<p> Embedded deterministic test (EDT) is a manufacturing test paradigm that combines the compression advantage of built-in self-test with the high fault coverage of deterministic stimuli inherent to methods based on automatic test pattern generation and external testers. Despite enabling the use of low cost testers for rapidly achieving high fault coverage, EDT must consciously use the available tester channels to ensure non-disruptive scaling to future devices of increased complexity. The focus of this thesis is to introduce a new EDT approach for systems-on-a-chip (SOCs) that are designed using embedded cores that are intellectual property (IP)-protected.</p> <p> Following an introduction to integrated circuit testing and an overview of the related work, we define the criteria that must be satisfied by the EDT approaches for the future SOCs of ever growing complexity. Then we observe that the necessary amount of compressed volume of test data transferred from the tester to the embedded cores in an SOC varies significantly during the testing process. This motivates a novel approach to compressed SOC testing based on time-multiplexing the tester channels. It is shown how the introduction of test control channels will reduce the number of required test data channels which will then have increased usage, as the embedded cores will receive compressed test data only when necessary. Through the use of modular and scalable hardware for on-chip test control and test data decompression, we define a new algorithmic framework for test data compression that is applicable to SOCs comprising IP-protected blocks. Experimental results indicate that our approach compares to the existing approaches for EDT that have similar design criteria and methodology constraints, while providing a seamless integration to low cost test equipment.</p> / Thesis / Master of Applied Science (MASc)

The automated testing of internal combustion engines is a field of considerable importance. This thesis describes a novel area in the form of dynamic testing. The investigation represents an original approach to the problem with which the author believes he has developed a new concept in engine testing. The resulting information, combined with an appreciation of the latest developments in automation equipment technology, has lead to a review of the requirements of a generalised engine test system together with an outline of the way in which it could be implemented. The automated engine test beds used during the work are described. The conventional methods of testing internal combustion engines are reviewed and a generalised approach to automating them proposed. This then leads to the suggestion of a new method using dynamic testing techniques specially evolved in the course of the work. On the basis of this the implementation of a dynamic full-load power curve as a replacement for its steady state equivalent was pursued. The second major use of dynamic techniques is for exhaust emission cycles. Both dynamic (USEPA Smoke Cycle) and steady-state (USEPA 13 Mode Cycle) cycles were performed. In the case of the former, outer digital loop techniques were used to improve control response. In performing the above work, use was made of both analog and digital simulation techniques for development purposes. This work was also extended by the development of a simulation of a material handling system to enable the control and optimisation of a production test facility to be studied. The testing methods associated with automated fault diagnosis are also analysed. On the basis of the above work an engine test system task analysis was generated and this new concept used to plan a microprocessor based engine test automation scheme.

Endometriose (EM) ist eine häufige gynäkologische Erkrankung, die bei betroffenen Frauen unter anderem mit chronischen Unterleibsschmerzen und Unfruchtbarkeit einhergeht (VALLE 2002). Bisher war es bei den zur Forschung verwendeten Modelltieren für EM (z.B. Rhesusaffe, ZONDERVAN et al. 2004; Weißbüschelaffe, EINSPANIER et al. 2006) nicht möglich festzustellen, ob bei ihnen schmerzhafte Beeinträchtigungen durch die Erkrankung bestehen. Um die Auswirkungen neuer Therapeutika auf das Wohlbefinden der Patientinnen bewerten zu können, werden Methoden benötigt, mit denen EM bedingte Beeinträchtigungen der Modelltiere dargestellt werden können. Daher war es das Ziel dieser Studie, bei einem Primatenmodell für EM, dem Weißbüschelaffen, neue nicht invasive Testsysteme zu etablieren, die zur Darstellung von EM bedingten Schmerzen und Beeinträchtigungen geeignet sind. Unter der Annahme, dass schmerzhafte Erkrankungen das Verhalten (WALLACE et al. 1990), die Beweglichkeit (FLECKNELL 1986) sowie die kognitiven Fähigkeiten (SMITH et al. 2006) der betroffenen Tiere beeinträchtigen können, wurden drei nicht invasive Testsysteme auf ihre Eignung untersucht, Schmerzen bei an EM erkrankten Weißbüschelaffen im Vergleich zu Kontrolltieren darzustellen. Zur Untersuchung des Verhaltens wurde die Videoüberwachung, für die motorischen Fähigkeiten der Futterbaum (modifiziert nach ROBERTS et al. 1993) und für die kognitiven Fähigkeiten der Wisconsin General Test Apparatus (WGTA, HARLOW 1949) sowie der Futterbaum verwendet. Im ersten Abschnitt dieser Studie wurde das Normalverhalten von neun Weißbüschelaffenpaaren per Videokamera über den gesamten Tagesverlauf von zwölf Stunden aufgezeichnet und unter anderem in Bezug auf Aktivität, soziale und eigene Körperpflege sowie Futter- und Wasseraufnahme analysiert. Der Verlauf der Tagesaktivität zeigte drei Maxima zwischen 7:00 und 8:00 Uhr, 11:00 und 12:00 Uhr sowie 14:00 und 15:00 Uhr, dabei war die ansteigende Aktivität als Futtersuchverhalten vor den Mahlzeiten zu werten. Das im ersten Abschnitt der Studie dargestellte Aktivitätsmuster wurde im zweiten Abschnitt verwendet, um die Versuche mit WGTA und Futterbaum besser in den Tagesverlauf der Tiere einzuordnen und darüber ihre Kooperativität zu steigern. Die Tiere führten die Tests immer zur gleichen Tageszeit durch, deshalb wurde somit eine optimale Vergleichbarkeit und Homogenität der Ergebnisse gewährleistet. Bei der Auswertung der Videodokumentation im zweiten Abschnitt dieser Studie zeigte sich, dass erkrankte Weibchen ihren Partner im Gegensatz zu den Kontrolltieren gar nicht pflegen (p=0,029) und die Aktivität der erkrankten Weibchen zwar deutlich, aber nicht signifikant (p=0,057) verringert war. Diese verringerte Aktivität ist möglicherweise ein Hinweis auf Schmerzen der an EM erkrankten Weibchen, während die nicht vorhandene soziale Körperpflege den partnerschaftlichen Problemen betroffener Frauen entsprechen könnte. In den ersten beiden kognitiven Tests mit dem WGTA führten die erkrankten Weibchen signifikant weniger Versuche pro Tag durch als die Kontrolltiere (p=0,006/ p=0,008). Darüber hinaus benötigten die erkrankten Tiere signifikant mehr Versuche, um den ersten Test zu verstehen (p=0,008). Diese Unterschiede zu den Kontrolltieren ließen sich in den folgenden drei Versuchsabschnitten nicht mehr nachweisen. Daraus lässt sich ableiten, dass die Weibchen mit EM sich schlecht auf neue Anforderungen einstellen und sich weniger lange auf eine gestellte Aufgabe konzentrieren können. Nach der International Primatological Society (MC CANN et al. 2007) kann eine verminderte Fähigkeit, sich auf neue Situationen einzustellen, als Anzeichen für Beeinträchtigungen gewertet werden. Bei der Auswertung der Futterbaum Testreihen, in denen sowohl kognitive als auch motorische Fähigkeiten der Tiere mit einer Art „Kletterbaum“ überprüft wurden, ergaben sich demgegenüber keine signifikanten Unterschiede zwischen der EM-Gruppe und den Kontrolltieren. Zusammenfassend eignen sich die Videodokumentation und der WGTA zur Darstellung von Beeinträchtigungen bei an EM erkrankten Weißbüschelaffen. Die beiden Testsysteme können in folgenden pharmakologischen Studien verwendet werden, um erstmals die Auswirkungen neuer Therapeutika auf das Wohlbefinden der Modelltiere zu bewerten. Zusätzlich ermöglichen die Ergebnisse dieser Studie ein Refinement (RUSSELL und BURCH 1959), da die bisher verwendeten invasiven Methoden (Laparoskopie, Laparotomie) zur Bewertung des Verhaltens der EM Läsionen unter einer Therapie ergänzt und sogar ersetzt werden könnten. / Endometriosis (EM) is a common gynecological disease, which is known to cause chronic pelvic pain and infertility in women (VALLE 2002). Up to now, it was not possible to assess, whether the animal models for research (e.g. rhesus macaque, ZONDERVAN et al. 2004; common marmoset, EINSPANIER et al. 2006) suffer from pain or impairments due to the disease. Therefore, new test systems are needed to obtain pain and discomfort in animal models for EM to enable the validation of new therapeutic agents with a view to the patients well being. It was the aim of this study, to establish new non invasive test systems to investigate signs of discomfort in an animal model for EM, the marmoset monkey. Assuming that painful diseases can influence the behaviour (WALLACE et al. 1990), the mobility (FLECKNELL 1986) and the cognitive abilities (SMITH et al. 2006) of animals, three non invasive test systems were reviewed for their ability to detect EM associated pain in common marmosets. They were based on behaviour (videotaping), mobility and exploratory behaviour (food tree, modified after ROBERTS et al. 1993) and cognitive abilities (Wisconsin General Test Apparatus (HARLOW 1949) and food tree). In the first part of this study, the daily activity patterns, allo- and autogrooming as well as water and food intake of nine common marmoset couples were monitored over a 12-hour light phase by video recording. The animals showed a trimodal course of activity per day with maxima from 7:00-8:00h, 11:00-12:00h and 15:00-16:00h. These activity maxima represented foraging behaviour, as they were followed by frequent food intake phases. The knowledge of the daily activity patterns allowed to optimize the experimental conditions for the tasks with the food tree and the Wisconsin General Test Apparatus (WGTA; HARLOW 1949) in the second part of this study. As every animal solved the tasks at the same time of day, the comparability and homogeneity of the results were optimized. By analysing the video documentation in the second part of this study, the females with EM, in contrast to the control females, did not show any social grooming behaviour (p=0.029). Furthermore, their activity level was almost significantly decreased (p=0.057). This reduced activity could indicate towards pain in the diseased females, while the lack of social grooming is similar to partnership problems in diseased women. The WGTA tasks revealed, that the females with EM performed significantly less trials per day in the first two settings (p=0.006/ p=0.008) and needed more trials to solve the first setting than the control animals (p=0.008). Those differences between diseased females and control animals were not detectable in the following three settings of the WGTA tasks. These results demonstrate, that EM affected marmosets have difficulties to concentrate on cognitive tasks and to cope with new situations. According to the International Primatological Society (MC CANN et al. 2007), these difficulties to cope with new situations can be interpreted as signs of distress. The food tree, a kind of jungle gym, was used to assess the animals` cognitive abilities as well as their mobility, but there were no significant differences between the EM diseased females and the control animals. In conclusion, the videotaping and the WGTA are suitable methods to demonstrate signs for impairments due to EM in marmoset monkeys. In following pharmacological studies, both test systems will allow to evaluate the benefit of new therapeutic agents on the animal model`s well being. In addition, the results of this study can help to refine procedures by replacing invasive methods like laparotomy according to the Refinement of RUSSELL and BURCH (1959).

As integrated circuits and printed circuit boards increase in complexity, testing becomes a major cost factor of the design and production of the complex devices. Testability has to be considered during the design of complex electronic systems, and automatic test systems have to be used in order to facilitate the test. This fact is now widely accepted in industry. Both design for testability and the usage of automatic test systems aim at reducing the cost of production testing or, sometimes, making it possible at all. Many design for testability methods and test systems are available which can be configured into a production test strategy, in order to achieve high quality of the final product. The designer has to select from the various options for creating a test strategy, by maximising the quality and minimising the total cost for the electronic system. This thesis presents a methodology for test strategy generation which is based on consideration of the economics during the life cycle of the electronic system. This methodology is a concurrent engineering approach which takes into account all effects of a test strategy on the electronic system during its life cycle by evaluating its related cost. This objective methodology is used in an original test strategy planning advisory system, which allows for test strategy planning for VLSI circuits as well as for digital electronic systems. The cost models which are used for evaluating the economics of test strategies are described in detail and the test strategy planning system is presented. A methodology for making decisions which are based on estimated costing data is presented. Results of using the cost models and the test strategy planning system for evaluating the economics of test strategies for selected industrial designs are presented.

Le but de cette thèse est d’étudier le diagnostic de systèmes de test utilisés en aéronautique chez AIRBUS HELICOPTERS, appelés bancs d’intégration avioniques.Les hélicoptères embarquent une vingtaine de fonctionnalités pour offrir aux clientsd’hélicoptère les fonctions qui vont lui permettre d’opérer son appareil dans toutes lesconditions de vol (visibilité réduite, accès restreint, terrain hostile, en zone de combat). Les tests d’intégration permettent de valider le système embarqué par rapport à un ensemble d’exigences définies par les autorités de certification européenne et américaine. Ils consistent à évaluer l’état des sous-systèmes avioniques au sein du système global, c’est-à-dire à l’aide de simulation de l’environnement réel de l’hélicoptère. Chez AIRBUS HELICOPTERS, pour diminuer le coût des tests réalisés sur l’hélicoptère, des tests préliminaires dans un environnement simulé, appelé banc d’intégration, sont effectués. Le banc d’intégration doit être compatible avec les différentes configurations de l’hélicoptère et les simulations de son environnement. Nous nous intéressons dans cette thèse au diagnostic du banc d’intégration avionique. La mise en œuvre de méthodes de diagnostic est indispensable pour identifier les causes de défaillances du banc d’intégration. Nous avons travaillé sur un modèle de diagnostic adapté au banc d’intégration. Les notions de diagnostic fonctionnel et structurel ont été définies et ont servi à la mise en place d’un algorithme de diagnostic. Nous avons ainsi défini des fonctions de vérification que nous avons intégrées au banc de test afin de valider notre méthode. / The aim of this thesis is to study the diagnostic of test systems used at Airbus HELICOPTERS called avionics test benches. Helicopters embark twenty features to offer helicopter customers functions that will enable to operate the aircraft in all flight conditions (reduced visibility, restricted area, hostile terrain, in a combat zone). Integration tests are used to validate the embedded system with regards to a set of requirements defined by the European and US certification authorities. The state of avionics subsystems is assessed within the overall system, that is to say, using simulation of the real environment of the helicopter. AIRBUS HELICOPTERS wants to reduce the cost of the tests of the helicopter, preliminary testing in a simulated environment, called integration benches. The integration bench must be compliant with the various configurations of the helicopter and simulation environment.We are interested in this thesis in the diagnosis of avionics integration bench. The implementation of diagnostic methods is essential to identify the causes of failures of integration benches. We work on a diagnostic model adapted to the integration bench. functional and structural diagnostic concepts were defined and used for the establishment of a diagnostic algorithm. We have defined verfications functions we have integrate on test benches to validate our method.

Endometriose (EM) ist eine häufige gynäkologische Erkrankung, die bei betroffenen Frauen unter anderem mit chronischen Unterleibsschmerzen und Unfruchtbarkeit einhergeht (VALLE 2002). Bisher war es bei den zur Forschung verwendeten Modelltieren für EM (z.B. Rhesusaffe, ZONDERVAN et al. 2004; Weißbüschelaffe, EINSPANIER et al. 2006) nicht möglich festzustellen, ob bei ihnen schmerzhafte Beeinträchtigungen durch die Erkrankung bestehen. Um die Auswirkungen neuer Therapeutika auf das Wohlbefinden der Patientinnen bewerten zu können, werden Methoden benötigt, mit denen EM bedingte Beeinträchtigungen der Modelltiere dargestellt werden können. Daher war es das Ziel dieser Studie, bei einem Primatenmodell für EM, dem Weißbüschelaffen, neue nicht invasive Testsysteme zu etablieren, die zur Darstellung von EM bedingten Schmerzen und Beeinträchtigungen geeignet sind. Unter der Annahme, dass schmerzhafte Erkrankungen das Verhalten (WALLACE et al. 1990), die Beweglichkeit (FLECKNELL 1986) sowie die kognitiven Fähigkeiten (SMITH et al. 2006) der betroffenen Tiere beeinträchtigen können, wurden drei nicht invasive Testsysteme auf ihre Eignung untersucht, Schmerzen bei an EM erkrankten Weißbüschelaffen im Vergleich zu Kontrolltieren darzustellen. Zur Untersuchung des Verhaltens wurde die Videoüberwachung, für die motorischen Fähigkeiten der Futterbaum (modifiziert nach ROBERTS et al. 1993) und für die kognitiven Fähigkeiten der Wisconsin General Test Apparatus (WGTA, HARLOW 1949) sowie der Futterbaum verwendet. Im ersten Abschnitt dieser Studie wurde das Normalverhalten von neun Weißbüschelaffenpaaren per Videokamera über den gesamten Tagesverlauf von zwölf Stunden aufgezeichnet und unter anderem in Bezug auf Aktivität, soziale und eigene Körperpflege sowie Futter- und Wasseraufnahme analysiert. Der Verlauf der Tagesaktivität zeigte drei Maxima zwischen 7:00 und 8:00 Uhr, 11:00 und 12:00 Uhr sowie 14:00 und 15:00 Uhr, dabei war die ansteigende Aktivität als Futtersuchverhalten vor den Mahlzeiten zu werten. Das im ersten Abschnitt der Studie dargestellte Aktivitätsmuster wurde im zweiten Abschnitt verwendet, um die Versuche mit WGTA und Futterbaum besser in den Tagesverlauf der Tiere einzuordnen und darüber ihre Kooperativität zu steigern. Die Tiere führten die Tests immer zur gleichen Tageszeit durch, deshalb wurde somit eine optimale Vergleichbarkeit und Homogenität der Ergebnisse gewährleistet. Bei der Auswertung der Videodokumentation im zweiten Abschnitt dieser Studie zeigte sich, dass erkrankte Weibchen ihren Partner im Gegensatz zu den Kontrolltieren gar nicht pflegen (p=0,029) und die Aktivität der erkrankten Weibchen zwar deutlich, aber nicht signifikant (p=0,057) verringert war. Diese verringerte Aktivität ist möglicherweise ein Hinweis auf Schmerzen der an EM erkrankten Weibchen, während die nicht vorhandene soziale Körperpflege den partnerschaftlichen Problemen betroffener Frauen entsprechen könnte. In den ersten beiden kognitiven Tests mit dem WGTA führten die erkrankten Weibchen signifikant weniger Versuche pro Tag durch als die Kontrolltiere (p=0,006/ p=0,008). Darüber hinaus benötigten die erkrankten Tiere signifikant mehr Versuche, um den ersten Test zu verstehen (p=0,008). Diese Unterschiede zu den Kontrolltieren ließen sich in den folgenden drei Versuchsabschnitten nicht mehr nachweisen. Daraus lässt sich ableiten, dass die Weibchen mit EM sich schlecht auf neue Anforderungen einstellen und sich weniger lange auf eine gestellte Aufgabe konzentrieren können. Nach der International Primatological Society (MC CANN et al. 2007) kann eine verminderte Fähigkeit, sich auf neue Situationen einzustellen, als Anzeichen für Beeinträchtigungen gewertet werden. Bei der Auswertung der Futterbaum Testreihen, in denen sowohl kognitive als auch motorische Fähigkeiten der Tiere mit einer Art „Kletterbaum“ überprüft wurden, ergaben sich demgegenüber keine signifikanten Unterschiede zwischen der EM-Gruppe und den Kontrolltieren. Zusammenfassend eignen sich die Videodokumentation und der WGTA zur Darstellung von Beeinträchtigungen bei an EM erkrankten Weißbüschelaffen. Die beiden Testsysteme können in folgenden pharmakologischen Studien verwendet werden, um erstmals die Auswirkungen neuer Therapeutika auf das Wohlbefinden der Modelltiere zu bewerten. Zusätzlich ermöglichen die Ergebnisse dieser Studie ein Refinement (RUSSELL und BURCH 1959), da die bisher verwendeten invasiven Methoden (Laparoskopie, Laparotomie) zur Bewertung des Verhaltens der EM Läsionen unter einer Therapie ergänzt und sogar ersetzt werden könnten.:Inhaltsverzeichnis Abkürzungsverzeichnis 1 Einleitung 1 2 Literaturübersicht 3 2.1 Endometriose 3 2.2 Tiermodelle für Endometriose 7 2.3 Methoden zur Darstellung von Beeinträchtigungen und Schmerzen bei Tieren 8 2.4 Der Weißbüschelaffe 10 3 Tiere, Material und Methoden 13 3.1 Tiere 13 3.2 Videodokumentation 16 3.3 Wisconsin General Test Apparatus (WGTA) 17 3.4 Futterbaum 20 3.5 Statistische Verfahren 22 4 Ergebnisse 24 4.1 Videodokumentation im ersten Studienabschnitt 24 4.2 Ergebnisse im zweiten Studienabschnitt 27 4.2.1 Videodokumentation 27 4.2.2 WGTA 29 4.2.3 Futterbaum 33 5 Diskussion 35 6 Zusammenfassung 41 7 Summary 43 8 Literaturverzeichnis 45 9 Anhang I 9.1 Paper „Behavioural tests as indicator for pain and distress in a primate endometriosis model“ eingereicht am 17.12.2009 bei Laboratory Animals I 9.2 Abstract zu dem Vortrag auf der 47. Wissenschaftlichen Tagung der Gesellschaft für Versuchstierkunde GV-SOLAS am 13.-15. September 2009 in Wien XIX 9.3 Abstract zu einem Poster, vorgestellt auf dem 7. Leipzig Research Festival for Life Sciences am 12. Dezember 2008 XX 9.4 Abstract zu dem Vortrag auf der 18. Tagung der DVG-Fachgruppe Physiologie und Biochemie am 9.-11. März 2008 in Leipzig XXI Danksagung / Endometriosis (EM) is a common gynecological disease, which is known to cause chronic pelvic pain and infertility in women (VALLE 2002). Up to now, it was not possible to assess, whether the animal models for research (e.g. rhesus macaque, ZONDERVAN et al. 2004; common marmoset, EINSPANIER et al. 2006) suffer from pain or impairments due to the disease. Therefore, new test systems are needed to obtain pain and discomfort in animal models for EM to enable the validation of new therapeutic agents with a view to the patients well being. It was the aim of this study, to establish new non invasive test systems to investigate signs of discomfort in an animal model for EM, the marmoset monkey. Assuming that painful diseases can influence the behaviour (WALLACE et al. 1990), the mobility (FLECKNELL 1986) and the cognitive abilities (SMITH et al. 2006) of animals, three non invasive test systems were reviewed for their ability to detect EM associated pain in common marmosets. They were based on behaviour (videotaping), mobility and exploratory behaviour (food tree, modified after ROBERTS et al. 1993) and cognitive abilities (Wisconsin General Test Apparatus (HARLOW 1949) and food tree). In the first part of this study, the daily activity patterns, allo- and autogrooming as well as water and food intake of nine common marmoset couples were monitored over a 12-hour light phase by video recording. The animals showed a trimodal course of activity per day with maxima from 7:00-8:00h, 11:00-12:00h and 15:00-16:00h. These activity maxima represented foraging behaviour, as they were followed by frequent food intake phases. The knowledge of the daily activity patterns allowed to optimize the experimental conditions for the tasks with the food tree and the Wisconsin General Test Apparatus (WGTA; HARLOW 1949) in the second part of this study. As every animal solved the tasks at the same time of day, the comparability and homogeneity of the results were optimized. By analysing the video documentation in the second part of this study, the females with EM, in contrast to the control females, did not show any social grooming behaviour (p=0.029). Furthermore, their activity level was almost significantly decreased (p=0.057). This reduced activity could indicate towards pain in the diseased females, while the lack of social grooming is similar to partnership problems in diseased women. The WGTA tasks revealed, that the females with EM performed significantly less trials per day in the first two settings (p=0.006/ p=0.008) and needed more trials to solve the first setting than the control animals (p=0.008). Those differences between diseased females and control animals were not detectable in the following three settings of the WGTA tasks. These results demonstrate, that EM affected marmosets have difficulties to concentrate on cognitive tasks and to cope with new situations. According to the International Primatological Society (MC CANN et al. 2007), these difficulties to cope with new situations can be interpreted as signs of distress. The food tree, a kind of jungle gym, was used to assess the animals` cognitive abilities as well as their mobility, but there were no significant differences between the EM diseased females and the control animals. In conclusion, the videotaping and the WGTA are suitable methods to demonstrate signs for impairments due to EM in marmoset monkeys. In following pharmacological studies, both test systems will allow to evaluate the benefit of new therapeutic agents on the animal model`s well being. In addition, the results of this study can help to refine procedures by replacing invasive methods like laparotomy according to the Refinement of RUSSELL and BURCH (1959).:Inhaltsverzeichnis Abkürzungsverzeichnis 1 Einleitung 1 2 Literaturübersicht 3 2.1 Endometriose 3 2.2 Tiermodelle für Endometriose 7 2.3 Methoden zur Darstellung von Beeinträchtigungen und Schmerzen bei Tieren 8 2.4 Der Weißbüschelaffe 10 3 Tiere, Material und Methoden 13 3.1 Tiere 13 3.2 Videodokumentation 16 3.3 Wisconsin General Test Apparatus (WGTA) 17 3.4 Futterbaum 20 3.5 Statistische Verfahren 22 4 Ergebnisse 24 4.1 Videodokumentation im ersten Studienabschnitt 24 4.2 Ergebnisse im zweiten Studienabschnitt 27 4.2.1 Videodokumentation 27 4.2.2 WGTA 29 4.2.3 Futterbaum 33 5 Diskussion 35 6 Zusammenfassung 41 7 Summary 43 8 Literaturverzeichnis 45 9 Anhang I 9.1 Paper „Behavioural tests as indicator for pain and distress in a primate endometriosis model“ eingereicht am 17.12.2009 bei Laboratory Animals I 9.2 Abstract zu dem Vortrag auf der 47. Wissenschaftlichen Tagung der Gesellschaft für Versuchstierkunde GV-SOLAS am 13.-15. September 2009 in Wien XIX 9.3 Abstract zu einem Poster, vorgestellt auf dem 7. Leipzig Research Festival for Life Sciences am 12. Dezember 2008 XX 9.4 Abstract zu dem Vortrag auf der 18. Tagung der DVG-Fachgruppe Physiologie und Biochemie am 9.-11. März 2008 in Leipzig XXI Danksagung

Doctor of Philosophy / Electrical and Computer Engineering / Anil Pahwa / Noel N. Schulz / Microgrids with distributed generators have changed how protection and control systems are designed. Protection systems in conventional U.S. distribution systems are radial with the assumption that current flows always from the utility source to the end user. However, in a microgrid with distributed generators, currents along power lines do not always flow in one direction. Therefore, protection systems must be adapted to different circuit paths depending on distributed generator sites in the microgrid and maximum fuse ampere ratings on busses. Adaptive overcurrent protection focuses on objectives and constraints based on operation, maximum load demand, equipment, and utility service limitations. Adaptive overcurrent protection was designed to protect the power lines and bus feeders of the microgrid with distributed generators by coordinating fuses and relays in the microgrid. Adaptive overcurrent protection was based on the relay setting group and protection logic methods. Non-real-time simulator (NRTS) and real-time simulator (RTS) experiments were performed with computer-based simulators. Tests with two relays in the loop proved that primary relays tripped faster than backup relays for selectivity coordination in the adaptive overcurrent protection system. Relay test results from tripping and non-tripping tests showed that adaptive inverse time overcurrent protection achieved selectivity, speed, and reliability. The RTS and NRTS with two relays in the loop techniques were described and compared in this work. The author was the first graduate student to implement real-time simulation with two relays in the loop at the Burns & McDonnell - K-State Smart Grid Laboratory. The RTS experimental circuit and project are detailed in this work so other graduate students can apply this technique with relays in the loop in smart grid research areas such as phasor measurement units, adaptive protection, communication, and cyber security applications.

Vibration testing of structures constitutes a crucial step in design and commissioning of engineering structures. The focus here is on simulating field conditions in a laboratory so that detailed investigations of the structural behavior under various future load scenarios can be carried out. A major enabling technology in recent years in this field of study, especially, in the context of earthquake engineering, and automotive testing, has been the development of servo-hydraulic actuation systems, which form the principal component of test facilities, such as, multi-axes shake tables for testing building structures under earthquake loads, multi-post testrigs for testing vehicles subjected to road loads, and reaction-wall based test systems for simulating horizontal effects of earthquake loads on building structures. These systems have enabled the conduct of systematic studies on simulation of nonlinear structures under transient loads, simulation of multi-component and spatially varying random loads, and combining numerical and experimental methods with a view to avoid scaling while testing small scale critical components of large built-up structures. The investigations reported in this thesis are in this area of research and are primarily aimed at exploring the potential of servo-hydraulic test systems to address a few intricate issues related to performance assessment of engineering vibrating systems. A broad-based overview of goals of experimental approaches in vibration engineering, including dynamic system characterization and performance assessment, is presented in Chapter 1. Also discussed are the brief details of vibration testing methods developed in the context of earthquake engineering (including quasi-static test, effective force test, shake table test, combined effective force and shake table test, various versions of pseudo-dynamic test, and real-time substructuring) and automotive vehicle testing (including input excitation based methods and response based methods). The discussion notes the remarkable success witnessed in combining mathematical methods and experimental techniques especially in problems of characterization of dynamic system properties. Similar success, however, is observed to be not wide-spread in the context of development of test methods aimed at performance assessment of vibrating systems. The review culminates with the identification of the following three problems to be tackled in the present thesis: (a) development of efficient experimental procedures to estimate time varying reliability of structures under multi-component earthquake loads and similar analysis of vehicle structures under spatially varying random road loads; the focus here is on achieving sampling variance reduction in estimating the reliability; (b) development of experimental procedures to determine optimal cross-power spectral density models of partially specified multi-component random loads so as to produce the highest and lowest response variance in a specified response variable; the focus here is on seismic tests of asymmetric structures under partially specified multi-component earthquake loads, and on characterizing optimal correlations between two parallel tracks which maximize or minimize the vehicle response; and (c) development of a modified pseudo-dynamic test procedure, to incorporate additional components in numerical and experimental modeling in terms of an augmented linearized variational equation, so as to assess and contain propagation of numerical and experimental errors. The subsequent three chapters of the thesis tackle these questions and in doing so the thesis makes the following contributions: (A) Inspired by the Girsanov transformation based Monte Carlo simulation method for estimating time-variant component reliability of vibrating systems, an experimental test procedure, which incorporates the Girsanov transformation step into its folds, has been developed to estimate the time-variant system reliability of engineering systems. The two main ingredients of application of this strategy consists of determination of a control vector, which is artificially introduced to facilitate reduction in sampling variance, and the formulation of the Radon-Nikodym derivative, which serves as the correction to be introduced in order to compensate for the addition of the artificial control. (B) In problems of response analysis of structures subjected to random earthquake loads and vibration of vehicles running on rough roads, it may not be always feasible to completely specify the external actions on the structures. In such situations, it is of interest to determine the most favorable and the least favorable responses, along with the models for missing information in the inputs which produce the extreme responses. The present study, again inspired by existing analytical solutions to this problem, develops an experimental procedure to characterize the optimal excitation models and associated responses. (C) In the context of PsD testing of nonlinear structure to earthquake loads, a refinement in the test procedure involving the treatment of a linearized variational equation is proposed. This has led to the estimation of the evolution of global error norm as test proceeds with time. The estimates of error thus obtained have been used to decide upon altering the time step of integration.

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Organizations gather enormous amounts of data and analyze these data to extract insights that can be useful for them and help them to make better decisions. Predictive data analytics is a crucial subfield within data analytics that make accurate predictions. Predictive data analytics extracts insights from data by using machine learning algorithms. This thesis presents the supervised learning algorithm to perform predicative data analytics in Embedded Test System at the Nordic Engineering Partner company. Predictive Maintenance is a concept that is often used in manufacturing industries which refers to predicting asset failures before they occur. The machine learning algorithms used in this thesis are support vector machines, multi-layer perceptrons, random forests, and gradient boosting. Both binary and multi-class classifier have been provided to fit the models, and cross-validation, sampling techniques, and a confusion matrix have been provided to accurately measure their performance. In addition to accuracy, recall, precision, f1, kappa, mcc, and roc auc measurements are used as well. The prediction models that are fitted achieve high accuracy.