Orientador: Cassiano Sydow Quilici / Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Artes / Made available in DSpace on 2018-08-27T20:34:42Z (GMT). No. of bitstreams: 1 Merlino_MariaLuciaMoreira_D.pdf: 1405066 bytes, checksum: db272b20e5633bde50dfe462523cf783 (MD5) Previous issue date: 2014 / Resumo: Esta pesquisa investiga as relações existentes entre os conceitos de reeducação e consciência corporal promovidos através da abordagem somática Rolfing®-Integração Estrutural e a noção de experiência, quando emergem novas percepções, imagens corporais e representações mentais, colocando-se a metáfora como um produto possível do processo de exploração e transformação perceptual. O Rolfing é um sistema de reeducação postural e do movimento que, através do toque e da palavra, pode produzir alterações estruturais e funcionais do sistema musculoesquelético, mudanças nas percepções e sensações processadas no corpo. Como consequência, podem ocorrer mudanças no relacionamento com o ambiente, consigo mesmo e com o outro. O conceito de memória corporal compreende as disposições, habilidades e hábitos adquiridos num contexto social e político, que influenciam a experiência e o comportamento da pessoa, o que resulta numa trama complexa de sensações corpóreas de particular importância nas abordagens somáticas. A investigação se desdobra em três estudos de caso, abordando a relação entre instrutor e aluno e a situação em que ocorre o atendimento, como um "processo" análogo ao fazer artístico. A qualidade do toque, atenção e presença do instrutor, resultam numa escuta específica das demandas da pessoa, envolvendo tanto os discursos gestuais quanto os verbais. Podem ocorrer insights transformadores no decorrer deste percurso, e quando isso acontece, a metáfora emerge como expressão desta transformação, sendo um mecanismo de apropriação destas mudanças e propiciando processos de auto entendimento a partir do reconhecimento de um corpo-sensível. Esta pesquisa propõe uma categorização das metáforas corporais que emergem destes processos agenciados por abordagens somáticas, que podem fazer ressonância com aspectos estéticos, criativos, emocionais e éticos do sujeito / Abstract: This research investigates the relationship between the concepts of body re-education and body awareness, promoted through the somatic approach of Rolfing® Structural Integration, and also the notion of experience, from which emerge new insights, new body images and mental representations that put metaphor as a possible product of the process of perceptual exploration and processing. Rolfing is a system of postural and movement re-education in which, by touch and word, it is possible to produce structural and functional changes in the musculoskeletal system, in perceptions, and in the sensations processed in the body. As a result, changes may occur in the relationship with the environment, with the self and with others. The concept of body memory comprises dispositions, skills and habits acquired in a social and political context that influence the experience and behavior of a person, resulting in a complex web of bodily sensations of particular importance in somatic approaches. The investigation unfolds through three case studies, addressing the relationship between instructor and client, and the situation in which occurs a "process" analogous to the making of art. The quality of touch, attention and presence of the instructor, results in a specific listening to the demands of the person, involving both gestural and verbal discourse. Insights may occur in the course of this journey and, when this happens, metaphor emerges as an expression of transformation and as a mechanism of appropriation of these changes, providing self-understanding from the recognition of the 'sensitive body'. This research proposes a categorization of the bodily metaphors that emerge from a somatic approach - metaphors that have resonance with aesthetic, creative, emotional and ethical aspects / Doutorado / Artes Cenicas / Doutora em Artes

Somatic complaints of children in primary care settings often go unexplained despite attempts to determine a cause. Recent research has linked violence exposure to stress symptomatology and associated somatic problems. Unknown, however, is whether specific physical symptom complaints can be attributed, at least in part, to violence exposure. Urban African-American 6- and 7-year-old children (N = 268), residing with their biological mothers, recruited before birth, and without prenatal exposure to hard illicit drugs participated. Children and mothers were evaluated in our hospital-based research laboratory, with teacher data collected by mail. Community violence exposure (Things I Have Seen and Heard), stress symptomatology (Levonn), and somatic complaints (teacher-and self-report items) were assessed. Additional data collected included prenatal alcohol exposure, socioeconomic status, domestic violence, maternal age, stress, somatic complaints and psychopathology, and child depression, abuse, and gender. Community violence witnessing and victimization were associated with stress symptoms (r= .26 and .25, respectively, p < .001); violence victimization was related to decreased appetite (r = .16, p < .01), difficulty sleeping (r = .21, p < .001), and stomachache complaints (r = .13, p < .05); witnessed violence was associated with difficulty sleeping (r = .13, p < .05) and headaches (r = .12, p < .05). All associations remained significant after control for confounding. Community violence exposure accounted for 10% of the variance in child stress symptoms, and children who had experienced community violence victimization had a 28% increased risk of appetite problems, a 94% increased risk of sleeping problems, a 57% increased risk of headaches, and a 174% increased risk of stomachaches. Results provide yet another possibility for clinicians to explore when treating these physical symptoms in children.

lin-28 was first characterized as a developmental timing regulator in Caenorhabditis elegans. Loss of lin-28 function (lin-28(lf)) mutants skip the hypodermal cell fates specific to the 2nd larval stage. Here, we studied two aspects of lin-28 which had not yet been investigated. First, we show that lin-28(lf) mutants exhibit reduced fertility associated with abnormal somatic gonadal morphology. In particular, the abnormal spermatheca-uterine valve morphology of lin-28(lf) hermaphrodites traps embryos in the spermatheca, which disrupts ovulation and causes embryonic lethality. The same genes downstream of lin-28 in the regulation of hypodermal developmental timing also act downstream of lin-28 in somatic gonadal morphogenesis and fertility. Importantly, we find that hypodermal expression, but not somatic gonadal expression, of lin-28 is sufficient for restoring normal somatic gonadal morphology in lin-28(lf) mutants. We propose that the abnormal somatic gonadal morphogenesis of lin-28(lf) hermaphrodites results from temporal discoordination between the accelerated hypodermal development and normally timed somatic gonadal development. Thus, our findings exemplify how a cell-intrinsic developmental timing program can also control proper development of other interacting tissues, cell non-autonomously. We also investigated the expression patterns and functions of two lin-28 isoforms in C. elegans. Our analysis of spatial expression patterns suggests that lin-28a and lin-28b are co-expressed in diverse tissues. Consistently, neither of isoform specific knock-out mutant, lin-28a(lf) or lin-28b(lf), exhibits defects in hypodermal development, somatic gonad, or fertility, indicating functional redundancy of two isoforms. Our study will contribute to further investigation of lin-28 isoforms by providing the mutants of each isoform as well as the primary analysis of their phenotypes.

In a series of body objects, this project aims to discover the specific emotion of hopelessness through the physical sensation of gravity. The project is investigating a femininity concept by exploring the emotions evoked when reading about the myth of Pandora and how she is used in academic reports such as Diseases of Women to argue upon discriminating arguments directed towards a female identity. The outcome of the workshops situate this project in a participatory driven field where somatic experiences make it possible to discuss sensitive topics such as hopelessness and gender equality. The outcome of the project is five sensorial body objects that suggest possibilities in designing wear to trigger emotions. It should be presented as a participatory installation in an exhibition.

Objective 1 was to investigate effects of heat stress and breed on milk and component yield for Holstein and Jersey cows on the same farm. Objective 2 was to determine the effects of breed on udder health as measured by somatic cell count (SCC) during times of heat stress. Data were collected from DHIA records of 142 Jersey cows and 586 Holstein cows from the University herd at Mississippi State University. During heat stress Jersey milk yield and 4% fat corrected milk (FCM) increased (P<0.01). Holstein milk yield and FCM decreased during heat stress (P<0.01). Heat stress affected somatic cell count (SCC) although effects varied by intensity of heat stress. Breed did not have an affect on SCC. Milk fat and protein percentages declined for both breeds in heat stress conditions. Milk fat but not milk protein of Jersey cows increased as stress increased from mild to severe.

Somatic Cell Nuclear Transfer (SCNT), commonly known as cloning, is the transfer of a somatic nucleus into an enucleated oocyte to produce a clone. The chromatin structure of somatic cells permits the expression of certain genes, while silencing the rest of the genome. The cytoplasm of oocytes can reprogram a somatic nucleus by reactivating the genes necessary for embryonic development and silencing the somatic genes. However, the low efficiency of SCNT indicates that successful nuclear reprogramming is a rare event. The objectives of this study were determine the extent of transcriptional reprogramming in bovine blastocysts produced by serial rounds of chromatin transfer (from first and fourth generations), using blastocysts produced by in vitro fertilization (IVF) as controls, to identify cumulative errors in the transcriptome profile. Differentially expressed genes were studied further to determine their function in embryonic development. We identified a set of transcripts consistently misregulated in cloned blastocyst, some of which had a more marked misregulation in the embryos produced by 4 successive rounds of cloning. Among the genes significantly upregulated in both CT groups compared to IVF blastocysts were both de novo DNA methylation enzymes DNMT3A and DNMT3B. Expression patterns, structural and functional analyses were performed for DNA methyltransferases. A high structural and functional conservation was observed for DNA methyltransferases among human, mouse, and bovine species. A set of genes that participate in early embryonic development, chromatin remodeling and DNA methylation were differentially regulated in cloned embryos and had not been fully annotated at the time of the analysis. We annotated those genes and submitted them to the Bovine Genome Sequencing Consortium database. These results have important implications for the selection of models for the study of DNA methylation during early development. The present study provides a valuable data set for identifying possible cumulative errors in somatic cell chromatin transfer that could hinder nuclear reprogramming shedding light on the epigenetic role in reprogramming and cell plasticity.

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