in vitro forming of cartilaginous tissue on the SFF-made substrates where the chondrocytes cellular response to the CPP implants was evaluated histologically and biochemically. In addition, an initial in vivo assessment of the CPP structures as bone substitutes was conducted using a rabbit medial femoral site model. Significant amount of new-bone was formed within the CPP porous constructs during the 6-week implantation period demonstrating appropriate biological response of SFF-made CPP structures for bone substitute applications. Another accomplishment of this thesis was the development of a mathematical model which predicts the compact density of powder layers spread by a counter-rotating roller in the SFF technique. The results may be used in the control of the apparent density of the final implant. The potential of the developed SFF method as an efficient and reproducible technique for the production of porous CPP structures for use in orthopaedics and musculoskeletal tissue regenerative applications was concluded.

Rapid prototyping (RP) is a set of fabrication technologies that are used to produce accurate parts directly from computer aided drawing (CAD) data. These technologies are unique in a way that they use an additive fabrication approach in which a three dimensional (3D) object is directly produced. In this thesis study, a RP application with a modular architecture is designed and implemented to satisfy the possible requirements of future rapid prototyping studies. After a functional classification, the developed RP software is divided into View, RP and Slice Modules. In the RP module, the process parameter selection and optimal build orientation determination steps are carried out. In the Slice Module, slicing and tool path generation steps are performed. View Module is used to visualize the inputs and outputs of the RP software. To provide 3D visualization support for View Module, a fully independent, open for development, high level 3D modeling environment and graphics library called Graphics Framework is developed. The resulting RP application is benchmarked with the RP software packages in the market according to their memory usage and process time. As a result of this benchmark, it is observed that the developed RP software has presented an equivalent performance with the other commercial RP applications and has proved its success.

The focus of this dissertation is on the development of a solid freeform fabrication (SFF) process for the design and manufacture of porous biodegradable orthopaedic implants from calcium polyphosphate (CPP). Porous CPP structures are used as bone substitutes for regenerating bone defects and/or as substrates in formation of so-called “biphasic” implants for repair of damaged osteochondral tissues. The CPP implants can be utilized in the treatment of many musculoskeletal diseases, osteochondral defects, and bone tumours while replacement of the defect site is required. In this study, the fabrication of CPP structures was developed through a powder-based SFF technique known as adhesive bonding 3D-printing. SFF is an advanced alternative to the “conventional” fabrication method consisting of gravity sintering of CPP pre-forms followed by machining to final form, as SFF enables rapid manufacturing of complex-shaped bio-structures with controlled internal architecture. To address the physical and structural properties of the porous SFF-made components, they were characterized using scanning electron microscopy, micro-CT scanning and mercury intrusion porosimetry. Specific surface area and permeability of the porous structures were also determined. Additionally, the chemical properties (crystallinity) of the specimens were identified by X-ray diffraction. The mechanical properties of the crystalline CPP material were also measured by micro- and nano-indentation. Moreover, the porous structures were tested by uniaxial and diametral mechanical compression to determine the compressive and tensile strengths, respectively. Furthermore, the effect of the stacked-layer orientation on the mechanical properties of the SFF-made constructs was investigated through the production of samples with horizontal or vertical stacked-layers. The properties of the SFF-made samples were compared with those of the conventionally-made CPP constructs. The SFF-made implants showed drastically higher compressive mechanical strength compared to the conventionally-formed samples with identical porosity. It was also shown that the orientation of the stacked-layer has substantial influence on the mechanical strengths. Moreover, this thesis examined the ability of in vitro forming of cartilaginous tissue on the SFF-made substrates where the chondrocytes cellular response to the CPP implants was evaluated histologically and biochemically. In addition, an initial in vivo assessment of the CPP structures as bone substitutes was conducted using a rabbit medial femoral site model. Significant amount of new-bone was formed within the CPP porous constructs during the 6-week implantation period demonstrating appropriate biological response of SFF-made CPP structures for bone substitute applications. Another accomplishment of this thesis was the development of a mathematical model which predicts the compact density of powder layers spread by a counter-rotating roller in the SFF technique. The results may be used in the control of the apparent density of the final implant. The potential of the developed SFF method as an efficient and reproducible technique for the production of porous CPP structures for use in orthopaedics and musculoskeletal tissue regenerative applications was concluded.

Thesis (M. Tech.) -- Central University of Technology, Free State, 2008 / As the tendency to use sol id freeform fabrication (SFF) technology for the manufacture of end use parts grew, so too did the need for a set of general guidelines that would aid designers with designs aimed specifically for rapid manufacture. Unfortunately, the revolutionary additive nature of SFF technology left certain fundamental principles of conventional design for manufacture and assembly outdated. This implied that whole chapters of theoretical work that had previously been done in this field had to be revised before it could be applied to rapid manufacturing. Furthermore, this additive nature of SFF technology seeded a series of new possibilities and new advantages that could be exploited in the manufacturing domain, and as a result drove design for rapid manufacturing principles even further apart from conventional design for manufacture and assembly philosophy. In this study the impact that rapid manufacture had on the conventional product development process and conventional design for manufacture and assembly guidelines were investigated. This investigation brought to light the inherent strengths and weaknesses of SFF, as well as the design for manufacture and assembly guidelines that became invalid, and consequently lead directly to the characterization of a set of design for rapid manufacture guidelines.

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