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Previous issue date: 2009-12-17 / Visceral leishmaniasis (VL) has a wide geographical distribution in tropical and subtropical areas of the planet, which is a protozoan parasite of the genus Leishmania. This pathogen is transmitted to the host through the sandflies bite, with its saliva, the immune response that leads to both. In the state of Rio Grande do Norte, 85% of the sand flies captured is Lutzomyia longipalpis, but the second most abundant, Lutzomyia evandroi, it deserves emphasis because its wide distribution and eclectic behavior. The exposure of people living in endemic areas for the insect vector VL greatly increases the chances of infection. This study aimed to evaluate aspects of the epidemiological profile of VL in endemic areas of human and nonendemic in the metropolitan area of Natal, as well as verify the abundance and seasonal fluctuations of sandflies species in two counties endemic for VL. Were collected in the municipalities of N?sia Floresta, Parnamirim, S?o Gon?alo do Amarante and Maca?ba, of which groups of females were separated for further dissection of the salivary glands and identification of species. The blood samples used were from individuals of two Natal s districts where it has never been reported cases of VL and neighborhoods of Parnamirim applicants who present cases of VL. In the municipality of N?sia Floresta, the most abundant species was L. evandroi with 38.39%, followed by L. longipalpis with 36.22%, L. walkeri 19.67% L. lenti 3.81%, L. wellcomei 1.39% and L. whitmani 0.52%. Already in Parnamirim the proportions were L. walkeri with 73.15%, L. evandroi with 10.55%, L. wellcomei 7.63%, L. longipalpis 6.37%, L. whitmani 1.46%, L. sordellii 0.52%, L. intermedia 0.21 and L. shanonni 0.1%. In both municipalities was observed higher abundance of species distributed in the initial months of the year, as February and March. The study showed that no difference in exposure to the vector of VL among individuals from endemic and non endemic area for this disease. But there are differences in exposure between individuals of L. longipalpis and L. evandroi, confirming the great powers of the first vector. It was also characterized as predominant phenotype in the population of endemic areas who had negative serologic responses to antigens of Leishmania and
result in negative Montenegro skin test (DTH), indicating that much of the population hasn t been bitten by infected insects / A Leishmaniose visceral (LV) tem vasta distribui??o geogr?ficas nas ?reas tropicais e subtropicais do planeta, cujo parasito ? um protozo?rio do g?nero Leishmania. Esse pat?geno ? transmitido aos hospedeiros atrav?s da picada do flebotom?neo, juntamente com sua saliva, o que leva resposta imunol?gica a ambos. No estado do Rio Grande do Norte, 85% da fauna flebotom?nica capturada corresponde a Lutzomyia longipalpis, por?m o segundo mais abundante, Lutzomyia evandroi, vem merecendo destaque devido ao seu comportamento ecl?tico e ampla distribui??o. A exposi??o de pessoas residentes em ?rea end?mica para a LV ao inseto vetor aumenta grandemente as chances de infec??o. O presente trabalho teve como objetivo avaliar aspectos do perfil epidemiol?gico de LV de ?rea end?mica e n?o end?mica na Regi?o Metropolitana de Natal, assim como verificar a abund?ncia e flutua??o sazonal de esp?cies de flebotom?neos em dois munic?pios end?micos para a LV. Foram realizadas coletas nos munic?pios de N?sia Floresta,
Parnamirim, S?o Gon?alo do Amarante e Maca?ba, dos quais foram separados grupos de f?meas para posterior disseca??o das gl?ndulas salivares e identifica??o das esp?cies. As amostras de sangue utilizadas foram provenientes de indiv?duos de dois bairros de Natal onde nunca fora relatado casos de LV e de bairros de Parnamirim que apresentam casos recorrentes de LV. No munic?pio de N?sia Floresta, a esp?cie mais abundante foi L. evandroi com 38,39%, seguida de L. longipalpis com 36,22%, L. walkeri 19,67%, L. lenti 3,81%, L. wellcomei 1,39% e L. whitmani 0,52%. J? em Parnamirim, as propor??es foram L. walkeri com 73,15%, L. evandroi com 10,55%, L. wellcomei 7,63%, L. longipalpis 6,37%, L. whitmani 1,46%, L. sordellii 0,52%, L. intermedia 0,21 e L. shanonni 0,1%. Em ambos munic?pios foi observado maior abund?ncia de esp?cies distribu?dos nos meses inicias do ano, como Fevereiro e Mar?o. O estudo mostrou que n?o h? diferen?a na exposi??o ao vetor da LV entre indiv?duos de ?rea end?mica e n?o end?mica para essa enfermidade. Por?m h? diferen?a na exposi??o de indiv?duos entre L. longipalpis e L. evandroi, confirmando a grandiosa compet?ncia vetorial do primeiro. Tamb?m foi poss?vel caracterizar como fen?tipo mais predominante na popula??o de ?rea end?mica aqueles que apresentavam respostas sorol?gicas negativas para ant?genos de Leishmania e resultado negativo no teste cut?neo de Montenegro (DTH), indicando que boa parte da popula??o est? sendo picada por insetos n?o infectados
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/12559 |
| Date | 17 December 2009 |
| Creators | Cavalcanti, Katrine Bezerra |
| Contributors | CPF:20007256434, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4786307T7&dataRevisao=null, Rocha, Hugo Alexandre de Oliveira, CPF:76111830449, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4799567J8&dataRevisao=null, Brand?o Filho, Sinval Pinto, CPF:16093275434, http://lattes.cnpq.br/8035260974761693, Ximenes, Maria de F?tima Freire de Melo |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Bioqu?mica, UFRN, BR, Bioqu?mica; Biologia Molecular |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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