Feria de Tecnología Móvil organizada la Dirección de Gestión del Conocimiento, Universidad Peruana de Ciencias Aplicadas (UPC). Noviembre 14, 2011. Lima, Perú. / Presentación utilizada para la conferencia: Reformando la Revolución Digital, en el marco de la I Feria de Tecnología Móvil organizada la Dirección de Gestión del Conocimiento que pertenece al Vicerrectorado de Planeamiento y Desarrollo de la Universidad Peruana de Ciencias Aplicadas (UPC).

This thesis is compromised of two distinct formulation sections, which are described below: New compression-coated tablet formulations were developed for amoxicillin/clavulanate. Amoxicillin in an outer coat was separated from clavulanic acid in a core tablet by inactive ingredients in a middle coat. A chewable compression-coated tablet formulation with 50% stearic acid in the middle coat showed high clavulanic acid stability in comparison to the marketed traditional tablet formulation. Stearic acid acted as a hydrophobic barrier that prevents passage of moisture through the outer coats into the core and it helped in the bonding of the outer coats to the core because it softens upon compression. The bioavailability of clavulanic acid, however, was reduced which was attributed to the effect of stearic acid. Stearic acid was removed from the formulation of swallow tablets and replaced with Avicel��, consequently, the outer coat did not adhere tightly to the core and tended to cap off, which resulted in low stability of clavulanic acid. In bioavailability studies of the swallow tablets, the two formulations were equivalent to the marketed formulation for amoxicillin, but not for clavulanic acid, which is most likely due to the small sample size studied and high intersubject variation. Nisin, an antimicrobial protein, was evaluated for ability to emulsify oil-in-water using conductivity measurements. In comparison to Tween�� 80 and ��-casein, nisin showed substantial emulsifying activity. The emulsifying activity was found to be highly concentration- and pH-dependent. Nisin was found to form a gel-like structure at the oil water interface which retarded release of the drug sulfasalazine. Interfacial tension kinetics exhibited by nisin at an oil-water interface were monitored with DuNoy tensiometry. Interfacial pressure kinetics were interpreted with reference to a simple model that allows for a protein to be adsorbed in structurally dissimilar states. The model suggested that nisin's tendency to adapt a more unfolded structure at the oil-water interface increases with decreasing concentration. The effects of nisin on drug release from oil-in-water emulsions, and on erythrocytes were evaluated as well. It was found that nisin retards drug release in emulsions and lyses red blood cells. / Graduation date: 1999

Dry powder coating of pharmaceutical dosage forms has been investigated as an alternative method to commonly used liquid based coating techniques. Eudragit[trademark] L 100-55 and Eudragit[trademark] L 30 D-55 have been employed in enteric film coatings using aqueous dispersions, organic solutions and compression coating. However, the copolymer has not been investigated in dry powder coating applications. Initially, formulation factors and processing parameters were investigated for the dry powder coating of chlorpheniramine maleate tablets using Eudragit[trademark] L 100-55 as the delayed release polymer. Powder coating was studied as a method to prevent the migration of an ionizable, highly water soluble model drug into the polymeric film during the coating process. Eudragit[trademark] L 100-55 was pre-plasticized with triethyl citrate (TEC) using hot-melt extrusion and subsequently ground into a fine powder. Polyethylene glycol 3350 (PEG 3350) was used as a primer and low melting coating excipient to enhance coating powder adhesion and to improve film formation. The powder coating process was performed in a modified laboratory scale spheronizer. For the dry-powder coating of sodium valproate tablets different subcoating materials were investigated to improve powder adhesion to the substrate and to reduce the level of Eudragit[trademark] L 100-55 required for gastric resistance. PEG 3350 and Methocel[trademark] K4M were incorporated in the Eudragit[trademark] E PO and Eudragit[trademark] RL PO subcoating formulations as pore forming materials. The miscibility of the PEG 3350 and Methocel[trademark] K4M in the film coating was correlated with their ability to function as pore forming agent. The film formation process of thermally cured Eudragit[trademark] L 100-55 dry-powder coatings was characterized. The influence of film additives on relative melt viscosity, surface free energy of the polymer and the mechanical properties of powder-cast films was studied. The influence of Eudragit[trademark] E PO in Eudragit[trademark] L 100-55 film coatings applied by a dry powder coating technique on the drug release mechanism was investigated. Calculation of the Flory-Huggins interaction parameter based on solubility parameters and different analytical techniques demonstrated immiscibility of the copolymers at processing conditions. A broad range of pH dependent theophylline release profiles were obtained as a function of the polymer blend ratio. / text

The Future Relationship of Print and E-Readers was based on reviewing print formats as they have been, are becoming and could be in the future. This research focused on people's experience with e-readers, tablets, smartphones and laptops. Examining print includes how advertising is processed in different formats. The primary research for this study was done through an electronic survey, after obtaining IRB approval. The results are displayed through different charts and graphs, showcasing the different statistics. There was some cross tabulation as well. In the future, it appears that both mediums could prove themselves valid if they are willing to present themselves as two unique formats that are also able to provide unity to an overall product brand image as well as internal advertising. In the future, the public will be more aware of the different uses of these formats while increasingly using them. Advertising will parallel this trend by increasing as companies grow in utilizing this format to communicate with the public. / text

Thesis (Ph. D.)--University of Wisconsin--Madison, 1969. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1959. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographies: leaves 56, 78.

Controlled and sustained release dosage forms are the focus of worldwide research. These dosage forms facilitate patient compliance by simplifying the dosage regimen, and decrease the risk of adverse effects by reducing large fluctuations in the plasma concentration of the drug. The objective of this study was to formulate a repeat-action tablet to provide a sustained release dose of pseudoephedrine sulfate (PSS), and an immediate release dose of both PSS and loratadine. The release profile was compared to that of a commercially available preparation, Clarityne-D®. This formulation developed presents a novel mechanism of sustaining the release of PSS. The prototype tablet consisted of a sustained release core coated with an ethylcellulose dispersion to introduce a lag phase into the release profile and a second outer film coat incorporating PSS and loratadine. The core comprised an ethylcellulose granulation of PSS compressed into a hydroxypropyl methylcellulose matrix. The release of PSS from prototypes was assessed using USP Apparatus 3, as this apparatus was more representative of in vivo conditions and discriminated more effectively between the different tablet compositions produced during development. All dissolution samples were analysed for PSS and loratadine using validated highperformance liquid chromatographic methods. The prototype sustained release cores were found to be more resistant than the reference product to elevated temperature and humidity (40°C/87% RH) with fewer observed changes to the release profiles following storage for up to six months. This study was a feasibility study to obtain proof of concept. The release profile obtained from the prototype tablets was similar (f₂ = 50.0) to that of the reference product. Further development and optimisation of this dosage form is necessary, including evaluation of the choice of hydrophobic polymer, the effect of compression force and tablet geometry and characterisation of the release mechanism from the coated matrix. Assessment of these factors is necessary in order to optimise the formulation with respect to the desired therapeutic objectives.

The aim of this study was to evaluate the effect of the type of lubricant, its concentration and mixing time with granules on the tablet hardness, ejection force and the lubrication index. Lactose was used as a filler in granules and polyvinylpyrolidone as a binder. Granules were prepared by wet granulation. Three types of talc were used in concentrations 1%, 3%, 5%, 7% a 10% and magnesium stearate in concetrations 1%, 2% a 3% as lubricants. Tablets were produced by tablet press DOTT Bonapace (model CPR-6) with the possibility to measure the force of the upper and lower punch and force-displacement. These values were used for the calculation of the lubrication index. The values of lubrication index were used for the lubricants comparison. The lubrication index with magnesium stearate did not change either with increasing concentration or with mixing time with granules. In case of each type of talc, the lubrication effect rose with increasing concentration but time of the mixing did not have any significant effect on the lubrication potential. Tablet strength decreased with higher lubricant concentration and longer mixing time when magnesium stearate was used. With increasing concentration of the lubricant tablet strength with talc first increased then stagnated or started to decrease. The higher...

Swedish schools have during the last few years started to providing pupils in high school with tablet-computers. By doing interviews I examine how pupils in high school use tablet-computers in different ways and how that affect their studies. From a sociocultural perspective and with the concept of artefacts I analyze how suitable tablet-computers are for studies on this level of education. My results show that the tablet-computers are used as the pupils primary study tool. They are available to all pupils and can be used in most parts of their studies and this creates new opportonities in how to interact with collective knowledge and with other people. The pupils in this study do not think that the tablet computers, at this pint are suitable when it comes to using them for examinations, advanced visual design and creating more extensive texts. My conclusion is that tabet-computers have qualities that could contribute to high school pupils studies in a meaningful way. However the strategies through which they are implemented are critical to whether tablets-computers actually will improve pupils studies or not.

Magíster en Educación mención Informática Educativa / La presente investigación tiene como objetivo determinar el incremento de las habilidades de comprensión lectora y la percepción de los alumnos de NB2 de educación general básica frente a la integración de aplicaciones educativas para tablet en la asignatura de Lenguaje y Comunicación. Para llevar a cabo este estudio se contó con el apoyo de Samsung y el Colegio Alemán de Santiago, quienes facilitaron los recursos tecnológicos necesarios, para que esta iniciativa pudiese prosperar. Esta investigación se realizó con un diseño cuasi-experimental, en la cual se trabajó con dos terceros básicos, uno de control y otro experimental. Se utilizó una metodología carácter cuantitativo, con aportes cualitativos que ayudaron a complementar la visión de este informe. En base a la metodología cuantitativa se midieron las habilidades de los estudiantes respecto a la comprensión lectora en un pre-test; luego se diseñó e implementó un programa de intervención que contempló la integración curricular de las tablets y sus aplicaciones educativas, para finalmente analizar los resultados obtenidos en el post-test. Paralelamente se estableció la percepción de los estudiantes respecto a la integración de tablet en el aula. Desde el punto de vista cuantitativo, se puede concluir que los estudiantes del grupo experimental no incrementaron su comprensión lectora con la integración de las tablets al proceso de enseñanza aprendizaje; no obstante, sus resultados fueron significativamente mejores que el grupo de control. Además, la integración de este dispositivo en el aula permitió disminuir la brecha entre los estudiantes más descendidos y el promedio del curso, logrando una mayor equidad. Finalmente, es muy importante destacar la motivación de los estudiantes en la sala de clases, pues mediante el focus group fue posible evidenciar su gran interés por aprender más con tablets, ya que creen que es una ventana a la tecnología del futuro