Diploma thesis "Patellofemoral pain syndrome and its affection by patellar taping" consists of two parts. The first general part summarises all present knowledge in the field of classification, diagnostics and therapy of this syndrome. The experimental part investigates a partial area of conservative therapy and a patellar taping technique according to McConnell. With the use of EMG records of a group of patients with patellofemoral pain syndrome it assesses the immediate effect of patellar taping on the pain intesity and timing of m. vastus medialis obliquus to m. vastus lateralis throughout three different movements. Powered by TCPDF (www.tcpdf.org)

The thesis titled Evaluation design therapy of neurogenic disorders of language in clinical speech therapy aims to find out what effect the speech reeducation to improve communication skills in people with acquired neurogenic communication disorders speech. Next, determine whether therapy plays a role during client environment, if the success rate of therapy affected patient's condition and the extent to which the clients are motivated to therapy. The theoretical part summarizes the findings from the literature on neurogenic communication disorders, aphasia and dysarthria. Each chapter is devoted to the terminological definition and definition, etiology, symptoms (for aphasia), classification, diagnostics and therapy. The practical part deals with the research survey. There are set targets mentioned methodology, research sample characteristics and place of the investigation. Following processing of four case studies. Which describes the therapy sessions and individual work with clients. KEYWORDS Neurogenic speech disorders, aphasia, dysarthria, logopedic therapy

The main aim of the study is to determine a body composition in participants of weight reduction program STOB, based on group cognitive behavioral therapy of obesity. The program lasted 12 weeks and participants underwent a cognitive behavioral therapy and followed a diet and physical activity plan. The body composition was measured by bioelectrical impedance InBody 230 at the initial and final lesson. We examined a participant's body weight, skeletal muscle, fat mass, abdominal fat mass and BMI. At the end of the weight reduction program participants lost 5% (-4,6kg) of their initial weight, achieved significant decrease in fat mass (average -4,3kg and -3%), lost 14,4cm2 of abdominal fat mass and mean BMI value decreased by 1,7. A muscle component hasn't significantly changed within the weight reduction program. The effect of 12 week weight reduction program STOB resulted in significant changes in body composition, which are associated with reduced risk of cardiovascular and metabolic complications of obesity. Using cognitive behavioral therapy as an obesity management strategy is positively evaluated especially for its effect on long term weight reduction and effective relapse prevention. Therefore a future study should be focused on a long term re-evaluation of changes in body composition in...

The progress of cell therapy can be greatly facilitated by using suitable experimental models. It is essential to verify the clinical usefulness of new healing procedures obtained in studies on laboratory animals by using a large animal model. One of suitable models well acceptable in medical community is undoubtedly the miniature pig, which resembles humans in terms of physiology and body proportions. This PhD thesis presents the summary of our experimental studies relating to possible exploitation of mesenchymal and neural stem cells in the healing of locomotive apparatus and neural tissue disorders in humans or animals. The first part of the thesis briefly describes the current issue of cell therapy and animal models, mesenchymal cells and/or their combination with new types of scaffolds, neurogenesis, neural stem cells and their potential application in therapy of spinal cord injury. The second part is focused on the goals and methodology, the individual publications being listed in the third part. Our experiments with iatrogenic physeal defect in rabbits, which served as a model of the occurrence of valgous deformation in the clinical practice, showed the positive preventive and therapeutical effects of a new type of scaffolds seeded with allogeneic mesenchymal stem cells in animals without...

Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Kateřina Erbenová Supervisor: PharmDr. Martina Čečková, Ph.D. Title of diploma thesis: Study of interactions antiretroviral drug maraviroc with drug transporters ABCB1 and ABCG2. Maraviroc is inhibitor of CCR5 HIV virus entry into the cells representing one of the important components of antiretroviral therapy. To optimize the treatment strategies and minimize the therapeutic risks of maraviroc-containing combination antiretroviral therapy, it is important to know the interactions of this drug with other antiretrovirals. In particular, interaction on membrane transporters may affect pharmacokinetics and thereby the tissue concentrations of administered drugs, leading to insufficient efficacy of the therapy or increased toxicity. The aim of this study was to experimentally evaluate interaction of maraviroc with the two most important active drug transporters of the ABC transporter superfamily, ABCB1 (P-glycoprotein) and ABCG2 (BCRP). Using in vitro methods employing cell lines we aimed to fulfil two main goals: (1) to evaluate the inhibitory effect of maraviroc on ABCB1 and ABCG2 transporters and (2) to study if any of these transporters could transfer maraviroc as their substrate. The data...

The aim of this diploma thesis is to implement a presentation layer for the Reminiscence Computer Therapy application. Reminiscence Therapy involves the discussion of the past memories and it is believed to help people with dementia to improve their well-being and sustain their memories. Computer Reminiscence Therapy involves technology in this therapy. The research introduces into Dementia and Reminiscence Therapy with and without using technologies. The application developed as part of this diploma thesis uses picture upload and speech recognition techniques for the memory input. This is used to support remembering of past memories and to increase discussion. The application can be used with or without the carer as well as with friends and family members. The six most important requirements on the developed application are the speech recognition, picture upload, asking questions about the previous recordings, asking questions about tagged friends, using old stories for discussion and presenting the statistics. The application was developed as a part of the competition made by AngelHack organization. Presentation, business and persistence layers of the application are discussed in this diploma thesis as well as user manual and persistence layer implementation of the requirements. The presentation layer was developed using React framework for JavaScript. Other libraries have to be used as well with the most important being Redux library for storing application state. This library affected the structure of the persistence layer.

The Thesis deals with the interconnection of the Gestalt approach and the Supervision. The aim of the thesis is to map and search the possible use of the principles and concepts of the Gestalt therapy in the field of offering the Supervision through the statements of experiences, attitudes, knowledges and the unique reality of six wise supervisors who know the theory and practice of the Gestalt approach. First, the Gestalt Therapy is presented, its basic principles and concepts are named. Then the Supervision is defined, its general principles are enumerated, its relation to the Psychotherapy is defined and pursuant the available resources the Supervision is viewed from the Gestalt Therapy pespective. Qualitative research which is the core of the work combines procedures of the Phenomenological method and the grounded theory. The results found during the research are presented by the paradigmatic model and the graphic model, which visualize Gestalt principles and concepts used in the supervision process. The results are accompanied by the vivid testimonies of the participants so the Thesis might inspire not only supervisors with the interest in the Gestalt Therapy. Eventually the results are summarized, discused and further action is offered. Key words: Gestalt Therapy, supervision, here and know,...

Influenza viruses cause respiratory illnesses which can vary in severity depending on the strain of the virus, as well as the age and health condition of the host. Influenza remains a major threat to public health due to its nature prone to suffer mutations. As a result, vaccines have to be reformulated annually and new strains may cause sporadic global pandemics. Furthermore, the recent emergence of resistant strains of the virus against the current standard of care (oseltamivir and zanamivir) underlines the need of novel anti-influenza therapeutics. The aim of this dissertation work is to contribute to the discovery of new anti-influenza inhibitors either by rational drug-design and optimization of oseltamivir structure, or by developing screening assays suitable for the discovery of novel inhibitors of the enzymes neuraminidase or RNA-polymerase. Scheme 1. Overview of the strategy used for the development of new anti-influenza therapeutics. The dashed arrows indicate the inhibitors that were converted into probes and their corresponding target enzymes Two main modification points were explored for the improvement of oseltamivir properties (Scheme 1); modifications at carbon C-3 aimed to overcome oseltamivir resistance caused by common mutations like H274Y, meanwhile modifications at carbon C-5...

Hierdie studie fokus op hoe persone wat van dwelms afhanklik is of was, hulle identiteit sien. Daar is ’n bekende diskoers wat sê: “Een keer ’n verslaafde, altyd ’n verslaafde.” Hierdie diskoers impliseer dat afhanklikheid deel van ’n persoon se identiteit word. In my studie poog ek om hierdie diskoers te dekonstrueer. Die AA (Alkoholiste Anoniem) se twaalf-stap-program word bestudeer. In hulle eerste stap word daar van persone wat van ’n chemiese stof afhanklik is, verwag om te erken dat hy/sy ’n afhanklike is. Hierdie erkenning van die AA se eerste stap, het ’n direkte invloed op persone wat van dwelms afhanklik is of was. Saam met die medenavorsers, word daar gepoog om ’n alternatiewe manier te vind om na afhanklikheid en identiteit te kyk. Hiermee saam speel die Christendom en ’n persoon se Godsbegrip ’n groot rol. Die Christendom het verskillende sieninge oor afhanklikheid en sonde. Hierdie studie poog nie om die sondebegrip van die Nuwe Testament te bestudeer nie, aangesien hierdie nie ’n Nuwe-Testamentiese studie is nie. Hoe God en die medenavorsers sonde verstaan, speel ’n rol in die begrip van hulle identiteit. Die narratiewe benadering maak van metafore gebruik. Hierdie studie gebruik die metafoor van ’n draak. Aanvanklik is dit ’n gevreesde draak wat persone wat afhanklik van dwelms is of was, wil verslind en ’n direkte impak het op hulle identiteit. ‘n Nuwe metafoor het ontwikkel. Die animasiefilm, “How to train your dragon,” is as vertrekpunt gebruik om ’n nuwe metafoor te ontwikkel waar die draak steeds gevaarlik is, maar getem kan word. Deur sekere aanpassings te maak, kan persone wat afhanklik is of was van dwelms, die draak beheer. Hierdie nuwe metafoor gee ook ’n nuwe identiteit aan die persoon wat afhanklik is of was van dwelms. Afhanklikheid word nie meer as deel van ’n persoon se identiteit beskou nie aangesien die hantering van die draak ’n nuwe perspektief in die lewe van hierdie persoon gee. In my studie maak ek van kwalitatiewe navorsing gebruik en beweeg ek vanuit die oogpunt van ’n postfundamentele Praktiese Teologiese benadering. / Thesis (PhD)--University of Pretoria, 2017. / Practical Theology / PhD / Unrestricted

This thesis discusses the photodynamic therapy (PDT) and it's application for dia- gnostics of tumours. The PDT is based on production of reactive oxygen species (ROS) from the molecules of photosensitizers (PS). PS are preferentially accumulated in disea- sed tissues, where ROS are produced and cause selective destruction of the target tissue, while surrounding healthy tissue remains intact. The photodynamic diagnostics uses the fluorescence of PS for digital and spectral imaging. This thesis is focused on detection of tumours from spectral characteristics of protoporphyrin IX fluorescence induced in tis- sue by methyl-aminolevulinate. The main part of the research was realised on rats' scars in vivo, the solutions of homogenized mouse fibroblasts were also studied. The way to distinguish between diseased and healthy tissue was found using measurements of fluo- rescence bleaching kinetics.