Global ETD Search

1	Untersuchungen zur regulierbaren transgenen Expression von Ribozymen und „Antisense"-Transkripten mit dem Ziel einer Reduktion der Prm3-Expression Kämper, Martin Rolf 02 May 2001 (has links) No description available. 570 Biowissenschaften, Biologie Mathematics and Computer Science Ribozyme Antisense Tet-System transgene Mäuse 42.13 42.15 42.20
2	Untersuchungen zur Expression, Funktion und Regulation ausgewählter Gene der Insulinfamilie / Expression, functional and regulation analysis of selected genes from the Insulinfamily Shirneshan, Katayoon 03 November 2005 (has links) No description available. 570 Biowissenschaften, Biologie Mathematics and Computer Science Insulinfamilie Knock Out Transgene Mäuse Diabetes mellitus Insulin family Knockout transgenic mice Diabetes mellitus 42.23 42.20 44.48 WF WJ WK
3	Increased Aβ Production Leads to Intracellular Accumulation of Aβ in Flotillin-1-Positive Endosomes Rajendran, Lawrence, Knobloch, Marlen, Geiger, Kathrin D., Dienel, Stephanie, Nitsch, Roger, Simons, Kai, Konietzko, Uwe 05 March 2014 (has links) (PDF) Extracellular accumulation of Aβ in β-amyloid plaques is thought to be associated with the neurodegeneration observed in Alzheimer’s disease (AD) patients, although a lack of correlation with cognitive decline raised doubts on this hypothesis. In different transgenic mouse models Aβ accumulates inside the cells and mice develop behavioral deficits well before visible extracellular β-amyloid accumulation. Here we show that intracellular Aβ accumulates in flotillin-1 positive endocytic vesicles. We also demonstrate that flotillin-1 is not only associated with intracellular Aβ in transgenic mice but also with extracellular β-amyloid plaques in AD patient brain sections. / Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. Amyloidose intrazellulär Aβ multivesikuläres Körper Alzheimer-Krankheit Endozytose transgene Mäuse Reggie-1 Alzheimer’s disease Endocytosis Transgenic mice Multivesicular bodies Intracellular Aβ Amyloid Reggie ddc:610 rvk:XA 10000
4	Über die funktionelle Analyse des murinen peroxisomalen Testis-spezifischen Gen 1 (Pxt1) / On the Functional Analysis of Murine Peroxisomal Testis Specific 1 (Pxt1) Gene Kaczmarek, Karina Paulina 19 January 2010 (has links) No description available. 570 Biowissenschaften, Biologie Biology (incl. Psychology) Pxt1 Bat3 Ccdc33 Spermatogenese Peroxisomen Apoptose transgene Mäuse Pxt1 Bat3 Ccdc33 spermatogenesis peroxisomes apoptosis transgenic mice 42.13 42.20 W
5	Zur Expression und Funktion von Prm3: ein ungewöhnliches Protamin / The Expression and Function of Prm3: an unusual Protamin Boinska, Dagmara 30 October 2002 (has links) No description available. 570 Biowissenschaften, Biologie Mathematics and Computer Science Spermatogenese Protamine Transgene Mäuse Tet-System Knock-out spermatogenesis protamins transgenic mice Tet-system knockout 42.13 42.15 42.20 WF WH WJ
6	Funktionelle Untersuchungen zum PTPN11-Genprodukt SHP2 und zu PTPN11 Mutanten, die dem Noonan-Syndrom zugrunde liegen / Functional analysis of PTPN11 gene product SHP2 and of PTPN11 mutants causing Noonan Syndrome Ufartes Mas, Roser 19 January 2003 (has links) No description available. 570 Biowissenschaften, Biologie Mathematics and Computer Science Noonan Syndrom PTPN11 SHP2 Phosphatase Transgene Mäuse Noonan Syndrome PTPN11 SHP2 Phosphatase transgenic mice 42.13 42.20 WJ WF
7	Expression and functional analyses of murine Pelota (Pelo) gene / Expressions- und funktionelle Analyse des murinen Pelota (Pelo)-Gens Buyandelger, Byambajav 17 January 2007 (has links) No description available. 500 Naturwissenschaften allgemein Mathematics and Computer Science Pelota Gen konditionelle knockout mäuse transgene mäuse spermatogenese Pelota gene conditional knockout mice transgenic mice spermatogenesis; 42 WK WF WH WJ
8	The role of Lissencephaly-1 protein in male germ cell differentiation / Über die Funktion des Lissencephaly-1 Proteins in der männlichen Keimzelldifferenzierung Drusenheimer, Nadja 01 July 2009 (has links) No description available. 570 Biowissenschaften, Biologie W Mathematics and Natural Science Lis1 Spermatogenese Gene-Trap transgene Mäuse Lis1 spermatogenesis gene-trap transgenic mice genetic rescue 42.13
9	Increased Aβ Production Leads to Intracellular Accumulation of Aβ in Flotillin-1-Positive Endosomes Rajendran, Lawrence, Knobloch, Marlen, Geiger, Kathrin D., Dienel, Stephanie, Nitsch, Roger, Simons, Kai, Konietzko, Uwe January 2007 (has links) Extracellular accumulation of Aβ in β-amyloid plaques is thought to be associated with the neurodegeneration observed in Alzheimer’s disease (AD) patients, although a lack of correlation with cognitive decline raised doubts on this hypothesis. In different transgenic mouse models Aβ accumulates inside the cells and mice develop behavioral deficits well before visible extracellular β-amyloid accumulation. Here we show that intracellular Aβ accumulates in flotillin-1 positive endocytic vesicles. We also demonstrate that flotillin-1 is not only associated with intracellular Aβ in transgenic mice but also with extracellular β-amyloid plaques in AD patient brain sections. / Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. info:eu-repo/classification/ddc/610 ddc:610
10	Expression and functional analysis of <i>Tex18</i> and <i>Stra8</i> genes in male germ cells / Expressions- und funktionelle Analyse der Gene <i>Tex18</i> und <i>Stra8</i> in männlichen Keimzellen Jaroszynski, Lukasz Pawel 03 November 2005 (has links) No description available. 570 Biowissenschaften, Biologie Mathematics and Computer Science <i>Tex18</i> <i>Stra8</i> spermatogenesis spermatogonial stem cells knock-out transgenic mice <i>Tex18</i> <i>Stra8</i> Spermatogenese Männliche Keimzelle Knock-out. Transgene Mäuse 42.13 42.20 42.23 WJ WF WK

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