Global ETD Search

1	Studium cytotoxicity vybraných chemoterapeutik určených pro léčbu leukémie na lidských nádorových buněčných liniích. / Study of the cytotoxicity of selected chemotherapeutics for the treatment of leukemia in human tumor cell lines. Štorkánová, Jesika January 2019 (has links) Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Bc. Jesika Štorkánová Supervisor: RNDr. Eva Novotná, Ph.D. Title of diploma thesis: Study of the cytotoxicity of selected chemotherapeutics for the treatment of leukemia in human tumor cell lines Leukemia represents a diverse group of malignant diseases with a hematopoietic disorder with different prognoses. As the incidence of patients with leukemia is increasing, is an effort to establish the treatment that will lead to successful therapy. One of the basic approaches to the treatment of leukemias is chemotherapy. Today it is known that the effectiveness of chemotherapy is influenced by a number of factors which can significantly affect the treatment strategy and thus decide on the outcome of the treatment itself. An important approach in chemotherapy is the selection of cytostatics with maximum efficacy for oncological disease and elimination cytostatics to which the cells are resistant based on the findings in in vitro conditions. The aim of this diploma thesis was to determine the inhibitory effects of in vitro selected chemotherapeutics in cell tumor lines. For determine the inhibitory effect, HCT116, HepG2 and HL-60 cell lines were selected using a colorimetric method based on the...
2	Cytotoxicity effects of metal oxide nanoparticles in human tumor cell lines Lozano, T., Rey, M., Rojas, E., Moya, S., Fleddermann, Jakob, Estrela-Lopis, Irina, Donath, Edwin, Wang, B., Mao, Z., Gao, C., González-Fernández, África 27 July 2022 (has links) Metallic and metal oxide nanoparticles (Nps) have a wide range of applications in various settings including household, cosmetics and chemical industries, as well as for coatings. Nevertheless, an in-depth study of the potential toxic effects of these Nps is still needed, in order to fulfill the mandatory requirement of ensuring the safety of workers, patients and the general public. In this study, Quick Cell colorimetric assays were used to evaluate the in vitro toxicity of different metal oxide Nps [Fe(II,III)Ox, TiOx, ZnO and CeO2] in several cell lines. The ZnO Nps were found to be highly toxic, with a lethal dose ≥100 μg/ml for all the cell lines studied. Western blot was also used to test the ability of the different Nps to activate the complement pathway. However, no activation of this cascade was observed when the Nps were added. In addition, the aggregation state and charge of the Nps in culture media was studied by dynamic light scattering (DLS) and measurement of zeta potential. Transmission Electron Microscopy was used to analyze Np uptake and localization at the cellular level. info:eu-repo/classification/ddc/530 ddc:530
3	Die Regulation der humanen H3-Histongene / The regulation of the human histone H3 genes Kössler, Heiner 06 November 2003 (has links) No description available. 570 Biowissenschaften, Biologie Mathematics and Computer Science Histon H3 Histongene Histongen-Expression Genregulation Transkriptionsregulation Promotoranalyse Tumorzelllinien Epigenetik CCAAT-Box CBF/NF-Y histone H3 histone gene histone gene expression gene regulation transcriptional regulation promoter analysis tumor cell lines epigenetics CCAAT-box CBF/NF-Y 42.13 42.15 WF

1

Page generated in 0.0817 seconds