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Previous issue date: 2013-01-22 / Aim: The aim of this study was to evaluate the progress of cognitive functions (memory; focused attention; executive, visual and spatial functions; language and processing speed), emotional aspects (depression; anxiety), fatigue, and motor ability of lower and upper limbs in patients with multiple sclerosis, and their association with time and severity of disease.Methods: A cohort study with a comparison group. The sample was composed of 54 patients with a diagnosed of multiple sclerosis followed for 1-4 years in an neuroimmunology outpatient clinic, as compared to a control group of 30 individuals. As from the second year of the study, 33 patients and a group of 32 control individuals were evaluated using the Multiple Sclerosis Functional Composite (MSFC) measure. The cognitive performance was evaluated through psychological tests: Digits, Cubes, Vocabulary, Memory of Wechsler Scale-III, Stroop Test, Boston Naming Test, phonological and semantic Verbal Fluency, Clock Drawing, Mini Exam of Mental State (MEMS), Beck s Anxiety and Depression Inventories, Fatigue Scale (MFIS), and the MSFC.Results: There was a significant impairment of immediate and delayed verbal memory and phonological verbal fluency (FAS) in the group with multiple sclerosis, as well as lower performance than the controls in visual memory, sustained attention, working memory, processing speed and motor functions. The Expanded Disability Status Scale (EDSS) was found to be significantly correlated with tests of general cognitive evaluation (MEMS and estimated IQ), memory tests (immediate and delayed, visual and verbal), fluency tests (FAS and Animals), and executive function test (Stroop). No correlation was found of any of the neuropsychological tests with time of disease. Delayed memory and fluency were significantly correlated with depressive symptoms.Conclusion: A statistically significant correlation was found between the results of general cognition evaluations, of the findings from all tests of Memory of the Wechsler Scale, of the Verbal Fluency tests and of the Stroop test (attention and processing speed) and the scales that measure the severity of disease. Concerning the motor function, the patients with MS showed a major loss in motor ability of upper limbs. There is deterioration of the cognitive functioning associated with the progression of the disease in patients with Multiple Sclerosis. A combination of cognitive, emotional and physical aspects should be considered in evaluating patients with multiple sclerosis, without dissociating their functionality / Objetivo: este estudo teve como objetivo principal avaliar a evolu??o das fun??es cognitivas (mem?ria, aten??o concentrada, fun??es executivas e viso-espaciais, linguagem e velocidade de processamento), aspectos emocionais (depress?o e ansiedade), fadiga e habilidade motora dos membros superiores e inferiores nos pacientes portadores de esclerose m?ltipla e sua associa??o com tempo e gravidade da doen?a.Metodologia: Estudo de coorte com grupo de compara??o. A amostra foi constitu?da por 54 pacientes acompanhados de 1 a 4 anos no ambulat?rio de neuroimunologia com diagn?stico de esclerose m?ltipla, comparados a um grupo controle constitu?do por 30 indiv?duos. A partir do 2o ano do estudo, 33 pacientes e um grupo de 32 indiv?duos controles tamb?m foram avaliados com a bateria MSFC (―Multiple Sclerosis Functional Composite measure‖). O desempenho cognitivo foi avaliado atrav?s dos testes neuropsicol?gicos: D?gitos, Cubos, Vocabul?rio, Mem?ria Wechsler Scale-III, Teste de Stroop, Teste de Nomea??o de Boston, Flu?ncia Verbal Fonol?gica e Sem?ntica, Desenho do Rel?gio, Mini Exame do Estado Mental, Invent?rios de Ansiedade e Depress?o de Beck, Escala de Fadiga-MFIS e a bateria MSFC.Resultados: Houve comprometimento significativo da mem?ria verbal imediata e tardia e fluencia verbal fonol?gica (FAS) no grupo com esclerose m?ltipla, bem como menor desempenho em compara??o com os controles na mem?ria visual, aten??o sustentada, mem?ria de trabalho, velocidade de processamento e fun??es motoras. Foi observada uma correla??o significativa do EDSS com os testes de avalia??o cognitiva global (MEEM e QI estimado), os testes de mem?ria (imediata e tardia, visual e verbal), os testes de flu?ncia (FAS e Animais) e com o teste de fun??es executivas (Stroop). N?o se observou correla??o de nenhum dos testes neuropsicol?gicos com o tempo de doen?a. As mem?rias tardias e a flu?ncia apresentaram uma correla??o significativa com os sintomas depressivos.Conclus?o: Foi encontrada uma correla??o estatisticamente significativa entre os resultados das avalia??es globais de cogni??o, dos achados de todos os testes de Mem?ria da Escala Wechsler, dos testes de Flu?ncia Verbal e do Teste Stroop (aten??o e velocidade de processamento) com as escalas que avaliam a gravidade da doen?a. Em rela??o ? fun??o motora, os pacientes com EM apresentaram uma perda mais importante na habilidade motora dos membros superiores. Ocorre deterioro do funcionamento cognitivo associado ? progress?o da doen?a em pacientes portadores de Esclerose M?ltipla. A combina??o de aspectos cognitivos, emocionais e f?sicos devem ser considerados na avalia??o destes pacientes, sem dissociar a sua funcionalidade
| Identifer | oai:union.ndltd.org:IBICT/oai:tede2.pucrs.br:tede/1720 |
| Date | 22 January 2013 |
| Creators | Pereira, Adriana Gutterres |
| Contributors | Silva Filho, Irenio Gomes da |
| Publisher | Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Programa de P?s-Gradua??o em Medicina e Ci?ncias da Sa?de, PUCRS, BR, Faculdade de Medicina |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da PUC_RS, instname:Pontifícia Universidade Católica do Rio Grande do Sul, instacron:PUC_RS |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 7620745074616285884, 500, 600, -8624664729441623247 |
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