The subject of the diploma theses is architectonical's study of the culture and public center. It's consisted of three buildings, located in the southwestern part of the Brno dam. The objects are functionally divided into yachtclub, café with a terrace and hotel. The buildings are designed as a wave shape that are visually lined. The design consists of a steel arch truss supported by steel columns. The cladding is made of masonry Porotherm 30 P + D fixed between the steel columbs. Glassed part of the building is designed by using structural glazing which is an aluminum facade system REYNAERS CW 86/SG. The top layer of a roof is made by white Siakaplan membrane foil. The color tones are white (Sikaplan, membrane roofing terraces), brown (wood paneling) and metal (metal veneer, exterior steel staircase).

The subject of this thesis is the recalculation and alternative construction design of roofing winter stadium in Znojmo. The building has a rectangular plan with dimensions of 84 x 63 m. The existing roof structure consists of truss purlins and main truss with parabolic chord, which are carried out by a pair of steel arch with a span of 84 m. The new design is processed in two options. The first option is the structure formed by triangular arch truss girder with truss purlins. The second option is a steel lamellar vault formed by vierendeel beams. After evaluating the design options was for a detailed solution chosen the first option.

<p>Noble metal nanostructures display collective oscillation of the surface conduction electrons upon light irradiation as a form of localized surface plasmon resonance (LSPR) properties. Size, shape and the refractive index of surrounding environment are the key features that controls the LSPR properties. Surface passivating ligands have the ability to modify the charge density of nanostructures to allow resonant wavelength to match that of the incident light, a phenomenon called “plasmoelectric effect,”. According to the drude model Red and blue shifts of LSPR peak of nanostructures are observed in the event of reducing and increasing charge density, respectively. However, herein we report unusual LSPR properties of gold triangular nanoprisms (Au TNPs) upon functionalization with para-substituted thiophenols (X-Ph-SH, X = -NH₂, -OCH₃, -CH₃, -H, -Cl, -CF₃, and -NO₂). Accordingly, we hypothesized that an appropriate energy level alignment between the Au Fermi energy and the HOMO or LUMO of ligands allows delocalization of surface plasmon excitation at the hybrid inorganic-organic interface, and thus provides a thermodynamically driven plasmoelectric effect. We further validated our hypothesis by calculating the HOMO and LUMO levels and also work function changes of Au TNPs upon functionalization with para substituted thiol. We further utilized our unique finding to design ultrasensitive plasmonic substrate for biosensing of cancer microRNA in bladder cancer and owe to unpresidential sensitivity of the developed Au TNPs based LSPR sensor, for the first time we have been utilized to analysis the tumor suppressor microRNA for more accurate diagnosis of BC. Additionally, we have been advancing our sensing platform to mitigate the false positive and negative responses of the sensing platform using surface enhanced fluorescence technique. This noninvasive, highly sensitive, highly specific, also does not have false positives technique provide strong key to detect cancer at very early stage, hence increase the cancer survival rate. Moreover, the electromagnetic field enhancement of Surface-Enhanced Raman Scattering (SERS) and other related surface-enhanced spectroscopic processes resulted from the LSPR property. This dissertation describes the design and development of entirely new SERS nanosensors using flexible SERS substrate based on unique LSPR property of Au TNPs and developed sensors shows excellent SERS activity (enhancement factor = ~6.0 x 106) and limit of detection (as low as 56 parts-per-quadrillions) with high selectivity by chemometric analyses among three commonly used explosives (TNT, RDX, and PETN). Further we achieved the programable self-assembly of Au TNPs using molecular tailoring to form a 3D supper lattice array based on the substrate effect. Here we achieved the highest reported sensitivity for potent drug analysis, including opioids and synthetic cannabinoids from human plasma obtained from the emergency room. This exquisite sensitivity is mainly due to the two reasons, including molecular resonance of the adsorbate molecules and the plasmonic coupling among the nanoparticles. Altogether we are highly optimistic that our research will not only increase the patient survival rate through early detection of cancer but also help to battle the “war against drugs” that together is expected to enhance the quality of human life. </p> <p> </p>

Many physical problems lead to boundary value problems for partial differential equations, which can be solved with the finite element method. In order to construct adaptive solution algorithms or to measure the error one aims at reliable a posteriori error estimators. Many such estimators are known, as well as their theoretical foundation. Some boundary value problems yield so-called anisotropic solutions (e.g. with boundary layers). Then anisotropic finite element meshes can be advantageous. However, the common error estimators for isotropic meshes fail when applied to anisotropic meshes, or they were not investigated yet. For rectangular or cuboidal anisotropic meshes a modified error estimator had already been derived. In this paper error estimators for anisotropic tetrahedral or triangular meshes are considered. Such meshes offer a greater geometrical flexibility. For the Poisson equation we introduce a residual error estimator, an estimator based on a local problem, several Zienkiewicz-Zhu estimators, and an L_2 error estimator, respectively. A corresponding mathematical theory is given.For a singularly perturbed reaction-diffusion equation a residual error estimator is derived as well. The numerical examples demonstrate that reliable and efficient error estimation is possible on anisotropic meshes. The analysis basically relies on two important tools, namely anisotropic interpolation error estimates and the so-called bubble functions. Moreover, the correspondence of an anisotropic mesh with an anisotropic solution plays a vital role. AMS(MOS): 65N30, 65N15, 35B25

When the finite element method is used to solve boundary value problems, the corresponding finite element mesh is appropriate if it is reflects the behavior of the true solution. A posteriori error estimators are suited to construct adequate meshes. They are useful to measure the quality of an approximate solution and to design adaptive solution algorithms. Singularly perturbed problems yield in general solutions with anisotropic features, e.g. strong boundary or interior layers. For such problems it is useful to use anisotropic meshes in order to reach maximal order of convergence. Moreover, the quality of the numerical solution rests on the robustness of the a posteriori error estimation with respect to both the anisotropy of the mesh and the perturbation parameters. There exist different possibilities to measure the a posteriori error in the energy norm for the singularly perturbed reaction-diffusion equation. One of them is the equilibrated residual method which is known to be robust as long as one solves auxiliary local Neumann problems exactly on each element. We provide a basis for an approximate solution of the aforementioned auxiliary problem and show that this approximation does not affect the quality of the error estimation. Another approach that we develope for the a posteriori error estimation is the hierarchical error estimator. The robustness proof for this estimator involves some stages including the strengthened Cauchy-Schwarz inequality and the error reduction property for the chosen space enrichment. In the rest of the work we deal with adaptive algorithms. We provide an overview of the existing methods for the isotropic meshes and then generalize the ideas for the anisotropic case. For the resulting algorithm the error reduction estimates are proven for the Poisson equation and for the singularly perturbed reaction-difussion equation. The convergence for the Poisson equation is also shown. Numerical experiments for the equilibrated residual method, for the hierarchical error estimator and for the adaptive algorithm confirm the theory. The adaptive algorithm shows its potential by creating the anisotropic mesh for the problem with the boundary layer starting with a very coarse isotropic mesh.

Die Pseudomomente dienen als Charakteristikum der Annäherung der Komponenten einer Summenverteilungsfunktion gegen die Komponenten der Grenzverteilungsfunktion. In der Terminologie der Pseudomomente werden Abschätzungen der Annäherung der Summenverteilungsfunktion gegen eine unbegrenz teilbare Verteilungsfunktion angegeben. Dabei werden die Aussagen ohne die Voraussetzung der sogenannten Infinitesimalitätsbedingung hergeleitet. Es werden Abschätzungen angegeben sowohl unter der Voraussetzung endlicher Streuungen als auch ohne diese Voraussetzung. Abschließend werden einige Literaturhinweise angegeben.:1. Einleitung S. 2 2. Abschätzungen unter Voraussetzung endlicher Streuungen S. 3 3. Abschätzungen ohne die Voraussetzung über die Existenz der Streuungen S. 6 4. Beweise S. 9 5. Beispiel S. 11 Literatur S. 12 / The pseudo-moments serve as a characteristic of the approach of the components of a cumulative distribution function to the components of the limit distribution function. In the terminology of pseudo-moments estimates of the approximation of the cumulative distribution function by an indefinite divisible distribution function can be specified. The results are derived without the assumption of the so-called condition of infinitesimality. There are given some estimations with or without the assumption of finite variances. Finally some references are given.:1. Einleitung S. 2 2. Abschätzungen unter Voraussetzung endlicher Streuungen S. 3 3. Abschätzungen ohne die Voraussetzung über die Existenz der Streuungen S. 6 4. Beweise S. 9 5. Beispiel S. 11 Literatur S. 12

In diesem Artikel werden notwendige und hinreichende Bedingungen für die Gültigkeit von Grenzwertsätzen für mittlere Abweichungen untersucht. In der Terminilogie von J.V.LINNIK (1971) werden die x-Bereiche für mittlere Abweichungen gewöhnlich als "sehr enge" Zonen der integralen normalen Anziehung bezeichnet. Darüber hinaus werden die Restglieder untersucht, die in den asymptotischen Beziehungen auftreten. Die Ordnung der Konvergenzgeschwindigkeit wird angegeben. Frühere Ergebnisse einiger Autoren werden verallgemeinert. Abschließend werden einige Literaturhinweise angegeben.:1. Einleitung S. 2 2. Allgemeine Grenzwertsätze für mittlere Abweichungen mit Angabe der Ordnung der Konvergenzgeschwindigkeit S. 3 3. Die Existenz von Momenten als notwendige Voraussetzung für die Gültigkeit von Grenzwertsätzen für mittlere Abweichungen S. 7 4. Beweise S. 10 Literatur S. 16 / In this paper we study necessary and sufficient conditions for the validity of limit theorems on moderate deviations. Usually x-zones for moderate deviations are called in the terminilogy by YU.V.LINNIK (1971) "very narrow" zones of integral normal attraction. Moreover we analyse the remainder term appearing in the asymptotic relations. Informations on the order of the rate of convergence are given. Earlier results by several authors are generalized. Finally some references are given.:1. Einleitung S. 2 2. Allgemeine Grenzwertsätze für mittlere Abweichungen mit Angabe der Ordnung der Konvergenzgeschwindigkeit S. 3 3. Die Existenz von Momenten als notwendige Voraussetzung für die Gültigkeit von Grenzwertsätzen für mittlere Abweichungen S. 7 4. Beweise S. 10 Literatur S. 16

The purpose of this study was to adapt a strategic management model for use in not-for-profit organisations in Namibia. Such organisations are facing increasingly turbulent environments and strategic management has been useful for allowing them to adapt better and to remain sustainable. Not-for-profit organisations, also known as the third sector, make a significant economic contribution; a contribution which, in Namibia, amounted to 2.1% of GDP in 2015/16. However, not-for-profit organisations are largely reliant on donor funding. In Namibia, such funding has declined by 33% since 2010, accounting for just 6% of total health expenditure in 2014/15. A triangular approach to strategic management, with a strategic focus on financial sustainability, programme sustainability and people sustainability, is deemed to be the most effective way to address sustainability in not-for-profit organisations. Accordingly, a qualitative study was undertaken to investigate the way in which not-for-profit organisations that receive PEPFAR funding and operate in the field of HIV/AIDS in Namibia conduct their strategic management. A pragmatic research philosophy was followed with an abductive approach to theory development. The research strategy comprised a case study conducted within a cross-sectional time frame. Purposive sampling was used to identify the 12 research participants, with whom semi-structured interviews were conducted. Data were subsequently analysed using content and thematic analysis. The study concluded that not-for-profit organisations in Namibia carry out limited strategic management. The thematic analysis, however, showed relationships between strategic management and sustainability, strategic management and financial sustainability, strategic management and programme sustainability, and strategic management and people sustainability. A strategic management model was subsequently adapted for use in not-for-profit organisations in Namibia. This model covers the stages of strategic management, namely, the business mission, external and internal analyses, strategy formulation, programme formulation, implementation, as well as feedback and control. Additionally, the model addresses strategic management and the triangular sustainability of organisations in terms of financial, programme and people aspects, and presents the tools necessary for both external and internal analysis during strategy making. This study concludes that the use of this adapted model for strategic management will contribute to the sustainability of not-for-profit organisations in Namibia. / Business Management / D. Phil. (Management Sciences)

Entering this thesis is to design a multifunctional urban / residential building in the complex topographical situation foot street bakery. The aim was to understand the functioning of the organism, its development potential and current problems. Solved plot is located in the heart of Old Brno at the intersection of Pekařská and Anenské. The concept of development should be based on a triangular plot, and its position in relation to the nearby center. The concept of functional layout must respect the basic operational and functional requirements, especially sunlight residential space and solving noise pollution. The aim of this proposal is viable urban area and a functional recovery, which evaluates and develops the character entered. Urban and architectural concept development triangular tip should reflect and complement the character of the site appropriately and its existing buildings.

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