Designing estimators based on low rank signal models is a common practice in signal processing. Some of these estimators are designed to use a single low rank snapshot vector, while others employ multiple snapshots. This dissertation deals with both these cases in different contexts. Separable nonlinear least squares is a popular tool to extract parameter estimates from a single snapshot vector. Asymptotic statistical properties of the separable non-linear least squares estimates are explored in the first part of the thesis. The assumptions imposed on the noise process and the data model are general. Therefore, the results are useful in a wide range of applications. Sufficient conditions are established for consistency, asymptotic normality and statistical efficiency of the estimates. An expression for the asymptotic covariance matrix is derived and it is shown that the estimates are circular. The analysis is extended also to the constrained separable nonlinear least squares problems. Nonparametric estimation of the material functions from wave propagation experiments is the topic of the second part. This is a typical application where a single snapshot vector is employed. Numerical and statistical properties of the least squares algorithm are explored in this context. Boundary conditions in the experiments are used to achieve superior estimation performance. Subsequently, a subspace based estimation algorithm is proposed. The subspace algorithm is not only computationally efficient, but is also equivalent to the least squares method in accuracy. Estimation of the frequencies of multiple real valued sine waves is the topic in the third part, where multiple snapshots are employed. A new low rank signal model is introduced. Subsequently, an ESPRIT like method named R-Esprit and a weighted subspace fitting approach are developed based on the proposed model. When compared to ESPRIT, R-Esprit is not only computationally more economical but is also equivalent in performance. The weighted subspace fitting approach shows significant improvement in the resolution threshold. It is also robust to additive noise.

This study investigates use of echocardiography to assess the related issues about whether the heart function of a subject examined is normal or not. Two-dimensional echocardiography can make the heart inspection, and provide very detailed informations for each part of the cardiovascular structures with a high degree of accuracy. Many studies indicated that the systolic and diastolic function with left ventricle of heart disease in patients was poorer than those of normal patients. Therefore it is of interest to study the systolic and diastolic function for examining whether there are heart problems. In this work, the data is the gray-scale values of left ventricular static ultrasound images. The gray-scale differences between systolic and diastolic period, are used to assess whether the patient suffers from the heart diseases or not. Here, we use factor analysis to simplify and select the crucial factors, namely the function in different area of the left ventricle. Finally, linear and quadratic discriminant analyses are used to distinguish the normal and the abnormal subjects.

One of the key challenges in the Oil & Gas industry is to best manage reservoirs under different conditions, constrained by production rates based on various economic scenarios, in order to meet energy demands and maximize profit. To address the energy demand challenges, a transformation in the paradigm of the utilization of "real-time" data has to be brought to bear, as one changes from a static decision making to a dynamical and data-driven management of production in conjunction with real-time risk assessment. The use of modern methods of computational modeling and simulation may be the only means to account for the two major tasks involved in this paradigm shift: (1) large-scale computations; and (2) efficient utilization of the deluge of data streams. Recently, history matching and optimization were brought together in the oil industry into an integrated and more structured approach called optimal closed-loop reservoir management. Closed-loop control algorithms have already been applied extensively in other engineering fields, including aerospace, mechanical, electrical and chemical engineering. However, their applications to porous media flow, such as - in the current practices and improvements in oil and gas recovery, in aquifer management, in bio-landfill optimization, and in CO2 sequestration have been minimal due to the large-scale nature of existing problems that generate complex models for controller design and real-time implementation. Their applicability to a realistic field is also an open topic because of the large-scale nature of existing problems that generate complex models for controller design and real-time implementation, hindering its applicability. Basically, three sources of high-dimensionality can be identified from the underlying reservoir models: size of parameter space, size of state space, and the number of scenarios or realizations necessary to account for uncertainty. In this paper we will address type problem of high dimensionality by focusing on the mitigation of the size of the state-space models by means of model-order reduction techniques in a systems framework. We will show how one can obtain accurate reduced order models which are amenable to fast implementations in the closed-loop framework .The research will focus on System Identification (System-ID) (Jansen, 2009) and Model Predictive Control (MPC) (Gildin, 2008) to serve this purpose. A mathematical treatment of System-ID and MPC as applied to reservoir simulation will be presented. Linear MPC would be studied on two specific reservoir models after generating low-order reservoir models using System-ID methods. All the comparisons are provided from a set of realistic simulations using the commercial reservoir simulator called Eclipse. With the improvements in oil recovery and reductions in water production effectively for both the cases that were considered, we could reinforce our stance in proposing the implementation of MPC and System-ID towards the ultimate goal of "real-time" production optimization.

A novel phrase recognition method is proposed. It eliminates the speech difference between intraspeaker or interspeaker by transform phrases to difference subspace. A new endpoint detection method is also proposed, it can detection the human speech signal more effectively. All methods are test and verify at Microsoft Windows environment.

Fault detection and diagnosis have gained central importance in the chemical process industries over the past decade. This is due to several reasons, one of them being that copious amount of data is available from a large number of sensors in process plants. Moreover, since industrial processes operate in closed loop with appropriate output feedback to attain certain performance objectives, instrument faults have a direct effect on the overall performance of the automation system. Extracting essential information about the state of the system and processing the measurements for detecting, discriminating, and identifying abnormal readings are important tasks of a fault diagnosis system. The goal of this dissertation is to develop such fault diagnosis systems, which use limited information about the process model to robustly detect, discriminate, and reconstruct instrumentation faults. Broadly, the proposed method consists of a novel nonlinear state and parameter estimator coupled with a fault detection, discrimination, and reconstruction system. The first part of this dissertation focuses on designing fault diagnosis systems that not only perform fault detection and isolation but also estimate the shape and size of the unknown instrument faults. This notion is extended to nonlinear processes whose structure is known but the parameters of the process are a priori uncertain and bounded. Since the uncertainty in the process model and instrument fault detection interact with each other, a novel two-time scale procedure is adopted to render overall fault diagnosis. Further, some techniques to enhance the convergence properties of the proposed state and parameter estimator are presented. The remaining part of the dissertation extends the proposed model-based fault diagnosis methodology to processes for which first principles modeling is either expensive or infeasible. This is achieved by using an empirical model identification technique called subspace identification for state-space characterization of the process. Finally the proposed methodology for fault diagnosis has been applied in numerical simulations to a non-isothermal CSTR (continuous stirred tank reactor), an industrial melter process, and a debutanizer plant.

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Computational methods for reducing the complexity of Finite Element (FE) models in structural dynamics are usually based on modal analysis. Classical approaches such as modal truncation, static condensation (Craig-Bampton, Guyan), and component mode synthesis (CMS) are available in many CAE tools such as ANSYS. In other disciplines, different techniques for Model Order Reduction (MOR) have been developed in the previous 2 decades. Krylov subspace methods are one possible choice and often lead to much smaller models than modal truncation methods given the same prescribed tolerance threshold. They have become available to ANSYS users through the tool mor4ansys. A disadvantage is that neither modal truncation nor CMS nor Krylov subspace methods preserve properties important to control design. System-theoretic methods like balanced truncation approximation (BTA), on the other hand, are directed towards reduced-order models for use in closed-loop control. So far, these methods are considered to be too expensive for large-scale structural models. We show that recent algorithmic advantages lead to MOR methods that are applicable to FE models in structural dynamics and that can easily be integrated into CAE software. We will demonstrate the efficiency of the proposed MOR method based on BTA using a control system including as plant the FE model of a machine tool.

The human genome contains tens of thousands of gene loci which code for an even greater number of protein and RNA products. The highly complex temporal and spatial expression of these genes makes possible all the biological processes of life. Altered gene expression by mutation or deregulation is fundamental for the development of many human diseases. The ultimate aim of this thesis was to identify gene expression changes relevant to cancer. The advent of genome-wide expression profiling techniques, such as microarrays, has provided powerful new tools to identify such changes and researchers are now faced with an explosion of gene expression data. Processing, comparing and integrating these data present major challenges. I approached these challenges by developing and assessing novel methods for cross-platform analysis of expression data, scalable subspace clustering, and curation of experimental gene regulation data from the published literature. I found that combining results from different expression platforms increases reliability of coexpression predictions. However, I also observed that global correlation between platforms was generally low, and few gene pairs reached reasonable thresholds for high-confidence coexpression. Therefore, I developed a novel subspace clustering algorithm, able to identify coexpressed genes in experimental subsets of very large gene expression datasets. Biological assessment against several metrics indicates that this algorithm performs well. I also developed a novel meta-analysis method to identify consistently reported genes from differential expression studies when raw data are unavailable. This method was applied to thyroid cancer, producing a ranked list of significantly over-represented genes. Tissue microarray analysis of some of these candidates and others identified a number of promising biomarkers for diagnostic and prognostic classification of thyroid cancer. Finally, I present ORegAnno (www.oreganno.org), a resource for the community-driven curation of experimentally verified regulatory sequences. This resource has proven a great success with ~30,000 sequences entered from over 900 publications by ~50 contributing users. These data, methods and resources contribute to our overall understanding of gene regulation, gene expression, and the changes that occur in cancer. Such an understanding should help identify new cancer mechanisms, potential treatment targets, and have significant diagnostic and prognostic implications.

Face and gait recognition problems are challenging due to largely varying appearances, highly complex pattern distributions, and insufficient training samples. This dissertation focuses on multilinear subspace learning for face and gait recognition, where low-dimensional representations are learned directly from tensorial face or gait objects. This research introduces a unifying multilinear subspace learning framework for systematic treatment of the multilinear subspace learning problem. Three multilinear projections are categorized according to the input-output space mapping as: vector-to-vector projection, tensor-to-tensor projection, and tensor-to-vector projection. Techniques for subspace learning from tensorial data are then proposed and analyzed. Multilinear principal component analysis (MPCA) seeks a tensor-to-tensor projection that maximizes the variation captured in the projected space, and it is further combined with linear discriminant analysis and boosting for better recognition performance. Uncorrelated MPCA (UMPCA) solves for a tensor-to-vector projection that maximizes the captured variation in the projected space while enforcing the zero-correlation constraint. Uncorrelated multilinear discriminant analysis (UMLDA) aims to produce uncorrelated features through a tensor-to-vector projection that maximizes a ratio of the between-class scatter over the within-class scatter defined in the projected space. Regularization and aggregation are incorporated in the UMLDA solution for enhanced performance. Experimental studies and comparative evaluations are presented and analyzed on the PIE and FERET face databases, and the USF gait database. The results indicate that the MPCA-based solution has achieved the best overall performance in various learning scenarios, the UMLDA-based solution has produced the most stable and competitive results with the same parameter setting, and the UMPCA algorithm is effective in unsupervised learning in low-dimensional subspace. Besides advancing the state-of-the-art of multilinear subspace learning for face and gait recognition, this dissertation also has potential impact in both the development of new multilinear subspace learning algorithms and other applications involving tensor objects.

Face and gait recognition problems are challenging due to largely varying appearances, highly complex pattern distributions, and insufficient training samples. This dissertation focuses on multilinear subspace learning for face and gait recognition, where low-dimensional representations are learned directly from tensorial face or gait objects. This research introduces a unifying multilinear subspace learning framework for systematic treatment of the multilinear subspace learning problem. Three multilinear projections are categorized according to the input-output space mapping as: vector-to-vector projection, tensor-to-tensor projection, and tensor-to-vector projection. Techniques for subspace learning from tensorial data are then proposed and analyzed. Multilinear principal component analysis (MPCA) seeks a tensor-to-tensor projection that maximizes the variation captured in the projected space, and it is further combined with linear discriminant analysis and boosting for better recognition performance. Uncorrelated MPCA (UMPCA) solves for a tensor-to-vector projection that maximizes the captured variation in the projected space while enforcing the zero-correlation constraint. Uncorrelated multilinear discriminant analysis (UMLDA) aims to produce uncorrelated features through a tensor-to-vector projection that maximizes a ratio of the between-class scatter over the within-class scatter defined in the projected space. Regularization and aggregation are incorporated in the UMLDA solution for enhanced performance. Experimental studies and comparative evaluations are presented and analyzed on the PIE and FERET face databases, and the USF gait database. The results indicate that the MPCA-based solution has achieved the best overall performance in various learning scenarios, the UMLDA-based solution has produced the most stable and competitive results with the same parameter setting, and the UMPCA algorithm is effective in unsupervised learning in low-dimensional subspace. Besides advancing the state-of-the-art of multilinear subspace learning for face and gait recognition, this dissertation also has potential impact in both the development of new multilinear subspace learning algorithms and other applications involving tensor objects.