The recombinant Hepatitis B surface antigen vaccine inadequately protects those living with HIV from Hepatitis B virus infection. This study utilized saved serum samples from a retrospective cohort of persons with HIV and documented vaccine-induced HBsAb seroconversion to determine factors associated with persistence of protective levels of HBsAb (≥10mIU/ml). HBsAb levels fell below 10mIU/ml in 27% of the cohort after a median follow-up of 43 months. HIV viral load suppression (<50copies/ml) at the time of vaccination was the major factor associated with persistence of protective levels of HBsAb (OR 3.83, p <0.01). Among individuals who lost protective levels of HBsAb, booster doses of vaccine re-instated the development of protective levels of HBsAb. Delaying or repeating HBV vaccination until after suppression of HIV viral load is achieved should be considered HBV antibody levels should be followed over time and boosters given with loss of protective levels of HBsAb.

Human Papilloma virus (HPV) can lead to cervical cancer, a common form of cancer in Sweden and globally. A vaccine has been developed for the most carcinogenic strains of HPV. In Sweden it is planned that the vaccine be included in the public national vaccination program for children. The aim of this study was to illustrate attitudes towards future sexual habits and preventive cervical cancer screening among young women and parents of girls vaccinated against HPV. This study is a part of a larger project where interviews with young women aged 17 to 26 years and parents of girls aged 13 to 17 years compose the foundation. In this study the interviews were analysed with qualitative latent content analysis, all together 21 interviews. The main result was that in both groups it was generally thought that neither future sexual habits nor participation in cervical cancer screening would be considerably affected. The young women however had deficient knowledge about what they were vaccinated against and the purpose of cervical cancer screening. The parents had better understanding. Accurate information about HPV, the HPV vaccine and cervical cancer screening in connection with vaccination is important for the outcome of future sexual habits and participation in cervical cancer screening. / Humant papillomvirus (HPV) kan leda till cervixcancer som är en vanlig cancersort både i Sverige och globalt. Ett vaccin har utvecklats mot de mest onkogena HPV-typerna. I Sverige ska HPV-vaccinet ingå i det allmänna nationella vaccinationsprogrammet för barn. Syftet med studien var att belysa inställningen till framtida sexualvanor och gynekologiska cellprovskontroller (GCK) bland unga kvinnor och föräldrar till flickor som HPV-vaccinerats. Denna studie är en del av ett större projekt där intervjuer med unga kvinnor 17-26 år samt med föräldrar till flickor 13-17 år utgör grunden. I denna studie analyserades intervjuerna med kvalitativ latent innehållsanalys, sammanlagt 21 intervjuer. Det huvudsakliga resultatet som framkom var att majoriteten av de unga kvinnorna och föräldrarna till flickorna inte trodde att framtida sexualvanor skulle förändras samt att deltagande i framtida GCK inte skulle påverkas nämnvärt. Det framkom dock att de unga kvinnorna hade bristfälliga kunskaper om vad de var vaccinerade emot och vad GCK var. Föräldrarna till flickorna hade större kunskap om vad vaccinering och GCK innebar än de unga kvinnorna. Vikten av rätt sorts information om HPV, HPV-vaccin och GCK i samband med vaccination framkom som ett betydande resultat för utfallet för de framtida sexualvanorna och deltagandet i GCK.

Two experiments were performed to evaluate effects of amprolium administration at specific times and concentrations in replacement broiler breeders of three genetic lines vaccinated against coccidiosis. Effects on performance parameters including body weight and flock uniformity, and post-vaccination oocyst cycling patterns were evaluated in addition to development of immunity following clinical Eimeria challenge according to gross and microscopic lesion scoring, post-challenge body weight gain (BWG), and total oocyst output. Experiment one was conducted on fresh pine shavings while experiment two was conducted on used litter remaining in treatment pens from the first trial. No significant differences were seen among treatment groups with regard to body weight in either trial. Increased magnitude of oocyst shedding was observed in trial one, Line A with the group receiving amprolium on day 10. Trends in the data indicated increased uniformity in Line A related to amprolium administration following day 21. The group in Line A receiving amprolium at day 10 showed a significantly lower degree of total oocyst output following challenge than the other medicated groups. The group receiving amprolium on day 10 in Line B showed significant reduction in post-vaccination oocyst shedding following treatment in both trials while all shedding was delayed in trial two when compared to the first trial. Effects on uniformity in Line B pullets varied between trials with trends indicating it being advantageous when used litter was a factor. Higher post-challenge BWG was observed in Line B pullets administered the low concentration at day 16 than the controls. Reductions in gross lesion development were seen in Line B pullets in both trials. Line C pullets receiving the highest concentration of amprolium at day 16 showed significantly less uniformity in trial one while the controls appeared to perform better than all medicated groups in trial two. All medicated groups in Line C exhibited delayed and increased magnitudes of oocyst shedding in trial two. These data indicate that the effects of amprolium on performance and immunity development are variable according to genetic strain and indicated that administration may be influenced by litter condition.

The purpose of this research was to investigate selected methods of mucosal immunization for commercial chickens. Induction of mucosal immunity in commercial chickens through the use of orally administered subunit vaccines or through immunomodulation of the host??s response to live vaccines may be a viable means to control enteric infections in commercial poultry. In the present investigations we evaluated a means for delivering protein antigen in the drinking water and the use of CpG-ODNs, a recently reported mucosal adjuvant, in order to both improve this response and to modulate the host??s immune response when vaccinated with field strains of Eimeria acervulina and Eimeria tenella. In order to evaluate the efficacy of immunizing commercial poultry with subunit vaccines through the drinking water we chose the model antigen Bovine Serum Albumin (BSA). Chicks were administered BSA via intraperitoneal (I.P.) injection, oral crop gavage, or orally through the addition of BSA to the drinking water. These experiments demonstrated the efficacy of drinking water administration to induce antibodyproduction in the serum, intestine, and bile. When BSA was co-administered with CpGODNs we observed a modest increase in this response dependent upon dose. To evaluate the immunomodulation of the host response to live parasite using CpG-ODNs we used three administration models. The first was a single dose of CpGODNs with a trickle immunization regime of Eimeria acervulina. The second was coadministration of CpG-ODNs with a clinical dose of Eimeria acervulina or tenella. The third was pre-administration of CpG-ODNs 24 hours prior to the clinical dose of either species. These studies demonstrate that the first and third models were effective in reducing lesions and improving performance.

Objective¡G Influenza is an important public health problem, and may seriously damage the elderly population. Although influenza vaccination is a safe, and can significantly reduces morbidity and influenza -related complication mortality in elderly people, however, the influenza vaccination rate did not reach expected goals. Therefore, to explore the potential factors that affect the vaccination rate becomes a critical research question. The purpose of this study was to apply the Health Belief Model, which includes demographic, health state and healthy behaviour, knowledge about influenza and influenza vaccine, perceived susceptility, perceived seriousness, perceived benefit and barrier, and cues to action variables, to understand factors motivating the community elderly people to receive influenza vaccination. Design: The sampling designs were stratified and systematic sampling with total 700 sample. During June 2007 , a structured questionnaire was sent to the elderly people¡]¡Ù65 years¡^in Kaohsiung city¡C Result: The male and female sample distribution rates were equally in 50%, average age was 72.87 years old and 59.6% elderly people had chronic disease (such as hypertension, heart disease and diabetes). Chi-square tests showed that ¡§chronic disease¡¨, ¡§health examination¡¨, ¡§always seek care from specific physician¡¨, ¡§exercise ¡§, ¡§ recognize about influenza and influenza vaccination¡¨, ¡§ perceived seriousness¡¨, ¡§ perceived benefit and barrier¡¨, were significantly associated with having ever been vaccinated. Logistic regression results indicated that ¡§think the influenza vaccination can effectively prevent influenza¡¨, ¡§regular health examination¡¨, ¡§cues to action¡¨ and ¡§perceived barriers¡¨ were found to be the significant predictors of acceptance of influenza vaccination. Conclusions¡GThe study results indicated that health care worker¡¦s attitude about influenza and influenza vaccination will directly influence community elderly people's cognition. Therefore, by educating the health care worker about influenza seriousness and the vaccination effectiveness may successfully promote vaccination rate. Through health education activities in the community, it may increase correct cognition about influenza and the benefit of vaccination. In addition, the health department needs to strengthen the health policy marketing in order to increase influenza vaccinations rate, reduce morbidity and influenza -related complication mortality.

Reproduction de : Thèse de doctorat : Sciences animales : Toulouse, INPT : 2006. / Titre provenant de l'écran-titre. Bibliogr. 295 réf.

Reproduction de : Thèse de doctorat : Sciences agronomiques : Toulouse, INPT : 2006. / Titre provenant de l'écran-titre. Bibliogr. 202 réf.

Thesis (M.A.)--East Carolina University, 2009. / Presented to the faculty of the Department of Health Education and Promotion. Advisor: Sharon M. Knight. Title from PDF t.p. (viewed May 4, 2010). Includes bibliographical references.

published_or_final_version / Community Medicine / Master / Master of Public Health

published_or_final_version / Nursing Studies / Master / Master of Nursing