Digital dermatitis is a top cause of lameness in dairy cattle that results in ulcerative lesions on the feet. Topical salicylic acid has been shown to provide similar efficacy to the antibiotic drugs used previously, but there is no milk withholding time established in the United States. The objective of this study was to provide data in order to establish this withholding period. A secondary objective was to evaluate outcomes among treatments. Treatment groups were topical applications of the following drugs: salicylic acid paste, salicylic acid powder, and tetracycline. The lesions were scored at day 0, day 7, and day 28 post-treatment. Milk samples were collected the day before treatment, 4 hours, 8 hours, 24 hours, 36 hours, and 48 hours post-treatment. Results indicated that most cows did not show detectable levels of salicylic acid after 24 hours.

The aim of this study sets out to better understand nephrology nurses’ lived experiences of dying and deaths of patients with ESKD following withdrawal of dialysis. A qualitative research design using an interpretative phenomenological approach was used to explore the experiences of a purposive heterogeneous sample of eight nephrology nurses who were working in private dialysis units. Information was gathered by phenomenological conversations and feed-back sessions. Colaizzi’s phenomenological method was employed to formulate four main themes: 1. Emotional trauma 2. Detachment 3. Loss of altruistic values in nursing 4. being-with-death For the participants in this study, emotional trauma was the most significant. The participants experienced a sense of powerlessness which caused emotions of hopelessness and anger and subsequently a sense of premature mourning and detachment. This state of hopelessness proved to be an obstacle in patient care, resulting in the altruistic values of nursing to be no longer applied. The participants’ ontological confrontation of being-with-death was evident, as they came to terms with the reality of their own death. Recommendations are offered to address the educational aspects of death and dying for nephrology nurses. This study endorses the need for further research into patients with ESKD ‘end-of-life’ which can influence how healthcare professionals should treat these patients during this phase.

Indiana University-Purdue University Indianapolis (IUPUI) / Mu opioid receptors (MORs) mediate the analgesic and rewarding effects of opioids. Most research has focused on MORs in GABAergic neurons; however, MORs are also in glutamatergic neurons and their role in opioid-related behaviors was unclear. Our lab previously showed that MORs inhibit glutamate transmission from vesicular glutamate transporter 2 (vGluT2)-expressing thalamostriatal synapses. The behavioral relevance of MORs in vGluT2-expressing neurons was unknown; therefore, I utilized a conditional MOR knockout mouse with MORs deleted in vGluT2-expressing neurons (MORflox-vGluT2cre). MORflox-vGluT2cre mice have disrupted opioid reward, locomotor stimulation, and withdrawal, compared to cre-recombinase negative littermate controls. However, other MOR-mediated behaviors, including opioid-induced antinociception, alcohol reward, and palatable substance consumption are intact. MORs are expressed in vGluT2 neurons in several reward-related brain regions, including the thalamus and lateral habenula (LHb). To determine whether MORs in these brain regions modulate opioid-related behaviors, an adeno-associated viral (AAV) vector encoding cre-recombinase was stereotaxically injected into the thalamus or LHb of MORflox mice to specifically delete MORs in these brain regions. Opioid reward and locomotor stimulation remained intact in both thalamic and LHb MOR knockout mice; however, basal locomotor activity was increased in LHb MOR knockout mice. Sucrose consumption was also intact in LHb MOR knockout mice. Interestingly, in LHb MOR KO mice opioid withdrawal-induced paw shakes were increased, while withdrawal-induced jumping was completely ablated. Our lab previously showed that MORs inhibit glutamate transmission from the anterior insular cortex (AIC), which is disrupted by in vivo alcohol exposure. To determine the role of AIC MORs, AIC MORs were deleted with AAV vectors. AIC MOR knockout mice had intact opioid, sucrose, and alcohol reward, but had increased basal locomotor activity. MORs in glutamatergic neurons are critical mediators of opioid reward; however, the specific glutamatergic neurons mediating the rewarding effects of opioids remains to be determined.

This study investigated effects of pilot-hole diameter, screw penetration depth depth, embedded screw orientation, magnitude of pushing-down force and turning speed on screw driving torques in particleboard (PB) and predicted screw driving torques for two PB clamped together. In addition, effects of material mechanical properties such as shear and tensile strength on screw direct withdrawal loads in PB were investigated and a model to predict screw direct withdrawal load capacity was developed. Furthermore, effects of screw driving torques on clamping pressure between two particleboards were investigated. It was concluded in general that stripping torques (STT) per thread for driving screws into tested PB materials had significantly higher means than seating torque (SET) per thread. The SET and STT per thread for screws driven into PB materials with 0.75-inch penetration depth was higher than 0.50-inch depth when no pilot-hole or pilot-holes with diameter of 1/8 in were drilled. Statistical analyses on screw driving torques for two PB materials clamped together, illustrated that the SET and STT tended to increase when the pilot-hole diameter decreased from 11/64 to 1/16 in. The prediction of the SET and STT values of driving screws through a face into an edge of PB materials can be predicted by the connection of two separate PB materials between a single face specimen with countersink in the surface and a single edge specimen. In addition, a face into a face PB connection, the prediction of both SET and STT can be predicted by connection of two separate face specimens. Results on shear and internal bond (IB) strength demonstrated that there was a clear trend that the shear and IB strengths were higher in the surface of the particleboards than the other levels. In the case of screw direct withdrawal (SDW), the results illustrated that the SDW values of particleboard types did not differ from each other when the pilot-hole diameters of 1/8 and 9/64 in used to drive the screw into the material.

Objectives The purpose of this study was to describe 30 people’s testimonies of their journeys from drug addiction to drug withdrawal in Taiwan. World Drug Report estimates the number of opioid users at 53 million, up 56 % from previous estimates, and that opioids are responsible for two thirds of the 585,000 people who died as a result of drug use in 2017. Methods This was a qualitative research design. The sample inclusion criteria: 1. Participants had drug abused experiences. 2. Participants received Christian Gospel Drug Withdraw Program. 3. Participants did their testimonies in the Good TV True Blog. There were 30 participants’ testimonies related to their drug withdrawn by gospel interventions during 2012-2020. These stories were posted on the Good TV channel in Chinese language in Taiwan that were written down by the author and translated from Chinese to English. The main themes were generated in this study. Results There were 24 male (80%) and 6 Female (20%) in this study. The mean age was 50.93 (SD = 10.47) (Range = 26-65). The major themes were (1) Using illegal drugs: Lack of knowledge and temptations (2) Drug addiction: An endless pain circle (3) Turning points: Love and Hope (4) Drug withdraw: Overcome the Temptations and Holy Spirit (5) Outcome: Faith and New Life. These 30 participants drug withdrew successfully, became Christians and started their new lives as well as helped other people quit drug and any other addiction. Discussion These are powerful testimonies to support that the gospel drug withdrawal programs and church activities are effective to help people drug withdrawal. These programs can be used in the Mental Health Nursing professions. Early education related to the negative impact of illegal drugs in the school is very important to prevent people’s drug addiction.

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Researchers have recognized that social withdrawal in early childhood is a complex and multifaceted construct which includes three main observed subtypes: reticence, solitary-passive withdrawal, and solitary-active withdrawal. Each is differentially associated with children's behavioral outcomes in Western societies (e.g., United States, Canada). Furthermore, potential gender differences may exist regarding the distinct associations between non-social behavior and indices of maladjustment across boys and girls due to differential societal and cultural gender-role expectations. Previous studies suggest that subtypes of observed social withdrawal can be identified in Chinese preschoolers. It is important to examine the behavioral correlates of observed withdrawn subtypes in the Chinese cultural context due to the social-cultural variations in what is considered as socially acceptable/adaptable behaviors between North America and China. Therefore, the purpose of this study was to examine the various behavioral correlates of different forms of nonsocial play among Chinese preschoolers and potential gender differences in the linkages. Teachers of 506 preschoolers from two cities in mainland China completed a battery of questionnaires that assessed various aspects of child behavioral outcomes in early childhood, including social withdrawal, assertiveness-prosociability, aggression, impulsive/disruptive behaviors, and anxiousness. Measurement models estimated with two-group confirmatory factor analyses yielded invariant factor structures for boys and girls for each of the behavioral measures. Distinct patterns of associations were found among behavioral correlates of subtypes of observed social withdrawal across boys and girls. Solitary-passive play was negatively associated with prosocial behaviors for girls and boys, positively related to impulsive behaviors for girls and boys, and negatively associated with victimization and anxious behavior for girls, but not boys. Solitary-active play was found to be negatively related to prosocial behaviors, positively associated with physical aggression, victimization, impulsive, and anxious behavior for girls and boys. Reticence was associated with less prosocial behavior for boys and girls. It was also positively associated with victimization, impulsiveness, and anxious behaviors for girls (but not boys). These gender difference findings and their implications for child adjustment in the Chinese cultural context are discussed.

While there has been research published on social withdrawal during childhood, little work has been done on the effects of social withdrawal during emerging adulthood. Since emerging adulthood is a time of transition and initiation to new environments and social contexts, it would be expected to be a time of great anxiety for individuals predisposed to social withdrawal (shyness). Shyer emerging adults are at risk for internalizing behaviors, lowered self-concept, and delayed entry into romantic relationships, therefore, they may also be more challenged when it comes to enacting prosocial behaviors. In addition, the inability to self-regulate emotions may mediate this relationship. This study utilized a sample of 774 college students (538 women, 236 men; 79% Caucasian; M = 20 years old) to test these hypotheses. Results showed that emerging adults who were more socially withdrawn were less likely to exhibit prosocial behaviors toward strangers, friends, and family members. In addition, results showed that the inability to self-regulate emotions, or cope, mediated this relationship in all cases. Implications include the salience of emotional self-regulation as a prerequisite to prosocial behavior directed toward multiple others and the possibly detrimental influence of shyness on relationship and community involvement during emerging adulthood.

Language serves as a mechanism through which children are able to interact and communicate with their others. Thus, when children do not produce language at a typical pace, there may be cause for concern. The primary purpose of the current study was to examine the language abilities of children displaying various forms of social withdrawal and children engaging in subtypes of aggression. Participants came from the Brigham Young University Child Laboratory (N = 141; Mage = 4.57; 53% female) and were observed and teachers and parents completed reports on children's behaviors and demographics. Results revealed reticent and solitary-passive children to produce less language compared to their non-withdrawn peers and comorbid aggressive children to produce more language compared to their non-aggressive, physically aggressive and relationally aggressive peers. I then discuss contextual and conceptual factors that may play a role in understanding the relation between language production, social withdrawal and aggression.

Language serves as a mechanism through which children are able to interact and communicate with their others. Thus, when children do not produce language at a typical pace, there may be cause for concern. The primary purpose of the current study was to examine the language abilities of children displaying various forms of social withdrawal and children engaging in subtypes of aggression. Participants came from the Brigham Young University Child Laboratory (N = 141; Mage = 4.57; 53% female) and were observed and teachers and parents completed reports on children's behaviors and demographics. Results revealed reticent and solitary-passive children to produce less language compared to their non-withdrawn peers and comorbid aggressive children to produce more language compared to their non-aggressive, physically aggressive and relationally aggressive peers. I then discuss contextual and conceptual factors that may play a role in understanding the relation between language production, social withdrawal and aggression.