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The effects of interplanetary shock impact angles have the potential to have far reaching consequences. By their nature, interplanetary shocks are a direct consequence of a variety of solar events including both Coronal Mass Ejections (CMEs) and Co-rotating Interaction Regions (CIRs). They have the ability to move the magnetopause, the boundary between the Earth's magnetosphere and the surrounding plasma, leading to ionospheric current systems and an enhanced ring current. Their association with a time-varying EMF also makes them potentially dangerous at a human level. This EMF can couple to electrical currents in technological infrastructure that can overload transformers, communication cables, and power grids. As IP shocks have the potential to have a large impact on our society, research to further our understanding of these events is prudent. We know that shocks can couple to currents and ULF waves in the magnetosphere-ionosphere system. Much of the current research into their behaviors has been focused on models and simulations and has indicated that the shock impact angle should affect the properties of the waves. To investigate the potential influence of the impact angle, data from a series of Antarctic magnetometers was collected and compared to a database of known interplanetary shocks to determine when the response to different shocks was detected at the magnetometer. For this investigation, we were concerned with determining what impact if any, the impact angle of the IP shock had on the generation of Pc5 waves. To that end, the power spectra both before and after the shock was calculated. This information was then combined with the shock impact angle to determine what effects if any, the shock impact angle had on Pc5 wave occurrence rates. From our research, it was determined that the impact angle of the interplanetary shock had a significant impact on the occurrence rate and properties of Pc5 waves observed by high-latitude ground magnetometers. / Master of Science / Interplanetary shocks, drive interactions between the solar wind and the Earth’s atmosphere, and they have the potential to have far reaching consequences. Caused by a variety of solar events including both Coronal Mass Ejections (CMEs) and Co-rotating Interaction Regions (CIRs), they have the ability to physically move the locations of regional boundaries of the ionized part of Earth’s atmosphere, leading to a variety of electromagnetic effects. They also pose a danger at the human level by generating electrical currents in technological infrastructure that can overload transformers, communication cables, and power grids. As they pose a danger to our society, understanding them is prudent. A large portion of the current research into their behaviors has been focused on models and simulations and has shown that the shock impact angle should affect the properties of the waves. For this investigation, data from a series of Antarctic sensors was collected and compared to a database of known interplanetary shocks to determine when different shocks were detected. Specifically, for our investigation, we were concerned with determining what impact if any, the impact angle of the IP shock had on the generation of Pc5 waves, a specific type of ULF wave. This was accomplished by calculating the power level at different frequencies both before and after the shock. This information was then combined with the shock impact angle to determine what effects if any, the shock impact angle had on Pc5 wave occurrence rates. From our research we found that the impact angle of the interplanetary shock had a significant impact on the generation of Pc5 waves.

Ultra-Low-Voltage operation, which can be considered an extreme case of voltage scaling, can greatly reduce the power consumption of circuits. Despite the fact that Ultra-Low-Voltage operation has been proven to be very effective by several successful prototypes in recent years, there is no fast, effective, and comprehensive technique for designers to estimate power and delay of a design operating in the Ultra-Low-Voltage region. While some frameworks and mathematical models exist to estimate power or delay, certain limitations exist, such as being applicable to either power or delay, or within a certain region of transistor operation. This thesis presents a simulation framework that can quickly and accurately characterize a circuit from nominal voltage all the way down into the subthreshold region. The framework uses the nominal frequency and power of a target circuit, which can be obtained using gate-level or transistor-level simulation tools as well as normalized ring oscillator curves to predict delay and power characteristics at lower operating voltages. A specific contribution of this thesis is to introduce a weighted average method, which is a major improvement to a previously published form of this framework. Another contribution is that the amount of process variation in ULV regions of a circuit can be estimated using the proposed framework. The weighted averages framework takes into account the types of gates that are used in the circuit and critical path to give a more accurate power and timing characterization. Despite being many orders of magnitude lower than the nominal voltage, the errors are no greater than 11.27 percent for circuit delay, 16.96 percent for active energy, and 4.86 percent for leakage power for the weighted averages technique. This is in contrast to the original framework which has a maximum error of 39.75, 17.60, and 8.90 percent for circuit delay, active energy, and leakage power, respectively. To validate our framework, a detailed analysis is given in the presence of a variety of design parameters such as fanout, transistor widths, et cetera. In addition, we also validate our framework for a range of sequential benchmark circuits. / Master of Science

This thesis focuses on specific crypto algorithms, Message Authentication Codes (MACs), running on ultra-low SWaP devices. The type of MACs we used is hash-based message authentication codes (HMAC) and cipher-block-chaining message authentication code (CBC-MAC). The most important thing about ultra-low SWaP devices is their energy usage. This thesis measures different implementations' execution times on ultra-low SWaP devices. We could understand which implementation is suitable for a specific device. In order to understand the crypto algorithm we used, this thesis briefly introduces the concept of hash-based message authentication codes (HMAC) and cipher-block-chaining message authentication code (CBC-MAC) from a high level, including their usage and advantage. The research method is empirical research. This thesis determines the execution times of different implementations. These two algorithms (HMAC and CBC-MAC) contain three implementations. The result comes from those implementations running on the devices we used. / Master of Science / The deployments of 5G cellular networks are now onboard. The demand increased due to consumers and the availability of more affordable devices. The amount of investment in 5G technology and infrastructure increases market interest in IoT. The 5G network security is essential. How to secure user privacy and their sensitive data while they use 5g network has become a big issue and needs to be solved. However, not all popular crypto algorithms are suited to all devices, especially in those resource-limited microcontrollers. In this thesis, we will deal with Message Authentication Codes that provide the data integrity check. With resource limit devices, energy usage is an important issue. We will identify which implementations have better energy usage depending on the device features. This thesis will use three implementations for each algorithm. The result of our experiment provide a straightforward way that helps people understand which implementation can run more efficiently on specific ultra-low devices.

Este trabalho propõe novas topologias de circuitos e técnicas de projeto para filtros ativos e amplificadores de ganho programável (PGA) com operação em ultra baixa tensão (ULV) e ultra-baixa potência (ULP). Os receptores de RF do tipo Bluetooth de baixa energia (BLE), utilizados nos circuitos de internet das coisas (IoT), são as aplicações alvo dos circuitos propostos neste trabalho. Na faixa de ULV são utilizados filtros do tipo RC-ativo, uma vez que possuem uma maior linearidade em relação aos filtros do tipo gmC. A operação em ULP é alcançada neste trabalho utilizando uma nova topologia de amplificador operacional de transcondutância (OTA), com único estágio, que apresenta uma alta eficiência e reduzida sensibilidade às variações de processo, tensão e temperatura (PVT). O baixo ganho de tensão do amplificador de estágio único e os efeitos das cargas resistivas de realimentação são compensados usando um transcondutor negativo, robusto a variações em PVT, conectado às entradas do OTA. A faixa dinâmica dos circuitos é elevada usando topologias totalmente diferenciais e as taxas de rejeição de modo comum e de fonte de alimentação são melhoradas utilizando circuitos de realimentação de modo-comum. Para possibilitar a operação na faixa de ULV todos os circuitos usam apenas dois transistores empilhados e o nível de inversão do canal é elevado através da polarização direta do substrato. Neste trabalho são propostas também uma ferramenta de análise do ponto de operação do transistor, baseando-se na simulação elétrica, e algumas metodologias de projetos para circuitos operando em ULV. Os circuitos e metodologias desenvolvidos foram utilizados para o projeto de um filtro passa-faixa complexo RC-ativo de terceira ordem, um amplificador de ganho programável e um filtro biquadrático do tipo Tow-Thomas com ganho programável, compatíveis com receptores de RF do padrão BLE. Para a implementação do PGA, uma nova topologia de transconductor negativo programável foi desenvolvida para permitir a compensação ótima do amplificador operacional em todos os modos de ganho. Todos os circuitos foram projetados para operar com uma tensão de alimentação de 0,4 V e foram prototipados em processos de fabricação CMOS e BiCMOS de 180 nm e 130 nm, respectivamente. Os resultados experimentais e de simulação pós-layout demonstram uma operação adequada em 0,4 V, uma ultra-baixa dissipação de potência, atingindo o mínimo de 10.9 ?W/polo, e a melhor figura-de-mérito (FoM) em relação aos outros filtros ativos e amplificadores disponíveis na literatura. / This thesis proposes novel circuit topologies and design techniques of ultra-low voltage (ULV) and ultra-low power (ULP) active-filters and programmable gain amplifiers (PGA) suitable for the Bluetooth low energy (BLE) RF receivers used in the Internet of Things (IoT) applications. The active-RC filters are preferred to the gm-C topologies at the ULV operation due to its improved linearity. However, the closed-loop operation increases the operational amplifier required voltage gain and its capacity to drive the resistive feedback load. In this work, the ULP dissipation is obtained by proposing a very efficient single-stage inverter-based operational transconductance amplifier (OTA) and a proper forward bulk biasing to reduce the sensitivity to process, voltage and temperature (PVT) variations. The low voltage gain and the resistive load effects on the single-stage OTA are completely compensated by using a PVT robust negative transconductor connected at the OTA inputs. The dynamic range is increased by using fully-differential topologies and common-mode feedback to improve the common-mode and power supply rejection rates. The operation at the ULV range is reached by using only two-stacked transistors in all the circuit implementations and bulk forward bias in some transistors to reduce the threshold voltage and to increase the channel inversion level. An operation point simulation-based tool and some design methodologies are also proposed in this work to design the ULV circuits. The proposed circuits were used to design a third-order active-RC complex band-pass filter (CxBPF), a programmable gain amplifier (PGA) and a Tow-Thomas biquad, with integrated programmable gain capability, suitable for BLE RF receivers. The PGA implementation uses a new programmable input negative transconductor to obtain the optimal closed-loop amplifier compensation in all the gain modes. The circuits were designed to operate at the power supply voltage of 0.4 V and are prototyped in 180 nm and 130 nm low-cost CMOS and BiCMOS process, respectively. The experimental and post-layout simulation results have demonstrated the proper ULV operation at 0.4 V, the ultra-low power dissipation down to 10.9 ?W/pole and the best figure-of-merit (FoM) among the state-of-the-art active-filters and amplifiers from the literature.

Master of Science / Department of Electrical and Computer Engineering / William B. Kuhn and Balasubramaniam Natarajan / This thesis presents an energy harvesting wireless sensor network (EHWSN) architecture customized for use within a space suit. The contribution of this research spans both physical (PHY) layer energy harvesting transceiver design and appropriate medium access control (MAC) layer solutions. The EHWSN architecture consists of a star topology with two types of transceiver nodes: a powered Gateway Radio (GR) node and multiple energy harvesting (EH) Bio-Sensor Radio (BSR) nodes. A GR node works as a central controller to receive data from BSR nodes and manages the EHWSN via command packets; low power BSR nodes work to obtain biological signals, packetize the data and transmit it to the GR node. To demonstrate the feasibility of an EHWSN at the PHY layer, a representative BSR node is designed and implemented. The BSR node is powered by a thermal energy harvesting system (TEHS) which exploits the difference between the temperatures of a space suit's cooling garment and the astronaut's body. It is shown that through appropriate control of the duty-cycle in transmission and receiving modes, it is possible for the transceiver to operate with less than 1mW power generated by the TEHS. A super capacitor, energy storage of TEHS, acts as an energy buffer between TEHS and power consuming units (processing units and transceiver radio). The super capacitor charges when a BSR node is in sleep mode and discharges when the node is active. The node switches from sleep mode to active mode whenever the super capacitor is fully charged. A voltage level monitor detects the system's energy level by measuring voltage across the super capacitor. Since the power generated by the TEHS is extremely low(less than 1mW) and a BSR node consumes relatively high power (approximately 250mW) during active mode, a BSR node must work under an extremely low duty cycle (approximately 0.4%). This ultra-low duty cycle complicates MAC layer design because a BSR node must sleep for more than 99.6% of overall operation time. Another challenge for MAC layer design is the inability to predict when the BSR node awakens from sleep mode due to unpredictability of the harvested energy. Therefore, two feasible MAC layer designs, CSA (carrier sense ALOHA based)-MAC and GRI (gateway radio initialized)-MAC, are proposed in this thesis.

Ultra-low doses (ULD) of the opioid receptor antagonists, naloxone and naltrexone, augment the analgesic actions of morphine, block the induction of tolerance, and reverse established tolerance by an unknown mechanism. Preclinical studies demonstrate that chronic morphine administration induces spinal gliosis and that inhibition of gliosis prevents the development of analgesic tolerance to opioids. Thus, this thesis investigated the inhibition of spinal gliosis as a mechanism by which ULD antagonists attenuate analgesic tolerance and opioid-induced hyperalgesia. Immune cell activation is implicated in the etiology of morphine tolerance and intrathecal catheterization, a technique commonly used to study the spinal effects of drugs, causes profound gliosis. Thus, the first study investigated the effects of catheter-induced gliosis on acute and chronic morphine analgesic tolerance. Catheterization-induced gliosis did not alter antinociceptive responses to acute intrathecal morphine; however, tolerance to chronic morphine was exacerbated in catheterized rats compared to sham and surgery-naïve controls. The potentiation of analgesic tolerance to chronic morphine by spinal gliosis provided evidence that glia modulate opioid analgesia; therefore, inhibition of opioid-induced activation of glia was explored as a potential mechanism by which ULD antagonists prevent tolerance. The second series of experiments reported morphine-induced activation of spinal microglia and astrocytes was blocked by co-administering ULD naltrexone with morphine. These findings prompted us to elucidate the specific molecular target through which ULD antagonists attenuate opioid analgesia. Activation of glial Toll-like receptor 4 (TLR4) induces gliosis and may contribute to analgesic tolerance and/or morphine-induced hyperalgesia (MIH). Antagonism of TLR4 by the opioid receptor-inactive (+) stereoisomer of naloxone was identified as a potential mechanism by which ULD antagonists modulate opioid analgesia. Tolerance and MIH developed in mice expressing non-functional TLR4 and in wildtype controls. Analgesic tolerance was stereoselectively blocked by ULD (-)naloxone, whereas MIH was blocked by both naloxone enantiomers. Collectively, these studies demonstrate analgesic tolerance and MIH occur through distinct mechanisms. ULD naloxone attenuates analgesic tolerance likely via an opioid receptor-mediated mechanism that is TLR4-independent. ULD antagonists do not attenuate tolerance via inhibition of spinal gliosis as hypothesized. In contrast, ULD antagonists prevent MIH by inhibiting opioid-induced gliosis in an opioid receptor- and TLR4-independent manner. Immune cell activation is implicated in the etiology of morphine tolerance and intrathecal catheterization, a technique commonly used to study the spinal effects of drugs, causes profound gliosis. Thus, the first study investigated the effects of catheter-induced gliosis on acute and chronic morphine analgesic tolerance. Catheterization-induced gliosis did not alter antinociceptive responses to acute intrathecal morphine; however, tolerance to chronic morphine was exacerbated in catheterized rats compared to sham and surgery-naïve controls. The potentiation of analgesic tolerance to chronic morphine by spinal gliosis provided evidence that glia modulate opioid analgesia; therefore, inhibition of opioid-induced activation of glia was explored as a potential mechanism by which ULD antagonists prevent tolerance. The second series of experiments reported morphine-induced activation of spinal microglia and astrocytes was blocked by co-administering ULD naltrexone with morphine. These findings prompted us to elucidate the specific molecular target through which ULD antagonists attenuate opioid analgesia. Activation of glial Toll-like receptor 4 (TLR4) induces gliosis and may contribute to analgesic tolerance and/or morphine-induced hyperalgesia (MIH). Antagonism of TLR4 by the opioid receptor-inactive (+) stereoisomer of naloxone was identified as a potential mechanism by which ULD antagonists modulate opioid analgesia. Tolerance and MIH developed in mice expressing non-functional TLR4 and in wildtype controls. Analgesic tolerance was stereoselectively blocked by ULD (-)naloxone, whereas MIH was blocked by both naloxone enantiomers. Collectively, these studies demonstrate analgesic tolerance and MIH occur through distinct mechanisms. ULD naloxone attenuates analgesic tolerance likely via an opioid receptor-mediated mechanism that is TLR4-independent. ULD antagonists do not attenuate tolerance via inhibition of spinal gliosis as hypothesized. In contrast, ULD antagonists prevent MIH by inhibiting opioid-induced gliosis in an opioid receptor- and TLR4-independent manner. / Thesis (Ph.D, Pharmacology & Toxicology) -- Queen's University, 2013-04-25 15:06:50.731

Analisa-se no presente trabalho o problema das medidas de relaxação dielétrica a U.B.F. (Ultra Baixa Frequência). Propõe-se um modelo de ponte para tais medidas capaz de varrer o intervalo 10-3 Hz-10Hz, baseada na medida de fase conforme a discussão original de Van Turnhout e colaboradores. Analisa-se também os principais problemas experimentais com tal equipamento de U.B.F. e descreve-se a sua construção e funcionamento. Analisa-se também o modelo teórico de correlação entre medidas de U.B.F. e descarga de eletreto com correntes termo-estimulado. Em particular calculamos uma correção para a expressão integral dado por Van Turnhout e colaboradores que leva em conta a influência da energia de ativação na correlação entre as duas técnicas. Tal conversão é significante para valores da energia de ativação menor que 0,5eV e que ocorrem experimentalmente com frequência / In the present work we investigate the problem of U.L.F. (Ultra Low Frequency) dielectric relaxation. An experimental model is proposed for a bridge covering the range of 10-3Hz-10Hz, based on phase shift measurements originally proposed by Van Turhout and collaborators. We also analyze the main experimental problems with such U.L. F. measurements and describe its construction and performance. We have also investigated the theoretical correlation between U.L.F. dielectric relaxation and electret thermal stimulated currents. We calculate in particular, a correction for the integral expression given by Turnhout and collaborators that takes into account the value of the activation energy in the relation between the two techniques. The correction is important for values of the activation energy below 0,5eV, which occur frequently in dielectric relaxation processes

No presente trabalho descreve-se: a determinação da permitividade dielétrica complexa através de medidas de fase; a aplicação de técnicas de correlação e análise em séries de Fourier, para a determinação da fase, amplitude, qualidade e deformação do sinal atrasado; os circuitos eletrônicos do medidor de fase e do oscilador de U.B.F. programável; a programação desenvolvida em FORTRAN IV e MACRO-ASSEMBLER para o computador PDP 11/45, utilizado para operar o medidor de fase e o oscilador de U.B.F. / In the present work we describe: the determination of the complex dielectric permittivity by phase shift measurements; the application of correlation and Fourier series analyses to determine the phase shift, amplitude, quality and deformation of the shifted signal; the designed electronic hardware of the phase meter and programmb1e ultra-low frequency oscillator; the developed software written in FORTRAN IV and MACRO- ASSEMBLER for PDP 11/45, to operate the phase meter