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Previous issue date: 2013-03-04 / Acute wheezing is a leading cause of hospitalization in infants. Previous studies have described a difference in the severity of the disease depends on the virus identified in a sample of air, but some studies show conflicting results. This study is therefore to evaluate the relationship between the causative pathogen of lower respiratory tract infection (LRTI) and length of stay in a sample of infants from Porto Alegre. The nasopharyngeal specimens for testing of respiratory viruses by immunofluorescence and polymerase chain reaction were collected between 09/2009 and 09/2011. We recruited patients at the Hospital S?o Lucas diagnosed with LRTI. We analyzed 122 samples from patients with LTRI, and of these, 65 (51.2%) were positive for respiratory syncytial virus infection (RSV). Besides these samples, 15 were positive for influenza, 5 to rhinovirus, parainfluenza to 10, 3 to metapneumov?rus and 3 for adenovirus. When we used length of stay as a marker of severity, patients with RSV were, on average, 6.74 ? 4.39 days hospitalized, while patients infected with other viruses were only 4.97 ? 2.64 days hospitalized, on average; this difference was statistically significant. However, when we used other risk factor as family history of asthma, number of siblings and sex, there was no significant difference. The study demonstrated high overall positive tests for virus, with the predominance of RSV. The study suggests that RSV may be considered as a risk factor for ITRI severity / As crises de sibil?ncia desencadeadas por v?rus est?o entre as principais causas de interna??o hospitalar em lactentes. Estudos pr?vios descreveram uma diferen?a na severidade da doen?a dependente do v?rus identificado em amostra de via a?rea, por?m alguns trabalhos apresentam resultados conflitantes. Este estudo tem, portanto, o objetivo de avaliar a rela??o entre o pat?geno causador da infec??o e tempo de interna??o, em uma amostra de lactentes de Porto Alegre. As amostras de secre??o nasofar?ngea para pesquisa de v?rus respirat?rios por imunofluoresc?ncia direta (IFD) e polymerase chain reaction (PCR) foram coletadas no per?odo 09/2009 e 09/2011. Foram recrutados pacientes internados no Hospital S?o Lucas da PUCRS com diagn?stico de infec??o do trato respirat?rio inferior (ITRI). Foram analisadas 122 amostras de pacientes com ITRI, e destas, 65 (51,2%) foram positivas para infec??o por v?rus sincicial respirat?rio (VSR). Al?m destas amostras, 15 foram positivas para influenza, 5 para rinov?rus, 10 para parainfluenza, 3 para metapneumov?rus e 3 para adenov?rus. Quando utilizamos o tempo de interna??o como um marcador de gravidade, pacientes com VSR ficaram, em m?dia, 6,74 ? 4,39 dias internados, enquanto pacientes sem VSR ficaram apenas 4,97 ? 2,64 dias internados, em m?dia, sendo esta diferen?a estatisticamente significativa. Por?m quando avaliados outros fatores de risco como hist?ria familiar de asma da m?e, n?mero de irm?os e sexo n?o houve uma diferen?a significativa. O estudo demonstrou uma positividade geral elevada para v?rus, com a predomin?ncia do VSR. Este estudo indica a possibilidade de que a infec??o por VSR possa influenciar marcadores gravidade em lactentes com ITRI
| Identifer | oai:union.ndltd.org:IBICT/oai:tede2.pucrs.br:tede/1416 |
| Date | 04 March 2013 |
| Creators | Silva, Jacqueline Ramos da |
| Contributors | Pinto, Leonardo Ara?jo |
| Publisher | Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Programa de P?s-Gradua??o em Medicina/Pediatria e Sa?de da Crian?a, PUCRS, BR, Faculdade de Medicina |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da PUC_RS, instname:Pontifícia Universidade Católica do Rio Grande do Sul, instacron:PUC_RS |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 3098206005268432148, 500, 600, -8624664729441623247 |
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