Global ETD Search

1	Macromolecule Delivery into Mammalian Cells Using Supercharged Proteins Cronican, James January 2012 (has links) Delivery of macromolecules into mammalian cells in vitro and in vivo has enabled new areas of research and offers the potential for powerful new treatment options. Recent research has generated many delivery platforms but these solutions remain limited by scope, potency and safety. We have reported a superpositively charged green fluorescent protein (+36 GFP) with the ability to deliver nucleic acids into a variety of mammalian cell lines in vitro and to potently deliver protein in vitro and in vivo without toxicity. These results have directed us to identify a subset of naturally occurring human proteins with similar but previously unknown cell-penetrating and protein delivery properties. Preliminary efforts have been made towards establishing the therapeutic potential for supercharged proteins replacement of the cytosolic enzyme, argininosuccinate synthase. Preliminary efforts have also been made towards enhancing endosomal escape with \(His_{39} GFP\). cell penetrating citrullinemia enzyme replacement macromolecule delivery protein delivery supercharge molecular biology
2	Návrh sacího traktu s variabilní délkou pro experimentální zážehový motor / Design of Intake manifold with variable length for experimental SI engine Jelínek, Petr January 2016 (has links) This thesis discusses of the intake tract four-stroke ignition internal combustion engine and the filling efficiency and opportunities to increase this efficiency and consequently to optimize the course of torque and power at the specified serial engine. 3D model is the last point of this thesis.
3	Field Theoretic Lagrangian From Off-shell Supermultiplet Gauge Quotients Katona, Gregory 01 January 2013 (has links) Recent efforts to classify off-shell representations of supersymmetry without a central charge have focused upon directed, supermultiplet graphs of hypercubic topology known as Adinkras. These encodings of Super Poincare algebras, depict every generator of a chosen supersymmetry as a node-pair transformtion between fermionic bosonic component fields. This research thesis is a culmination of investigating novel diagrammatic sums of gauge-quotients by supersymmetric images of other Adinkras, and the correlated building of field theoretic worldline Lagrangians to accommodate both classical and quantum venues. We find Ref [40], that such gauge quotients do not yield other stand alone or "proper" Adinkras as afore sighted, nor can they be decomposed into supermultiplet sums, but are rather a connected "Adinkraic network". Their iteration, analogous to Weyl's construction for producing all finite-dimensional unitary representations in Lie algebras, sets off chains of algebraic paradigms in discrete-graph and continuous-field variables, the links of which feature distinct, supersymmetric Lagrangian templates. Collectively, these Adiankraic series air new symbolic genera for equation to phase moments in Feynman path integrals. Guided in this light, we proceed by constructing Lagrangians actions for the N = 3 supermultiplet YI /(iDI X) for I = 1, 2, 3, where YI and X are standard, Salam-Strathdee superfields: YI fermionic and X bosonic. The system, bilinear in the component fields exhibits a total of thirteen free parameters, seven of which specify Zeeman-like coupling to external background (magnetic) fluxes. All but special subsets of this parameter space describe aperiodic oscillatory responses, some of which are found to be surprisingly controlled by the golden ratio, [phi] = 1.61803, Ref [52]. It is further determined that these Lagrangians allow an N = 3 - > 4 supersymmetric extension to the Chiral-Chiral and Chiral-twistedChiral multiplet, while a subset admits two inequivalent such extensions. In a natural proiii gression, a continuum of observably and usefully inequivalent, finite-dimensional off-shell representations of worldline N = 4 extended supersymmetry are explored, that are variate from one another but in the value of a tuning parameter, Ref [53]. Their dynamics turns out to be nontrivial already when restricting to just bilinear Lagrangians. In particular, we find a 34-parameter family of bilinear Lagrangians that couple two differently tuned supermultiplets to each other and to external magnetic fluxes, where the explicit parameter dependence is unremovable by any field redefinition and is therefore observable. This offers the evaluation of X-phase sensitive, off-shell path integrals with promising correlations to group product decompositions and to deriving source emergences of higher-order background flux-forms on 2-dimensional manifolds, the stacks of which comprise space-time volumes. Application to nonlinear sigma models would naturally follow, having potential use in M- and F- string theories. Supersymmetry superspace supermultiplet adinkra automata adiankraic tensor product decomposition group theoretic lorentz group su(2) so(3) gauge quotient isomorphism surjective bijective image mapping indefinite adiankraic network sequence super poincare group haag lopuszanski sohnius theorem string theory m theory f theory nonlinear sigma model (numerical) algebraic geometry algebraic paradigms worldsheet worldsheet stacks supersymmetric lagrangians ansatz templates super potentials quantum mechanics field theory fermionic bosonic (super) zeeman background flux fields supergravity superfields young tableaux susy tableaux controlled chaos supercharge continuum chiral chiral twisted chiral Physics

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