Les marges conjuguées de l'Atlantique Sud sont le produit du rifting et de la rupture du continent Pangée. Ce continent présente une hétérogénéité crustale et lithosphérique importante, dont la prise en compte est un objectif de la thèse. Afin de comprendre la rupture continentale à l'échelle lithosphérique de systèmes de rhéologies préexistantes très différentes, nous avons effectué des modélisations, analogique et numérique. Les modèles analogiques s'attachent à montrer l'effet des forces externes sur un tel système hétérogène tandis que les modèles numériques, thermomécaniques, se concentrent sur l'impact des anomalies de fusion du manteau sur le rifting avec une telle configuration.Avec la modélisation analogique, l'effet des forces aux limites sur un système composé de deux segments de rhéologies différentes a été testé à l’échelle de la lithosphère pour comprendre l'influence de l'hétérogénéité rhéologique dans un système en extension. Les résultats montrent que dans un système combiné, toute l'extension se produit dans le segment faible et que le contact entre les deux segments ne joue pratiquement aucun rôle dans l'initiation des failles. Lorsque le segment le plus faible contient une couche résistante dans le manteau supérieur, le rift évolue en deux phases. La première phase montre un système de failles larges où la déformation est distribuée. Une fois que la partie résistante du manteau supérieur est suffisamment affaiblie, l'extension se localise le long d'une zone de faille étroite. Si l'extension continuait, la rupture se produirait à cet emplacement, dans une partie plutôt homogène alors que le système est latéralement hétérogène. Le résultat de ce système extensif serait des marges asymétriques avec une croûte faible/hyper-étirée sur deux marges.Les résultats numériques montrent que, dans le cas de la rupture continentale induite par un panache, le mode de rupture «central», où la rupture se localise au-dessus du point de l'impact du panache, est une forme de rupture continentale parmi d'autres. Ainsi, lorsque l'anomalie de fusion du manteau est localisée de manière décalée par rapport au contact entre les segments rhéologiques, un mode de rupture "décalé" peut se développer. Dans ce cas, le matériel du panache atteint la base de la lithosphère et s’écoule latéralement jusqu’au contact entre les deux segments rhéologiques où le rifting se localise in fine. La partie du matériel qui n’arrive pas au centre de la zone de rupture, se situe au niveau de la croûte inférieure ou bien plus profond, ressemblant aux corps de densité/vitesse élevées imagés le long des marges de l'Atlantique Sud. De plus, le mode «décalé» reproduit l'asymétrie des marges conjuguées... / The South Atlantic conjugate margins are the product of continental rifting and break-up of Pangea, which was made up of different crustal features prior to rifting. This study investigates continental rift initiation and break-up of alternative lithospheric setups, consisting of large segments with different rheological strength, with the use of analogue and numerical modelling. The analogue models investigate the effect of far-field forces on a system that consist of multiple rheological segments, whereas the numerical models include thermal processes and focus on the impact of initial plume emplacement on such a setup.Lithosphere-scale analogue models consisting of two different rheological compartments have been subjected to extensional forces, to understand effect of far-field forces on large rheological heterogeneities in a system within an extensional tectonic regime. The results show that in such a system, the weaker segment accommodates all the extension. At the contact between the two compartments no rift-initiation is observed. In the presence of a strong sub-Moho mantle, the rift evolution consists of two phases. The first phase is a wide or distributed rift event. Once the strong part of the upper mantle has sufficiently weakened, the rift localizes and a narrow rift continues to accommodate the extension. If extension would continue, break-up would happen at the location of the narrow rift, thereby breaking a rather homogenous part within a laterally heterogeneous system. This would result in asymmetric margins with hyperextended, weak crust on both margins.The numerical results show that, in the case of plume-induced continental break-up, the classical ‘central’ mode of break-up, where the break-up centre develops above the plume-impingement point is not the only form of continental break-up. When the mantle anomaly is located off-set from the contact between rheological segments, a ‘shifted’ mode of break-up may develop. In this case, the mantle plume material rises to the base of the lithosphere and migrates laterally to the contact between two rheological segments where rifting initiates. Mantle material that does not reach the spreading centre and remains at lower crustal depths, resemble high density/high velocity bodies at depth found along the South Atlantic margin and providing geometric asymmetry.Further investigation on the exact influence of the initial plume position with respect to the contact between the rheological compartments shows that there is a critical distance for which the system develops either ‘central’ (or ‘plume-induced’) continental break-up or ‘shifted’ (or ‘structural inherited’) continental break-up. For Moho temperatures of 500 – 600 oC, there is a window of ~50 km where the system creates two break-up branches. These results explain complex rift systems with both vertical penetration of plume material into the overlying lithosphere as well as reactivated inherited structures developing break-up systems both aided by the same mantle plume...

Thesis (MPH.) -- University of Limpopo, 2021 / Dry eye disease (DED) is defined as a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. It is accompanied by increased osmolality of the tear film and inflammation of the ocular surface. DED is one of the most frequently established diagnoses in ophthalmology and represents a growing public health concern, with consequences that remain widely underestimated. There is variability of clinical manifestations and diagnostic criteria which leads to poor correlation between clinical signs and symptoms, therefore resulting in difficulties to assess prevalence of DED despite an improved understanding of pathogenic factors of acquired DED. However, its prevalence has been reported to range from 74% to 33% worldwide and the current study aimed to investigate the prevalence of DED and its determinants amongst people consulting at Focus Optometrists in Kwa-Mhlanga Township in Mpumalanga Province. Methodology: The current study was quantitative in nature and it followed a cross-sectional descriptive design to address the research question. The study population were people consulting at Focus Optometrists in Kwa-Mhlanga Township in Mpumalanga Province in which two standardized optometry diagnostic tests (Schimer test and the tear film break up time) were used for data collection coupled with a comprehensive case history which was taken for all participants. Data analysis was done using the STATA statistical software version 12 for Windows (STATA Corporation, College Station, Texas). Frequency tables were used to make comparisons between groups for continuous and categorical variables using student t-test, and chi-square test. P-value less than 0.05 at 95% confidence level were regarded as significant. Results: A total of 236 participants were recruited and the mean age of the participants was 39.7 in which majority of participants were females and there was a statistical significance difference in age groups of both males and females at p-value=0.011. Majority of the participants have reported to have experience of sensitivity to light vi and foreign body sensation sometimes. The poor vision and blurred vision have been reported by majority of participants sometimes and the prevalence of dry eye disease was found to be 80.9% and the risk of the dry eye disease in the current study was found significantly increasing with old age. Those who were older (35 years above) were 4.2 times more likely to develop dry eye disease at p-value <0.001 as compared to young participants. Female gender was found not to be protective of developing dry eye disease in the current and participants who were single, having secondary and education qualifications were more likely to develop dry eye disease. Participants with ocular conditions, systemic disease, surgery and those with high blood pressure were more likely to develop dry disease Conclusion: The prevalence of dry eye disease in the current study was found to be very high and therefore, patients coming to the clinic from the age of 40 with underlying systemic diseases should be screened for dry eyes. Dry eye disease can be a major contributor of refractive error in the visual systems and or can also be a sign or a symptom of hormonal or related ocular or systemic disease. More eye care awareness should be done at primary eye care level to detect the cause or to eliminate future associated symptoms.

The master thesis introduces the topic of a period of family breakdown. It focuses on the benefits and difficulties of assisted handover of a child between parents who undergo a problematic separation. The content of the literature review section describes the development of family breakdown and the process of transformation of the family as a whole into a new phase. Emphasis is placed on the risk factors and conflicts that arise during the break-up period and on the issue of highly conflictual divorces. It covers the means of trained professionals suited to help such families allowing the resolution of disputes. The focus is on assisted handover. The empirical part of a qualitative nature maps out the central topics related to the service of assisted handover of a child from the parents' point of view. Data analysis was processed using the method of thematic analysis based on semi-structured interviews with parents using assisted child handover service. The output reflects the significant areas of the parents' split-up, as well as the benefits and difficulties of the service of assisted handover service as described by the parents using this service.

Syftet med denna uppsats var att ge en bild av kunskapsläget kring våld i nära relationer och då specifikt det våld som drabbar kvinnor i relationer med män. I fokus för uppsatsen hamnade forskningsfrågorna varför kvinnor stannar i parrelationer där våld förekommer och vad som möjliggör för kvinnor att lämna en relation där våld förekommer. Studier baserade på kvalitativa intervjuer med respondenter som har erfarenhet av våld i nära relation analyserades. Som utgångspunkt för att tolka resultaten, antogs tre olika teoretiska perspektiv vilka var följande: normaliseringsprocessen, uppbrottsprocessen och ett intersektionellt perspektiv. Genom en kvalitativ innehållsanalys, utröntes de tre olika teman: resurser, kultur, samt makt och normalisering. Faktorerna som påverkar våldsutsatta kvinnors beslut att stanna i eller lämna en våldsam relation, visade sig bland annat kunna vara resurser i form av utbildning, ekonomi, materiellt och emotionellt stöd från samhällets instanser, frivilligorganisationer samt stöd från nära vänner och familj. Kulturella övertygelser och känslomässig förbindelse till förövaren visade sig också vara påverkande faktorer. Slutsatser som kunde dras från denna uppsats var att stödet som erbjuds kvinnorna är en grundförutsättning, samt det viktiga arbetet att informera om det stöd som finns och vart den utsatta kan vända sig. Det går sedan inte att påskynda kvinnans process att lämna, utan det måste vara kvinnas eget beslut då kvinnan är redo. / The purpose of this essay was to provide an image of the state of knowledge regarding violence in intimate relationships and specifically the violence that affects women in relationships with men. The essay focused on the research questions why women stay in couple relationships where violence occurs and what makes it possible for women to leave a relationship where violence occurs. Studies based on qualitative interviews who have experience of violence in a close relationship were analyzed.  As a starting point for interpreting the results, three different perspectives were adopted which were the following: the normalization process, the break- up process and an intersectional perspective. Through a qualitative content analysis, the three different themes of resources, culture and power and normalization were found. The factors that influence the abused women´s decision to stay in or leave a violent relationship were found to be, among other things, resources in the form of education, finances, material and emotional support from both society´s bodies, voluntary organizations as well as support from close friends and family. Cultural beliefs and emotional connection to the perpetrator were also found to be influencing factors. Conclusions that could be drawn from this essay were that the support offered to women is a basic prerequisite, as well as the important work of informing about the support that is available and where the vulnerable can turn. It is then not possible to speed up the woman´s process of leaving, it must be the woman´s own decision when the woman is ready.

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Fossil fuel is an important energy source, but is unavoidabiy running out. Since the cellulosic material is the most abundant source of organic matter, the ethanol, which is produced from cellulosic waste materials, is gaining more and more attention. These materials are cheap, renewable and their availability makes them superior compared to other raw materials. The cellulose must be hydrolyzed to glucose before it can be fermented to ethanol. The enzymatic hydrolysis of cellulose using cellulase enzymes is the most widely used method. The production cost of cellulase enzymes is the major cost in ethanol manufacture. To optimize the cost of ethanol production, enzyme stability needs to be improved through maintaining the activity of the enzymes and by optimizing the production of the cellulase. The aim of researchers, engineers and industrials is to get more biomass for the same cost. The filamentous fungus Trichoderma reesei has a long history in the production of the cellulase enzymes. This production can be influenced strongly by varying the growth media and culture conditions (pH, temperature, DO, agitation,... ). At present, it is my opinion that no modelling study has included both the hydrodynamic and kinetic aspects to investigate the effect of shear and mass transfer on the morphology of microorganisms that influence the rheology of the broth and production of cellulase. This thesis presents the development of a mathematical model for cellulase production and the growth of biomass in an airlift bioreactor. The kinetic model is coupled with the methodology of two-phase flow using mathematical models based on the bubble break-up and coalescence to predict mass transfer rate, which is one of the critical factor in the fermentation. A comparison between the results obtained by the developed model and the experimental data is given and discussed. The design proposed for the airlift geometry by Ahamed and Vermette enables us to get a high mass transfer and production rate. The results are very promising with respect to the potential of such a model for industrial use as a prediction tool, and even for design.

La dépression et l’antidépresseur, phénomènes plus vastes, plus complexes que l’ordre biomédical ne l’entend, répondent à des logiques qui dépassent les seules considérations organiques, corporelles. Certaines recherches montrent d’ailleurs que ces deux entités sont autonomes l'une de l'autre, signifiant que les antidépresseurs sont prescrits pour des raisons indépendantes de la prévalence de problèmes de santé mentale. C’est dans cette optique que, dans ce mémoire, nous examinons les raisons pour lesquelles les individus ont recours aux antidépresseurs suite à une rupture conjugale. C’est à l’aide des récits de huit femmes ayant pris des antidépresseurs suite à une rupture conjugale qu’on a donc investigué les rouages du recours à ces médicaments. À la lumière des résultats, on observe effectivement que la prise d’antidépresseurs semble répondre à une logique qui soit extra–médicale. D’abord par le constat que seules trois d’entres ces huit femmes ont justifié leur prise d’antidépresseurs par la réception d’un diagnostic formel de dépression. Ensuite, par la découverte qu’elle se déploie essentiellement selon une double symbolique au centre duquel prime le lien social. En effet, on a recours aux antidépresseurs suite à une rupture conjugale parce qu’ils sont à la fois l’incarnation d’un lien de confiance avec un être semblable à soi, empathique, le médecin, et le symbole d’un retour à la vie dite ‘normale’ où les manières d’être et d’interagir sont conformes à celles du groupe auquel on s’identifie. On croit que l’importance accordée à la confiance au médecin et à la normalisation quant au recours à l’antidépresseur témoignent du resserrement des liens d’identification propre à l’individualisme contemporain lesquels, en opposition aux grands récits de jadis, sont désormais axés sur une intimité de valeurs et d’objectifs entre semblables. / Depression and antidepressants are far more complex phenomenons than the biomedical order pretends. Some research show that these two entities are independant from one another, meaning that antidepressants are prescribed for reasons independant of mental health problems. In this master’s thesis we examine why individuals have recourse to antidepressants following a relationship break-up; the relationship (marital or not) break-up being a critical situation associated with the prevalence of depression. Eight women who took antidepressants following a relationship break-up were interviewed for this study. The findings show that the recourse to antidepressants appears to respond to a logic that is non-medical. First, by the fact that only three of the eight women interviewed justified their recourse to antidepressants by receiving a diagnosis of depression. Second, by the discovery that these women relied on antidepressants because they are the embodiment of a relationship of trust with someone familiar to themselves, the doctor, and the symbol of a return to a ‘normal’ life.

O objetivo desse trabalho foi estudar a viabilidade de adaptação do Implantador Iônico da Universidade de São Paulo para a técnica de Accelerator Mass Spectrometry (AMS), tendo em vista as baixas energias utilizadas por este acelerador de partículas. A técnica de AMS, amplamente utilizada para a análise de Carbono-14 no estudo de datação de fósseis, requer que algum componente do acelerador garanta a quebra de moléculas de massa 14, contaminantes no processo de medição dos átomos de carbono com massa 14. Com a utilização de energias da ordem de dezenas de keV no acelerador, o estudo do processo de quebra de moléculas para estas energias foi realizado através do projeto, construção e caracterização de um stripper gasoso. Para caracterizar o stripper implementado foram realizadas medidas de seção de choque para troca de carga do feixe e quebra molecular em função da pressão de gás injetado no stripper. Também investigou-se a influência do átomo utilizado como gás, através de três diferentes gases injetados no stripper: Hélio, Argônio e Xenônio. Alguns feixes posivos foram produzidos no Implantador para o estudo destas seções de choques: Ar+, Ar(2+), CO+, CO2(+) e O2(+). O projeto do stripper foi idealizado para minimizar a variação de pressão no interior do implantador, visando preservar as condições da fonte de íons. Curvas de perfil de pressão de gás dentro do tubo do stripper foram calculadas segundo as teorias da Tecnologia do Vácuo que permitiram tanto a estimativa desta variação quanto a quantidade de gás no interior do stripper. Também foram realizados estudos do perfil de pressão em stripper com outras geometrias (cônicas abertas e fechadas), buscando estimar a otimização da espessura do stripper em função da injeção de gás em sua base. Baseando-se nos resultados, foram apontadas mudanças necessárias no atual estágio de adaptação desse acelerador de partículas para que se torne possível a concepção de um sistema AMS em sua linha de pesquisa. / The present work aimed on studying the feasibility of adapting the Ion Implanter of University of Sao Paulo to the Accelerator Mass Spectrometry technique, taking into account the low energies employed by this type of particle accelerator. The AMS technique, largely applied to the Carbon-14 analysis for fossil dating, requires the breaking of molecules with mass 14 by some component in the accelerator, since these lead to interference on the Carbon-14 counting process. By employing energies on the level of keV in the accelerator, the study of the breaking process of the molecules for this energy was accomplished by means desiring, building and characterization of a gaseous stripper. In order to characterize the installed stripper, measurements were taken of the charge state exchange and molecular break up process as a function of the pressure of the gas injection into the stripper. The influence of the atom employed as gas was also investigated. The experiments were realized with the following different gases: Helium, Argon and Xenon. Some positive beams were produced on the implanter: Ar+, \\Ar(2+), CO+, CO2(+) and O2(+). The designed stripper was idealized to minimize the pressure variation on the inside of the implanter in order to preserve the conditions of the ion source. Pressure profiles of the gas inside the stripper were calculated according to the Vacuum Technology theory, which allowed estimating the quantity of gas inside the stripper. Studies on the pressure profile for different stripper geometries (open and closed conic forms) were also carried out to estimate the optimization of the stripper thickness as a function of the gas injection on its base. Based on the results, specifications for further work and changes on the current system were listed to make it possible to implement the AMS system.

The overarching theme of the thesis was to investigate the association between smart device use and computer vision syndrome. The initial study designed and developed the Open Field Tear film Analyser (OFTA) enabling a continuous, real-time assessment of the tear film and blink characteristics during smart device use. The monocular OFTA prototype was validated and showed good intra- and inter-observer repeatability relative to the Oculus Keratograph 5M and Bausch and Lomb one position keratometer. Subsequently, tear osmolarity following engagement with reading and gaming tasks on smart device and paper platforms was investigated. Discrete measures of osmolarity pre- and post-engagement with the tasks were obtained with the TearLab osmometer; osmolarity values differed between platforms when participants were engaged in a gaming task but no such difference was observed with the reading task. In addition, the influence of repeated measurements on tear osmolarity was also explored. To simulate the habitual binocular viewing conditions normally associated with smart device use, the binocular OFTA was developed. The device was used to assess the tear film and blink characteristics whilst engaging with reading and gaming tasks on smart device and paper platforms. The results revealed differences in blink characteristics and non-invasive tear break up time between the different platforms and tasks assessed. In addition, the thesis also reports on an investigation examining the real-time accommodative response to various targets displayed on smart devices using an open-field autorefractor with a Badal lens system adaptation. The results showed that accommodative latency, accommodative lag, mean velocity of accommodation, speed of disaccommodation and mean velocity of disaccommodation varied across the different platforms. Through the use of validated subjective questionnaires and smartphone apps, the relationship between duration of smartphone use and symptoms of dry eye were examined. The findings of this study demonstrated that longer duration of smartphone and personal computer use were associated with higher risk of dry eyes as indicated by subjective questionnaire outcomes.

Process industries are in general depending, in one way or the other, on fluid mechanics.Specifically, paper manufacturing, which probably is the dominant processindustry in Sweden, is depending on the flow of cellulose fibres suspended in water.As a part of the process the suspension, consisting of fibres in water, is spread out onor between two moving permeable weaves, i.e. wires. The speed of this is usually 10–30 m/s and the suspension is spread out by a plane jet issuing from a headbox nozzle.It has been show that the conditions in the headbox and jet have a large influence onthe quality of the final paper sheet. Primarily, streaks in the paper sheet are believedto be the result of streamwise streaks in the headbox jet.The thesis is aimed at the flow phenomena which occur in the headbox jet. Theinvestigations have been made with numerical calculations, stability theory and modelexperiments using water, as well as experiments with a real paper machine headboxand fibre suspension. In the thesis an introduction to the hydrodynamics of planeliquid jets is presented together with a description of the paper forming process andthe fluid mechanics of headbox flow.The basic flow and stability of a two-dimensional plane liquid jet has been investigatedby numerical calculations, stability theory and experiments. The calculationsof the laminar basic flow is successfully compared to pitot-tube measurements of thestreamwise velocity profile. By visualisations of the flow it is found that wave disturbanceson the jet has a severe effect on the flow. These waves can be predicted bylinear stability theory, which shows the presence of five convectively unstable modes.These can be divided into three types and by comparison with the experiments thetype of the visible waves is determined. These waves seem to initiate a break-up ofthe jet, which leads to strong streamwise streaks inside the jet.By flow visualisation of headbox flow of an experimental paper machine, togetherwith analysis of the resulting paper structure using the wavelet method the correspondencebetween flow disturbances and paper quality was investigated. It was shownthat the wave instability, which is present on the low Reynolds number water jet, alsocan be found in the real the headbox jet. It is shown that these waves play an importantrole in the dynamics of the headbox jet and also have an influence on the final papersheet. / QC 20100825